A Combination Therapy For Kras Driven Lung Adenocarcinomas Using Lipophilic Bisphosphonates And Rapamycin

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Organophosphorus Chemistry

Author : Viktor Iaroshenko
Publisher : John Wiley & Sons
ISBN 13 : 3527672265
Total Pages : 802 pages
Book Rating : 4.5/5 (276 download)

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Book Synopsis Organophosphorus Chemistry by : Viktor Iaroshenko

Download or read book Organophosphorus Chemistry written by Viktor Iaroshenko and published by John Wiley & Sons. This book was released on 2019-01-07 with total page 802 pages. Available in PDF, EPUB and Kindle. Book excerpt: Filling the gap for an up-to-date reference that presents the field of organophosphorus chemistry in a comprehensive and clearly structured way, this one-stop source covers the chemistry, properties, and applications from life science and medicine. Divided into two parts, the first presents the chemistry of various phosphorus-containing compounds and their synthesis, including ylides, acids, and heterocycles. The second part then goes on to look at applications in life science and bioorganic chemistry. Last but not least, such important practical aspects as 31P-NMR and protecting strategies for these compounds are presented. For organic, bioinorganic, and medicinal chemists, as well as those working on organometallics, and for materials scientists. The book, a contributed work, features a team of renowned scientists from around the world whose expertise spans the many aspects of modern organophosphorus chemistry.

Bioactive Essential Oils and Cancer

Author : Damião Pergentino de Sousa
Publisher : Springer
ISBN 13 : 3319191446
Total Pages : 299 pages
Book Rating : 4.3/5 (191 download)

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Book Synopsis Bioactive Essential Oils and Cancer by : Damião Pergentino de Sousa

Download or read book Bioactive Essential Oils and Cancer written by Damião Pergentino de Sousa and published by Springer. This book was released on 2015-09-10 with total page 299 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides a general overview of the therapeutic potential of the essential oils in cancer and highlights some promising future directions. It integrates chemistry, pharmacology, and medicine while discussing bioactive essential oils in experimental models and clinical studies of cancer. The book is a valuable resource for all engaged in the study of natural products and their synthetic derivatives, particularly for those interested in academic research and pharmaceutical and food industries dedicated in the discovery of useful agents for the therapy or prevention of cancer.

Cancer Nanotheranostics

Author : Muthupandian Saravanan
Publisher : Springer Nature
ISBN 13 : 3030743306
Total Pages : 362 pages
Book Rating : 4.0/5 (37 download)

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Book Synopsis Cancer Nanotheranostics by : Muthupandian Saravanan

Download or read book Cancer Nanotheranostics written by Muthupandian Saravanan and published by Springer Nature. This book was released on 2021-10-05 with total page 362 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nanotechnology is an interdisciplinary research field that integrates chemistry, engineering, biology, and medicine. Nanomaterials offer tremendous opportunity as well as challenges for researchers. Of course, cancer is one of the world's most common health problems, responsible for many deaths. Exploring efficient anticancer drugs could revolutionize treatment options and help manage cancer mortality. Nanomedicine plays a significant role in developing alternative and more effective treatment strategies for cancer theranostics. This book mainly focuses on the emerging trends using nanomaterials and nanocomposites as alternative anticancer material’s. The book is divided into three main topic areas: how to overcome existing traditional approaches to combat cancer, applying multiple mechanisms to target the cancer cells, and how nanomaterials can be used as effective carriers. The contents highlight recent advances in interdisciplinary research on processing, morphology, structure, and properties of nanostructured materials and their applications to combat cancer.Cancer Nanotheranostics is comprehensive in that it discusses all aspects of cancer nanotechnology. Because of the vast amount of information, it was decided to split this material into two volumes. In the first volume of Cancer Nanotheranostics, we discuss the role of different nanomaterials for cancer therapy, including lipid-based nanomaterials, protein and peptide-based nanomaterials, polymer-based nanomaterials, metal-organic nanomaterials, porphyrin-based nanomaterials, metal-based nanomaterials, silica-based nanomaterials, exosome-based nanomaterials and nano-antibodies. In the second volume, we discuss the nano-based diagnosis of cancer, nano-oncology for clinical applications, nano-immunotherapy, nano-based photothermal cancer therapy, nano-erythrosomes for cancer drug delivery, regulatory perspectives of nanomaterials, limitations of cancer nanotheranostics, the safety of nano-biomaterials for cancer nanotheranostics, multifunctional nanomaterials for targeting cancer nanotheranostics, and the role of artificial intelligence in cancer nanotheranostics.

Lung Cancer and Personalized Medicine

Author : Aamir Ahmad
Publisher : Springer
ISBN 13 : 3319242237
Total Pages : 236 pages
Book Rating : 4.3/5 (192 download)

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Book Synopsis Lung Cancer and Personalized Medicine by : Aamir Ahmad

Download or read book Lung Cancer and Personalized Medicine written by Aamir Ahmad and published by Springer. This book was released on 2015-12-14 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt: This, the first of two volumes on personalized medicine in lung cancer, touches on the core issues related to the understanding of lung cancer—statistics and epidemiology of lung cancer—along with the incidence of lung cancer in non-smokers. A major focus of this volume is the state of current therapies against lung cancer—immune, targeted therapies against EGFR TKIs, KRAS, ALK, angiogenesis; the associated challenges, especially resistance mechanisms; and recent progress in targeted drug development based on metal chemistry. Chapters are written by some of the leading experts in the field, who provide a better understanding of lung cancer, the factors that make it lethal, and current research focused on developing personalized treatment plans. With a unique mix of topics, this volume summarizes the current state-of-knowledge on lung cancer and the available therapies.

First Aid for the USMLE Step 1 2020, Thirtieth edition

Author : Tao Le
Publisher : McGraw-Hill Education / Medical
ISBN 13 : 9781260462043
Total Pages : 832 pages
Book Rating : 4.4/5 (62 download)

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Book Synopsis First Aid for the USMLE Step 1 2020, Thirtieth edition by : Tao Le

Download or read book First Aid for the USMLE Step 1 2020, Thirtieth edition written by Tao Le and published by McGraw-Hill Education / Medical. This book was released on 2020-01-06 with total page 832 pages. Available in PDF, EPUB and Kindle. Book excerpt: Publisher's Note: Products purchased from Third Party sellers are not guaranteed by the publisher for quality, authenticity, or access to any online entitlements included with the product. EXCEL ON THE USMLE® STEP 1 WITH HELP FROM THE WORLD’S MOST POPULAR MEDICAL REVIEW BOOK! Trust First AidTM to help you score your highest on this high-stakes exam Written by students who excelled on the Step 1 exam and reviewed by top faculty for accuracy, this indispensable guide provides you with a blueprint of all the content you’re likely to find on the exam. Packed with insider advice for students from students, First Aid for the USMLE® Step 1 2020 will help maximize your study time. Features A complete framework for USMLE Step 1 preparation 1,300+ must-know topics with mnemonics to focus your study 1,000+ color photos and illustrations to help you visualize processes, disorders, and clinical findings Rapid Review section presents high-yield tables associating diseases with their clinical findings, treatments, and pathophysiology Updated every year to ensure all content is relevant and high-yield, reflecting the most current USMLE blueprint

First Aid for the USMLE Step 1

Author : Vikas Bhushan
Publisher : McGraw Hill Professional
ISBN 13 : 0071545131
Total Pages : 588 pages
Book Rating : 4.0/5 (715 download)

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Book Synopsis First Aid for the USMLE Step 1 by : Vikas Bhushan

Download or read book First Aid for the USMLE Step 1 written by Vikas Bhushan and published by McGraw Hill Professional. This book was released on 2007-01-09 with total page 588 pages. Available in PDF, EPUB and Kindle. Book excerpt: The #1 Review for the USMLE Step 1 - written by students who aced the boards! 900+ must-know facts and mnemonics organized by organ systems and general principles 24 pages of color photos like those on the exam 100+ clinical vignettes Brand new Pathology chapter and totally revised Behavioral Science chapter The famous “First Aid Ratings” - 300+ medical test prep resources rated by students Updated exam preparation guide with advice from Step 1 veterans Strategies that maximize your study time and deliver the results you want

Proteasome Inhibitors in Cancer Therapy

Author : Julian Adams
Publisher : Springer Science & Business Media
ISBN 13 : 1592597947
Total Pages : 319 pages
Book Rating : 4.5/5 (925 download)

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Book Synopsis Proteasome Inhibitors in Cancer Therapy by : Julian Adams

Download or read book Proteasome Inhibitors in Cancer Therapy written by Julian Adams and published by Springer Science & Business Media. This book was released on 2004-05-25 with total page 319 pages. Available in PDF, EPUB and Kindle. Book excerpt: A panel of leading academic and pharmaceutical investigators takes stock of the remarkable work that has been accomplished to date with proteasome inhibitors in cancer, and examines emerging therapeutic possibilities. The topics range from a discussion of the chemistry and cell biology of the proteasome and the rationale for proteasome inhibitors in cancer to a review of current clinical trials underway. The discussion of rationales for testing proteasome inhibitors in cancer models covers the role of the proteasome in NF-kB activation, the combining of conventional chemotherapy and radiation with proteasome inhibition, notably PS-341, new proteasome methods of inhibiting viral maturation, and the role of protesome inhibition in the treatment of AIDS. The authors also document the development of bortezomib (VelcadeTM) in Phase I clinical trials and in a multicentered Phase II clinical trials in patients with relapsed and refractory myeloma.

First Aid for the USMLE Step 1 2021, Thirty First Edition

Author : Tao Lee
Publisher :
ISBN 13 :
Total Pages : 46 pages
Book Rating : 4.7/5 (69 download)

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Book Synopsis First Aid for the USMLE Step 1 2021, Thirty First Edition by : Tao Lee

Download or read book First Aid for the USMLE Step 1 2021, Thirty First Edition written by Tao Lee and published by . This book was released on 2021-02-09 with total page 46 pages. Available in PDF, EPUB and Kindle. Book excerpt: BUY NOW AND ENJOY FAST DELIVERY Publisher's Note: Products purchased from Third Party sellers are not guaranteed by the publisher for quality, authenticity, or access to any online entitlements included with the product. YOU NEED THIS UPDATED EDITION OF FIRST AID TO EXCEL ON THE REVISED USMLE(R) STEP 1! First Aid(TM) remains the most trusted name in USMLE(R) review―just ask any medical student! A complete framework for USMLE Step 1 preparation, annually updated with crowdsourced contributions from thousands of students Updated exam preparation advice for USMLE Step 1 pass/fail, Step 1 blueprint changes, and COVID-19 impacts New section on communication skills reflects the latest Step 1 content New focus on diversity, equity and inclusion incorporates race and ethnic considerations, as well as gender neutral terminology Nearly 1,400 must-know topics with mnemonics to focus your study 1,200+ color photos and illustration―170+ new or revised―help you visualize processes, disorders, and clinic findings Rapid Review section for efficient last-minute preparation Bonus material and real-time updates exclusively at FirstAidTeam.com

Tumor Suppressor Par-4

Author : Vivek M. Rangnekar
Publisher : Springer Nature
ISBN 13 : 3030805581
Total Pages : 329 pages
Book Rating : 4.0/5 (38 download)

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Book Synopsis Tumor Suppressor Par-4 by : Vivek M. Rangnekar

Download or read book Tumor Suppressor Par-4 written by Vivek M. Rangnekar and published by Springer Nature. This book was released on 2022-01-01 with total page 329 pages. Available in PDF, EPUB and Kindle. Book excerpt: Par-4 is a naturally occurring tumor suppressor. Studies have indicated that overexpression of Par-4 selectively induces apoptosis in cancer cells while leaving normal, health, cells unaffected. Mechanisms contributing to this cancer-selective action of Par-4 have been associated with PKA activation of intracellular Par-4 in cancer cells or GRP78 expression primarily on the surface of cancer cells. On the other hand, endogenous Par-4 sensitizes cells to the action of a broad range of apoptotic inducers acting via the extrinsic and intrinsic pathways. A number of binding partners of Par-4 have been identified and shown to regulate Par-4 function in cancer and other diseases, such as Alzheimer’s and major depression. Recent studies have recognized a number of natural products, dietary supplements, synthetic molecules and FDA-approved drugs that induce the secretion of Par-4 protein to cause apoptosis in primary or metastatic tumors, one of which is in clinical trials. More than 50 different laboratories worldwide are involved in Par-4 based research of this unique protein that has progressed from the bench to clinical trials. This second, companion volume will provide a comprehensive overview of Par-4’s role in cancer and other diseases. Chapters are written by leading researchers, and will be useful for a broad audience across the scientific community, particularly students and trainees, who are the next generation of scientists and clinicians to participate in new studies and discoveries on Par-4.

Life Over Cancer

Author : Keith Block
Publisher : Bantam
ISBN 13 : 0553801147
Total Pages : 610 pages
Book Rating : 4.5/5 (538 download)

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Book Synopsis Life Over Cancer by : Keith Block

Download or read book Life Over Cancer written by Keith Block and published by Bantam. This book was released on 2009-04-21 with total page 610 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dr. Keith Block is at the global vanguard of innovative cancer care. As medical director of the Block Center for Integrative Cancer Treatment in Evanston, Illinois, he has treated thousands of patients who have lived long, full lives beyond their original prognoses. Now he has distilled almost thirty years of experience into the first book that gives patients a systematic, research-based plan for developing the physical and emotional vitality they need to meet the demands of treatment and recovery. Based on a profound understanding of how body and mind can work together to defeat disease, this groundbreaking book offers: • Innovative approaches to conventional treatments, such as “chronotherapy”–chemotherapy timed to patients’ unique circadian rhythms for enhanced effectiveness and reduced toxicity • Dietary choices that make the biochemical environment hostile to cancer growth and recurrence, and strengthen the immune system’s ability to attack remaining cancer cells • Precise supplement protocols to tame treatment side effects, relieve disease-related symptoms, and modify processes like inflammation and glycemia that can fuel cancer if left untreated • A new paradigm for exercise and stress reduction that restores your strength, reduces anxiety and depression, and supports the body’s own ability to heal • A complete program for remission maintenance–a proactive plan to make sure the cancer never returns Also included are “quick-start” maps to help you find the information you need right now and many case histories that will support and inspire you. Encouraging, compassionate, and authoritative, Life over Cancer is the guide patients everywhere have been waiting for.

After Cancer Care

Author : Gerald Lemole
Publisher : Rodale Books
ISBN 13 : 1623365031
Total Pages : 306 pages
Book Rating : 4.6/5 (233 download)

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Book Synopsis After Cancer Care by : Gerald Lemole

Download or read book After Cancer Care written by Gerald Lemole and published by Rodale Books. This book was released on 2015-08-25 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt: After the intense experience and range of emotion that comes with surgery, radiation, or chemotherapy (or all three), cancer patients often find themselves with little or no guidance when it comes to their health post-treatment. After Cancer Care is the much-needed authoritative, approachable guide that fills this gap. It includes information on how to maintain physical health—with chapters on epigenetics, nutrition, and exercise—as well as emotional health through stress management techniques. The cutting-edge and growingly popular science of Epigenetics has shown that you are not stuck with your genetic history: your choices in diet, exercise, and even relationships can help determine whether or not your genes promote cancer, and therefore determine your propensity for relapse. Your lifestyle has an effect on the most common types of cancer including breast cancer, prostate cancer, melanoma, endometrial cancer, colon cancer, bladder cancer, and lymphoma. The doctors present easy-to-incorporate lifestyle changes to help you “turn on” hundreds of genes that fight cancer, and “turn off” the ones that encourage cancer, while recommending lifestyle plans to address each type. In addition, they share 34 healthy recipes and tips on staying active and exercising, detoxifying your house and environment, and taking supplements to help prevent relapse. With more than three decades of post-cancer-care experience, Drs. Lemole, Mehta, and McKee break down the science into palatable, practical takeaways so that you can drastically improve your quality of life and enjoy many years of cancer-free serenity.

First Aid Cases for the USMLE Step 1, Fourth Edition

Author : Tao Le
Publisher : McGraw Hill Professional
ISBN 13 : 1260143147
Total Pages : 489 pages
Book Rating : 4.2/5 (61 download)

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Book Synopsis First Aid Cases for the USMLE Step 1, Fourth Edition by : Tao Le

Download or read book First Aid Cases for the USMLE Step 1, Fourth Edition written by Tao Le and published by McGraw Hill Professional. This book was released on 2018-12-22 with total page 489 pages. Available in PDF, EPUB and Kindle. Book excerpt: CASES AND MORE CASES PREPARE YOU FOR SUCCESS ON THE USMLE® STEP 1Now in full color, this powerful study guide provides valuable experience in working through the patient cases you will be presented on exam day. Our active learning questions reinforce must-know concepts with hundreds of high-yield clinical images and illustrations. Chapters are keyed to Dr. Le’s First Aid for the USMLE Step 1, which allows you to simultaneously study cases and master high-yield facts from the #1-rated resource for Step 1 exam prep. Everything you need to excel on exam day:•350 updated cases prepare you to anticipate commonly tested concepts on the USMLE® Step 1•Active learning questions and answers reinforce important concepts•A NEW full-color design bolstered by 300+ concept-clarifying clinical images and illustrations•Concise yet complete with relevant pathophysiology explanations•Organization mirrors First Aid for the USMLE Step 1 for side-by-side study

First Aid for the USMLE Step 1 2018, 28th Edition

Author : Vikas Bhushan
Publisher : McGraw-Hill Education / Medical
ISBN 13 : 9781260116120
Total Pages : 816 pages
Book Rating : 4.1/5 (161 download)

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Book Synopsis First Aid for the USMLE Step 1 2018, 28th Edition by : Vikas Bhushan

Download or read book First Aid for the USMLE Step 1 2018, 28th Edition written by Vikas Bhushan and published by McGraw-Hill Education / Medical. This book was released on 2017-12-21 with total page 816 pages. Available in PDF, EPUB and Kindle. Book excerpt: SCORE YOUR HIGHEST ON THE USMLE® STEP 1 WITH HELP FROM THE WORLD’S MOST POPULAR MEDICAL REVIEW BOOK An unmatched collection of more than 1,300 must-know facts and mnemonics provide a complete framework for your USMLE® preparation and coursework! This annually updated review delivers a comprehensive collection of high-yield facts and mnemonics that pinpoint exactly what you need to know to pass the exam. Co-authored by medical students who recently took the boards, it provides a complete framework to help you prepare for the most stressful exam of your career. Here's why this is the ultimate USMLE Step 1 review:•A complete framework for USMLE® Step 1 preparation, annually updated with crowdsourced contributions from thousands of students •Written by students who excelled on their Step 1 exam and reviewed by top faculty for accuracy•1,300 must-know topics with mnemonics to focus your study•1,000+ color photos and illustrations – 100 new or revised -- help you visualize processes, disorders, and clinical findings•Student-proven study and exam prep tips backed by learning science•Reorganized Rapid Review section for efficient, last-minute preparation•Revised and expanded recommendations for high-yield print and digital study resources s•Bonus material and real-time updates exclusively at FirstAidTeam.com

Neonatal and Infant Dermatology E-Book

Author : Lawrence F. Eichenfield
Publisher : Elsevier Health Sciences
ISBN 13 : 1455726397
Total Pages : 752 pages
Book Rating : 4.4/5 (557 download)

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Book Synopsis Neonatal and Infant Dermatology E-Book by : Lawrence F. Eichenfield

Download or read book Neonatal and Infant Dermatology E-Book written by Lawrence F. Eichenfield and published by Elsevier Health Sciences. This book was released on 2014-08-25 with total page 752 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neonatal and Infant Dermatology is a unique comprehensive and heavily illustrated reference on the dermatologic diseases of newborns and infants. It includes discussions of common and uncommon conditions seen in infants at birth and in the first few months of life. With over 600 superb photographs of normal and abnormal skin conditions including images of rare conditions, this easily accessible resource is essential for pediatricians, neonatologists, and dermatologists as well as other healthcare professionals involved in the diagnosis and treatment of dermatologic diseases in infants and newborns. - Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. - Get the depth of coverage you need to effectively diagnose skin conditions in neonates and infants. - Expedite effective differential diagnoses with guidance from algorithms, lists, text, boxes and supporting images. - Benefit from the experience of over 60 contributors from around the world lead by Drs. Lawrence F. Eichenfield and Ilona J. Frieden, two of the most important names in the fields of dermatology and pediatrics. - Glean all essential, up-to-date, need-to-know information with new chapters on Papulosquamous and Lichenoid Disorders, Acneiform and Sweat-gland disorders and two individual chapters on Vascular Malformations and Vascular Tumors. - See what to expect and how to proceed with new, high-quality illustrations and photos that provide even more visual examples of abnormal and normal conditions. - Take it with you anywhere! Access the full text, image library, and more online at Expert Consult.

USMLE Step 1 Lecture Notes 2021: 7-Book Set

Author : Kaplan Medical
Publisher : Simon and Schuster
ISBN 13 : 1506259340
Total Pages : 401 pages
Book Rating : 4.5/5 (62 download)

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Book Synopsis USMLE Step 1 Lecture Notes 2021: 7-Book Set by : Kaplan Medical

Download or read book USMLE Step 1 Lecture Notes 2021: 7-Book Set written by Kaplan Medical and published by Simon and Schuster. This book was released on 2020-12 with total page 401 pages. Available in PDF, EPUB and Kindle. Book excerpt: Kaplan Medical's USMLE Step 1 Lecture Notes 2021: 7-Book Set offers in-depth review with a focus on high-yield topics in every discipline—a comprehensive approach that will help you deepen your understanding while focusing your efforts where they'll count the most. Used by thousands of medical students each year to succeed on USMLE Step 1, Kaplan's official lecture notes are packed with full-color diagrams and clear review. The 7 volumes—Pathology, Pharmacology, Physiology, Biochemistry/Medical Genetics, Immunology/Microbiology, Anatomy, and Behavioral Science/Social Sciences—are updated annually by Kaplan's all-star expert faculty. The Best Review 2,000 pages covering every discipline you'll need on this section of the boards Full-color diagrams and charts for better comprehension and retention Clinical correlations and bridges between disciplines highlighted throughout Chapter summary study guides at the end of every chapter for easier review Up-To-Date Content Clinical updates included in all 7 volumes to align with recent changes Organized in outline format with high-yield summary boxes for efficient study

Hearing Impairment and Disability

Author : Ariel Tenenbaum
Publisher :
ISBN 13 : 9781536179699
Total Pages : 245 pages
Book Rating : 4.1/5 (796 download)

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Book Synopsis Hearing Impairment and Disability by : Ariel Tenenbaum

Download or read book Hearing Impairment and Disability written by Ariel Tenenbaum and published by . This book was released on 2020 with total page 245 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Much research has been conducted to provide researchers and hearing healthcare professionals with updated information in regard to hearing assessments, results interpretation and case management. This ongoing research is particularly imperative to guide clinicians with optimized methods in assessing and managing pediatric patients with hearing impairment and disability. As such, tremendous research efforts have been made in determining the most optimum methods in assessing hearing using both subjective and objective tests. Since hearing loss can occur due to disrupted peripheral and/or central auditory pathway, there is also a growing interest to study children with auditory processing disorder (APD). Even though notable achievements have been observed in understanding APD, more research is required, particularly in establishing a gold standard APD test and its specific interventions. Aditionally, having an objective test such as speech-evoked auditory brainstem response is beneficial to understand how speech sounds are encoded within the brainstem region in hearing-impaired children, as well as in those with compromised neural function. In this book, we have gathered research from Malaysia and India in this field and hope it will be of interest to our readers"--

Tumor Suppressor Par-4

Author : Vivek M. Rangnekar
Publisher : Springer
ISBN 13 : 9783030735715
Total Pages : 323 pages
Book Rating : 4.7/5 (357 download)

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Book Synopsis Tumor Suppressor Par-4 by : Vivek M. Rangnekar

Download or read book Tumor Suppressor Par-4 written by Vivek M. Rangnekar and published by Springer. This book was released on 2022-01-09 with total page 323 pages. Available in PDF, EPUB and Kindle. Book excerpt: Par-4 is a tumor suppressor protein first discovered and identified in 1993 by Dr. Vivek Rangnekar’s laboratory in prostate cancer cells undergoing apoptosis. Par-4 (later also known as PAWR) is a naturally occurring tumor suppressor. Studies have indicated that Par-4 selectively induces apoptosis in cancer cells while leaving normal, healthy, cells unaffected. Mechanisms contributing to the cancer-selective action of Par-4 have been associated with protein kinase A activation of intracellular Par-4 in cancer cells or GRP78 expression primarily on the surface of cancer cells. Par-4 is downregulated, inactivated or mutated in diverse cancers. This first of two volumes will be the first on the market on the topic of Par-4, and will provide the opportunity for researchers to discuss the future direction of studies, broaden the scope of research, and contribute a more complete understanding of the molecule’s structural features, key functional domains, regulation and relevant basic and clinical/translational facets.