A Mathematical Modeling Framework To Simulate And Analyze Cell Type Transitions

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A mathematical modeling framework to simulate and analyze cell type transitions

Author : Daniella Schittler
Publisher : Logos Verlag Berlin GmbH
ISBN 13 : 3832539352
Total Pages : 192 pages
Book Rating : 4.8/5 (325 download)

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Book Synopsis A mathematical modeling framework to simulate and analyze cell type transitions by : Daniella Schittler

Download or read book A mathematical modeling framework to simulate and analyze cell type transitions written by Daniella Schittler and published by Logos Verlag Berlin GmbH. This book was released on 2015-03-20 with total page 192 pages. Available in PDF, EPUB and Kindle. Book excerpt: The quantitative understanding of changes in cell types, referred to as cell type transitions, is fundamental to advance fields such as stem cell research, immunology, and cancer therapies. This thesis provides a mathematical modeling framework to simulate and analyze cell type transitions. The novel methodological approaches and models presented here address diverse levels which are essential in this context: Gene regulatory network models represent the cell type-determining gene expression dynamics. Here, a novel construction method for gene regulatory network models is introduced, which allows to transfer results from generic low-dimensional to realistic high-dimensional gene regulatory network models. For populations of cells, a generalized model class is proposed that accounts for multiple cell types, division numbers, and the full label distribution. Analysis and solution methods are presented for this new model class, which cover common cell population experiments and allow to exploit the full information from data. The modeling and analysis methods presented here connect formerly isolated approaches, and thereby contribute to a holistic framework for the quantitative understanding of cell type transitions.

Multiscale Modeling of Cancer

Author : Vittorio Cristini
Publisher : Cambridge University Press
ISBN 13 : 1139491504
Total Pages : 299 pages
Book Rating : 4.1/5 (394 download)

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Book Synopsis Multiscale Modeling of Cancer by : Vittorio Cristini

Download or read book Multiscale Modeling of Cancer written by Vittorio Cristini and published by Cambridge University Press. This book was released on 2010-09-09 with total page 299 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mathematical modeling, analysis and simulation are set to play crucial roles in explaining tumor behavior, and the uncontrolled growth of cancer cells over multiple time and spatial scales. This book, the first to integrate state-of-the-art numerical techniques with experimental data, provides an in-depth assessment of tumor cell modeling at multiple scales. The first part of the text presents a detailed biological background with an examination of single-phase and multi-phase continuum tumor modeling, discrete cell modeling, and hybrid continuum-discrete modeling. In the final two chapters, the authors guide the reader through problem-based illustrations and case studies of brain and breast cancer, to demonstrate the future potential of modeling in cancer research. This book has wide interdisciplinary appeal and is a valuable resource for mathematical biologists, biomedical engineers and clinical cancer research communities wishing to understand this emerging field.

Systems Modeling: Approaches and Applications - Volume II

Author : Alberto Jesus Martin
Publisher : Frontiers Media SA
ISBN 13 : 2832507123
Total Pages : 333 pages
Book Rating : 4.8/5 (325 download)

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Book Synopsis Systems Modeling: Approaches and Applications - Volume II by : Alberto Jesus Martin

Download or read book Systems Modeling: Approaches and Applications - Volume II written by Alberto Jesus Martin and published by Frontiers Media SA. This book was released on 2022-11-25 with total page 333 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Simulating Normal and Arrhythmic Dynamics: From Sub-Cellular to Tissue and Organ Level

Author : Hans Dierckx
Publisher : Frontiers Media SA
ISBN 13 : 2889630676
Total Pages : 276 pages
Book Rating : 4.8/5 (896 download)

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Book Synopsis Simulating Normal and Arrhythmic Dynamics: From Sub-Cellular to Tissue and Organ Level by : Hans Dierckx

Download or read book Simulating Normal and Arrhythmic Dynamics: From Sub-Cellular to Tissue and Organ Level written by Hans Dierckx and published by Frontiers Media SA. This book was released on 2019-10-04 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Dynamical Systems, PDEs and Networks for Biomedical Applications: Mathematical Modeling, Analysis and Simulations

Author : André H. Erhardt
Publisher : Frontiers Media SA
ISBN 13 : 2832514588
Total Pages : 209 pages
Book Rating : 4.8/5 (325 download)

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Book Synopsis Dynamical Systems, PDEs and Networks for Biomedical Applications: Mathematical Modeling, Analysis and Simulations by : André H. Erhardt

Download or read book Dynamical Systems, PDEs and Networks for Biomedical Applications: Mathematical Modeling, Analysis and Simulations written by André H. Erhardt and published by Frontiers Media SA. This book was released on 2023-02-15 with total page 209 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Mathematics for Healthcare

Author : Krasimira Tsaneva-Atanasova
Publisher : Frontiers Media SA
ISBN 13 : 2889455777
Total Pages : 284 pages
Book Rating : 4.8/5 (894 download)

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Book Synopsis Mathematics for Healthcare by : Krasimira Tsaneva-Atanasova

Download or read book Mathematics for Healthcare written by Krasimira Tsaneva-Atanasova and published by Frontiers Media SA. This book was released on 2018-09-28 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt: In 1996, and with extraordinary prescience, Panfilov and Holden had highlighted in their seminal book 'Computational Biology of the Heart' that biology was, potentially, the most mathematical of all sciences. Fast-forward 20 years and we have seen an explotion of applications of mathematics in not only biology, but healthcare that has already produced significant breakthroughs not imaginable more than 20 years ago. Great strides have been made in explaining through quantitative methods the underlying mechanisms of human disease, not without considerable ingenuity and effort. Biological mechanisms are bewildering: complex, ever evolving, multi-scale, variable, difficult to fully access and understand. This poses immense challenges to the computational physiology community that, nevertheless, has developed an impressive arsenal of tools and methods in a vertiginous race to combat disease with the tall order of improving human healthcare. Mechanistic models are now contending with the advent of machine learning in healthcare and the hope is that both approaches will be used synergistically since the complexity of human patophysiology and the difficulty of acquiring human datasets will require both, deductive and inductive methods. This Research Topic presents work that is currently at the frontier in computational physiology with a striking range of applications, from diabetes to graft failure and using a multitude of mathematical tools. This collection of articles represents a snapshot in a field that is moving a dizzying speed, bringing understanding of fundamental mechanism and solutions to healthcare problems experienced by healthcare systems all over the world.

Scientific and Technical Aerospace Reports

Author :
Publisher :
ISBN 13 :
Total Pages : 704 pages
Book Rating : 4.:/5 (31 download)

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Book Synopsis Scientific and Technical Aerospace Reports by :

Download or read book Scientific and Technical Aerospace Reports written by and published by . This book was released on 1995 with total page 704 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Systems Biology of Cell Signaling

Author : Zhike Zi
Publisher : Frontiers Media SA
ISBN 13 : 2889742814
Total Pages : 224 pages
Book Rating : 4.8/5 (897 download)

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Book Synopsis Systems Biology of Cell Signaling by : Zhike Zi

Download or read book Systems Biology of Cell Signaling written by Zhike Zi and published by Frontiers Media SA. This book was released on 2022-02-17 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt: Topic Editor Prof. Xing is in collaboration with ATCC (https://www.atcc.org/) on testing some of their cell lines in research. All other Topic Editors declare no competing interests with regards to the Research Topic subject.

Mathematical Modeling and Simulation

Author : Kai Velten
Publisher : John Wiley & Sons
ISBN 13 : 3527839402
Total Pages : 498 pages
Book Rating : 4.5/5 (278 download)

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Book Synopsis Mathematical Modeling and Simulation by : Kai Velten

Download or read book Mathematical Modeling and Simulation written by Kai Velten and published by John Wiley & Sons. This book was released on 2024-08-19 with total page 498 pages. Available in PDF, EPUB and Kindle. Book excerpt: Learn to use modeling and simulation methods to attack real-world problems, from physics to engineering, from life sciences to process engineering Reviews of the first edition (2009): "Perfectly fits introductory modeling courses [...] and is an enjoyable reading in the first place. Highly recommended [...]" Zentralblatt MATH, European Mathematical Society, 2009 "This book differs from almost all other available modeling books in that [the authors address] both mechanistic and statistical models as well as 'hybrid' models. [...] The modeling range is enormous." SIAM Society of Industrial and Applied Mathematics, USA, 2011 This completely revised and substantially extended second edition answers the most important questions in the field of modeling: What is a mathematical model? What types of models do exist? Which model is appropriate for a particular problem? What are simulation, parameter estimation, and validation? What kind of mathematical problems appear and how can these be efficiently solved using professional free of charge open source software? The book addresses undergraduates and practitioners alike. Although only basic knowledge of calculus and linear algebra is required, the most important mathematical structures are discussed in sufficient detail, ranging from statistical models to partial differential equations and accompanied by examples from biology, ecology, economics, medicine, agricultural, chemical, electrical, mechanical, and process engineering. About 200 pages of additional material include a unique chapter on virtualization, Crash Courses on the data analysis and programming languages R and Python and on the computer algebra language Maxima, many new methods and examples scattered throughout the book, an update of all software-related procedures, and a comprehensive book software providing templates for typical modeling tasks in thousands of code lines. The book software includes GmLinux, an operating system specifically designed for this book providing preconfigured and ready-to-use installations of OpenFOAM, Salome, FreeCAD/CfdOF workbench, ParaView, R, Maxima/wxMaxima, Python, Rstudio, Quarto/Markdown and other free of charge open source software used in the book.

Machine Learning and Mathematical Models for Single-Cell Data Analysis

Author : Le Ou-Yang
Publisher : Frontiers Media SA
ISBN 13 : 2832501842
Total Pages : 118 pages
Book Rating : 4.8/5 (325 download)

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Book Synopsis Machine Learning and Mathematical Models for Single-Cell Data Analysis by : Le Ou-Yang

Download or read book Machine Learning and Mathematical Models for Single-Cell Data Analysis written by Le Ou-Yang and published by Frontiers Media SA. This book was released on 2022-11-29 with total page 118 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Computational Analysis of Biochemical Systems

Author : Eberhard O. Voit
Publisher : Cambridge University Press
ISBN 13 : 9780521785792
Total Pages : 556 pages
Book Rating : 4.7/5 (857 download)

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Book Synopsis Computational Analysis of Biochemical Systems by : Eberhard O. Voit

Download or read book Computational Analysis of Biochemical Systems written by Eberhard O. Voit and published by Cambridge University Press. This book was released on 2000-09-04 with total page 556 pages. Available in PDF, EPUB and Kindle. Book excerpt: Teaches the use of modern computational methods for the analysis of biomedical systems using case studies and accompanying software.

Modeling and Simulation in the Medical and Health Sciences

Author : John A. Sokolowski
Publisher : John Wiley & Sons
ISBN 13 : 1118003195
Total Pages : 270 pages
Book Rating : 4.1/5 (18 download)

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Book Synopsis Modeling and Simulation in the Medical and Health Sciences by : John A. Sokolowski

Download or read book Modeling and Simulation in the Medical and Health Sciences written by John A. Sokolowski and published by John Wiley & Sons. This book was released on 2012-01-25 with total page 270 pages. Available in PDF, EPUB and Kindle. Book excerpt: This edited book is divided into three parts: Fundamentals of Medical and Health Sciences Modeling and Simulation introduces modeling and simulation in the medical and health sciences; Medical and Health Sciences Models provides the theoretical underpinnings of medical and health sciences modeling; and Modeling and Simulation Applications in Medical and Health Sciences focuses on teaching, training, and research applications. The book begins with a general discussion of modeling and simulation from the modeling and simulation discipline perspective. This discussion grounds the reader in common terminology. It also relates this terminology to concepts found in the medical and health care (MHC) area to help bridge the gap between developers and MHC practitioners. Three distinct modes of modeling and simulation are described: live, constructive, and virtual. The live approach explains the concept of using real (live) people employing real equipment for training purposes. The constructive mode is a means of engaging medical modeling and simulation. In constructive simulation, simulated people and simulated equipment are developed to augment real-world conditions for training or experimentation purposes. The virtual mode is perhaps the most fascinating as virtual operating rooms and synthetic training environments are being produced for practitioners and educators at break-neck speed. In this mode, real people are employing simulated equipment to improve physical skills and decision-making ability.

Selected Water Resources Abstracts

Author :
Publisher :
ISBN 13 :
Total Pages : 936 pages
Book Rating : 4.E/5 ( download)

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Book Synopsis Selected Water Resources Abstracts by :

Download or read book Selected Water Resources Abstracts written by and published by . This book was released on 1986 with total page 936 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Model-informed decision making in the preclinical stages of pharmaceutical research and development

Author : Rui Li
Publisher : Frontiers Media SA
ISBN 13 : 2832514766
Total Pages : 181 pages
Book Rating : 4.8/5 (325 download)

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Book Synopsis Model-informed decision making in the preclinical stages of pharmaceutical research and development by : Rui Li

Download or read book Model-informed decision making in the preclinical stages of pharmaceutical research and development written by Rui Li and published by Frontiers Media SA. This book was released on 2023-05-10 with total page 181 pages. Available in PDF, EPUB and Kindle. Book excerpt:

The Handbook of Brain Theory and Neural Networks

Author : Michael A. Arbib
Publisher : MIT Press
ISBN 13 : 0262011972
Total Pages : 1328 pages
Book Rating : 4.2/5 (62 download)

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Book Synopsis The Handbook of Brain Theory and Neural Networks by : Michael A. Arbib

Download or read book The Handbook of Brain Theory and Neural Networks written by Michael A. Arbib and published by MIT Press. This book was released on 2003 with total page 1328 pages. Available in PDF, EPUB and Kindle. Book excerpt: This second edition presents the enormous progress made in recent years in the many subfields related to the two great questions : how does the brain work? and, How can we build intelligent machines? This second edition greatly increases the coverage of models of fundamental neurobiology, cognitive neuroscience, and neural network approaches to language. (Midwest).

Integrative Computational Systems Biology Approaches in Immunology and Medicine

Author : Lars Kaderali
Publisher : Frontiers Media SA
ISBN 13 : 2889458016
Total Pages : 290 pages
Book Rating : 4.8/5 (894 download)

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Book Synopsis Integrative Computational Systems Biology Approaches in Immunology and Medicine by : Lars Kaderali

Download or read book Integrative Computational Systems Biology Approaches in Immunology and Medicine written by Lars Kaderali and published by Frontiers Media SA. This book was released on 2019-04-09 with total page 290 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Dynamic Models in Biology

Author : Stephen P. Ellner
Publisher : Princeton University Press
ISBN 13 : 1400840961
Total Pages : 352 pages
Book Rating : 4.4/5 (8 download)

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Book Synopsis Dynamic Models in Biology by : Stephen P. Ellner

Download or read book Dynamic Models in Biology written by Stephen P. Ellner and published by Princeton University Press. This book was released on 2011-09-19 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt: From controlling disease outbreaks to predicting heart attacks, dynamic models are increasingly crucial for understanding biological processes. Many universities are starting undergraduate programs in computational biology to introduce students to this rapidly growing field. In Dynamic Models in Biology, the first text on dynamic models specifically written for undergraduate students in the biological sciences, ecologist Stephen Ellner and mathematician John Guckenheimer teach students how to understand, build, and use dynamic models in biology. Developed from a course taught by Ellner and Guckenheimer at Cornell University, the book is organized around biological applications, with mathematics and computing developed through case studies at the molecular, cellular, and population levels. The authors cover both simple analytic models--the sort usually found in mathematical biology texts--and the complex computational models now used by both biologists and mathematicians. Linked to a Web site with computer-lab materials and exercises, Dynamic Models in Biology is a major new introduction to dynamic models for students in the biological sciences, mathematics, and engineering.