A Molecular Epidemiologic Case-Case Study of Prostate Cancer

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ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (946 download)

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Book Synopsis A Molecular Epidemiologic Case-Case Study of Prostate Cancer by :

Download or read book A Molecular Epidemiologic Case-Case Study of Prostate Cancer written by and published by . This book was released on 2001 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Although prostate cancer is the most common cancer in western countries, risk factors for this disease have not been well characterized. Furthermore, research on genetic susceptibility to prostate cancer is in its infancy. This study builds upon an ongoing project by adding genetic susceptibility markers. Additionally, we accrued new patients with metastatic disease. Constitutional markers are being evaluated as predictors of prostate cancer risk including: (a) polymorphisms within the androgen receptor and 5-Alpha-reductase genes, vitamin D receptor; (b) relative expression levels of several mismatched repair genes (hMSH2 and hMLH1) and radiosensitivity related genes (ATM, GADD45, XRCC1), and (c) frequency of replication errors in tumor and normal DNA. These data will be integrated with epidemiologic and clinical information. Results from this research may identify markers of progression, which could help in the diagnosis and treatment of prostate cancer. Our findings indicate that decreased mismatched repair gene expression may be associated with increased risk of prostate cancer. These results suggest that DNA damage-repair pathways may be involved in prostate carcinogenesis. Incorporation of data obtained form this research to ongoing studies in our department, including the metastatic patients, will allow us to confirm this finding and further explore the molecular basis of the underlying mechanisms of prostate cancer etiology.

A Molecular Epidemiologic Case-Case Study of Prostate Cancer Susceptibility

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ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (946 download)

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Book Synopsis A Molecular Epidemiologic Case-Case Study of Prostate Cancer Susceptibility by :

Download or read book A Molecular Epidemiologic Case-Case Study of Prostate Cancer Susceptibility written by and published by . This book was released on 1999 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Although prostate cancer is the most common cancer in western countries, risk factors for this disease have not been well characterized. Furthermore, research on genetic susceptibility to prostate cancer is in its infancy. This study builds upon an ongoing project by adding genetic susceptibility markers. Additionally, we are accruing 100 new patients with metastatic disease, Constitutional markers are being evaluated as predictors of prostate cancer risk including: (a) polymorphisms within the androgen receptor and 5-alpha-reductase genes, (b) relative expression levels of several mismatch repair genes (hMSH2 and hMLH1) and radiosensitivity related genes (ATM, GADD45, XRCC1), and (c) frequency of replication errors in tumor and normal DNA. These data will be integrated with epidemiologic and clinical information. Results from this research may identify markers of progression, which could help in the diagnosis and treatment of prostate cancer. Our preliminary findings indicate that decreased mismatch repair gene expression may be associated with increased risk of prostate cancer. These results suggest that DNA damage-repair pathways may be involved in prostate carcinogenesis. Incorporation of more data from this study, including the metastatic patients, will allow us to confirm this finding and further explore the molecular basis of the underlying mechanisms of prostate cancer etiology.

Molecular Epidemiology of Prostate Cancer

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Publisher :
ISBN 13 :
Total Pages : 15 pages
Book Rating : 4.:/5 (742 download)

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Book Synopsis Molecular Epidemiology of Prostate Cancer by :

Download or read book Molecular Epidemiology of Prostate Cancer written by and published by . This book was released on 2004 with total page 15 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the Final Report for this project. It provides new updated information since the last report, which was submitted in June 2004, and provides an overall summary of progress, and remaining steps required to meet the study objectives. Although those objectives were not completed during the funding period, they will be completed using other funding sources. The objective of this case-control study is to determine whether oxidative damage is a risk factor for prostate cancer, and whether this mechanism mediates the association between dietary fat and prostate cancer risk. Specifically, cases and controls will be compared with respect to malondialdehyde (MDA) in serum as a measure of oxidative stress, and deoxyguanosine malondialdehyde (dG-MDA) in peripheral lymphocytes and prostate tumor samples as a measure of oxidative DNA damage. In addition to these measures, dietary intake of fats and specific fatty acids, and of antioxidants will be considered as potential effect modifiers or confounding factors, as will serum antioxidant levels. Enrollment of cases and controls, collection of questionnaire data, and collection of serum, plasma and lymphocytes has been completed.

Male Reproductive Cancers

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Publisher : Springer Science & Business Media
ISBN 13 : 1441904492
Total Pages : 347 pages
Book Rating : 4.4/5 (419 download)

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Book Synopsis Male Reproductive Cancers by : William D. Foulkes

Download or read book Male Reproductive Cancers written by William D. Foulkes and published by Springer Science & Business Media. This book was released on 2009-12-17 with total page 347 pages. Available in PDF, EPUB and Kindle. Book excerpt: Knowledge about cancer genetics is rapidly expanding, and has implications for all aspects of cancer research and treatment, including molecular causation, diagnosis, prevention, screening, and treatment. Additionally, while cancer genetics has traditionally focused on mutational events that have their primary effect within the cancer cell, recently the focus has widened, with evidence of the importance of epigenetic events and of cellular interactions in cancer development. The role of common genetic variation in determining the range of individual susceptibility within the population is increasingly recognized, and is now being widely addressed using information from the Human Genome Project. These new research directions will highlight determinants of cancer that lie outside the cancer cell, suggest new targets for intervention, and inform the design of strategies for prevention in groups at increased risk. Today, the NCI is putting more and more money into research into the genetics of cancer. The very first of the NCI’s stated research priorities is a project called The Cancer Genome Atlas. The Cancer Genome Atlas (TCGA) is a comprehensive and coordinated effort to accelerate the understanding of the molecular basis of cancer through the application of genome analysis technologies, including large-scale genome sequencing. The NCI and the NHGRI (National Human Genome Research Institute, where the series editor is employed) have each committed $50 million over three years to the TCGA Pilot Project. This book proposes cover the latest findings in the genetics of male reproductive cancers; specifically cancers of the prostate and testes. The volume will cover the epidemiology of these cancers; model systems, pathology, molecular genetics, and inherited susceptibility.

Pathology and Epidemiology of Cancer

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Publisher : Springer
ISBN 13 : 3319351532
Total Pages : 664 pages
Book Rating : 4.3/5 (193 download)

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Book Synopsis Pathology and Epidemiology of Cancer by : Massimo Loda

Download or read book Pathology and Epidemiology of Cancer written by Massimo Loda and published by Springer. This book was released on 2016-09-01 with total page 664 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book integrates the disciplines of cancer pathology and epidemiology to provide a synergistic and complementary approach to understanding the molecular mechanisms of cancer. This book provides relevant information on the diagnostic, prognostic and predictive molecular pathology of cancer. Epidemiological studies, including descriptive epidemiology, risk factors and molecular mechanisms of disease inform on the etiology and progression of cancer. The text concentrates on major cancers that are currently prevalent and those for which substantial molecular, pathological and epidemiological data is available. Each section is designed to provide an overview of that cancer type in terms of basic biology, review the current epidemiological data surrounding that cancer type and provide information on common practices and challenges related to the molecular pathology of that cancer type. Several relevant techniques in molecular pathology, which facilitate diagnosis and treatment are also explored. Pathology and Epidemiology of Cancer provides a succinct and comprehensive overview of multiple cancer types to guide clinicians during patient care and to guide scientists for innovations in research. It represents an integral resource for pathologists, epidemiologists, medical students as well as translational, basic and clinical science researchers who are all working to progress the field of cancer in terms of diagnosis, treatment and prevention.

Mechanisms of Carcinogenesis

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Publisher : World Health Organization
ISBN 13 :
Total Pages : 464 pages
Book Rating : 4.:/5 (318 download)

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Book Synopsis Mechanisms of Carcinogenesis by : Patricia A. Buffler

Download or read book Mechanisms of Carcinogenesis written by Patricia A. Buffler and published by World Health Organization. This book was released on 2004 with total page 464 pages. Available in PDF, EPUB and Kindle. Book excerpt: During the last two decades, molecular epidemiology has become an important discipline in cancer research. It has evolved towards the development, validation and application of markers of susceptibility and, more recently, markers of mechanisms of cancer development. This volume on mechanisms of carcinogenesis covers from an interdisciplinary perspective, the contribution of molecular epidemiology to the understanding of mechanisms of carcinogenesis, and represents a further contribution to the development of molecular epidemiology as a major cancer research domain.

Studies of the Genetic Epidemiology and Molecular Genetics of Human Prostate Cancer

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Publisher :
ISBN 13 :
Total Pages : 260 pages
Book Rating : 4.:/5 (279 download)

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Book Synopsis Studies of the Genetic Epidemiology and Molecular Genetics of Human Prostate Cancer by : Bob S. Carter

Download or read book Studies of the Genetic Epidemiology and Molecular Genetics of Human Prostate Cancer written by Bob S. Carter and published by . This book was released on 1992 with total page 260 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Analysis of Cancer Risks in Populations Near Nuclear Facilities

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Publisher : National Academies Press
ISBN 13 : 0309255716
Total Pages : 424 pages
Book Rating : 4.3/5 (92 download)

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Book Synopsis Analysis of Cancer Risks in Populations Near Nuclear Facilities by : National Research Council

Download or read book Analysis of Cancer Risks in Populations Near Nuclear Facilities written by National Research Council and published by National Academies Press. This book was released on 2012-06-29 with total page 424 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the late 1980s, the National Cancer Institute initiated an investigation of cancer risks in populations near 52 commercial nuclear power plants and 10 Department of Energy nuclear facilities (including research and nuclear weapons production facilities and one reprocessing plant) in the United States. The results of the NCI investigation were used a primary resource for communicating with the public about the cancer risks near the nuclear facilities. However, this study is now over 20 years old. The U.S. Nuclear Regulatory Commission requested that the National Academy of Sciences provide an updated assessment of cancer risks in populations near USNRC-licensed nuclear facilities that utilize or process uranium for the production of electricity. Analysis of Cancer Risks in Populations near Nuclear Facilities: Phase 1 focuses on identifying scientifically sound approaches for carrying out an assessment of cancer risks associated with living near a nuclear facility, judgments about the strengths and weaknesses of various statistical power, ability to assess potential confounding factors, possible biases, and required effort. The results from this Phase 1 study will be used to inform the design of cancer risk assessment, which will be carried out in Phase 2. This report is beneficial for the general public, communities near nuclear facilities, stakeholders, healthcare providers, policy makers, state and local officials, community leaders, and the media.

Prostate Cancer Prevention

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Publisher : Springer Science & Business Media
ISBN 13 : 3642451950
Total Pages : 167 pages
Book Rating : 4.6/5 (424 download)

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Book Synopsis Prostate Cancer Prevention by : Jack Cuzick

Download or read book Prostate Cancer Prevention written by Jack Cuzick and published by Springer Science & Business Media. This book was released on 2014-02-15 with total page 167 pages. Available in PDF, EPUB and Kindle. Book excerpt: Prostate cancer is by far the most common cancer in men and the second leading cause of death due to cancer. It comprises a mixed group of tumours displaying varying clinical behaviour: while some have a very aggressive course, others are rather indolent. Prevention of prostate cancer and discrimination between aggressive and indolent forms are important clinical goals and the acquisition of significant new evidence on means of achieving these aims makes this book particularly timely. A wide range of topics are covered by leading authorities in the field. The biology and natural history of prostate cancer are reviewed and the role of lifestyle and dietary factors, assessed. Detailed attention is paid to risk prediction biomarkers and to the role of novel high-throughput nucleic acid-based technologies in improving risk prediction and thereby allowing tailored approaches to cancer prevention. Potential means of chemoprevention of prostate cancer are also reviewed in depth, covering the very positive new data on the impact of aspirin as well as evidence regarding 5α-reductase inhibitors, DFMO and lycopene. Guidance is provided on the differentiation of aggressive from indolent disease and the policy and research implications of recent findings are examined. This book will be of interest to both clinicians and researchers.

Molecular Biology of Prostate Cancer

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Publisher : Walter de Gruyter
ISBN 13 : 3110807270
Total Pages : 220 pages
Book Rating : 4.1/5 (18 download)

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Book Synopsis Molecular Biology of Prostate Cancer by : Manfred Wirth

Download or read book Molecular Biology of Prostate Cancer written by Manfred Wirth and published by Walter de Gruyter. This book was released on 2013-05-22 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Evaluation of Biomarkers and Surrogate Endpoints in Chronic Disease

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Publisher : National Academies Press
ISBN 13 : 0309157277
Total Pages : 335 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Evaluation of Biomarkers and Surrogate Endpoints in Chronic Disease by : Institute of Medicine

Download or read book Evaluation of Biomarkers and Surrogate Endpoints in Chronic Disease written by Institute of Medicine and published by National Academies Press. This book was released on 2010-06-25 with total page 335 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many people naturally assume that the claims made for foods and nutritional supplements have the same degree of scientific grounding as those for medication, but that is not always the case. The IOM recommends that the FDA adopt a consistent scientific framework for biomarker evaluation in order to achieve a rigorous and transparent process.

Molecular Epidemiology

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Publisher : Academic Press
ISBN 13 : 0323138578
Total Pages : 609 pages
Book Rating : 4.3/5 (231 download)

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Book Synopsis Molecular Epidemiology by : Paul A. Schulte

Download or read book Molecular Epidemiology written by Paul A. Schulte and published by Academic Press. This book was released on 2012-12-02 with total page 609 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book will serve as a primer for both laboratory and field scientists who are shaping the emerging field of molecular epidemiology. Molecular epidemiology utilizes the same paradigm as traditional epidemiology but uses biological markers to identify exposure, disease or susceptibility. Schulte and Perera present the epidemiologic methods pertinent to biological markers. The book is also designed to enumerate the considerations necessary for valid field research and provide a resource on the salient and subtle features of biological indicators.

Clinical Oncology

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Publisher :
ISBN 13 : 9780443075452
Total Pages : 0 pages
Book Rating : 4.0/5 (754 download)

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Book Synopsis Clinical Oncology by : Martin D. Abeloff

Download or read book Clinical Oncology written by Martin D. Abeloff and published by . This book was released on 2000 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: A must-have reference, this new edition provides practical information on treatment guidelines, details of diagnosis and therapy, and personal recommendations on patient management from experts in the field. Consistently formatted chapters allow for a user-friendly presentation for quick access of key information by the practicing clinician. Completely updated, this new edition includes all of the latest developments in treatment strategies of medical, surgical and radiation oncologists.

Prostate Cancer

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Publisher : Springer Science & Business Media
ISBN 13 : 1597452246
Total Pages : 512 pages
Book Rating : 4.5/5 (974 download)

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Book Synopsis Prostate Cancer by : Leland W. K. Chung

Download or read book Prostate Cancer written by Leland W. K. Chung and published by Springer Science & Business Media. This book was released on 2007-11-10 with total page 512 pages. Available in PDF, EPUB and Kindle. Book excerpt: Prostate Cancer: Biology, Genetics, and the New Therapeutics, Second Edition, reviews new, valuable approaches to the treatment of prostate cancer in men. The latest edition contains new material on molecular imaging, new treatments for prostate cancer, molecular targets, cell signaling pathways, bioinformatics, and pathogenomics. The book details the latest innovations and advances in prostate cancer and may be used as a rapid reference text for readers. The volume profiles the latest advances in cancer research and treatment and includes profound studies in prostate stem cells, cancer-host interactions, hedgehog signaling in development and cancer, cholesterol and cell signaling, gene therapy for advanced prostate cancer, and noninvasive strategies such as molecular imaging to visualize gene expression. This new edition also investigates expression profiling and somatic alterations in prostate cancer progression and linkage studies of prostate cancer families to identify susceptibility genes. The issues of racial differences in prostate cancer mortality, radiotherapy for the treatment of locally advanced prostate cancer, recombinant antibody candidates for treatment, taxane-based chemotherapy, lethal phenotypes, and novel and efficient translation clinical trials are also presented in great depth. Prostate Cancer: Biology, Genetics, and the New Therapeutics, Second Edition, provides readers with a general reference for prostate cancer from prevention to therapy and will be of value to clinicians, scientists, and administrators who strive to solve the cancer problem.

How Tobacco Smoke Causes Disease

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Publisher :
ISBN 13 :
Total Pages : 728 pages
Book Rating : 4.:/5 (318 download)

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Book Synopsis How Tobacco Smoke Causes Disease by : United States. Public Health Service. Office of the Surgeon General

Download or read book How Tobacco Smoke Causes Disease written by United States. Public Health Service. Office of the Surgeon General and published by . This book was released on 2010 with total page 728 pages. Available in PDF, EPUB and Kindle. Book excerpt: This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.

Prostate Cancer

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Publisher : Springer Nature
ISBN 13 : 303032656X
Total Pages : 483 pages
Book Rating : 4.0/5 (33 download)

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Book Synopsis Prostate Cancer by : Scott M. Dehm

Download or read book Prostate Cancer written by Scott M. Dehm and published by Springer Nature. This book was released on 2020-01-03 with total page 483 pages. Available in PDF, EPUB and Kindle. Book excerpt: The purpose of this book is to provide a contemporary overview of the causes and consequences of prostate cancer from a cellular and genetic perspective. Written by experts in the fields of epidemiology, toxicology, cell biology, genetics, genomics, cell-cell interactions, cell signaling, hormone signaling, and transcriptional regulation, the text covers aspects of prostate cancer from disease initiation to metastasis. Chapters explore in depth the cells of origin for prostate cancer, its genomic subtypes, neural transcription factors in disease progression, epigenetic regulation of chromatin, and many other topics. This book distinguishes itself from other texts on prostate cancer by its focus on cellular and genetic mechanisms, as opposed to clinical diagnosis and management. As a result, this book will be of broad interest to basic and translational scientists with familiarity of these topics, as well as to trainees at earlier stages of their research careers.

Biomedical Index to PHS-supported Research

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Publisher :
ISBN 13 :
Total Pages : 1398 pages
Book Rating : 4.F/5 ( download)

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Book Synopsis Biomedical Index to PHS-supported Research by :

Download or read book Biomedical Index to PHS-supported Research written by and published by . This book was released on 1987 with total page 1398 pages. Available in PDF, EPUB and Kindle. Book excerpt: