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A Mathematical Model Of Alzheimers Disease
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Book Synopsis Alzheimer's Disease: Biology, Biophysics And Computational Models by : Don Kulasiri
Download or read book Alzheimer's Disease: Biology, Biophysics And Computational Models written by Don Kulasiri and published by World Scientific. This book was released on 2022-01-06 with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt: Alzheimer's disease (AD) is the leading cause of dementia and, unfortunately, remains incurable. The social, emotional and financial implications of AD are immeasurable, and about 47 million people worldwide are affected by AD or other forms of dementia. As lifespans are improved by healthcare systems worldwide, age-associated neurodegenerative diseases are imposing an increasing challenge to science. It is becoming imperative for us to understand the causes of these diseases, AD in particular, at molecular and cellular levels. Starting with the broader picture from a biological perspective, this book takes the reader through fascinating dynamics within and outside of neurons in the brain.Alzheimer's Disease: Biology, Biophysics and Computational Models helps the reader to understand AD from mechanistic and biochemical perspectives at intra- and inter-cellular levels. It focuses on biochemical pathways and modeling associated with AD. Some of the recent research on biophysics and computational models related to AD are explained using context-driven computational and mathematical modeling and essential biology is discussed to understand the modeling research.
Download or read book Tau Biology written by Akihiko Takashima and published by Springer Nature. This book was released on 2020-02-24 with total page 405 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents essential studies and cutting-edge research results on tau, which is attracting increasing interest as a target for the treatment of Alzheimer's disease. Tau is well known as a microtubule-associated protein that is predominantly localized in the axons of neurons. In various forms of brain disease, neuronal loss occurs, with deposition of hyperphosphorylated tau in the remaining neurons. Important questions remain regarding the way in which tau forms hyperphosphorylated and fibrillar deposits in neurons, and whether tau aggregation represents the toxic pathway leading to neuronal death. With the help of new technologies, researchers are now solving these long-standing questions. In this book, readers will find the latest expert knowledge on all aspects of tau biology, including the structure and role of the tau molecule, tau localization and function, the pathology, drivers, and markers of tauopathies, tau aggregation, and treatments targeting tau. Tau Biology will be an invaluable source of information and fresh ideas for those involved in the development of more effective therapies and for all who seek a better understanding of the biology of the aging brain.
Book Synopsis Mathematical Modeling, Computational Intelligence Techniques and Renewable Energy by : Manoj Sahni
Download or read book Mathematical Modeling, Computational Intelligence Techniques and Renewable Energy written by Manoj Sahni and published by Springer Nature. This book was released on 2021-02-28 with total page 544 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents new knowledge and recent developments in all aspects of computational techniques, mathematical modeling, energy systems, applications of fuzzy sets and intelligent computing. The book is a collection of best selected research papers presented at the International Conference on “Mathematical Modeling, Computational Intelligence Techniques and Renewable Energy,” organized by the Department of Mathematics, Pandit Deendayal Petroleum University, in association with Forum for Interdisciplinary Mathematics, Institution of Engineers (IEI) – Gujarat and Computer Society of India (CSI) – Ahmedabad. The book provides innovative works of researchers, academicians and students in the area of interdisciplinary mathematics, statistics, computational intelligence and renewable energy.
Book Synopsis Experimental and Numerical Investigations in Materials Science and Engineering by : Nenad Mitrovic
Download or read book Experimental and Numerical Investigations in Materials Science and Engineering written by Nenad Mitrovic and published by Springer. This book was released on 2018-09-03 with total page 241 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a collection of high-quality peer-reviewed research papers presented at the International Conference of Experimental and Numerical Investigations and New Technologies (CNNTech2018), held in Zlatibor, Serbia from 4 to 6 July 2018. The book discusses a wide variety of industrial, engineering and scientific applications of engineering techniques. Researchers from academia and the industry share their original work and exchange ideas, experiences, information, techniques, applications and innovations in the field of mechanical engineering, materials science, chemical and process engineering, experimental techniques, numerical methods and new technologies.
Book Synopsis Towards Intelligent Systems Modeling and Simulation by : Samsul Ariffin Abdul Karim
Download or read book Towards Intelligent Systems Modeling and Simulation written by Samsul Ariffin Abdul Karim and published by Springer Nature. This book was released on 2021-09-17 with total page 439 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book creates the emergence of disruptive technologies that have led to a significant change in the role of mathematics and statistics for problem solving, with the use of sophisticated software and hardware in solving complex systems and process. In the era of digital technology, mathematics and statistics need to be highly relevant to be able to cater for the needs of IR4.0 such as big data analytics, simulation, autonomous system, and cloud computing. Motivated by this development, a total of 26 chapters are contributed by respectable experts for this book. The main scope of the book is to conduct a new system of modeling and simulations on solving differential equations, nonlinear equations, energy, epidemiology, and risk assessment. This book is of interest for postgraduate students, researchers as well as other scientists who are working in numerical modeling and simulations based on efficient mathematical and statistical techniques.
Book Synopsis Fundamentals of Computational Neuroscience by : Thomas Trappenberg
Download or read book Fundamentals of Computational Neuroscience written by Thomas Trappenberg and published by Oxford University Press. This book was released on 2010 with total page 417 pages. Available in PDF, EPUB and Kindle. Book excerpt: The new edition of Fundamentals of Computational Neuroscience build on the success and strengths of the first edition. Completely redesigned and revised, it introduces the theoretical foundations of neuroscience with a focus on the nature of information processing in the brain.
Book Synopsis Mathematical Modelling in Biomedicine by : Vitaly Volpert
Download or read book Mathematical Modelling in Biomedicine written by Vitaly Volpert and published by MDPI. This book was released on 2021-01-26 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mathematical modelling in biomedicine is a rapidly developing scientific discipline at the intersection of medicine, biology, mathematics, physics, and computer science. Its progress is stimulated by fundamental scientific questions and by the applications to public health. This book represents a collection of papers devoted to mathematical modelling of various physiological problems in normal and pathological conditions. It covers a broad range of topics including cardiovascular system and diseases, heart and brain modelling, tumor growth, viral infections, and immune response. Computational models of blood circulation are used to study the influence of heart arrhythmias on coronary blood flow and on operating modes for left-ventricle-assisted devices. Wave propagation in the cardiac tissue is investigated in order to show the influence of tissue heterogeneity and fibrosis. The models of tumor growth are used to determine optimal protocols of antiangiogenic and radiotherapy. The models of viral hepatitis kinetics are considered for the parameter identification, and the evolution of viral quasi-species is investigated. The book presents the state-of-the-art in mathematical modelling in biomedicine and opens new perspectives in this passionate field of research.
Download or read book Dementia Care written by Jonathan Waite and published by Oxford University Press. This book was released on 2009 with total page 437 pages. Available in PDF, EPUB and Kindle. Book excerpt: This care manual covers a wide range of information in a short, easily accessible handbook format. It follows the pathway of dementia, from first presentation through to final stages of the illness, and is aimed at the multipdisciplinary care team.
Book Synopsis Oxford Textbook of Cognitive Neurology and Dementia by : Masud Husain
Download or read book Oxford Textbook of Cognitive Neurology and Dementia written by Masud Husain and published by Oxford University Press. This book was released on 2018-10-29 with total page 513 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume covers the dramatic developments that have occurred in basic neuroscience and clinical research in cognitive neurology and dementia. It is based on the clinical approach to the patient, and provides essential knowledge that is fundamental to clinical practice.
Book Synopsis Acquisition of Complex Arithmetic Skills and Higher-Order Mathematics Concepts by : David C. Geary
Download or read book Acquisition of Complex Arithmetic Skills and Higher-Order Mathematics Concepts written by David C. Geary and published by Academic Press. This book was released on 2017-08-01 with total page 362 pages. Available in PDF, EPUB and Kindle. Book excerpt: Acquisition of Complex Arithmetic Skills and Higher-Order Mathematics Concepts focuses on typical and atypical learning of complex arithmetic skills and higher-order math concepts. As part of the series Mathematical Cognition and Learning, this volume covers recent advances in the understanding of children's developing competencies with whole-number arithmetic, fractions, and rational numbers. Each chapter covers these topics from multiple perspectives, including genetic disorders, cognition, instruction, and neural networks. - Covers innovative measures and recent methodological advances in mathematical thinking and learning - Contains contributions that improve instruction and education in these domains - Informs policy aimed at increasing the level of mathematical proficiency in the general public
Book Synopsis Models of Calcium Signalling by : Geneviève Dupont
Download or read book Models of Calcium Signalling written by Geneviève Dupont and published by Springer. This book was released on 2016-06-07 with total page 453 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book discusses the ways in which mathematical, computational, and modelling methods can be used to help understand the dynamics of intracellular calcium. The concentration of free intracellular calcium is vital for controlling a wide range of cellular processes, and is thus of great physiological importance. However, because of the complex ways in which the calcium concentration varies, it is also of great mathematical interest.This book presents the general modelling theory as well as a large number of specific case examples, to show how mathematical modelling can interact with experimental approaches, in an interdisciplinary and multifaceted approach to the study of an important physiological control mechanism. Geneviève Dupont is FNRS Research Director at the Unit of Theoretical Chronobiology of the Université Libre de Bruxelles; Martin Falcke is head of the Mathematical Cell Physiology group at the Max Delbrück Center for Molecular Medicine, Berlin; Vivien Kirk is an Associate Professor in the Department of Mathematics at the University of Auckland, New Zealand; James Sneyd is a Professor in the Department of Mathematics at The University of Auckland, New Zealand.
Book Synopsis Bioinformatics and Biomedical Engineering by : Ignacio Rojas
Download or read book Bioinformatics and Biomedical Engineering written by Ignacio Rojas and published by Springer. This book was released on 2019-04-30 with total page 605 pages. Available in PDF, EPUB and Kindle. Book excerpt: The two-volume set LNBI 11465 and LNBI 11466 constitutes the proceedings of the 7th International Work-Conference on Bioinformatics and Biomedical Engineering, IWBBIO 2019, held in Granada, Spain, in May 2019. The total of 97 papers presented in the proceedings, was carefully reviewed and selected from 301 submissions. The papers are organized in topical sections as follows: Part I: High-throughput genomics: bioinformatics tools and medical applications; omics data acquisition, processing, and analysis; bioinformatics approaches for analyzing cancer sequencing data; next generation sequencing and sequence analysis; structural bioinformatics and function; telemedicine for smart homes and remote monitoring; clustering and analysis of biological sequences with optimization algorithms; and computational approaches for drug repurposing and personalized medicine. Part II: Bioinformatics for healthcare and diseases; computational genomics/proteomics; computational systems for modelling biological processes; biomedical engineering; biomedical image analysis; and biomedicine and e-health.
Book Synopsis Calcium Signalling and Disease by : Ernesto Carafoli
Download or read book Calcium Signalling and Disease written by Ernesto Carafoli and published by Springer Science & Business Media. This book was released on 2007-09-29 with total page 591 pages. Available in PDF, EPUB and Kindle. Book excerpt: Authors highlight several promising discoveries in the field of calcium signaling that provide new information about both genetic and acquired pathologies. Their discussions will give you new insights into the underlying causes of congenital and acquired diseases and point the way to new, even more promising research and therapies.
Download or read book Modeling Life written by Alan Garfinkel and published by Springer. This book was released on 2017-09-06 with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book develops the mathematical tools essential for students in the life sciences to describe interacting systems and predict their behavior. From predator-prey populations in an ecosystem, to hormone regulation within the body, the natural world abounds in dynamical systems that affect us profoundly. Complex feedback relations and counter-intuitive responses are common in nature; this book develops the quantitative skills needed to explore these interactions. Differential equations are the natural mathematical tool for quantifying change, and are the driving force throughout this book. The use of Euler’s method makes nonlinear examples tractable and accessible to a broad spectrum of early-stage undergraduates, thus providing a practical alternative to the procedural approach of a traditional Calculus curriculum. Tools are developed within numerous, relevant examples, with an emphasis on the construction, evaluation, and interpretation of mathematical models throughout. Encountering these concepts in context, students learn not only quantitative techniques, but how to bridge between biological and mathematical ways of thinking. Examples range broadly, exploring the dynamics of neurons and the immune system, through to population dynamics and the Google PageRank algorithm. Each scenario relies only on an interest in the natural world; no biological expertise is assumed of student or instructor. Building on a single prerequisite of Precalculus, the book suits a two-quarter sequence for first or second year undergraduates, and meets the mathematical requirements of medical school entry. The later material provides opportunities for more advanced students in both mathematics and life sciences to revisit theoretical knowledge in a rich, real-world framework. In all cases, the focus is clear: how does the math help us understand the science?
Book Synopsis Improving the Utility and Translation of Animal Models for Nervous System Disorders by : Institute of Medicine
Download or read book Improving the Utility and Translation of Animal Models for Nervous System Disorders written by Institute of Medicine and published by National Academies Press. This book was released on 2013-04-25 with total page 111 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nervous system diseases and disorders are highly prevalent and substantially contribute to the overall disease burden. Despite significant information provided by the use of animal models in the understanding of the biology of nervous system disorders and the development of therapeutics; limitations have also been identified. Treatment options that are high in efficacy and low in side effects are still lacking for many diseases and, in some cases are nonexistent. A particular problem in drug development is the high rate of attrition in Phase II and III clinical trials. Why do many therapeutics show promise in preclinical animal models but then fail to elicit predicted effects when tested in humans? On March 28 and 29, 2012, the Institute of Medicine Forum on Neuroscience and Nervous System Disorders convened the workshop "Improving Translation of Animal Models for Nervous System Disorders" to discuss potential opportunities for maximizing the translation of new therapies from animal models to clinical practice. The primary focus of the workshop was to examine mechanisms for increasing the efficiency of translational neuroscience research through discussions about how and when to use animal models most effectively and then best approaches for the interpretation of the data collected. Specifically, the workshop objectives were to: discuss key issues that contribute to poor translation of animal models in nervous system disorders, examine case studies that highlight successes and failures in the development and application of animal models, consider strategies to increase the scientific rigor of preclinical efficacy testing, explore the benefits and challenges to developing standardized animal and behavioral models. Improving the Utility and Translation of Animal Models for Nervous System Disorders: Workshop Summary also identifies methods to facilitate development of corresponding animal and clinical endpoints, indentifies methods that would maximize bidirectional translation between basic and clinical research and determines the next steps that will be critical for improvement of the development and testing of animal models of disorders of the nervous system.
Book Synopsis Mathematical Modeling of Natural Phenomena by : Ranis Ibragimov
Download or read book Mathematical Modeling of Natural Phenomena written by Ranis Ibragimov and published by . This book was released on 2017-12 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mathematical modeling in the form of differential equations is a branch of applied mathematics that includes topics from physics, engineering, environmental and computer science. The mathematical model is an approximate description of real processes. Mathematical modeling can be thought of as a three step process: 1) Physical situation; 2) Mathematical formulation; 3) Solution by purely operations of the mathematical problem; 4) Physical interpretation of the mathematical solution. Over the centuries, Step 2 took on a life of its own. Mathematics was studied on its own, devoid of any contact with a physical problem; this is known as pure mathematics. Applied mathematics and mathematical modeling deals with all three steps. Improvements of approximations or their extensions to more general situations may increase the complexity of mathematical models significantly. Before the 18th century, applied mathematics and its methods received the close attention of the best mathematicians who were driven by a desire to develop approximate descriptions of natural phenomena. The goal of asymptotic and perturbation methods is to find useful, approximate solutions to difficult problems that arise from the desire to understand a physical process. Exact solutions are usually either impossible to obtain or too complicated to be useful. Approximate, useful solutions are often tested by comparison with experiments or observations rather than by rigorous mathematical methods. Hence, the authors will not be concerned with rigorous proofs in this book. The derivation of approximate solutions can be done in two different ways. First, one can find an approximate set of equations that can be solved, or, one can find an approximate solution of a set of equations. Usually one must do both. Models of natural science show that the possibilities of applying differential equations for solving problems in the disciplines of the natural scientific cycle are quite wide. This book represents a unique blend of the traditional analytical and numerical methods enriched by the authors developments and applications to ocean and atmospheric sciences. The overall viewpoint taken is a theoretical, unified approach to the study of both the atmosphere and the oceans. One of the key features in this book is the combination of approximate forms of the basic mathematical equations of mathematical modeling with careful and precise analysis. The approximations are required to make any progress possible, while precision is needed to make the progress meaningful. This combination is often the most elusive for student to appreciate. This book aims to highlight this issue by means of accurate derivation of mathematical models with precise analysis and MATLAB applications. This book is meant for undergraduate and graduate students interested in applied mathematics, differential equations and mathematical modeling of real world problems. This book might also be interested in experts working in the field of physics concerning the ocean and atmosphere.
Book Synopsis Computational Statistics and Mathematical Modeling Methods in Intelligent Systems by : Radek Silhavy
Download or read book Computational Statistics and Mathematical Modeling Methods in Intelligent Systems written by Radek Silhavy and published by Springer Nature. This book was released on 2019-09-19 with total page 437 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents real-world problems and exploratory research in computational statistics, mathematical modeling, artificial intelligence and software engineering in the context of the intelligent systems. This book constitutes the refereed proceedings of the 3rd Computational Methods in Systems and Software 2019 (CoMeSySo 2019), a groundbreaking online conference that provides an international forum for discussing the latest high-quality research results.
