A Detrimental Feedback Loop

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Biological Clocks, Rhythms, and Oscillations

Author : Daniel B. Forger
Publisher : MIT Press
ISBN 13 : 0262552817
Total Pages : 369 pages
Book Rating : 4.2/5 (625 download)

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Book Synopsis Biological Clocks, Rhythms, and Oscillations by : Daniel B. Forger

Download or read book Biological Clocks, Rhythms, and Oscillations written by Daniel B. Forger and published by MIT Press. This book was released on 2024-08-06 with total page 369 pages. Available in PDF, EPUB and Kindle. Book excerpt: An introduction to the mathematical, computational, and analytical techniques used for modeling biological rhythms, presenting tools from many disciplines and example applications. All areas of biology and medicine contain rhythms, and these behaviors are best understood through mathematical tools and techniques. This book offers a survey of mathematical, computational, and analytical techniques used for modeling biological rhythms, gathering these methods for the first time in one volume. Drawing on material from such disciplines as mathematical biology, nonlinear dynamics, physics, statistics, and engineering, it presents practical advice and techniques for studying biological rhythms, with a common language. The chapters proceed with increasing mathematical abstraction. Part I, on models, highlights the implicit assumptions and common pitfalls of modeling, and is accessible to readers with basic knowledge of differential equations and linear algebra. Part II, on behaviors, focuses on simpler models, describing common properties of biological rhythms that range from the firing properties of squid giant axon to human circadian rhythms. Part III, on mathematical techniques, guides readers who have specific models or goals in mind. Sections on “frontiers” present the latest research; “theory” sections present interesting mathematical results using more accessible approaches than can be found elsewhere. Each chapter offers exercises. Commented MATLAB code is provided to help readers get practical experience. The book, by an expert in the field, can be used as a textbook for undergraduate courses in mathematical biology or graduate courses in modeling biological rhythms and as a reference for researchers.

Cellular Oscillatory Mechanisms

Author : Miguel Maroto
Publisher : Springer Science & Business Media
ISBN 13 : 0387097945
Total Pages : 166 pages
Book Rating : 4.3/5 (87 download)

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Book Synopsis Cellular Oscillatory Mechanisms by : Miguel Maroto

Download or read book Cellular Oscillatory Mechanisms written by Miguel Maroto and published by Springer Science & Business Media. This book was released on 2008-12-19 with total page 166 pages. Available in PDF, EPUB and Kindle. Book excerpt: Oscillatory dynamics are a central feature of a wide range of biological processes. This text fully explores cellular oscillations, focusing particularly on elucidating the basic mechanisms that underlie these oscillations.

Feedback Systems

Author : Karl Johan Åström
Publisher : Princeton University Press
ISBN 13 : 069121347X
Total Pages : pages
Book Rating : 4.6/5 (912 download)

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Book Synopsis Feedback Systems by : Karl Johan Åström

Download or read book Feedback Systems written by Karl Johan Åström and published by Princeton University Press. This book was released on 2021-02-02 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The essential introduction to the principles and applications of feedback systems—now fully revised and expanded This textbook covers the mathematics needed to model, analyze, and design feedback systems. Now more user-friendly than ever, this revised and expanded edition of Feedback Systems is a one-volume resource for students and researchers in mathematics and engineering. It has applications across a range of disciplines that utilize feedback in physical, biological, information, and economic systems. Karl Åström and Richard Murray use techniques from physics, computer science, and operations research to introduce control-oriented modeling. They begin with state space tools for analysis and design, including stability of solutions, Lyapunov functions, reachability, state feedback observability, and estimators. The matrix exponential plays a central role in the analysis of linear control systems, allowing a concise development of many of the key concepts for this class of models. Åström and Murray then develop and explain tools in the frequency domain, including transfer functions, Nyquist analysis, PID control, frequency domain design, and robustness. Features a new chapter on design principles and tools, illustrating the types of problems that can be solved using feedback Includes a new chapter on fundamental limits and new material on the Routh-Hurwitz criterion and root locus plots Provides exercises at the end of every chapter Comes with an electronic solutions manual An ideal textbook for undergraduate and graduate students Indispensable for researchers seeking a self-contained resource on control theory

Biological Feedback

Author : Rene Thomas
Publisher : CRC Press
ISBN 13 : 9780849367663
Total Pages : 328 pages
Book Rating : 4.3/5 (676 download)

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Book Synopsis Biological Feedback by : Rene Thomas

Download or read book Biological Feedback written by Rene Thomas and published by CRC Press. This book was released on 1990-09-25 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: Clearly explaining the logical analysis of biological control phenomena, Biological Feedback answers questions concerning everything from regulation to logic. This rare monograph presents a formal methodology for analyzing the dynamic behavior of complex systems. The easy-to-read text describes a simple logical formalization called "kinetic logic". The reader discovers how this method is used to predict all possible patterns of behavior of which a system is capable. It includes specific conditions required for each pattern. It also explains how to modify an incorrect model in order to account for the observed behavior. The authors give special attention to the two basic types of simple feedback loops: positive and negative. This volume is filled with easy-to-use tables, providing quick reference throughout the book. The subject matter is of great interest to everyone working in molecular genetics and developmental biology. Researchers, immunologists, physical chemists, physicists, electrical engineers, economists, and mathematicians will find this unique text to be an informative, indispensable resource.

Vertebrate Endocrinology

Author : David O. Norris
Publisher : Academic Press
ISBN 13 : 0123964652
Total Pages : 599 pages
Book Rating : 4.1/5 (239 download)

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Book Synopsis Vertebrate Endocrinology by : David O. Norris

Download or read book Vertebrate Endocrinology written by David O. Norris and published by Academic Press. This book was released on 2013-05-04 with total page 599 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vertebrate Endocrinology represents more than just a treatment of the endocrine system-it integrates hormones with other chemical bioregulatory agents not classically included with the endocrine system. It provides a complete overview of the endocrine system of vertebrates by first emphasizing the mammalian system as the basis of most terminology and understanding of endocrine mechanisms and then applies that to non-mammals. The serious reader will gain both an understanding of the intricate relationships among all of the body systems and their regulation by hormones and other bioregulators, but also a sense of their development through evolutionary time as well as the roles of hormones at different stages of an animal's life cycle. - Includes new full color format includes over 450 full color, completely redrawn image - Features a companion web site hosting all images from the book as PPT slides and .jpeg files - Presents completedly updated and revitalized content with new chapters, such as Endocrine Disrupters and Behavioral Endocrinology - Offers new clinical correlation vignettes throughout

Model Rules of Professional Conduct

Author : American Bar Association. House of Delegates
Publisher : American Bar Association
ISBN 13 : 9781590318737
Total Pages : 216 pages
Book Rating : 4.3/5 (187 download)

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Book Synopsis Model Rules of Professional Conduct by : American Bar Association. House of Delegates

Download or read book Model Rules of Professional Conduct written by American Bar Association. House of Delegates and published by American Bar Association. This book was released on 2007 with total page 216 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Model Rules of Professional Conduct provides an up-to-date resource for information on legal ethics. Federal, state and local courts in all jurisdictions look to the Rules for guidance in solving lawyer malpractice cases, disciplinary actions, disqualification issues, sanctions questions and much more. In this volume, black-letter Rules of Professional Conduct are followed by numbered Comments that explain each Rule's purpose and provide suggestions for its practical application. The Rules will help you identify proper conduct in a variety of given situations, review those instances where discretionary action is possible, and define the nature of the relationship between you and your clients, colleagues and the courts.

Innovative Medicine

Author : Kazuwa Nakao
Publisher : Springer
ISBN 13 : 4431556516
Total Pages : 330 pages
Book Rating : 4.4/5 (315 download)

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Book Synopsis Innovative Medicine by : Kazuwa Nakao

Download or read book Innovative Medicine written by Kazuwa Nakao and published by Springer. This book was released on 2015-10-13 with total page 330 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is devoted to innovative medicine, comprising the proceedings of the Uehara Memorial Foundation Symposium 2014. It remains extremely rare for the findings of basic research to be developed into clinical applications, and it takes a long time for the process to be achieved. The task of advancing the development of basic research into clinical reality lies with translational science, yet the field seems to struggle to find a way to move forward. To create innovative medical technology, many steps need to be taken: development and analysis of optimal animal models of human diseases, elucidation of genomic and epidemiological data, and establishment of “proof of concept”. There is also considerable demand for progress in drug research, new surgical procedures, and new clinical devices and equipment. While the original research target may be rare diseases, it is also important to apply those findings more broadly to common diseases. The book covers a wide range of topics and is organized into three complementary parts. The first part is basic research for innovative medicine, the second is translational research for innovative medicine, and the third is new technology for innovative medicine. This book helps to understand innovative medicine and to make progress in its realization.

Thanks for the Feedback

Author : Douglas Stone
Publisher : Penguin
ISBN 13 : 0143127136
Total Pages : 370 pages
Book Rating : 4.1/5 (431 download)

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Book Synopsis Thanks for the Feedback by : Douglas Stone

Download or read book Thanks for the Feedback written by Douglas Stone and published by Penguin. This book was released on 2015-03-31 with total page 370 pages. Available in PDF, EPUB and Kindle. Book excerpt: The coauthors of the New York Times–bestselling Difficult Conversations take on the toughest topic of all: how we see ourselves Douglas Stone and Sheila Heen have spent the past fifteen years working with corporations, nonprofits, governments, and families to determine what helps us learn and what gets in our way. In Thanks for the Feedback, they explain why receiving feedback is so crucial yet so challenging, offering a simple framework and powerful tools to help us take on life’s blizzard of offhand comments, annual evaluations, and unsolicited input with curiosity and grace. They blend the latest insights from neuroscience and psychology with practical, hard-headed advice. Thanks for the Feedback is destined to become a classic in the fields of leadership, organizational behavior, and education.

Out-of-Equilibrium (Supra)molecular Systems and Materials

Author : Nicolas Giuseppone
Publisher : John Wiley & Sons
ISBN 13 : 3527821988
Total Pages : 448 pages
Book Rating : 4.5/5 (278 download)

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Book Synopsis Out-of-Equilibrium (Supra)molecular Systems and Materials by : Nicolas Giuseppone

Download or read book Out-of-Equilibrium (Supra)molecular Systems and Materials written by Nicolas Giuseppone and published by John Wiley & Sons. This book was released on 2021-03-30 with total page 448 pages. Available in PDF, EPUB and Kindle. Book excerpt: A must-have resource that covers everything from out-of-equilibrium chemical systems and materials to dissipative self-assemblies Out-of-Equilibrium Supramolecular Systems and Materials presents a comprehensive overview of the synthetic approaches that use supramolecular bonds in various out-of-thermodynamic equilibrium situations. With contributions from noted experts on the topic, the text contains information on the design of dissipative self-assemblies that maintain their structures when fueled by an external source of energy. The contributors also examine molecules and nanoscale objects and materials that can produce mechanical work based on molecular machines. Additionally, the book explores non-equilibrium supramolecular polymers that can be trapped in kinetically stable states, as well as out-of-equilibrium chemical systems and oscillators that are important to understand the emergence of complex behaviors and, in particular, the origin of life. This important book: Offers comprehensive coverage of fields from design of dissipative self-assemblies to non-equilibrium supramolecular polymers Presents information on a highly emerging and interdisciplinary topic Includes contributions from internationally renowned scientists Written for chemists, physical chemists, biochemists, material scientists, Out-of-Equilibrium Supramolecular Systems and Materials is an indispensable resource written by top scientists in the field.

Structured Electronic Design

Author : Chris J.M. Verhoeven
Publisher : Springer Science & Business Media
ISBN 13 : 0306487322
Total Pages : 366 pages
Book Rating : 4.3/5 (64 download)

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Book Synopsis Structured Electronic Design by : Chris J.M. Verhoeven

Download or read book Structured Electronic Design written by Chris J.M. Verhoeven and published by Springer Science & Business Media. This book was released on 2007-05-08 with total page 366 pages. Available in PDF, EPUB and Kindle. Book excerpt: Analog design is one of the more difficult aspects of electrical engineering. The main reason is the apparently vague decisions an experienced designer makes in optimizing his circuit. To enable fresh designers, like students electrical engineering, to become acquainted with analog circuit design, structuring the analog design process is of utmost importance. Structured Electronic Design: Negative-Feedback Amplifiers presents a design methodology for negative-feedback amplifiers. The design methodology enables to synthesize a topology and to, at the same time, optimize the performance of that topology. Key issues in the design methodology are orthogonalization, hierarchy and simple models. Orthogonalization enables the separate optimization of the three fundamental quality aspects: noise, distortion and bandwidth. Hierarchy ensures that the right decisions are made at the correct level of abstraction. The use of simple models, results in simple calculations yielding maximum-performance indicators that can be used to reject wrong circuits relatively fast. The presented design methodology divides the design of negative-feedback amplifiers in six independent steps. In the first two steps, the feedback network is designed. During those design steps, the active part is assumed to be a nullor, i.e. the performance with respect to noise, distortion and bandwidth is still ideal. In the subsequent four steps, an implementation for the active part is synthesized. During those four steps the topology of the active part is synthesized such that optimum performance is obtained. Firstly, the input stage is designed with respect to noise performance. Secondly, the output stage is designed with respect to clipping distortion. Thirdly, the bandwidth performance is designed, which may require the addition of an additional amplifying stage. Finally, the biasing circuitry for biasing the amplifying stages is designed. By dividing the design in independent design steps, the total global optimization is reduced to several local optimizations. By the specific sequence of the design steps, it is assured that the local optimizations yield a circuit that is close to the global optimum. On top of that, because of the separate dedicated optimizations, the resource use, like power, is tracked clearly. Structured Electronic Design: Negative-Feedback Amplifiers presents in two chapters the background and an overview of the design methodology. Whereafter, in six chapters the separate design steps are treated with great detail. Each chapter comprises several exercises. An additional chapter is dedicated to how to design current sources and voltage source, which are required for the biasing. The final chapter in the book is dedicated to a thoroughly described design example, showing clearly the benefits of the design methodology. In short, this book is valuable for M.Sc.-curriculum Electrical Engineering students, and of course, for researchers and designers who want to structure their knowledge about analog design further.

Anatomy and Physiology

Author : J. Gordon Betts
Publisher :
ISBN 13 : 9781947172807
Total Pages : 0 pages
Book Rating : 4.1/5 (728 download)

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Book Synopsis Anatomy and Physiology by : J. Gordon Betts

Download or read book Anatomy and Physiology written by J. Gordon Betts and published by . This book was released on 2013-04-25 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Control Systems

Author : William Bolton
Publisher : Newnes
ISBN 13 : 0080529984
Total Pages : 193 pages
Book Rating : 4.0/5 (85 download)

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Book Synopsis Control Systems by : William Bolton

Download or read book Control Systems written by William Bolton and published by Newnes. This book was released on 2002-01-30 with total page 193 pages. Available in PDF, EPUB and Kindle. Book excerpt: Working through this student-centred text readers will be brought up to speed with the modelling of control systems using Laplace, and given a solid grounding of the pivotal role of control systems across the spectrum of modern engineering. A clear, readable text is supported by numerous worked example and problems.* Key concepts and techniques introduced through applications* Introduces mathematical techniques without assuming prior knowledge* Written for the latest vocational and undergraduate courses

The Hypothalamus-Pituitary-Adrenal Axis

Author :
Publisher : Elsevier
ISBN 13 : 0080559360
Total Pages : 413 pages
Book Rating : 4.0/5 (85 download)

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Book Synopsis The Hypothalamus-Pituitary-Adrenal Axis by :

Download or read book The Hypothalamus-Pituitary-Adrenal Axis written by and published by Elsevier. This book was released on 2008-09-12 with total page 413 pages. Available in PDF, EPUB and Kindle. Book excerpt: The hypothalamic-pituitary-adrenal axis controls reactions to stress and regulates various body processes such as digestion, the immune system, mood and sexuality, and energy usage. This volume focuses on the role it plays in the immune system and provides substantive experimental and clinical data to support current understanding in the field, and potential applications of this knowledge in the treatment of disease. - Evidence presented in this book suggests that the nervous, endocrine, and immune systems form the Neuroendoimmune Supersystem, which integrates all the biological functions of higher organisms both in health and disease for their entire life cycle - Contributors include both the scientists who initiated the work on the HPA axis and on the autonomic nervous system, and those who joined the field later

Suprachiasmatic Nucleus

Author : David C. Klein
Publisher : Oxford University Press, USA
ISBN 13 : 9780195062502
Total Pages : 498 pages
Book Rating : 4.0/5 (625 download)

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Book Synopsis Suprachiasmatic Nucleus by : David C. Klein

Download or read book Suprachiasmatic Nucleus written by David C. Klein and published by Oxford University Press, USA. This book was released on 1991 with total page 498 pages. Available in PDF, EPUB and Kindle. Book excerpt: Based on a conference funded by the National Institutes of Health, this timely book is the most up-to-date and definitive reference on the suprachiasmatic nucleus (SCN), the part of the brain that controls circadian rhythms in mammals. These biological rhythms range from daily fluctuations in metabolism to seasonal and annual cycles. This book comprehensive and incisive review of the SCN covers anatomy and physiology, intrinsic SCN rhythms, circadian rhythms, neuropharmacology, transplants, and development.

Policy Implications of Greenhouse Warming

Author : National Academy of Engineering
Publisher : National Academies Press
ISBN 13 : 0309043867
Total Pages : 945 pages
Book Rating : 4.3/5 (9 download)

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Book Synopsis Policy Implications of Greenhouse Warming by : National Academy of Engineering

Download or read book Policy Implications of Greenhouse Warming written by National Academy of Engineering and published by National Academies Press. This book was released on 1992-02-01 with total page 945 pages. Available in PDF, EPUB and Kindle. Book excerpt: Global warming continues to gain importance on the international agenda and calls for action are heightening. Yet, there is still controversy over what must be done and what is needed to proceed. Policy Implications of Greenhouse Warming describes the information necessary to make decisions about global warming resulting from atmospheric releases of radiatively active trace gases. The conclusions and recommendations include some unexpected results. The distinguished authoring committee provides specific advice for U.S. policy and addresses the need for an international response to potential greenhouse warming. It offers a realistic view of gaps in the scientific understanding of greenhouse warming and how much effort and expense might be required to produce definitive answers. The book presents methods for assessing options to reduce emissions of greenhouse gases into the atmosphere, offset emissions, and assist humans and unmanaged systems of plants and animals to adjust to the consequences of global warming.

The Origins of Feedback Control

Author : Otto Mayr
Publisher : MIT Press (MA)
ISBN 13 : 9780262630566
Total Pages : 176 pages
Book Rating : 4.6/5 (35 download)

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Book Synopsis The Origins of Feedback Control by : Otto Mayr

Download or read book The Origins of Feedback Control written by Otto Mayr and published by MIT Press (MA). This book was released on 1975-01 with total page 176 pages. Available in PDF, EPUB and Kindle. Book excerpt: A case study in the intellectual history of technology, the book spans the invention of feedback control devices in all degrees of realization, from the verbally expressed idea to the industrially proved apparatus.

Computational Systems Biology

Author : Andres Kriete
Publisher : Academic Press
ISBN 13 : 0124059384
Total Pages : 549 pages
Book Rating : 4.1/5 (24 download)

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Book Synopsis Computational Systems Biology by : Andres Kriete

Download or read book Computational Systems Biology written by Andres Kriete and published by Academic Press. This book was released on 2013-11-26 with total page 549 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensively revised second edition of Computational Systems Biology discusses the experimental and theoretical foundations of the function of biological systems at the molecular, cellular or organismal level over temporal and spatial scales, as systems biology advances to provide clinical solutions to complex medical problems. In particular the work focuses on the engineering of biological systems and network modeling. - Logical information flow aids understanding of basic building blocks of life through disease phenotypes - Evolved principles gives insight into underlying organizational principles of biological organizations, and systems processes, governing functions such as adaptation or response patterns - Coverage of technical tools and systems helps researchers to understand and resolve specific systems biology problems using advanced computation - Multi-scale modeling on disparate scales aids researchers understanding of dependencies and constraints of spatio-temporal relationships fundamental to biological organization and function.