Acid Proteases Structure Function And Biology

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Acid Proteases: Structure, Function, and Biology

Author : Jordan Tang
Publisher : Springer Science & Business Media
ISBN 13 : 1475707193
Total Pages : 350 pages
Book Rating : 4.4/5 (757 download)

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Book Synopsis Acid Proteases: Structure, Function, and Biology by : Jordan Tang

Download or read book Acid Proteases: Structure, Function, and Biology written by Jordan Tang and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 350 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the past ten years, a number of proceedings of symposia on the structure and function of proteolytic enzymes have been pub lished. Their coverage of acid proteases has been limited, mainly due to the lack of significant new information on the structure of these enzymes. In the last four years, however, the primary and tertiary structures of a number of acid proteases have been deter mined, prompting the need to discuss the meanings of the old data and the possibilities for new experimentations. It was for this purpose that the "Conference on Acid Proteases: Structure, Function, and Biology" was organized. It took place at the University of Oklahoma on November 21-24, 1976. This book is a collection of the main lectures delivered at the Conference. Acid Proteases, by definition refers to a group of proteases having an optimal pH in acidic solutions. The classic examples are pepsin and chymosin. Some catalytic features are obviously shared by these proteases, most notably, their inhibition by pepstatin. The use of active center-directed inactivators such as diazoacetyl norleucine methyl ester and 1,2-epoxy-3-(p-nitrophenoxy)propane has shown that two catalytic aspartyl residues are present in most of these enzymes. These apparent cornmon features have prompted the suggestion by several investigators to name this group of enzymes "aspartyl proteases" or "carboxyl proteases".

Acid Proteases

Author : Jordan Tang
Publisher :
ISBN 13 : 9781475707205
Total Pages : 370 pages
Book Rating : 4.7/5 (72 download)

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Book Synopsis Acid Proteases by : Jordan Tang

Download or read book Acid Proteases written by Jordan Tang and published by . This book was released on 2014-01-15 with total page 370 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Structure–Function Relationships of Proteolytic Enzymes

Author : P. Desnuelle
Publisher : Elsevier
ISBN 13 : 1483261174
Total Pages : 310 pages
Book Rating : 4.4/5 (832 download)

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Book Synopsis Structure–Function Relationships of Proteolytic Enzymes by : P. Desnuelle

Download or read book Structure–Function Relationships of Proteolytic Enzymes written by P. Desnuelle and published by Elsevier. This book was released on 2014-05-10 with total page 310 pages. Available in PDF, EPUB and Kindle. Book excerpt: Structure–Function Relationships of Proteolytic Enzymes provides information pertinent to the fundamental aspects of proteolytic enzymes. This book presents the historical role of proteolytic enzyme as a group in protein and enzyme chemistry. Organized into 23 chapters, this book begins with an overview of the results obtained from investigation on the chymotrypsinogens of porcine origin. This text then examines the differences of amino acid sequence between chymotrypsin, trypsin, and elastase that affect the substrate binding site, which reflect the specificity differences between these enzymes. Other chapters consider the kinetic parameters related to the trypsin-catalyzed hydrolysis of several model peptides. This book discusses as well the acetylation of trypsin, which result in functional consequences varying from complete inactivation to promotion of activity. The final chapter deals with the physical properties of stem bromelain in comparison with the data for three other sulfhydryl proteases of plant origin. This book is a valuable resource for enzymologists, microbiologists, and biochemists.

Mechanisms of Catalysis

Author :
Publisher : Academic Press
ISBN 13 : 9780080865966
Total Pages : 459 pages
Book Rating : 4.8/5 (659 download)

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Book Synopsis Mechanisms of Catalysis by :

Download or read book Mechanisms of Catalysis written by and published by Academic Press. This book was released on 1991-01-28 with total page 459 pages. Available in PDF, EPUB and Kindle. Book excerpt: The remarkable expansion of information leading to a deeper understanding of enzymes on the molecular level necessitated the development of this volume which not only introduces new topics to The Enzymes series but presents new information on some covered in Volume I and II of this edition.

Mechanisms of Protease Action

Author : Laszlo Polgar
Publisher : CRC Press
ISBN 13 : 9780849369018
Total Pages : 236 pages
Book Rating : 4.3/5 (69 download)

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Book Synopsis Mechanisms of Protease Action by : Laszlo Polgar

Download or read book Mechanisms of Protease Action written by Laszlo Polgar and published by CRC Press. This book was released on 1989-01-31 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt: A uniform treatment of the four protease groups and a discussion of the differences and similarities in their action is presented in this important new publication. Serine, cysteine, aspartate, and zinc proteases are systematically discussed by nomenclature, evolution, specificity and their regulatory role. The chemistry of the peptide bond, including the catalysis of ester and peptide hydrolyses, is explained. For each protease group the emphasis is placed on the structure and function. Kinetics, enzyme modifications, isotope effects, subzero temperature investigations, nuclear magnetic resonance measurements, X-ray diffraction data, binding of transition-state analogs, zymogen activation, and site-specific mutagenesis are combined to rationalize the action of proteases. Both natural and synthetic inhibitors are considered because of their importance in mechanistic studies and drug design.

Molecular Biology of The Cell

Author : Bruce Alberts
Publisher :
ISBN 13 : 9780815332183
Total Pages : 0 pages
Book Rating : 4.3/5 (321 download)

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Book Synopsis Molecular Biology of The Cell by : Bruce Alberts

Download or read book Molecular Biology of The Cell written by Bruce Alberts and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Aspartic Proteinases

Author : Kenji Takahashi
Publisher : Springer Science & Business Media
ISBN 13 : 1461518717
Total Pages : 614 pages
Book Rating : 4.4/5 (615 download)

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Book Synopsis Aspartic Proteinases by : Kenji Takahashi

Download or read book Aspartic Proteinases written by Kenji Takahashi and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 614 pages. Available in PDF, EPUB and Kindle. Book excerpt: The 5th International Conference on Aspartic Proteinases was held on September 19 through 24, 1993, at Naito Museum of Pharmaceutical Science and Industry, Kawashima cho, Gifu Prefecture, Japan, about 15 miles northwest of Nagoya City. About 100 scientists attended the conference, including 52 from 14 countries outside Japan, and 32 papers were presented by invited speakers, and 58 papers as posters. The purpose of this conference was to present and discuss new information on the structure, function, and biology, and related topics, including biomedical implications, of aspartic proteinases, and this book is a collec tion of nearly all the papers presented at the meeting. Aspartic proteinases belong to one of the four major classes of proteinases, the others being serine, cysteine, and metalloproteinases, and are so called since they have two catalytic aspartic acid residues in common in their active sites. Most of them are optimally active at acidic pH, hence the long-used name "acid proteinases," which, indeed, was the major title of the first conference of this series. However, some of them are active at around neutral pH, indicating their physiological roles in a wider range of pH than hitherto considered.

Structure and Function of the Aspartic Proteinases

Author : Ben M. Dunn
Publisher : Springer Science & Business Media
ISBN 13 : 1468460129
Total Pages : 561 pages
Book Rating : 4.4/5 (684 download)

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Book Synopsis Structure and Function of the Aspartic Proteinases by : Ben M. Dunn

Download or read book Structure and Function of the Aspartic Proteinases written by Ben M. Dunn and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 561 pages. Available in PDF, EPUB and Kindle. Book excerpt: In September, 1990, a group of 160 scientists from 19 countries and 21 of the United States met at the Red Lion Inn in Rohnert Park, Sonoma County, California. The purpose of this meeting was to share new information from recent research on the Aspartic Proteinases. This book is a compilation of the information transferred in that forum. The Aspartic Proteinases include all those enzymes from the "fourth" class of proteolytic enzymes, the first three being the Serine, Cysteine and Metalloproteinases. Of course, all the scientists in attendance at the Sonoma Aspartic Proteinase Conference would agree that our current level of understanding of the structure and function of the Aspartic Proteinase class of enzymes is clearly first class. The reasons for this require a bit of historical perspective. The group of scientists who are engaged in study of this family of enzymes first met as a separate entity in 1976, in Norman, Oklahoma, at a meeting organized by Jordan Tang of the Oklahoma Medical Research Foundation. This was an exciting time, as the first crystal structures of some of these enzymes were described by Blundell, James and Davies. During that conference, the relationship between the two halves of the mammalian and fungal enzymes was recognized and this has provided a structural foundation for analysis of the retroviral enzymes, which came later. A book was published by Plenum Press documenting l this conference, and the current book is an update to that important work.

Proteases: Structure and Function

Author : Klaudia Brix
Publisher : Springer
ISBN 13 : 9783709119396
Total Pages : 0 pages
Book Rating : 4.1/5 (193 download)

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Book Synopsis Proteases: Structure and Function by : Klaudia Brix

Download or read book Proteases: Structure and Function written by Klaudia Brix and published by Springer. This book was released on 2016-08-23 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proteolysis is an irreversible posttranslational modification affecting each and every protein from its biosynthesis to its degradation. Limited proteolysis regulates targeting and activity throughout the lifetime of proteins. Balancing proteolysis is therefore crucial for physiological homeostasis. Control mechanisms include proteolytic maturation of zymogens resulting in active proteases and the shut down of proteolysis by counteracting endogenous protease inhibitors. Beyond the protein level, proteolytic enzymes are involved in key decisions during development that determine life and death – from single cells to adult individuals. In particular, we are becoming aware of the subtle role that proteases play in signaling events within proteolysis networks, in which the enzymes act synergistically and form alliances in a web-like fashion. Proteases come in different flavors. At least five families of mechanistically distinct enzymes and even more inhibitor families are known to date, many family members are still to be studied in detail. We have learned a lot about the diversity of the about 600 proteases in the human genome and begin to understand their physiological roles in the degradome. However, there are still many open questions regarding their actions in pathophysiology. It is in this area where the development of small molecule inhibitors as therapeutic agents is extremely promising. Approaching proteolysis as the most important, irreversible post-translational protein modification essentially requires an integrated effort of complementary research disciplines. In fact, proteolytic enzymes seem as diverse as the scientists working with these intriguing proteins. This book reflects the efforts of many in this exciting field of research where team and network formations are essential to move ahead.

Plant Proteases

Author : Mercedes Diaz-Mendoza
Publisher : Frontiers Media SA
ISBN 13 : 2889633993
Total Pages : 157 pages
Book Rating : 4.8/5 (896 download)

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Book Synopsis Plant Proteases by : Mercedes Diaz-Mendoza

Download or read book Plant Proteases written by Mercedes Diaz-Mendoza and published by Frontiers Media SA. This book was released on 2020-01-24 with total page 157 pages. Available in PDF, EPUB and Kindle. Book excerpt: Plant proteases are involved in most aspects of plant physiology and development, playing key roles in the generation of signaling molecules and as regulators of essential cellular processes such as cell division and metabolism. They take part in important pathways like protein turnover by the degradation of misfolded proteins and the ubiquitin-proteasome pathway, and they are responsible for post-translational modifications of proteins by proteolysis at highly specific sites. Proteases are also implicated in a great variety of environmentally controlled processes, including mobilization of storage proteins during seed germination, development of seedlings, senescence, programmed cell death and defense mechanisms against pests and pathogens. However, in spite of their importance, little is known about the functions and mode of actions of specific plant proteases. This Research Topic collects contributions covering diverse aspects of plant proteases research.

Structure-function Relationships of Proteolytic Enzymes

Author : Pierre Desnuelle
Publisher :
ISBN 13 :
Total Pages : 309 pages
Book Rating : 4.:/5 (79 download)

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Book Synopsis Structure-function Relationships of Proteolytic Enzymes by : Pierre Desnuelle

Download or read book Structure-function Relationships of Proteolytic Enzymes written by Pierre Desnuelle and published by . This book was released on 1970 with total page 309 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pancreatic proteases. Microbial proteases. Pepsin and related enzymes. Sulfhydryl proteases.

Handbook of Proteolytic Enzymes, Volume 1

Author : Alan J. Barrett
Publisher : Elsevier
ISBN 13 : 0080984150
Total Pages : 1182 pages
Book Rating : 4.0/5 (89 download)

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Book Synopsis Handbook of Proteolytic Enzymes, Volume 1 by : Alan J. Barrett

Download or read book Handbook of Proteolytic Enzymes, Volume 1 written by Alan J. Barrett and published by Elsevier. This book was released on 2012-12-02 with total page 1182 pages. Available in PDF, EPUB and Kindle. Book excerpt: Handbook of Proteolytic Enzymes, Second Edition, Volume 1: Aspartic and Metallo Peptidases is a compilation of numerous progressive research studies on proteolytic enzymes. This edition is organized into two main sections encompassing 328 chapters. This handbook is organized around a system for the classification of peptidases, which is a hierarchical one built on the concepts of catalytic type, clan, family and peptidase. The concept of catalytic type of a peptidase depends upon the chemical nature of the groups responsible for catalysis. The recognized catalytic types are aspartic, cysteine, metallo, serine, threonine, and the unclassified enzymes, while clans and families are groups of homologous peptidases. Homology at the level of a family of peptidases is shown by statistically significant relationship in amino acid sequence to a representative member called the type example, or to another member of the family that has already been shown to be related to the type example. Each chapter discusses the history, activity, specificity, structural chemistry, preparation, and biological aspects of the enzyme. This book will prove useful to enzyme chemists and researchers.

Co- and Post-Translational Modifications of Therapeutic Antibodies and Proteins

Author : T. Shantha Raju
Publisher : John Wiley & Sons
ISBN 13 : 1119053366
Total Pages : 293 pages
Book Rating : 4.1/5 (19 download)

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Book Synopsis Co- and Post-Translational Modifications of Therapeutic Antibodies and Proteins by : T. Shantha Raju

Download or read book Co- and Post-Translational Modifications of Therapeutic Antibodies and Proteins written by T. Shantha Raju and published by John Wiley & Sons. This book was released on 2019-03-15 with total page 293 pages. Available in PDF, EPUB and Kindle. Book excerpt: A Comprehensive Guide to Crucial Attributes of Therapeutic Proteins in Biological Pharmaceuticals With this book, Dr. Raju offers a valuable resource for professionals involved in research and development of biopharmaceutical and biosimilar drugs. This is a highly relevant work, as medical practitioners have increasingly turned to biopharmaceutical medicines in their search for safe and reliable treatments for complex diseases, while pharmaceutical researchers seek to expand the availability of biopharmaceuticals and create more affordable biosimilar alternatives. Readers receive a thorough overview of the major co-translational modifications (CTMs) and post-translational modifications (PTMs) of therapeutic proteins relevant to the development of biotherapeutics. The majority of chapters detail individual CTMs and PTMs that may affect the physicochemical, biochemical, biological, pharmacokinetic, immunological, toxicological etc. properties of proteins. In addition, readers are guided on the methodology necessary to analyze and characterize these modifications. Thus, readers gain not only an understanding of CTMs/PTMs, but also the ability to design and assess their own structure-function studies for experimental molecules. Specific features and topics include: Discussion of the research behind and expansion of biopharmaceuticals Twenty chapters detailing relevant CTMs and PTMs of proteins, such as glycosylation, oxidation, phosphorylation, methylation, proteolysis, etc. Each chapter offers an introduction and guide to the mechanisms and biological significance of an individual CTM or PTM, including practical guidance for experiment design and analysis An appendix of biologic pharmaceuticals currently on the market, along with an assessment of their PTMs and overall safety and efficacy This volume will prove a key reference on the shelves of industry and academic researchers involved in the study and development of biochemistry, molecular biology, biopharmaceuticals and proteins in medicine, particularly as biopharmaceuticals and biosimilars become ever more prominent tools in the field of healthcare.

The Exocrine Pancreas

Author : Stephen Pandol
Publisher : Morgan & Claypool Publishers
ISBN 13 : 1615041389
Total Pages : 66 pages
Book Rating : 4.6/5 (15 download)

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Book Synopsis The Exocrine Pancreas by : Stephen Pandol

Download or read book The Exocrine Pancreas written by Stephen Pandol and published by Morgan & Claypool Publishers. This book was released on 2011 with total page 66 pages. Available in PDF, EPUB and Kindle. Book excerpt: The secretions of the exocrine pancreas provide for digestion of a meal into components that are then available for processing and absorption by the intestinal epithelium. Without the exocrine pancreas, malabsorption and malnutrition result. This chapter describes the cellular participants responsible for the secretion of digestive enzymes and fluid that in combination provide a pancreatic secretion that accomplishes the digestive functions of the gland. Key cellular participants, the acinar cell and the duct cell, are responsible for digestive enzyme and fluid secretion, respectively, of the exocrine pancreas. This chapter describes the neurohumoral pathways that mediate the pancreatic response to a meal as well as details of the cellular mechanisms that are necessary for the organ responses, including protein synthesis and transport and ion transports, and the regulation of these responses by intracellular signaling systems. Examples of pancreatic diseases resulting from dysfunction in cellular mechanisms provide emphasis of the importance of the normal physiologic mechanisms.

Industrial Enzymes

Author : Julio Polaina
Publisher : Springer Science & Business Media
ISBN 13 : 1402053770
Total Pages : 629 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Industrial Enzymes by : Julio Polaina

Download or read book Industrial Enzymes written by Julio Polaina and published by Springer Science & Business Media. This book was released on 2007-05-16 with total page 629 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent developments in genetic engineering and protein chemistry are bringing ever more powerful means of analysis to bear on the study of enzyme structure. This volume reviews the most important types of industrial enzymes. In a balanced manner it covers three interrelated aspects of paramount importance for enzyme performance: three-dimensional protein structure, physicochemical and catalytic properties, and the range of both classical and novel applications.

Structure-function Relationships of Proteolytic Enzymes

Author :
Publisher :
ISBN 13 : 9780122118500
Total Pages : 309 pages
Book Rating : 4.1/5 (185 download)

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Book Synopsis Structure-function Relationships of Proteolytic Enzymes by :

Download or read book Structure-function Relationships of Proteolytic Enzymes written by and published by . This book was released on 1970 with total page 309 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Nutrient Metabolism

Author : Martin Kohlmeier
Publisher : Academic Press
ISBN 13 : 0123877881
Total Pages : 899 pages
Book Rating : 4.1/5 (238 download)

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Book Synopsis Nutrient Metabolism by : Martin Kohlmeier

Download or read book Nutrient Metabolism written by Martin Kohlmeier and published by Academic Press. This book was released on 2015-05-12 with total page 899 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nutrient Metabolism, Second Edition, provides a comprehensive overview of the supply and use of nutrients in the human body and how the body regulates intake. Chapters detail the principles determining digestion and absorption of food ingredients and how these compounds and their metabolites get into the brain, cross the placenta and pass through the kidneys. Each nutrient’s coverage contains a nutritional summary that describes its function, its food sources, dietary requirements, potential health risks if deficient, and impact of excessive intake. This handbook contains the latest information on the scope of structures, processes, genes and cofactors involved in maintaining a healthy balance of nutrient supplies. Of interest to a wide range of professionals because nutrient issues connect to so many audiences, the book contains a useful link to dietary supplements. Latest research findings on health and clinical effects of nutrients and of interventions affecting nutrient supply or metabolism Each nutrient covered contains a nutritional summary describing its function, food sources, dietary requirements, potential health risks if deficient, and impact of excessive intake. Nutrient information immediately accessible--from source to effect--in one volume