2015 Which New Directions For Alzheimers Disease

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2015: Which new directions for Alzheimer's disease?

Author : Ludovic Martin
Publisher : Frontiers Media SA
ISBN 13 : 288919535X
Total Pages : 125 pages
Book Rating : 4.8/5 (891 download)

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Book Synopsis 2015: Which new directions for Alzheimer's disease? by : Ludovic Martin

Download or read book 2015: Which new directions for Alzheimer's disease? written by Ludovic Martin and published by Frontiers Media SA. This book was released on 2015-06-03 with total page 125 pages. Available in PDF, EPUB and Kindle. Book excerpt: According to the World Health Organization, more than 40 million people in the world are affected with dementia. To date, 60-70% of the cases of dementia are attributed to the Alzheimer's disease (AD). This neurodegenerative disorder gradually takes place over a period of at least 20 years before the onset of symptoms, which are impaired memory, apathy and depression. The characteristics of AD consist in neurofibrillary tangles (intraneuronal aggregates of hyperphosphorylated tau proteins) and senile plaques (dense extraneuronal deposits composed of amyloid ß (Aß)). The other features linked to these two core pathological hallmarks of AD are inflammation, oxidative stress, progressive synaptic and neuronal loss. In past years, some of the emerging therapeutic strategies against AD were employed to deal with the pathological hallmarks of the disease. Science teams all over the world try to restore the tau phosphorylation equilibrium. Their purpose is to interfere with the aggregation of tau and decrease its amount of proteins per se as well. Furthermore, they are trying either to stimulate the elimination processes of the aggregated tau proteins or to stop the formation of Aß peptides. This could be reached by the stimulation of the classic techniques of protein degradation such as the autophagic pathway, or by the targeted immunotherapy. In this Research Topic, we wish to summarize and review the etiology of AD and the related therapeutic opportunities for the next decades. To fully understand the precise mechanisms underlying AD, research findings, reviews, new insights and new approaches include AD and related tauopathies, tau phosphorylation balance, pharmacological compounds against AD, neuroprotection strategies and new therapeutic ways but also risk factors for AD and AD genetic information are included in this issue.

Treating Alzheimer's Disease

Author : Howard Fillit
Publisher :
ISBN 13 :
Total Pages : 172 pages
Book Rating : 4.:/5 (437 download)

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Book Synopsis Treating Alzheimer's Disease by : Howard Fillit

Download or read book Treating Alzheimer's Disease written by Howard Fillit and published by . This book was released on 2004 with total page 172 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Preventing Cognitive Decline and Dementia

Author : National Academies of Sciences, Engineering, and Medicine
Publisher : National Academies Press
ISBN 13 : 0309459591
Total Pages : 181 pages
Book Rating : 4.3/5 (94 download)

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Book Synopsis Preventing Cognitive Decline and Dementia by : National Academies of Sciences, Engineering, and Medicine

Download or read book Preventing Cognitive Decline and Dementia written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2017-10-05 with total page 181 pages. Available in PDF, EPUB and Kindle. Book excerpt: Societies around the world are concerned about dementia and the other forms of cognitive impairment that affect many older adults. We now know that brain changes typically begin years before people show symptoms, which suggests a window of opportunity to prevent or delay the onset of these conditions. Emerging evidence that the prevalence of dementia is declining in high-income countries offers hope that public health interventions will be effective in preventing or delaying cognitive impairments. Until recently, the research and clinical communities have focused primarily on understanding and treating these conditions after they have developed. Thus, the evidence base on how to prevent or delay these conditions has been limited at best, despite the many claims of success made in popular media and advertising. Today, however, a growing body of prevention research is emerging. Preventing Cognitive Decline and Dementia: A Way Forward assesses the current state of knowledge on interventions to prevent cognitive decline and dementia, and informs future research in this area. This report provides recommendations of appropriate content for inclusion in public health messages from the National Institute on Aging.

Future Directions for the Demography of Aging

Author : National Academies of Sciences, Engineering, and Medicine
Publisher : National Academies Press
ISBN 13 : 0309474108
Total Pages : 409 pages
Book Rating : 4.3/5 (94 download)

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Book Synopsis Future Directions for the Demography of Aging by : National Academies of Sciences, Engineering, and Medicine

Download or read book Future Directions for the Demography of Aging written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2018-07-21 with total page 409 pages. Available in PDF, EPUB and Kindle. Book excerpt: Almost 25 years have passed since the Demography of Aging (1994) was published by the National Research Council. Future Directions for the Demography of Aging is, in many ways, the successor to that original volume. The Division of Behavioral and Social Research at the National Institute on Aging (NIA) asked the National Academies of Sciences, Engineering, and Medicine to produce an authoritative guide to new directions in demography of aging. The papers published in this report were originally presented and discussed at a public workshop held in Washington, D.C., August 17-18, 2017. The workshop discussion made evident that major new advances had been made in the last two decades, but also that new trends and research directions have emerged that call for innovative conceptual, design, and measurement approaches. The report reviews these recent trends and also discusses future directions for research on a range of topics that are central to current research in the demography of aging. Looking back over the past two decades of demography of aging research shows remarkable advances in our understanding of the health and well-being of the older population. Equally exciting is that this report sets the stage for the next two decades of innovative researchâ€"a period of rapid growth in the older American population.

How Not to Study a Disease

Author : Karl Herrup
Publisher : MIT Press
ISBN 13 : 0262546019
Total Pages : 269 pages
Book Rating : 4.2/5 (625 download)

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Book Synopsis How Not to Study a Disease by : Karl Herrup

Download or read book How Not to Study a Disease written by Karl Herrup and published by MIT Press. This book was released on 2023-03-07 with total page 269 pages. Available in PDF, EPUB and Kindle. Book excerpt: An authority on Alzheimer's disease offers a history of past failures and a roadmap that points us in a new direction in our journey to a cure. For decades, some of our best and brightest medical scientists have dedicated themselves to finding a cure for Alzheimer's disease. What happened? Where is the cure? The biggest breakthroughs occurred twenty-five years ago, with little progress since. In How Not to Study a Disease, neurobiologist Karl Herrup explains why the Alzheimer's discoveries of the 1990s didn't bear fruit and maps a direction for future research. Herrup describes the research, explains what's taking so long, and offers an approach for resetting future research. Herrup offers a unique insider's perspective, describing the red flags that science ignored in the rush to find a cure. He is unsparing in calling out the stubbornness, greed, and bad advice that has hamstrung the field, but his final message is a largely optimistic one. Herrup presents a new and sweeping vision of the field that includes a redefinition of the disease and a fresh conceptualization of aging and dementia that asks us to imagine the brain as a series of interconnected "neighborhoods." He calls for changes in virtually every aspect of the Alzheimer's disease research effort, from the drug development process, to the mechanisms of support for basic research, to the often-overlooked role of the scientific media, and more. With How Not to Study a Disease, Herrup provides a roadmap that points us in a new direction in our journey to a cure for Alzheimer's.

Future Directions for Drug Development for the Treatment of Alzheimer's Disease

Author : Paul G. Conway
Publisher :
ISBN 13 :
Total Pages : 76 pages
Book Rating : 4.:/5 (354 download)

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Book Synopsis Future Directions for Drug Development for the Treatment of Alzheimer's Disease by : Paul G. Conway

Download or read book Future Directions for Drug Development for the Treatment of Alzheimer's Disease written by Paul G. Conway and published by . This book was released on 1991 with total page 76 pages. Available in PDF, EPUB and Kindle. Book excerpt:

New Directions in Geriatric Medicine

Author : Lee Ann Lindquist
Publisher : Springer
ISBN 13 : 3319281372
Total Pages : 163 pages
Book Rating : 4.3/5 (192 download)

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Book Synopsis New Directions in Geriatric Medicine by : Lee Ann Lindquist

Download or read book New Directions in Geriatric Medicine written by Lee Ann Lindquist and published by Springer. This book was released on 2016-04-09 with total page 163 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is designed to present the clinical geriatric trends within general internal medicine and family practice, which practitioners often encounter in caring for their older adult patients. Chapters focus on increasingly difficult clinical decisions that practitioners have to make in caring for older adults, who often experience medical complications due to memory loss, physical disability, and multiple chronic conditions. Written by experts in geriatric medicine, each of these chapters start with the most up-to-date clinical geriatric research and provide specific examples or case studies on how to use this information to address the clinical needs of older adult patients. In addition, there is a set of concise “take-home points” for each chapter that are easy to commit to memory and implement in clinical care of aging patients. As the only book to focus on current trends in geriatric research and evidence-based eldercare practice, Clinical Trends in Geriatric Medicine is of great value to internists, family practitioners, geriatricians, nurses, and physician assistants who care for older adults.

An Expert Explains New Treatments for Alzheimer's Disease

Author : Recardim Smith Evalina
Publisher : Independently Published
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.8/5 (599 download)

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Book Synopsis An Expert Explains New Treatments for Alzheimer's Disease by : Recardim Smith Evalina

Download or read book An Expert Explains New Treatments for Alzheimer's Disease written by Recardim Smith Evalina and published by Independently Published. This book was released on 2024-07-31 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: An Expert Explains New Treatments for Alzheimer's Disease Stay at the forefront of Alzheimer's disease management with An Expert Explains New Treatments for Alzheimer's Disease. This insightful guide offers a comprehensive overview of the latest advancements in treatment options for Alzheimer's, presented by experts in the field. Whether you're a healthcare professional, researcher, or caregiver, this book provides valuable information on cutting-edge therapies and emerging strategies for managing this challenging condition. In this book, you'll explore: Introduction to Alzheimer's Disease: Gain a foundational understanding of Alzheimer's disease, including its symptoms, progression, and impact on patients and families. The book sets the stage for exploring new treatment approaches by providing essential background information. Overview of Current Treatments: Discover an overview of the existing treatments for Alzheimer's disease, including medications and non-pharmacological interventions. The book provides context for understanding how new treatments fit into the current landscape of care. Innovative Drug Therapies: Learn about the latest advancements in pharmaceutical treatments for Alzheimer's. The book covers new drug classes, novel mechanisms of action, and recent breakthroughs in drug development, including amyloid-beta and tau-targeting therapies. Biological and Genetic Approaches: Explore biological and genetic approaches to treating Alzheimer's disease. The book provides insights into gene therapy, stem cell research, and other innovative methods that aim to address the underlying causes of the disease. Clinical Trials and Research: Stay informed about ongoing clinical trials and research studies that are shaping the future of Alzheimer's treatment. The book highlights key trials, emerging therapies, and their potential impact on patient care. Non-Pharmacological Interventions: Discover new non-pharmacological interventions that complement drug therapies. The book covers advancements in cognitive training, lifestyle modifications, and other holistic approaches that support brain health and function. Personalized Medicine: Learn about the role of personalized medicine in Alzheimer's treatment. The book discusses how individualized approaches based on genetic, biomarker, and clinical profiles can enhance treatment effectiveness and patient outcomes. Expert Opinions and Insights: Gain valuable insights from leading experts in the field of Alzheimer's research and treatment. The book includes interviews, case studies, and expert analyses that provide a deeper understanding of new treatment strategies. Challenges and Future Directions: Understand the challenges and limitations associated with new treatments for Alzheimer's disease. The book discusses issues such as efficacy, safety, and accessibility, as well as future directions in research and development. Practical Considerations for Implementation: Discover practical considerations for implementing new treatments in clinical practice. The book provides guidance on integrating new therapies into patient care plans, addressing potential side effects, and navigating treatment options. An Expert Explains New Treatments for Alzheimer's Disease is an invaluable resource for anyone seeking to stay informed about the latest advancements in Alzheimer's treatment. With expert insights, comprehensive coverage, and practical guidance, this book provides essential information for improving patient care and advancing the fight against Alzheimer's disease.

DEVELOPING A DRUG TO TREAT ALZHEIMER'S DISEASE

Author : JAY. WRIGHT
Publisher :
ISBN 13 : 9781036406059
Total Pages : 0 pages
Book Rating : 4.4/5 (6 download)

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Book Synopsis DEVELOPING A DRUG TO TREAT ALZHEIMER'S DISEASE by : JAY. WRIGHT

Download or read book DEVELOPING A DRUG TO TREAT ALZHEIMER'S DISEASE written by JAY. WRIGHT and published by . This book was released on 2024 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

The Growing Gap in Life Expectancy by Income

Author : National Academies of Sciences, Engineering, and Medicine
Publisher : National Academies Press
ISBN 13 : 030931710X
Total Pages : 243 pages
Book Rating : 4.3/5 (93 download)

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Book Synopsis The Growing Gap in Life Expectancy by Income by : National Academies of Sciences, Engineering, and Medicine

Download or read book The Growing Gap in Life Expectancy by Income written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2015-09-17 with total page 243 pages. Available in PDF, EPUB and Kindle. Book excerpt: The U.S. population is aging. Social Security projections suggest that between 2013 and 2050, the population aged 65 and over will almost double, from 45 million to 86 million. One key driver of population aging is ongoing increases in life expectancy. Average U.S. life expectancy was 67 years for males and 73 years for females five decades ago; the averages are now 76 and 81, respectively. It has long been the case that better-educated, higher-income people enjoy longer life expectancies than less-educated, lower-income people. The causes include early life conditions, behavioral factors (such as nutrition, exercise, and smoking behaviors), stress, and access to health care services, all of which can vary across education and income. Our major entitlement programs - Medicare, Medicaid, Social Security, and Supplemental Security Income - have come to deliver disproportionately larger lifetime benefits to higher-income people because, on average, they are increasingly collecting those benefits over more years than others. This report studies the impact the growing gap in life expectancy has on the present value of lifetime benefits that people with higher or lower earnings will receive from major entitlement programs. The analysis presented in The Growing Gap in Life Expectancy by Income goes beyond an examination of the existing literature by providing the first comprehensive estimates of how lifetime benefits are affected by the changing distribution of life expectancy. The report also explores, from a lifetime benefit perspective, how the growing gap in longevity affects traditional policy analyses of reforms to the nation's leading entitlement programs. This in-depth analysis of the economic impacts of the longevity gap will inform debate and assist decision makers, economists, and researchers.

Alzheimer's Disease Drug Development

Author : Jeffrey Cummings
Publisher : Cambridge University Press
ISBN 13 : 1108838669
Total Pages : 575 pages
Book Rating : 4.1/5 (88 download)

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Book Synopsis Alzheimer's Disease Drug Development by : Jeffrey Cummings

Download or read book Alzheimer's Disease Drug Development written by Jeffrey Cummings and published by Cambridge University Press. This book was released on 2022-03-31 with total page 575 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides a definitive overview of the complex ecosystem facilitating Alzheimer's Disease drug research and development. Demonstrates a drug's journey from in the lab, clinical trial testing, regulatory review, and marketing by pharmaceutical companies. Details the use of artificial intelligence, clinical trial management, and financing models.

Reducing the Impact of Dementia in America

Author : National Academies of Sciences Engineering and Medicine
Publisher :
ISBN 13 : 9780309495035
Total Pages : pages
Book Rating : 4.4/5 (95 download)

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Book Synopsis Reducing the Impact of Dementia in America by : National Academies of Sciences Engineering and Medicine

Download or read book Reducing the Impact of Dementia in America written by National Academies of Sciences Engineering and Medicine and published by . This book was released on 2022-04-26 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: As the largest generation in U.S. history - the population born in the two decades immediately following World War II - enters the age of risk for cognitive impairment, growing numbers of people will experience dementia (including Alzheimer's disease and related dementias). By one estimate, nearly 14 million people in the United States will be living with dementia by 2060. Like other hardships, the experience of living with dementia can bring unexpected moments of intimacy, growth, and compassion, but these diseases also affect people's capacity to work and carry out other activities and alter their relationships with loved ones, friends, and coworkers. Those who live with and care for individuals experiencing these diseases face challenges that include physical and emotional stress, difficult changes and losses in their relationships with life partners, loss of income, and interrupted connections to other activities and friends. From a societal perspective, these diseases place substantial demands on communities and on the institutions and government entities that support people living with dementia and their families, including the health care system, the providers of direct care, and others. Nevertheless, research in the social and behavioral sciences points to possibilities for preventing or slowing the development of dementia and for substantially reducing its social and economic impacts. At the request of the National Institute on Aging of the U.S. Department of Health and Human Services, Reducing the Impact of Dementia in America assesses the contributions of research in the social and behavioral sciences and identifies a research agenda for the coming decade. This report offers a blueprint for the next decade of behavioral and social science research to reduce the negative impact of dementia for America's diverse population. Reducing the Impact of Dementia in America calls for research that addresses the causes and solutions for disparities in both developing dementia and receiving adequate treatment and support. It calls for research that sets goals meaningful not just for scientists but for people living with dementia and those who support them as well. By 2030, an estimated 8.5 million Americans will have Alzheimer's disease and many more will have other forms of dementia. Through identifying priorities social and behavioral science research and recommending ways in which they can be pursued in a coordinated fashion, Reducing the Impact of Dementia in America will help produce research that improves the lives of all those affected by dementia.

Limbic-predominant Age-related TDP-43 Encephalopathy

Author : Beller Health
Publisher : Independently Published
ISBN 13 : 9781097268511
Total Pages : 114 pages
Book Rating : 4.2/5 (685 download)

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Book Synopsis Limbic-predominant Age-related TDP-43 Encephalopathy by : Beller Health

Download or read book Limbic-predominant Age-related TDP-43 Encephalopathy written by Beller Health and published by Independently Published. This book was released on 2019-05-13 with total page 114 pages. Available in PDF, EPUB and Kindle. Book excerpt: Book 9 focuses on a new dementia type, LATE, mistaken as Alzheimer's disease until now.LATE stands for Limbic-predominant age-related TDP-43 encephalopathy, the protein buildup responsible for this dementia. This book is organic, like the series, meaning we never consider our books as finished. Science evolves, which is why our books go through continuous updates. Since LATE is a new dementia classification, we expect continuous further information to emerge. Watch Amazon alerts for potential digital updates. We provide free digital copies on all paperback purchases, so everybody receives free updates.

Emerging Technologies for Diagnosing Alzheimer's Disease

Author : Marianne Boenink
Publisher : Springer
ISBN 13 : 1137540974
Total Pages : 300 pages
Book Rating : 4.1/5 (375 download)

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Book Synopsis Emerging Technologies for Diagnosing Alzheimer's Disease by : Marianne Boenink

Download or read book Emerging Technologies for Diagnosing Alzheimer's Disease written by Marianne Boenink and published by Springer. This book was released on 2016-09-13 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book explores international biomedical research and development on the early diagnosis of Alzheimer's disease. It offers timely, multidisciplinary reflections on the social and ethical issues raised by promises of early diagnostics and asks under which conditions emerging diagnostic technologies can be considered a responsible innovation. The initial chapters in this edited volume provide an overview and a critical discussion of recent developments in biomedical research on Alzheimer's disease. Subsequent contributions explore the values at stake in current practices of dealing with Alzheimer's disease and dementia, both within and outside the biomedical domain. Novel diagnostic technologies for Alzheimer's disease emerge in a complex and shifting field, full of controversies. Innovating with care requires a precise mapping of how concepts, values and responsibilities are filled in through the confrontation of practices. In doing so, the volume offers a practice-based approach of responsible innovation that is also applicable to other fields of innovation.

Dementia and Human Rights

Author : Suzanne Cahill
Publisher : Policy Press
ISBN 13 : 1447331419
Total Pages : 287 pages
Book Rating : 4.4/5 (473 download)

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Book Synopsis Dementia and Human Rights by : Suzanne Cahill

Download or read book Dementia and Human Rights written by Suzanne Cahill and published by Policy Press. This book was released on 2018-03-28 with total page 287 pages. Available in PDF, EPUB and Kindle. Book excerpt: The time has come to further challenge biomedical and clinical thinking about dementia, which has for so long underpinned policy and practice. Framing dementia as a disability, this book takes a rights-based approach to expand the debate. Applying a social constructionist lens, it builds on earlier critical perspectives by bringing together concepts including disability, social inclusion, personhood, equality, participation, dignity, empowerment, autonomy and solidarity. Launching the debate into new and exciting territory, the book argues that people living with dementia come within the UN Convention on the Rights of Persons with Disabilities and therefore have full entitlement to all the rights the Convention enshrines. A human rights-based approach has not to date been fully applied to interrogate the lived experience and policy response to dementia. With the fresh analytical tools provided in this book, policy makers and practitioners will will gain new insights into how this broader perspective can be used to further promote the quality of life and quality of care for all those affected by dementia.

Social Work Practice with People with Dementia

Author : Peter Scourfield
Publisher : Taylor & Francis
ISBN 13 : 1000597113
Total Pages : 185 pages
Book Rating : 4.0/5 (5 download)

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Book Synopsis Social Work Practice with People with Dementia by : Peter Scourfield

Download or read book Social Work Practice with People with Dementia written by Peter Scourfield and published by Taylor & Francis. This book was released on 2022-07-08 with total page 185 pages. Available in PDF, EPUB and Kindle. Book excerpt: Social Work Practice with People with Dementia critically discusses the cultural and discursive contexts in which social work with dementia takes place. This is because how we think about dementia influences how we treat people living with the condition. The book also explains the demographic context that has made dementia a global public health priority in recent years. The different forms of dementia are discussed in a way that is accessible to a non-medical readership. The book discusses the different settings and circumstances in which social work with people with dementia and their carers takes place and examines the chief elements of the social work role. In doing this, it explains the professional knowledge, skills and values that social workers need in order to practice effectively in this area of growing importance. Part of this is appreciating how approaches to dementia care have evolved over time. In this context, the book discusses how the dominant bio-medical model has been challenged by person-centred and rights-based approaches. As a key part of social work is to offer people choices, the book provides information about a wide range of health, social care and other services that are available, whilst also highlighting the gaps that exist for different groups and in different areas. Case studies and activities help the reader apply theory to practice. Social Work Practice with People with Dementia will be of particular interest to social work students and early career social workers, primarily in a UK context. However, it contains much relevant information about dementia and dementia practice for anyone involved with adult health and social care both in the UK and around the world.

Mild Cognitive Impairment and Dementia

Author : Glenn E. Smith
Publisher : Oxford University Press
ISBN 13 : 0199764182
Total Pages : 416 pages
Book Rating : 4.1/5 (997 download)

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Book Synopsis Mild Cognitive Impairment and Dementia by : Glenn E. Smith

Download or read book Mild Cognitive Impairment and Dementia written by Glenn E. Smith and published by Oxford University Press. This book was released on 2013-03-21 with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reviews the neuropsychology of common and a few rare neurodegenerative conditions. The mild cognitive impairment prodrome of each condition is highlighted. Chapters include an autopsy-confirmed case presentation from the authors' files, current diagnostic criteria, epidemiology, neuropathology/neurophysiology, genetics, neuroimaging, associated clinical features, differential neuropsychological features and possible interventions.