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Book Synopsis Synthesis and application of ?-configured [18/19F]FDGs by : Mathias Elgland
Download or read book Synthesis and application of ?-configured [18/19F]FDGs written by Mathias Elgland and published by Linköping University Electronic Press. This book was released on 2018-02-21 with total page 125 pages. Available in PDF, EPUB and Kindle. Book excerpt: Positron emission tomography (PET) is a non-invasive imaging method that renders three-dimensional images of tissue that selectively has taken up a radiolabelled organic compound, referred to as a radiotracer. This excellent technique provides clinicians with a tool to monitor disease progression and to evaluate how the patient respond to treatment. The by far most widely employed radiotracer in PET is called 2-deoxy-2-[18F]fluoro-D-glucose ([18F]FDG), which is often referred to as the golden standard in PET. From a molecular perspective, [18F]FDG is an analogue of glucose where a hydroxyl group has been replaced with a radioactive fluorine atom (18F). It is well known that covalent attachment of carbohydrates (i.e., glycosylation) to biomolecules tend to improve their properties in the body, in terms of; improved pharmacokinetics, increased metabolic stability and faster clearance from blood and other non-specific tissue. It is therefore natural to pursuit the development of a [18F]fluoroglycosylation method where [18F]FDG is chemically conjugated to a ligand with high affinity for a given biological target (e.g., tumors or disease-associated protein aggregates). This thesis describes a novel [18F]fluoroglycosylation method that in a simple and general manner facilitate the conjugation of [18F]FDG to biological ligands using click chemistry. The utility of the developed [18F]fluoroglycosylation method is demonstrated by radiolabelling of curcumin, thus forming a tracer that may be employed for diagnosis of Alzheimer’s disease. Moreover, a set of oligothiophenes were fluoroglycosylated for potential diagnosis of Alzheimer’s disease but also for other much rarer protein misfolding diseases (e.g., Creutzfeldt-Jakob disease and systemic amyloidosis). In addition, the synthesis of a series of 19F-fluoroglycosylated porphyrins is described which exhibited promising properties not only to detect but also to treat melanoma cancer. Lastly, the synthesis of a set of 19F-fluorinated E-stilbenes, structurally based on the antioxidant resveratrol is presented. The E-stilbenes were evaluated for their capacity to spectrally distinguish between native and protofibrillar transthyretin in the pursuit of finding diagnostic markers for the rare but severe disease, transthyretin amyloidosis.
Author :United States. Congress. House. Select Committee on Assassinations Publisher : ISBN 13 : Total Pages :764 pages Book Rating :4.3/5 (126 download)
Book Synopsis Investigation of the Assassination of President John F. Kennedy: September 18, 19, 20, and 21, 1978 by : United States. Congress. House. Select Committee on Assassinations
Download or read book Investigation of the Assassination of President John F. Kennedy: September 18, 19, 20, and 21, 1978 written by United States. Congress. House. Select Committee on Assassinations and published by . This book was released on 1978 with total page 764 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Flood on Piney River, November 18-19, 1957, in Vicinity of Spring City, Tennessee by : Tennessee Valley Authority. Division of Water Control Planning
Download or read book Flood on Piney River, November 18-19, 1957, in Vicinity of Spring City, Tennessee written by Tennessee Valley Authority. Division of Water Control Planning and published by . This book was released on 1961 with total page 134 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Annals of the New York Academy of Sciences by : New York Academy of Sciences
Download or read book Annals of the New York Academy of Sciences written by New York Academy of Sciences and published by . This book was released on 1927 with total page 596 pages. Available in PDF, EPUB and Kindle. Book excerpt: Records of meetings 1808-1916 in v. 11-27.
Book Synopsis The Jersey Bulletin and Dairy World by :
Download or read book The Jersey Bulletin and Dairy World written by and published by . This book was released on 1918 with total page 906 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Journal of the Royal Statistical Society by : Royal Statistical Society (Great Britain)
Download or read book Journal of the Royal Statistical Society written by Royal Statistical Society (Great Britain) and published by . This book was released on 1909 with total page 932 pages. Available in PDF, EPUB and Kindle. Book excerpt: Published papers whose appeal lies in their subject-matter rather than their technical statistical contents. Medical, social, educational, legal,demographic and governmental issues are of particular concern.
Book Synopsis A Manual for the Use of the General Court by : Massachusetts. General Court
Download or read book A Manual for the Use of the General Court written by Massachusetts. General Court and published by . This book was released on 1925 with total page 778 pages. Available in PDF, EPUB and Kindle. Book excerpt: Contains rules of both branches of the General Court, the constitution of the commonwealth and that of the United States, lists of executive, legislative and judicial departments of the state, etc.
Author :United States. Congress. House. Committee on Education and Labor. Subcommittee on Elementary, Secondary, and Vocational Education Publisher : ISBN 13 : Total Pages :782 pages Book Rating :4.:/5 (319 download)
Book Synopsis Vocational and Occupational Education: Hearings held in Washington D.C., February 18, 19, 25, 26 .... vol. 2. Hearings held in Washington, D.C. March 20, 25 26 .... vol. 3. Hearings held in Springfield, Ill., September 15, 1975; Cedar Rapids, Iowa, September 16, 1975 by : United States. Congress. House. Committee on Education and Labor. Subcommittee on Elementary, Secondary, and Vocational Education
Download or read book Vocational and Occupational Education: Hearings held in Washington D.C., February 18, 19, 25, 26 .... vol. 2. Hearings held in Washington, D.C. March 20, 25 26 .... vol. 3. Hearings held in Springfield, Ill., September 15, 1975; Cedar Rapids, Iowa, September 16, 1975 written by United States. Congress. House. Committee on Education and Labor. Subcommittee on Elementary, Secondary, and Vocational Education and published by . This book was released on 1975 with total page 782 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Annual and Biennial Reports for ... Made to the ... General Assembly of the State of Ohio by : Ohio
Download or read book Annual and Biennial Reports for ... Made to the ... General Assembly of the State of Ohio written by Ohio and published by . This book was released on 1910 with total page 934 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Legislative Document by : New York (State). Legislature
Download or read book Legislative Document written by New York (State). Legislature and published by . This book was released on 1919 with total page 1020 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Nautical Almanac and Astronomical Ephemeris by : Great Britain. Nautical Almanac Office
Download or read book The Nautical Almanac and Astronomical Ephemeris written by Great Britain. Nautical Almanac Office and published by . This book was released on 1886 with total page 572 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis City Document ... by : Worcester (Mass.)
Download or read book City Document ... written by Worcester (Mass.) and published by . This book was released on 1915 with total page 1164 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Legislative Manual Containing a List of State Officers, Executive and Judicial, Members-elect of the House and Senate ... House and Senate Rules ... Constitution of the State ... and a Condensed Epitomy of Legislative Work and Procedure ... by : Colorado. Dept. of State
Download or read book Legislative Manual Containing a List of State Officers, Executive and Judicial, Members-elect of the House and Senate ... House and Senate Rules ... Constitution of the State ... and a Condensed Epitomy of Legislative Work and Procedure ... written by Colorado. Dept. of State and published by . This book was released on 1903 with total page 326 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis House of Commons Debates, Official Report by : Canada. Parliament. House of Commons
Download or read book House of Commons Debates, Official Report written by Canada. Parliament. House of Commons and published by . This book was released on 1909 with total page 1200 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Catalogue written by Marietta College and published by . This book was released on 1918 with total page 90 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Biennial Report of the Superintendent of Public Instruction by : Virginia. Dept. of Education
Download or read book Biennial Report of the Superintendent of Public Instruction written by Virginia. Dept. of Education and published by . This book was released on 1910 with total page 720 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Report on the meteorology of India by : India. Meteorological Department
Download or read book Report on the meteorology of India written by India. Meteorological Department and published by . This book was released on 1887 with total page 548 pages. Available in PDF, EPUB and Kindle. Book excerpt:
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