Kinase Inhibitor Drugs

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Publisher : John Wiley & Sons
ISBN 13 : 1118210905
Total Pages : 463 pages
Book Rating : 4.1/5 (182 download)

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Book Synopsis Kinase Inhibitor Drugs by : Rongshi Li

Download or read book Kinase Inhibitor Drugs written by Rongshi Li and published by John Wiley & Sons. This book was released on 2011-09-20 with total page 463 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive resource on case studies of marketed kinase drugs and promising drug trials Since the discovery of protein kinase activity in 1954, the field of protein kinase drug discovery has advanced dramatically. With the ongoing clinical success of the Bcr-Abl kinase inhibitor Gleevec in the treatment of chronic myelogenous leukemia and seven additional marketed kinase inhibitor drugs, researchers have compelling evidence that kinase inhibitors can be highly efficacious in the treatment of diseases caused by aberrant activity of protein kinase. Currently more than 100 protein kinase inhibitors are in clinical development. In one comprehensive volume, the editors, Dr. Rongshi Li and Dr. Jeffrey Stafford, present timely and important case studies of marketed kinase drugs and several of the most advanced kinase inhibitors in clinical trials. Kinase Inhibitor Drugs includes: Case studies from leading investigators and experts in the field that provide firsthand accounts of kinase inhibitor discovery Current thinking on kinase structure, biochemistry, and signal transduction pathways Information on state-of-the-art technologies and tools such as structure-based and fragment-based drug discovery A lineup of clinical-phase growth factor receptor inhibitors Inhibitors of cell cycle kinases The discovery of allosteric inhibitors of MEK kinase Information on pharmacogenomics and its application to kinase inhibitor clinical development

Journal of the National Cancer Institute

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Publisher :
ISBN 13 :
Total Pages : 1032 pages
Book Rating : 4.E/5 ( download)

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Book Synopsis Journal of the National Cancer Institute by :

Download or read book Journal of the National Cancer Institute written by and published by . This book was released on 2005 with total page 1032 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Advances in Cancer Research

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Publisher : Elsevier
ISBN 13 : 0080471013
Total Pages : 429 pages
Book Rating : 4.0/5 (84 download)

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Book Synopsis Advances in Cancer Research by :

Download or read book Advances in Cancer Research written by and published by Elsevier. This book was released on 2011-07-29 with total page 429 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Advances in Cancer Research series provides invaluable information on the exciting and fast-moving field of cancer research. This volume stands as the first ever thematic volume in the series, focusing on the topic of genomics in cancer drug development. The chapters included in this book represent the cutting-edge information in the field and span such topics as Mass Spectrometry: Uncovering the Cancer Proteome for Diagnostics; Biomarker Discovery in Epithelial Ovarian Cancer by Genomic Approaches; The Application of siRNA Technology to Cancer Biology Discovery; Ribozyme Technology for Cancer Gene Target Identification and Validation; Cancer Cell-Based Genomic and Small Molecule Screens; Tumour Antigens as Surrogate Markers and Targets for Therapy and Vaccines; Practices and Pitfalls of Mouse Cancer Models in Drug Discovery; Biomarker Assay Translation from Discovery to Clinical Studies in Cancer Drug Development – Quantification of Emerging Protein Biomarkers; Molecular Optical Imaging of Therapeutic Targets of Cancer; Cancer Drug Approval in the United States, Europe and Japan.

Nanomaterials for Medical Diagnosis and Therapy

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Publisher : John Wiley & Sons
ISBN 13 : 9783527313907
Total Pages : 768 pages
Book Rating : 4.3/5 (139 download)

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Book Synopsis Nanomaterials for Medical Diagnosis and Therapy by : Challa S. S. R. Kumar

Download or read book Nanomaterials for Medical Diagnosis and Therapy written by Challa S. S. R. Kumar and published by John Wiley & Sons. This book was released on 2007-04-16 with total page 768 pages. Available in PDF, EPUB and Kindle. Book excerpt: Following an overview of nanotechnologies for diagnostic purposes, this book goes on to look at nanoparticle-based magnetic resonance, molecular and other imaging applications, as well as the potential roles of carbon nanotubes and bionanoparticles in biomedical applications. The book's main focus is on drug delivery systems based on nonporous and nanosize materials, solid lipid and polymeric nanoparticles, intelligent hydrogels, core-shell nanoparticles, and nanocapsules, rounded off by a discussion of their biomedical applications. The final part of this volume covers such biomedical strategies as gene therapy, synthetic gene-transfer vectors and targeted delivery.

Hematopathology in Oncology

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Publisher : Springer Science & Business Media
ISBN 13 : 1402079206
Total Pages : 305 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Hematopathology in Oncology by : William G. Finn

Download or read book Hematopathology in Oncology written by William G. Finn and published by Springer Science & Business Media. This book was released on 2006-04-18 with total page 305 pages. Available in PDF, EPUB and Kindle. Book excerpt: - Provides the reader with insight into the emerging roles of the pathologist and clinical labortory - This volume includes all the latest concepts in the field

Frontiers in Medicinal Chemistry , Volume (1)

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Publisher : Bentham Science Publishers
ISBN 13 : 1608052044
Total Pages : 680 pages
Book Rating : 4.6/5 (8 download)

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Book Synopsis Frontiers in Medicinal Chemistry , Volume (1) by : Atta-ur Rahman

Download or read book Frontiers in Medicinal Chemistry , Volume (1) written by Atta-ur Rahman and published by Bentham Science Publishers. This book was released on 2010-12-10 with total page 680 pages. Available in PDF, EPUB and Kindle. Book excerpt: ""Frontiers in Medicinal Chemistry" is an Ebook series devoted to the review of areas of important topical interest to medicinal chemists and others in allied disciplines. "Frontiers in Medicinal Chemistry" covers all the areas of medicinal chemistry, incl"

EGFR Activity as a Determinant of Response to EGFR-targeted Therapy

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Publisher : Leuven University Press
ISBN 13 : 9789058675538
Total Pages : 194 pages
Book Rating : 4.6/5 (755 download)

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Book Synopsis EGFR Activity as a Determinant of Response to EGFR-targeted Therapy by : Sandra Van Schaeybroeck

Download or read book EGFR Activity as a Determinant of Response to EGFR-targeted Therapy written by Sandra Van Schaeybroeck and published by Leuven University Press. This book was released on 2006 with total page 194 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Protein Tyrosine Kinases

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Publisher : Springer Science & Business Media
ISBN 13 : 1592599621
Total Pages : 599 pages
Book Rating : 4.5/5 (925 download)

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Book Synopsis Protein Tyrosine Kinases by : Doriano Fabbro

Download or read book Protein Tyrosine Kinases written by Doriano Fabbro and published by Springer Science & Business Media. This book was released on 2007-11-13 with total page 599 pages. Available in PDF, EPUB and Kindle. Book excerpt: Leading researchers, from the Novartis group that pioneered Gleevec/GlivecTM and around the world, comprehensively survey the state of the art in the drug discovery processes (bio- and chemoinformatics, structural biology, profiling, generation of resistance, etc.) aimed at generating PTK inhibitors for the treatment of various diseases, including cancer. Highlights include a discussion of the rationale and the progress made towards generating "selective" low molecular-weight kinase inhibitors; an analysis of the normal function, role in disease, and application of platelet-derived growth factor antagonists; and a summary of the factors involved in successful structure-based drug design. Additional chapters address the advantages and disadvantages of in vivo preclinical models for testing protein kinase inhibitors with antitumor activity and the utility of different methods in the drug discovery and development process for determining "on-target" vs "off-target" effects of kinase inhibitors.

Anticancer Research

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Publisher :
ISBN 13 :
Total Pages : 802 pages
Book Rating : 4.:/5 ( download)

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Book Synopsis Anticancer Research by :

Download or read book Anticancer Research written by and published by . This book was released on 2005 with total page 802 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Cancer Research

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Publisher :
ISBN 13 :
Total Pages : 798 pages
Book Rating : 4.E/5 ( download)

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Book Synopsis Cancer Research by :

Download or read book Cancer Research written by and published by . This book was released on 2009-07 with total page 798 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Emerging Therapeutic Targets in Ovarian Cancer

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Publisher : Springer Science & Business Media
ISBN 13 : 1441972161
Total Pages : 299 pages
Book Rating : 4.4/5 (419 download)

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Book Synopsis Emerging Therapeutic Targets in Ovarian Cancer by : Stan Kaye

Download or read book Emerging Therapeutic Targets in Ovarian Cancer written by Stan Kaye and published by Springer Science & Business Media. This book was released on 2010-11-23 with total page 299 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Science

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Publisher :
ISBN 13 :
Total Pages : 970 pages
Book Rating : 4.:/5 (31 download)

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Book Synopsis Science by : John Michels (Journalist)

Download or read book Science written by John Michels (Journalist) and published by . This book was released on 2001-06 with total page 970 pages. Available in PDF, EPUB and Kindle. Book excerpt:

The International Journal of Biological Markers

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Publisher :
ISBN 13 :
Total Pages : 374 pages
Book Rating : 4.:/5 ( download)

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Book Synopsis The International Journal of Biological Markers by :

Download or read book The International Journal of Biological Markers written by and published by . This book was released on 2001 with total page 374 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Environmental Health Perspectives

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Publisher :
ISBN 13 :
Total Pages : 1576 pages
Book Rating : 4.E/5 ( download)

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Book Synopsis Environmental Health Perspectives by :

Download or read book Environmental Health Perspectives written by and published by . This book was released on 2004 with total page 1576 pages. Available in PDF, EPUB and Kindle. Book excerpt:

In Vivo

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Publisher :
ISBN 13 :
Total Pages : 456 pages
Book Rating : 4.:/5 ( download)

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Book Synopsis In Vivo by :

Download or read book In Vivo written by and published by . This book was released on 2008 with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Cumulated Index Medicus

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Publisher :
ISBN 13 :
Total Pages : 1840 pages
Book Rating : 4.3/5 (243 download)

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Book Synopsis Cumulated Index Medicus by :

Download or read book Cumulated Index Medicus written by and published by . This book was released on 2000 with total page 1840 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Index Medicus

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Publisher :
ISBN 13 :
Total Pages : 2432 pages
Book Rating : 4.:/5 (319 download)

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Book Synopsis Index Medicus by :

Download or read book Index Medicus written by and published by . This book was released on 2004 with total page 2432 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.