Improving and Accelerating Therapeutic Development for Nervous System Disorders

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Author :
Publisher : National Academies Press
ISBN 13 : 0309292492
Total Pages : 107 pages
Book Rating : 4.3/5 (92 download)

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Book Synopsis Improving and Accelerating Therapeutic Development for Nervous System Disorders by : Institute of Medicine

Download or read book Improving and Accelerating Therapeutic Development for Nervous System Disorders written by Institute of Medicine and published by National Academies Press. This book was released on 2014-02-06 with total page 107 pages. Available in PDF, EPUB and Kindle. Book excerpt: Improving and Accelerating Therapeutic Development for Nervous System Disorders is the summary of a workshop convened by the IOM Forum on Neuroscience and Nervous System Disorders to examine opportunities to accelerate early phases of drug development for nervous system drug discovery. Workshop participants discussed challenges in neuroscience research for enabling faster entry of potential treatments into first-in-human trials, explored how new and emerging tools and technologies may improve the efficiency of research, and considered mechanisms to facilitate a more effective and efficient development pipeline. There are several challenges to the current drug development pipeline for nervous system disorders. The fundamental etiology and pathophysiology of many nervous system disorders are unknown and the brain is inaccessible to study, making it difficult to develop accurate models. Patient heterogeneity is high, disease pathology can occur years to decades before becoming clinically apparent, and diagnostic and treatment biomarkers are lacking. In addition, the lack of validated targets, limitations related to the predictive validity of animal models - the extent to which the model predicts clinical efficacy - and regulatory barriers can also impede translation and drug development for nervous system disorders. Improving and Accelerating Therapeutic Development for Nervous System Disorders identifies avenues for moving directly from cellular models to human trials, minimizing the need for animal models to test efficacy, and discusses the potential benefits and risks of such an approach. This report is a timely discussion of opportunities to improve early drug development with a focus toward preclinical trials.

Accelerate

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Author :
Publisher : IT Revolution
ISBN 13 : 1942788355
Total Pages : 251 pages
Book Rating : 4.9/5 (427 download)

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Book Synopsis Accelerate by : Nicole Forsgren, PhD

Download or read book Accelerate written by Nicole Forsgren, PhD and published by IT Revolution. This book was released on 2018-03-27 with total page 251 pages. Available in PDF, EPUB and Kindle. Book excerpt: Winner of the Shingo Publication Award Accelerate your organization to win in the marketplace. How can we apply technology to drive business value? For years, we've been told that the performance of software delivery teams doesn't matter―that it can't provide a competitive advantage to our companies. Through four years of groundbreaking research to include data collected from the State of DevOps reports conducted with Puppet, Dr. Nicole Forsgren, Jez Humble, and Gene Kim set out to find a way to measure software delivery performance―and what drives it―using rigorous statistical methods. This book presents both the findings and the science behind that research, making the information accessible for readers to apply in their own organizations. Readers will discover how to measure the performance of their teams, and what capabilities they should invest in to drive higher performance. This book is ideal for management at every level.

Accelerating Innovation

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Author :
Publisher : Van Nostrand Reinhold Company
ISBN 13 :
Total Pages : 184 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Accelerating Innovation by : Marvin L. Patterson

Download or read book Accelerating Innovation written by Marvin L. Patterson and published by Van Nostrand Reinhold Company. This book was released on 1993 with total page 184 pages. Available in PDF, EPUB and Kindle. Book excerpt: "The time for rehashing America's lost battles on the world market has passed." "Now it's time to address a critical component of the economic battle plan: the product development process that creates the products that satisfy customer needs. How quickly these weapons of economic war are developed, how competitive they are, how timely they are deployed, and how supportable they are will determine the failure or success of American business in the 1990s." "Here is the right book at the right time...a concise blueprint to transform product development from a collection of ad hoc activities into an integrated, smoothly operating process. Written by the Director of Corporate Engineering for Hewlett-Packard, one of the most successfully innovative companies in America today, Accelerating Innovation shows how successful, well-tested concepts from the manufacturing domain can be readily transformed into the needy world of new product innovation." "Filled with clear-sighted analysis and practical explanations, this book will help management unleash innovation and creativity in development processes to meet the urgent need for bringing new technology to customers faster and more effectively than the competition." "Discover how to cope with the limited life span of today's products...anticipate changing consumer needs and desires...close the gap between new technology and products that apply it...bring leading-edge products to market fast...eliminate profit-threatening gaps between the "death" of obsolete products and the introduction of new ones...and enjoy higher returns on investment." "Accelerating Innovation provides a results-oriented model for transferring to product development the strategies that are moving manufacturers from the old era to the new one. Numerous real-life examples give you powerful insights into the time-based factoring and total quality management principles used so successfully in manufacturing and shows how to implement them in the product development cycle. Key chapters address how to shorten the innovation cycle time, applying the principle that success springs from focusing on the right issues; manage organization change so that change goes where you want it to go - and quickly, transfer quality principles used on the assembly line to the process of developing raw information and adding value to it, reduce innovation time by implementing the cost of quality principle (cost as a function of when an error is detected), manage information flow and bottlenecks, minimize changeover time; and much, much more." "Does your organization really have a handle on new product development? Are goals, objectives, processes, metrics, and controls in place? Are you equipped to create new products rationally and systematically, while continuously reducing innovation cycle times?" "Accelerating Innovation presents new thinking that will help you answer these questions with a resounding "yes." In product development, doing business the same old way is a formula for disaster. The time to act is long before the livelihood of the product development function is ever threatened. And if a company is trying to catch up, then it has to improve faster than its toughest competition if it ever expects to win." "Finally, here is a guide that can give you the critical advantage you need for success in product development - success that is no longer a luxury, but a necessity for survival."--BOOK JACKET.Title Summary field provided by Blackwell North America, Inc. All Rights Reserved

Accelerating New Food Product Design and Development

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Author :
Publisher : John Wiley & Sons
ISBN 13 : 1119149304
Total Pages : 416 pages
Book Rating : 4.1/5 (191 download)

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Book Synopsis Accelerating New Food Product Design and Development by : Jacqueline H. Beckley

Download or read book Accelerating New Food Product Design and Development written by Jacqueline H. Beckley and published by John Wiley & Sons. This book was released on 2017-10-23 with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written primarily for directors and managers of food design and development, food scientists, technologists, and product developers, this book explains all the necessary information in order to help meet the increasing demands for innovation in an industry that is providing fewer resources. This updated edition, by a group of seasoned food industry business professionals and academics, provides a real-world perspective of what is occurring in the food industry right now, offers strategic frameworks for problem solving and R&D strategies, and presents methods needed to accelerate and optimize new product development. Accelerating New Food Product Design and Development, Second Edition features five brand new chapters covering all the changes that have occurred within the last decade: A Flavor Supplier Perspective, An Ingredient Supplier Perspective, Applying Processes that Accelerate New Product Development, Looking at How the University Prepares Someone for a Career in Food, and Innovative Packaging and Its Impact on Accelerated Product Development. Offers new perspectives on what really goes on during the development process Includes updated chapters fully describing the changes that have occurred in the food industry, both from a developer’s point of view as well as the consumer requirements Features a completely rewritten chapter covering the importance of packaging which is enhanced through 3D printing All of this against the impact on speed to market Filled with unique viewpoints of the business from those who really know and a plethora of new information, Accelerating New Food Product Design and Development, Second Edition will be of great interest to all professionals engaged in new food product design and development.

Development

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Author :
Publisher : Oxford University Press
ISBN 13 : 0198736258
Total Pages : 217 pages
Book Rating : 4.1/5 (987 download)

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Book Synopsis Development by : Ian Goldin

Download or read book Development written by Ian Goldin and published by Oxford University Press. This book was released on 2018 with total page 217 pages. Available in PDF, EPUB and Kindle. Book excerpt: What is development -- How does development happen? -- Why are some countries rich and others poor? -- What can be done to accelerate development? -- The evolution of development aid -- Sustainable development -- Globalization and development -- The future of development.

Accelerating the Development of Biomarkers for Drug Safety

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Author :
Publisher : National Academies Press
ISBN 13 : 0309142318
Total Pages : 101 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Accelerating the Development of Biomarkers for Drug Safety by : Institute of Medicine

Download or read book Accelerating the Development of Biomarkers for Drug Safety written by Institute of Medicine and published by National Academies Press. This book was released on 2009-07-20 with total page 101 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biomarkers can be defined as indicators of any biologic state, and they are central to the future of medicine. As the cost of developing drugs has risen in recent years, reducing the number of new drugs approved for use, biomarker development may be a way to cut costs, enhance safety, and provide a more focused and rational pathway to drug development. On October 24, 2008, the IOM's Forum on Drug Discovery, Development, and Translation held "Assessing and Accelerating Development of Biomarkers for Drug Safety," a one-day workshop, summarized in this volume, on the value of biomarkers in helping to determine drug safety during development.

Accelerating Your Development as a Leader

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Author :
Publisher : John Wiley & Sons
ISBN 13 : 0470937033
Total Pages : 165 pages
Book Rating : 4.4/5 (79 download)

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Book Synopsis Accelerating Your Development as a Leader by : Robert Barner

Download or read book Accelerating Your Development as a Leader written by Robert Barner and published by John Wiley & Sons. This book was released on 2011-09-14 with total page 165 pages. Available in PDF, EPUB and Kindle. Book excerpt: An invaluable resource for HR professionals and executive coaches, this book focuses on how to reduce the time needed to prepare high-potential (HIPO) leaders for next-level positions. Providing the leading trends, tools, and techniques in the industry, the book demystifies the process of HIPO development. It includes a powerful five-step process for increasing leaders' readiness, as well as a complete set of tools for running workshops on developmental planning and coaching. This text also serves as a core text for the author's Executive Coaching Certificate Programs.

Accelerating Leadership Development

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Author :
Publisher : John Wiley & Sons
ISBN 13 : 1118464737
Total Pages : 322 pages
Book Rating : 4.1/5 (184 download)

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Book Synopsis Accelerating Leadership Development by : Jocelyn Berard

Download or read book Accelerating Leadership Development written by Jocelyn Berard and published by John Wiley & Sons. This book was released on 2013-07-25 with total page 322 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proven strategies and innovative solutions for developing and retaining successful leaders Many organizations today are facing a crisis of leadership. As the Baby Boomer generation exits the workforce, companies are struggling to find qualified leaders to fill critical roles. Accelerating Leadership Development offers solutions for leadership development, management, and retention from award-winning development firm Global Knowledge. Accelerating Leadership Development provides a proven model to help companies develop high-potential employees with the competencies and knowledge capital to assume critical roles successfully. It includes practical and rigorous tools that enable organizations to identify targets and predict those targets' success with six measurable factors. With this proven development system, companies can develop a pipeline of ready leaders with high levels of engagement and retention. Features actionable, effective principles and strategies for leadership development using a results-oriented framework Chapters address communication and delegation strategies, effective feedback models, shifting of responsibility and accountability to direct reports, and contemporary coaching and development approaches Based on in-depth research and client interactions from one of the most prominent names in workforce development For any business that experiences a leadership failure or a lack of qualified leaders for vital positions, the consequences can be devastating. This practical and effective guide to leadership development offers real solutions for long-term excellence.

Rare Diseases and Orphan Products

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Author :
Publisher : National Academies Press
ISBN 13 : 0309158060
Total Pages : 442 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Rare Diseases and Orphan Products by : Institute of Medicine

Download or read book Rare Diseases and Orphan Products written by Institute of Medicine and published by National Academies Press. This book was released on 2011-04-03 with total page 442 pages. Available in PDF, EPUB and Kindle. Book excerpt: Rare diseases collectively affect millions of Americans of all ages, but developing drugs and medical devices to prevent, diagnose, and treat these conditions is challenging. The Institute of Medicine (IOM) recommends implementing an integrated national strategy to promote rare diseases research and product development.

Accelerating growth and development in the SDG Era

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Author :
Publisher : Observer Research Foundation
ISBN 13 : 9387407845
Total Pages : 24 pages
Book Rating : 4.3/5 (874 download)

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Book Synopsis Accelerating growth and development in the SDG Era by : Kurian, Oommen C.

Download or read book Accelerating growth and development in the SDG Era written by Kurian, Oommen C. and published by Observer Research Foundation. This book was released on 2018-03-01 with total page 24 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Accelerating Growth and Poverty Reduction

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Author :
Publisher : Academic Foundation
ISBN 13 : 9788171883455
Total Pages : 340 pages
Book Rating : 4.8/5 (834 download)

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Book Synopsis Accelerating Growth and Poverty Reduction by : Arvind Virmani

Download or read book Accelerating Growth and Poverty Reduction written by Arvind Virmani and published by Academic Foundation. This book was released on 2004 with total page 340 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Book Is Based On Policy Papers Written During The Nineties At The Ministry Of Finance. The Fundamental Objective Of Economic Policy Is To Generate Equitable Economic Growth And Thus Bring About The Increased Well Being Of All Citizens. The Goal Of These Policy Papers Was To Remove Policy Distortions That Were Hindering Growth And Productivity And To Introduce Economic And Institutional Reforms That Would Accelerate Growth. The Policy Recommendations Were Shaped By Theory And Empirical Evidence On The One Hand, And By Institutional/Organisational And Socio-Political Constraints On The Other.

Accelerating Development of Late-successional Conditions in Young Managed Douglas-fir Stands

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Publisher :
ISBN 13 :
Total Pages : 64 pages
Book Rating : 4.:/5 (319 download)

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Book Synopsis Accelerating Development of Late-successional Conditions in Young Managed Douglas-fir Stands by : Steven Lee Garman

Download or read book Accelerating Development of Late-successional Conditions in Young Managed Douglas-fir Stands written by Steven Lee Garman and published by . This book was released on 2003 with total page 64 pages. Available in PDF, EPUB and Kindle. Book excerpt: The goal of this simulation study was to provide information for defining thinning regimes for young Douglas-fir (Pseudotsuga menziesii (Mirb.) Franco) stands in the Central Cascades Adaptive Management Area, located in west-central Oregon. Specifically, this study used the ZELIG. PNW (3.0) gap model to evaluate effects of experimental thinning treatments on the development of late-successional attributes and on extracted merchantable volume. Sixty-four thinning treatments were simulated for four rotation intervals (260, 180, 100, and 80 years) starting with a 40-year-old managed Douglas-fir stand. The amount of time for five late successional attributes to reach defined threshold levels, long-term developmental trends of these attributes, and amount of extracted merchantable volume were recorded for each treatment. Stand conditions of selected treatments were used in a subsequent harvest rotation in which 64 additional experimental thinning treatments were applied and evaluated. A total of 1,744 thinning treatments was evaluated in this study. Results of this study confirm previous recommendations for accelerating development of late-successional attributes in young managed stands. Additionally, results show the potential for a range of thinning treatments to attain late-successional conditions in about the same amount of time, but with different tradeoffs in terms of merchantable volume and long-term stand conditions. In general, heavy thinning of existing stands at ages 40 and 60 years promoted rapid development of large boles, vertical diversity, and tree-species diversity, but provided the least amount of extracted volume and required artificial creation of dead wood. Treatments that retained more than 40 percent of the original overstory and thinned to 99 trees per hectare at age 60 delayed attainment of late-successional conditions by 10 to 30 years but provided 12 to 20 percent more extracted volume, resulted in higher levels of most late-successional attributes at the end of a rotation, and required less artificial creation of dead wood. Treatments providing the fastest development of late-successional conditions in subsequent rotations varied with the amount of canopy cover retained at the end of the first rotation. For stands starting with ÃÃY30 percent canopy cover, delaying the first commercial thin for 40 years promoted the most rapid development of vertical structure and shadetolerant stems. Lower canopy-retention levels required heavy or light thins in subsequent entries, depending on the rotation interval, for rapid development of late-successional attributes.

Innovate Products Faster

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Publisher :
ISBN 13 : 9781470002909
Total Pages : 240 pages
Book Rating : 4.0/5 (29 download)

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Book Synopsis Innovate Products Faster by : John Carter

Download or read book Innovate Products Faster written by John Carter and published by . This book was released on 2012 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Accelerating Growth and Structural Transformation: Ghana's Options for Reaching Middle-Income Country Status

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Author :
Publisher : Intl Food Policy Res Inst
ISBN 13 :
Total Pages : 76 pages
Book Rating : 4./5 ( download)

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Book Synopsis Accelerating Growth and Structural Transformation: Ghana's Options for Reaching Middle-Income Country Status by : Clemens Breisinger, Xinshen Diao, James Thurlow, Bingxin Yu, and Shashidhara Kolavalli

Download or read book Accelerating Growth and Structural Transformation: Ghana's Options for Reaching Middle-Income Country Status written by Clemens Breisinger, Xinshen Diao, James Thurlow, Bingxin Yu, and Shashidhara Kolavalli and published by Intl Food Policy Res Inst. This book was released on with total page 76 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Accelerating Sustainable Energy Transition(s) in Developing Countries

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Author :
Publisher : Routledge
ISBN 13 : 1351726846
Total Pages : 207 pages
Book Rating : 4.3/5 (517 download)

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Book Synopsis Accelerating Sustainable Energy Transition(s) in Developing Countries by : Laurence L Delina

Download or read book Accelerating Sustainable Energy Transition(s) in Developing Countries written by Laurence L Delina and published by Routledge. This book was released on 2017-10-19 with total page 207 pages. Available in PDF, EPUB and Kindle. Book excerpt: Accelerating sustainable energy transitions away from carbon-based fuel sources needs to be high on the agendas of developing countries. It is key in achieving their climate mitigation promises and sustainable energy development objectives. To bring about rapid transitions, simultaneous turns are imperative in hardware deployment, policy improvements, financing innovation, and institutional strengthening. These systematic turns, however, incur tensions when considering the multiple options available and the disruptions of entrenched power across pockets of transition innovations. These heterogeneous contradictions and their trade-offs, and uncertainties and risks have to be systematically recognized, understood, and weighed when making decisions. This book explores how the transitions occur in fourteen developing countries and broadly surveys their technological, policy, financing, and institutional capacities in response to the three key aspects of energy transitions: achieving universal energy access, harvesting energy efficiency, and deploying renewable energy. The book shows how fragmented these approaches are, how they occur across multiple levels of governance, and how policy, financing, and institutional turns could occur in these complex settings. This book will be of interest to students and scholars of energy and climate policy, development studies, international relations, politics, strategic studies, and geography. It is also useful to policymakers and development practitioners.

Accelerating Development Velocity Using Docker

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Publisher : Apress
ISBN 13 : 1484239369
Total Pages : 161 pages
Book Rating : 4.4/5 (842 download)

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Book Synopsis Accelerating Development Velocity Using Docker by : Kinnary Jangla

Download or read book Accelerating Development Velocity Using Docker written by Kinnary Jangla and published by Apress. This book was released on 2018-11-05 with total page 161 pages. Available in PDF, EPUB and Kindle. Book excerpt: Discover how a software engineer can leverage Docker in order to expedite development velocity. This book focuses on the fundamental concepts this program is built upon and explores how it can help you get your services up and running inside Docker containers. You'll also review tips on how to debug microservices applications that run inside Docker containers. Tech companies are now developing complex softwares that are comprised of multiple services running on different platforms, and Docker has become an essential part of coordinating the communication between these services and platforms. This book addresses problems caused by drifting microservices, debugging across services, inconsistent environments across machines, and coordinating development of machine learning systems between a team of developers, etc. Accelerating Development Velocity Using Docker puts you on the path to transforming your complex systems into more efficient ones. What You'll Learn Setup Docker and employ quick solutions to road blocks Review challenges associated with debugging microservices that sit behind a complex application Leverage Docker features to seamlessly get multiple microservices up and running Debug inside a Docker container Review advanced use cases of Docker that can help consistency of development environments· Who This Book Is For Ideal for new to mid-level infrastructure engineers who want to learn how to make their development environments efficient across their and cross teams, or for students who aspire to learn basics of how to debug distributed systems and how to develop efficient applications.

Accelerating Economic Growth

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Author :
Publisher : Springer Nature
ISBN 13 : 3031071956
Total Pages : 181 pages
Book Rating : 4.0/5 (31 download)

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Book Synopsis Accelerating Economic Growth by : Jakub Growiec

Download or read book Accelerating Economic Growth written by Jakub Growiec and published by Springer Nature. This book was released on 2022-09-07 with total page 181 pages. Available in PDF, EPUB and Kindle. Book excerpt: What made it possible for the human species to conquer the world, build a global digital economy, and still want more? What drives technological progress and economic growth in the long run and on a global scale? And how will technological progress, economic growth, and the overall prosperity of human civilization unfold in the future? This book sheds new light on these big questions by incorporating findings from physics, anthropology, psychology, history, philosophy, and computer science in a brand-new theory of economic growth. Looking back across the millennia, it identifies five major technological revolutions which have transformed humankind’s capacity to process energy and information—the cognitive, agricultural, scientific, industrial, and digital revolutions—and characterizes the new avenues of economic development which they have opened while also exponentially accelerating growth.