A Primer On Experiments With Mixtures

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A Primer on Experiments with Mixtures

Author : John A. Cornell
Publisher : John Wiley & Sons
ISBN 13 : 0470907428
Total Pages : 376 pages
Book Rating : 4.4/5 (79 download)

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Book Synopsis A Primer on Experiments with Mixtures by : John A. Cornell

Download or read book A Primer on Experiments with Mixtures written by John A. Cornell and published by John Wiley & Sons. This book was released on 2011-09-26 with total page 376 pages. Available in PDF, EPUB and Kindle. Book excerpt: The concise yet authoritative presentation of key techniques for basic mixtures experiments Inspired by the author's bestselling advanced book on the topic, A Primer on Experiments with Mixtures provides an introductory presentation of the key principles behind experimenting with mixtures. Outlining useful techniques through an applied approach with examples from real research situations, the book supplies a comprehensive discussion of how to design and set up basic mixture experiments, then analyze the data and draw inferences from results. Drawing from his extensive experience teaching the topic at various levels, the author presents the mixture experiments in an easy-to-follow manner that is void of unnecessary formulas and theory. Succinct presentations explore key methods and techniques for carrying out basic mixture experiments, including: Designs and models for exploring the entire simplex factor space, with coverage of simplex-lattice and simplex-centroid designs, canonical polynomials, the plotting of individual residuals, and axial designs Multiple constraints on the component proportions in the form of lower and/or upper bounds, introducing L-Pseudocomponents, multicomponent constraints, and multiple lattice designs for major and minor component classifications Techniques for analyzing mixture data such as model reduction and screening components, as well as additional topics such as measuring the leverage of certain design points Models containing ratios of the components, Cox's mixture polynomials, and the fitting of a slack variable model A review of least squares and the analysis of variance for fitting data Each chapter concludes with a summary and appendices with details on the technical aspects of the material. Throughout the book, exercise sets with selected answers allow readers to test their comprehension of the material, and References and Recommended Reading sections outline further resources for study of the presented topics. A Primer on Experiments with Mixtures is an excellent book for one-semester courses on mixture designs and can also serve as a supplement for design of experiments courses at the upper-undergraduate and graduate levels. It is also a suitable reference for practitioners and researchers who have an interest in experiments with mixtures and would like to learn more about the related mixture designs and models.

Experiments with Mixtures

Author : John A. Cornell
Publisher : John Wiley & Sons
ISBN 13 :
Total Pages : 344 pages
Book Rating : 4.:/5 (44 download)

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Book Synopsis Experiments with Mixtures by : John A. Cornell

Download or read book Experiments with Mixtures written by John A. Cornell and published by John Wiley & Sons. This book was released on 1981 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt: The general mixture problem. General remarks about response surface methods. An historical perspective. References and recommended reading. The original mixture problem. The use of independent variables. Multiple constraints on the component proportions. The analysis of mixture data. Other mixture model forms. Matrix algebra, least squares, and the analysis of variance.

How to Run Mixture Experiments for Product Quality

Author : John A. Cornell
Publisher : ASQ Quality Press
ISBN 13 :
Total Pages : 108 pages
Book Rating : 4.0/5 ( download)

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Book Synopsis How to Run Mixture Experiments for Product Quality by : John A. Cornell

Download or read book How to Run Mixture Experiments for Product Quality written by John A. Cornell and published by ASQ Quality Press. This book was released on 1990 with total page 108 pages. Available in PDF, EPUB and Kindle. Book excerpt: This set of helpful analytical tools is written for practitioners who perform and analyze mixture experiments. It is a concise treatment of techniques for designing, modeling, and interpreting data from these experiments.Contents:An Overview The Simplex-Lattice Designs and Associated Polynomial Models Multiple Constraints of the Component Proportions The Analysis of Mixture Data The Inclusion of Process Variables in Mixture Experiments

Theory and Application of Uniform Experimental Designs

Author : Kai-Tai Fang
Publisher : Springer
ISBN 13 : 9811320411
Total Pages : 300 pages
Book Rating : 4.8/5 (113 download)

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Book Synopsis Theory and Application of Uniform Experimental Designs by : Kai-Tai Fang

Download or read book Theory and Application of Uniform Experimental Designs written by Kai-Tai Fang and published by Springer. This book was released on 2018-10-02 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book provides necessary knowledge for readers interested in developing the theory of uniform experimental design. It discusses measures of uniformity, various construction methods of uniform designs, modeling techniques, design and modeling for experiments with mixtures, and the usefulness of the uniformity in block, factorial and supersaturated designs. Experimental design is an important branch of statistics with a long history, and is extremely useful in multi-factor experiments. Involving rich methodologies and various designs, it has played a key role in industry, technology, sciences and various other fields. A design that chooses experimental points uniformly scattered on the domain is known as uniform experimental design, and uniform experimental design can be regarded as a fractional factorial design with model uncertainty, a space-filling design for computer experiments, a robust design against the model specification, and a supersaturated design and can be applied to experiments with mixtures.

Formulation Simplified

Author : Mark J. Anderson
Publisher : Taylor & Francis
ISBN 13 : 1351677527
Total Pages : 190 pages
Book Rating : 4.3/5 (516 download)

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Book Synopsis Formulation Simplified by : Mark J. Anderson

Download or read book Formulation Simplified written by Mark J. Anderson and published by Taylor & Francis. This book was released on 2018-04-17 with total page 190 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many chemists – especially those most brilliant in their field – fail to appreciate the power of planned experimentation. They dislike the mathematical aspects of statistical analysis. In addition, these otherwise very capable chemists also dismissed predictive models based only on empirical data. Ironically, in the hands of subject matter experts like these elite chemists, the statistical methods of mixture design and analysis provide the means for rapidly converging on optimal compositions. What differentiates Formulation Simplified from the standard statistical texts on mixture design is that the authors make the topic relatively easy and fun to read. They provide a whole new collection of insighful original studies that illustrate the essentials of mixture design and analysis. Solid industrial examples are offered as problems at the end of many chapters for those who are serious about trying new tools on their own. Statistical software to do the computations can be freely accessed via a web site developed in support of this book.

Design and Analysis of Experiments, Volume 3

Author : Klaus Hinkelmann
Publisher : John Wiley & Sons
ISBN 13 : 0470530685
Total Pages : 598 pages
Book Rating : 4.4/5 (75 download)

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Book Synopsis Design and Analysis of Experiments, Volume 3 by : Klaus Hinkelmann

Download or read book Design and Analysis of Experiments, Volume 3 written by Klaus Hinkelmann and published by John Wiley & Sons. This book was released on 2012-02-14 with total page 598 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides timely applications, modifications, and extensions of experimental designs for a variety of disciplines Design and Analysis of Experiments, Volume 3: Special Designs and Applications continues building upon the philosophical foundations of experimental design by providing important, modern applications of experimental design to the many fields that utilize them. The book also presents optimal and efficient designs for practice and covers key topics in current statistical research. Featuring contributions from leading researchers and academics, the book demonstrates how the presented concepts are used across various fields from genetics and medicinal and pharmaceutical research to manufacturing, engineering, and national security. Each chapter includes an introduction followed by the historical background as well as in-depth procedures that aid in the construction and analysis of the discussed designs. Topical coverage includes: Genetic cross experiments, microarray experiments, and variety trials Clinical trials, group-sequential designs, and adaptive designs Fractional factorial and search, choice, and optimal designs for generalized linear models Computer experiments with applications to homeland security Robust parameter designs and split-plot type response surface designs Analysis of directional data experiments Throughout the book, illustrative and numerical examples utilize SAS®, JMP®, and R software programs to demonstrate the discussed techniques. Related data sets and software applications are available on the book's related FTP site. Design and Analysis of Experiments, Volume 3 is an ideal textbook for graduate courses in experimental design and also serves as a practical, hands-on reference for statisticians and researchers across a wide array of subject areas, including biological sciences, engineering, medicine, and business.

Handbook of Design and Analysis of Experiments

Author : Angela Dean
Publisher : CRC Press
ISBN 13 : 146650434X
Total Pages : 946 pages
Book Rating : 4.4/5 (665 download)

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Book Synopsis Handbook of Design and Analysis of Experiments by : Angela Dean

Download or read book Handbook of Design and Analysis of Experiments written by Angela Dean and published by CRC Press. This book was released on 2015-06-26 with total page 946 pages. Available in PDF, EPUB and Kindle. Book excerpt: This carefully edited collection synthesizes the state of the art in the theory and applications of designed experiments and their analyses. It provides a detailed overview of the tools required for the optimal design of experiments and their analyses. The handbook covers many recent advances in the field, including designs for nonlinear models and algorithms applicable to a wide variety of design problems. It also explores the extensive use of experimental designs in marketing, the pharmaceutical industry, engineering and other areas.

The Analysis of Covariance and Alternatives

Author : Bradley Huitema
Publisher : John Wiley & Sons
ISBN 13 : 1118067460
Total Pages : 562 pages
Book Rating : 4.1/5 (18 download)

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Book Synopsis The Analysis of Covariance and Alternatives by : Bradley Huitema

Download or read book The Analysis of Covariance and Alternatives written by Bradley Huitema and published by John Wiley & Sons. This book was released on 2011-10-24 with total page 562 pages. Available in PDF, EPUB and Kindle. Book excerpt: A complete guide to cutting-edge techniques and best practices for applying covariance analysis methods The Second Edition of Analysis of Covariance and Alternatives sheds new light on its topic, offering in-depth discussions of underlying assumptions, comprehensive interpretations of results, and comparisons of distinct approaches. The book has been extensively revised and updated to feature an in-depth review of prerequisites and the latest developments in the field. The author begins with a discussion of essential topics relating to experimental design and analysis, including analysis of variance, multiple regression, effect size measures and newly developed methods of communicating statistical results. Subsequent chapters feature newly added methods for the analysis of experiments with ordered treatments, including two parametric and nonparametric monotone analyses as well as approaches based on the robust general linear model and reversed ordinal logistic regression. Four groundbreaking chapters on single-case designs introduce powerful new analyses for simple and complex single-case experiments. This Second Edition also features coverage of advanced methods including: Simple and multiple analysis of covariance using both the Fisher approach and the general linear model approach Methods to manage assumption departures, including heterogeneous slopes, nonlinear functions, dichotomous dependent variables, and covariates affected by treatments Power analysis and the application of covariance analysis to randomized-block designs, two-factor designs, pre- and post-test designs, and multiple dependent variable designs Measurement error correction and propensity score methods developed for quasi-experiments, observational studies, and uncontrolled clinical trials Thoroughly updated to reflect the growing nature of the field, Analysis of Covariance and Alternatives is a suitable book for behavioral and medical scineces courses on design of experiments and regression and the upper-undergraduate and graduate levels. It also serves as an authoritative reference work for researchers and academics in the fields of medicine, clinical trials, epidemiology, public health, sociology, and engineering.

Strategies for Formulations Development

Author : Ronald Snee
Publisher : SAS Institute
ISBN 13 : 1629605301
Total Pages : 294 pages
Book Rating : 4.6/5 (296 download)

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Book Synopsis Strategies for Formulations Development by : Ronald Snee

Download or read book Strategies for Formulations Development written by Ronald Snee and published by SAS Institute. This book was released on 2016-09-27 with total page 294 pages. Available in PDF, EPUB and Kindle. Book excerpt: Strategies for Formulations Development: A Step-by-Step Guide Using JMP is based on the authors' significant practical experience partnering with scientists to develop strategies to accelerate the formulation (mixtures) development process. The authors not only explain the most important methods used to design and analyze formulation experiments, but they also present overall strategies to enhance both the efficiency and effectiveness of the development process. With this book you will be able to: Approach the development process from a strategic viewpoint with the overall end result in mind. Design screening experiments to identify components that are most important to the performance of the formulation. Design optimization experiments to identify the maximum response in the design space. Analyze both screening and optimization experiments using graphical and numerical methods. Optimize multiple criteria, such as the quality, cost, and performance of product formulations. Design and analyze formulation studies that involve both formulation components and process variables using methods that reduce the required experimentation by up to 50%. Linking dynamic graphics with powerful statistics, JMP helps construct a visually compelling narrative to interactively share findings that are coherent and actionable by colleagues and decision makers. Using this book, you can take advantage of computer generated experiment designs when classical designs do not suffice, given the physical and economic constraints of the experiential environment. Strategies for Formulations Development: A Step-by-Step Guide Using JMP(R) is unique because it provides formulation scientists with the essential information they need in order to successfully conduct formulation studies in the chemical, biotech, and pharmaceutical industries.

Statistical Methods for Survival Data Analysis

Author : Elisa T. Lee
Publisher : John Wiley & Sons
ISBN 13 : 1118593057
Total Pages : 389 pages
Book Rating : 4.1/5 (185 download)

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Book Synopsis Statistical Methods for Survival Data Analysis by : Elisa T. Lee

Download or read book Statistical Methods for Survival Data Analysis written by Elisa T. Lee and published by John Wiley & Sons. This book was released on 2013-09-23 with total page 389 pages. Available in PDF, EPUB and Kindle. Book excerpt: Praise for the Third Edition “. . . an easy-to read introduction to survival analysis which covers the major concepts and techniques of the subject.” —Statistics in Medical Research Updated and expanded to reflect the latest developments, Statistical Methods for Survival Data Analysis, Fourth Edition continues to deliver a comprehensive introduction to the most commonly-used methods for analyzing survival data. Authored by a uniquely well-qualified author team, the Fourth Edition is a critically acclaimed guide to statistical methods with applications in clinical trials, epidemiology, areas of business, and the social sciences. The book features many real-world examples to illustrate applications within these various fields, although special consideration is given to the study of survival data in biomedical sciences. Emphasizing the latest research and providing the most up-to-date information regarding software applications in the field, Statistical Methods for Survival Data Analysis, Fourth Edition also includes: Marginal and random effect models for analyzing correlated censored or uncensored data Multiple types of two-sample and K-sample comparison analysis Updated treatment of parametric methods for regression model fitting with a new focus on accelerated failure time models Expanded coverage of the Cox proportional hazards model Exercises at the end of each chapter to deepen knowledge of the presented material Statistical Methods for Survival Data Analysis is an ideal text for upper-undergraduate and graduate-level courses on survival data analysis. The book is also an excellent resource for biomedical investigators, statisticians, and epidemiologists, as well as researchers in every field in which the analysis of survival data plays a role.

Experiments with Mixtures

Author :
Publisher :
ISBN 13 :
Total Pages : 447 pages
Book Rating : 4.:/5 (658 download)

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Book Synopsis Experiments with Mixtures by :

Download or read book Experiments with Mixtures written by and published by . This book was released on 1979 with total page 447 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Nonparametric Statistical Methods

Author : Myles Hollander
Publisher : John Wiley & Sons
ISBN 13 : 1118553292
Total Pages : 978 pages
Book Rating : 4.1/5 (185 download)

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Book Synopsis Nonparametric Statistical Methods by : Myles Hollander

Download or read book Nonparametric Statistical Methods written by Myles Hollander and published by John Wiley & Sons. This book was released on 2013-11-25 with total page 978 pages. Available in PDF, EPUB and Kindle. Book excerpt: Praise for the Second Edition “This book should be an essential part of the personal library of every practicing statistician.”—Technometrics Thoroughly revised and updated, the new edition of Nonparametric Statistical Methods includes additional modern topics and procedures, more practical data sets, and new problems from real-life situations. The book continues to emphasize the importance of nonparametric methods as a significant branch of modern statistics and equips readers with the conceptual and technical skills necessary to select and apply the appropriate procedures for any given situation. Written by leading statisticians, Nonparametric Statistical Methods, Third Edition provides readers with crucial nonparametric techniques in a variety of settings, emphasizing the assumptions underlying the methods. The book provides an extensive array of examples that clearly illustrate how to use nonparametric approaches for handling one- or two-sample location and dispersion problems, dichotomous data, and one-way and two-way layout problems. In addition, the Third Edition features: The use of the freely available R software to aid in computation and simulation, including many new R programs written explicitly for this new edition New chapters that address density estimation, wavelets, smoothing, ranked set sampling, and Bayesian nonparametrics Problems that illustrate examples from agricultural science, astronomy, biology, criminology, education, engineering, environmental science, geology, home economics, medicine, oceanography, physics, psychology, sociology, and space science Nonparametric Statistical Methods, Third Edition is an excellent reference for applied statisticians and practitioners who seek a review of nonparametric methods and their relevant applications. The book is also an ideal textbook for upper-undergraduate and first-year graduate courses in applied nonparametric statistics.

Empirical Model Building

Author : James R. Thompson
Publisher : John Wiley & Sons
ISBN 13 : 1118109627
Total Pages : 460 pages
Book Rating : 4.1/5 (181 download)

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Book Synopsis Empirical Model Building by : James R. Thompson

Download or read book Empirical Model Building written by James R. Thompson and published by John Wiley & Sons. This book was released on 2011-11-30 with total page 460 pages. Available in PDF, EPUB and Kindle. Book excerpt: Praise for the First Edition "This...novel and highly stimulating book, which emphasizes solving real problems...should be widely read. It will have a positive and lasting effect on the teaching of modeling and statistics in general." - Short Book Reviews This new edition features developments and real-world examples that showcase essential empirical modeling techniques Successful empirical model building is founded on the relationship between data and approximate representations of the real systems that generated that data. As a result, it is essential for researchers who construct these models to possess the special skills and techniques for producing results that are insightful, reliable, and useful. Empirical Model Building: Data, Models, and Reality, Second Edition presents a hands-on approach to the basic principles of empirical model building through a shrewd mixture of differential equations, computer-intensive methods, and data. The book outlines both classical and new approaches and incorporates numerous real-world statistical problems that illustrate modeling approaches that are applicable to a broad range of audiences, including applied statisticians and practicing engineers and scientists. The book continues to review models of growth and decay, systems where competition and interaction add to the complextiy of the model while discussing both classical and non-classical data analysis methods. This Second Edition now features further coverage of momentum based investing practices and resampling techniques, showcasing their importance and expediency in the real world. The author provides applications of empirical modeling, such as computer modeling of the AIDS epidemic to explain why North America has most of the AIDS cases in the First World and data-based strategies that allow individual investors to build their own investment portfolios. Throughout the book, computer-based analysis is emphasized and newly added and updated exercises allow readers to test their comprehension of the presented material. Empirical Model Building, Second Edition is a suitable book for modeling courses at the upper-undergraduate and graduate levels. It is also an excellent reference for applied statisticians and researchers who carry out quantitative modeling in their everyday work.

Statistics for Imaging, Optics, and Photonics

Author : Peter Bajorski
Publisher : John Wiley & Sons
ISBN 13 : 0470509457
Total Pages : 420 pages
Book Rating : 4.4/5 (75 download)

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Book Synopsis Statistics for Imaging, Optics, and Photonics by : Peter Bajorski

Download or read book Statistics for Imaging, Optics, and Photonics written by Peter Bajorski and published by John Wiley & Sons. This book was released on 2011-10-17 with total page 420 pages. Available in PDF, EPUB and Kindle. Book excerpt: A vivid, hands-on discussion of the statistical methods in imaging, optics, and photonics applications In the field of imaging science, there is a growing need for students and practitioners to be equipped with the necessary knowledge and tools to carry out quantitative analysis of data. Providing a self-contained approach that is not too heavily statistical in nature, Statistics for Imaging, Optics, and Photonics presents necessary analytical techniques in the context of real examples from various areas within the field, including remote sensing, color science, printing, and astronomy. Bridging the gap between imaging, optics, photonics, and statistical data analysis, the author uniquely concentrates on statistical inference, providing a wide range of relevant methods. Brief introductions to key probabilistic terms are provided at the beginning of the book in order to present the notation used, followed by discussions on multivariate techniques such as: Linear regression models, vector and matrix algebra, and random vectors and matrices Multivariate statistical inference, including inferences about both mean vectors and covariance matrices Principal components analysis Canonical correlation analysis Discrimination and classification analysis for two or more populations and spatial smoothing Cluster analysis, including similarity and dissimilarity measures and hierarchical and nonhierarchical clustering methods Intuitive and geometric understanding of concepts is emphasized, and all examples are relatively simple and include background explanations. Computational results and graphs are presented using the freely available R software, and can be replicated by using a variety of software packages. Throughout the book, problem sets and solutions contain partial numerical results, allowing readers to confirm the accuracy of their approach; and a related website features additional resources including the book's datasets and figures. Statistics for Imaging, Optics, and Photonics is an excellent book for courses on multivariate statistics for imaging science, optics, and photonics at the upper-undergraduate and graduate levels. The book also serves as a valuable reference for professionals working in imaging, optics, and photonics who carry out data analyses in their everyday work.

Sampling

Author : Steven K. Thompson
Publisher : John Wiley & Sons
ISBN 13 : 1118162943
Total Pages : 470 pages
Book Rating : 4.1/5 (181 download)

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Book Synopsis Sampling by : Steven K. Thompson

Download or read book Sampling written by Steven K. Thompson and published by John Wiley & Sons. This book was released on 2012-02-08 with total page 470 pages. Available in PDF, EPUB and Kindle. Book excerpt: Praise for the Second Edition "This book has never had a competitor. It is the only book that takes a broad approach to sampling . . . any good personal statistics library should include a copy of this book." —Technometrics "Well-written . . . an excellent book on an important subject. Highly recommended." —Choice "An ideal reference for scientific researchers and other professionals who use sampling." —Zentralblatt Math Features new developments in the field combined with all aspects of obtaining, interpreting, and using sample data Sampling provides an up-to-date treatment of both classical and modern sampling design and estimation methods, along with sampling methods for rare, clustered, and hard-to-detect populations. This Third Edition retains the general organization of the two previous editions, but incorporates extensive new material—sections, exercises, and examples—throughout. Inside, readers will find all-new approaches to explain the various techniques in the book; new figures to assist in better visualizing and comprehending underlying concepts such as the different sampling strategies; computing notes for sample selection, calculation of estimates, and simulations; and more. Organized into six sections, the book covers basic sampling, from simple random to unequal probability sampling; the use of auxiliary data with ratio and regression estimation; sufficient data, model, and design in practical sampling; useful designs such as stratified, cluster and systematic, multistage, double and network sampling; detectability methods for elusive populations; spatial sampling; and adaptive sampling designs. Featuring a broad range of topics, Sampling, Third Edition serves as a valuable reference on useful sampling and estimation methods for researchers in various fields of study, including biostatistics, ecology, and the health sciences. The book is also ideal for courses on statistical sampling at the upper-undergraduate and graduate levels.

Optimal Learning

Author : Warren B. Powell
Publisher : John Wiley & Sons
ISBN 13 : 1118309847
Total Pages : 416 pages
Book Rating : 4.1/5 (183 download)

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Book Synopsis Optimal Learning by : Warren B. Powell

Download or read book Optimal Learning written by Warren B. Powell and published by John Wiley & Sons. This book was released on 2013-07-09 with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt: Learn the science of collecting information to make effective decisions Everyday decisions are made without the benefit of accurate information. Optimal Learning develops the needed principles for gathering information to make decisions, especially when collecting information is time-consuming and expensive. Designed for readers with an elementary background in probability and statistics, the book presents effective and practical policies illustrated in a wide range of applications, from energy, homeland security, and transportation to engineering, health, and business. This book covers the fundamental dimensions of a learning problem and presents a simple method for testing and comparing policies for learning. Special attention is given to the knowledge gradient policy and its use with a wide range of belief models, including lookup table and parametric and for online and offline problems. Three sections develop ideas with increasing levels of sophistication: Fundamentals explores fundamental topics, including adaptive learning, ranking and selection, the knowledge gradient, and bandit problems Extensions and Applications features coverage of linear belief models, subset selection models, scalar function optimization, optimal bidding, and stopping problems Advanced Topics explores complex methods including simulation optimization, active learning in mathematical programming, and optimal continuous measurements Each chapter identifies a specific learning problem, presents the related, practical algorithms for implementation, and concludes with numerous exercises. A related website features additional applications and downloadable software, including MATLAB and the Optimal Learning Calculator, a spreadsheet-based package that provides an introduction to learning and a variety of policies for learning.

Clinical Trial Design

Author : Guosheng Yin
Publisher : John Wiley & Sons
ISBN 13 : 1118183320
Total Pages : 368 pages
Book Rating : 4.1/5 (181 download)

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Book Synopsis Clinical Trial Design by : Guosheng Yin

Download or read book Clinical Trial Design written by Guosheng Yin and published by John Wiley & Sons. This book was released on 2013-06-07 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: A balanced treatment of the theories, methodologies, and design issues involved in clinical trials using statistical methods There has been enormous interest and development in Bayesian adaptive designs, especially for early phases of clinical trials. However, for phase III trials, frequentist methods still play a dominant role through controlling type I and type II errors in the hypothesis testing framework. From practical perspectives, Clinical Trial Design: Bayesian and Frequentist Adaptive Methods provides comprehensive coverage of both Bayesian and frequentist approaches to all phases of clinical trial design. Before underpinning various adaptive methods, the book establishes an overview of the fundamentals of clinical trials as well as a comparison of Bayesian and frequentist statistics. Recognizing that clinical trial design is one of the most important and useful skills in the pharmaceutical industry, this book provides detailed discussions on a variety of statistical designs, their properties, and operating characteristics for phase I, II, and III clinical trials as well as an introduction to phase IV trials. Many practical issues and challenges arising in clinical trials are addressed. Additional topics of coverage include: Risk and benefit analysis for toxicity and efficacy trade-offs Bayesian predictive probability trial monitoring Bayesian adaptive randomization Late onset toxicity and response Dose finding in drug combination trials Targeted therapy designs The author utilizes cutting-edge clinical trial designs and statistical methods that have been employed at the world's leading medical centers as well as in the pharmaceutical industry. The software used throughout the book is freely available on the book's related website, equipping readers with the necessary tools for designing clinical trials. Clinical Trial Design is an excellent book for courses on the topic at the graduate level. The book also serves as a valuable reference for statisticians and biostatisticians in the pharmaceutical industry as well as for researchers and practitioners who design, conduct, and monitor clinical trials in their everyday work.