Translational Toxicology

Download Translational Toxicology PDF Online Free

Author :
Publisher : Humana Press
ISBN 13 : 331927449X
Total Pages : 384 pages
Book Rating : 4.3/5 (192 download)

DOWNLOAD NOW!


Book Synopsis Translational Toxicology by : Claude L. Hughes

Download or read book Translational Toxicology written by Claude L. Hughes and published by Humana Press. This book was released on 2016-03-23 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bringing together a distinguished interdisciplinary team of contributors, this volume provides a comprehensive exploration of translational toxicology—a systematic approach to developing therapeutic interventions that can protect against, mitigate, or reverse the effects of exposures. In particular, the book addresses modes of action and biomarkers, developmental risks of exposures, and potential translational toxicology therapeutics. The result is a compelling application of developmental toxicology in a new therapeutic discipline that is destined to become part of standard medical practice. Translational Toxicology: Defining a New Therapeutic Discipline is an essential text for regulatory authorities, scientists, and physicians who are concerned with environmental exposures, public health, nutrition, and pharmaceutical research and development. Basic science, epidemiological, and clinical investigators will also find this book a significant resource.

Scientific Frontiers in Developmental Toxicology and Risk Assessment

Download Scientific Frontiers in Developmental Toxicology and Risk Assessment PDF Online Free

Author :
Publisher : National Academies Press
ISBN 13 : 0309070864
Total Pages : 348 pages
Book Rating : 4.3/5 (9 download)

DOWNLOAD NOW!


Book Synopsis Scientific Frontiers in Developmental Toxicology and Risk Assessment by : National Research Council

Download or read book Scientific Frontiers in Developmental Toxicology and Risk Assessment written by National Research Council and published by National Academies Press. This book was released on 2000-12-21 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt: Scientific Frontiers in Developmental Toxicology and Risk Assessment reviews advances made during the last 10-15 years in fields such as developmental biology, molecular biology, and genetics. It describes a novel approach for how these advances might be used in combination with existing methodologies to further the understanding of mechanisms of developmental toxicity, to improve the assessment of chemicals for their ability to cause developmental toxicity, and to improve risk assessment for developmental defects. For example, based on the recent advances, even the smallest, simplest laboratory animals such as the fruit fly, roundworm, and zebrafish might be able to serve as developmental toxicological models for human biological systems. Use of such organisms might allow for rapid and inexpensive testing of large numbers of chemicals for their potential to cause developmental toxicity; presently, there are little or no developmental toxicity data available for the majority of natural and manufactured chemicals in use. This new approach to developmental toxicology and risk assessment will require simultaneous research on several fronts by experts from multiple scientific disciplines, including developmental toxicologists, developmental biologists, geneticists, epidemiologists, and biostatisticians.

Zebrafish

Download Zebrafish PDF Online Free

Author :
Publisher : John Wiley & Sons
ISBN 13 : 1118102142
Total Pages : 360 pages
Book Rating : 4.1/5 (181 download)

DOWNLOAD NOW!


Book Synopsis Zebrafish by : Patricia McGrath

Download or read book Zebrafish written by Patricia McGrath and published by John Wiley & Sons. This book was released on 2012-01-03 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt: Zebrafish: Methods for Assessing Drug Safety and Toxicity offers a practical guide for using zebrafish as a tool for toxicology studies. Consolidating key protocols and approaches to help researchers navigate the important and evolving field of zebrafish models for toxicity screening, this new title describes the methods for using the zebrafish as a model organism to assess compound-induced toxicity on all major organs. Individual chapters that concentrate on assays for each organ system are included and various analytical tools including microscopy, microplate readers, high content imaging systems, ECG, blood pressure monitors, high speed video and motion detectors are described.

Zebrafish as a Model for Pharmacological and Toxicological Research

Download Zebrafish as a Model for Pharmacological and Toxicological Research PDF Online Free

Author :
Publisher : Frontiers Media SA
ISBN 13 : 2889769879
Total Pages : 207 pages
Book Rating : 4.8/5 (897 download)

DOWNLOAD NOW!


Book Synopsis Zebrafish as a Model for Pharmacological and Toxicological Research by : Carla Denise Bonan

Download or read book Zebrafish as a Model for Pharmacological and Toxicological Research written by Carla Denise Bonan and published by Frontiers Media SA. This book was released on 2022-09-16 with total page 207 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Drug Discovery Toxicology

Download Drug Discovery Toxicology PDF Online Free

Author :
Publisher : John Wiley & Sons
ISBN 13 : 1119053390
Total Pages : 899 pages
Book Rating : 4.1/5 (19 download)

DOWNLOAD NOW!


Book Synopsis Drug Discovery Toxicology by : Yvonne Will

Download or read book Drug Discovery Toxicology written by Yvonne Will and published by John Wiley & Sons. This book was released on 2016-03-22 with total page 899 pages. Available in PDF, EPUB and Kindle. Book excerpt: As a guide for pharmaceutical professionals to the issues and practices of drug discovery toxicology, this book integrates and reviews the strategy and application of tools and methods at each step of the drug discovery process. • Guides researchers as to what drug safety experiments are both practical and useful • Covers a variety of key topics – safety lead optimization, in vitro-in vivo translation, organ toxicology, ADME, animal models, biomarkers, and –omics tools • Describes what experiments are possible and useful and offers a view into the future, indicating key areas to watch for new predictive methods • Features contributions from firsthand industry experience, giving readers insight into the strategy and execution of predictive toxicology practices

Vascular Development

Download Vascular Development PDF Online Free

Author :
Publisher : John Wiley & Sons
ISBN 13 : 0470319429
Total Pages : 260 pages
Book Rating : 4.4/5 (73 download)

DOWNLOAD NOW!


Book Synopsis Vascular Development by : Derek J. Chadwick

Download or read book Vascular Development written by Derek J. Chadwick and published by John Wiley & Sons. This book was released on 2007-08-20 with total page 260 pages. Available in PDF, EPUB and Kindle. Book excerpt: The formation of blood vessels is an essential aspect of embryogenesis in vertebrates. It is a central feature of numerous post-embryonic processes, including tissue and organ growth and regeneration. It is also part of the pathology of tumour formation and certain inflammatory conditions. In recent years, comprehension of the molecular genetics of blood vessel formation has progressed enormously and studies in vertebrate model systems, especially the mouse and the zebrafish, have identified a common set of molecules and processes that are conserved throughout vertebrate embryogenesis while, in addition, highlighting aspects that may differ between different animal groups. The discovery in the past decade of the crucial role of new blood vessel formation for the development of cancers has generated great interest in angiogenesis (the formation of new blood vessels from pre-existing ones), with its major implications for potential cancer-control strategies. In addition, there are numerous situations where therapeutic treatments either require or would be assisted by vasculogenesis (the de novo formation of blood vessels). In particular, post-stroke therapies could include treatments that stimulate neovascularization of the affected tissues. The development of such treatments, however, requires thoroughly understanding the developmental properties of endothelial cells and the basic biology of blood vessel formation. While there are many books on angiogenesis, this unique book focuses on exactly this basic biology and explores blood vessel formation in connection with tissue development in a range of animal models. It includes detailed discussions of relevant cell biology, genetics and embryogenesis of blood vessel formation and presents insights into the cross-talk between developing blood vessels and other tissues. With contributions from vascular biologists, cell biologists and developmental biologists, a comprehensive and highly interdisciplinary volume is the outcome.

Methods of Behavior Analysis in Neuroscience

Download Methods of Behavior Analysis in Neuroscience PDF Online Free

Author :
Publisher : CRC Press
ISBN 13 : 1420041819
Total Pages : 341 pages
Book Rating : 4.4/5 (2 download)

DOWNLOAD NOW!


Book Synopsis Methods of Behavior Analysis in Neuroscience by : Jerry J. Buccafusco

Download or read book Methods of Behavior Analysis in Neuroscience written by Jerry J. Buccafusco and published by CRC Press. This book was released on 2000-08-29 with total page 341 pages. Available in PDF, EPUB and Kindle. Book excerpt: Using the most well-studied behavioral analyses of animal subjects to promote a better understanding of the effects of disease and the effects of new therapeutic treatments on human cognition, Methods of Behavior Analysis in Neuroscience provides a reference manual for molecular and cellular research scientists in both academia and the pharmaceutic

Dioxins and Health

Download Dioxins and Health PDF Online Free

Author :
Publisher : Springer Science & Business Media
ISBN 13 : 9780306447853
Total Pages : 740 pages
Book Rating : 4.4/5 (478 download)

DOWNLOAD NOW!


Book Synopsis Dioxins and Health by : A. Schecter

Download or read book Dioxins and Health written by A. Schecter and published by Springer Science & Business Media. This book was released on 1994-12-31 with total page 740 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book originated in a series of cross-disciplinary conversations in the years 1984-1990 between the editor, who is a physician-researcher involved in clinical and laboratory research, and a dioxin toxicologist. During the years in which the conversations took place, an extraordinary amount of new scientific literature was published related to dioxins, defined for purposes of this text as the chlorinated dibenzo-p-dioxins, dibenzofurans, polychlorinated biphe nyls (PCB's) and other compounds that are structurally and toxicologically similar to 2,3,7,8-tetrachlorodibenzo-p-dioxin (2,3,7 ,8-TCDD), the most extensively studied and most toxic of this group of chemicals. Dioxins also began to interest not only chemists and toxicologists, but also specialists from diverse disciplines such as wildlife and environmental science, immunology, neuroscience,public health, epidemiology, med icine, government, law, sociology, and journalism. Specialists from such varied disciplines, while familiar with their own literature, frequently did not have time to follow the dioxin literature outside their specialty area. In addition, each specialty had unique knowledge, methods, and perspectives. Cross disciplinary conversation was necessary, but all too frequently, specialists from the various disciplines did not speak the same language, resulting in misunderstanding.

Drug Discovery and Evaluation: Safety and Pharmacokinetic Assays

Download Drug Discovery and Evaluation: Safety and Pharmacokinetic Assays PDF Online Free

Author :
Publisher : Springer
ISBN 13 : 9783642252396
Total Pages : 0 pages
Book Rating : 4.2/5 (523 download)

DOWNLOAD NOW!


Book Synopsis Drug Discovery and Evaluation: Safety and Pharmacokinetic Assays by : H. Gerhard Vogel

Download or read book Drug Discovery and Evaluation: Safety and Pharmacokinetic Assays written by H. Gerhard Vogel and published by Springer. This book was released on 2013-02-27 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: -A landmark in the continuously changing world of drugs -Essential reading for scientists and managers in the pharmaceutical industry involved in drug finding, drug development and decision making in the development process -Of use for government institutions and committees working on official guidelines for drug evaluation worldwide

The Zebrafish

Download The Zebrafish PDF Online Free

Author :
Publisher : Cambridge University Press
ISBN 13 : 1139620630
Total Pages : 157 pages
Book Rating : 4.1/5 (396 download)

DOWNLOAD NOW!


Book Synopsis The Zebrafish by : Joseph A. Holden

Download or read book The Zebrafish written by Joseph A. Holden and published by Cambridge University Press. This book was released on 2013-01-21 with total page 157 pages. Available in PDF, EPUB and Kindle. Book excerpt: The zebrafish (Danio rerio) is a valuable and common model for researchers working in the fields of genetics, oncology and developmental sciences. This full-color atlas will aid experimental design and interpretation in these areas by providing a fundamental understanding of zebrafish anatomy. Over 150 photomicrographs are included and can be used for direct comparison with histological slides, allowing quick and accurate identification of the anatomic structures of interest. Hematoxylin and eosin stained longitudinal and transverse sections demonstrate gross anatomic relationships and illustrate the microscopic anatomy of major organs. Unlike much of the current literature, this book is focused exclusively on the zebrafish, eliminating the need for researchers to exclude structures that are only found in other fish.

New Technologies for Toxicity Testing

Download New Technologies for Toxicity Testing PDF Online Free

Author :
Publisher : Springer Science & Business Media
ISBN 13 : 1461430550
Total Pages : 282 pages
Book Rating : 4.4/5 (614 download)

DOWNLOAD NOW!


Book Synopsis New Technologies for Toxicity Testing by : Michael Balls

Download or read book New Technologies for Toxicity Testing written by Michael Balls and published by Springer Science & Business Media. This book was released on 2012-03-22 with total page 282 pages. Available in PDF, EPUB and Kindle. Book excerpt: The central theme running through this volume on New Technologies for Toxicity Testing is the development and application of advanced techniques for cell and tissue culture, as well as new markers and endpoints of toxicity, as alternatives to the traditional paradigm of relying on data from laboratory animal tests to undertake labelling and risk assessment. Of course, many of the techniques and methods described in this volume are in the early stages of development, and much work will be needed to ensure their further improvement, optimisation and validation. However, we are confident that this will be achieved and that, just as with the in vitro assays that were validated and granted regulatory acceptance over the last decade, these, and many other new, advanced methods, will likewise become part of the toxicologist’s improved toolbox for coping with increasingly stringent and numerous regulatory requirements and test chemicals, while placing less reliance on traditional testing paradigms.

The Zebrafish: Cellular and Developmental Biology, Part B

Download The Zebrafish: Cellular and Developmental Biology, Part B PDF Online Free

Author :
Publisher : Academic Press
ISBN 13 : 0123870372
Total Pages : 317 pages
Book Rating : 4.1/5 (238 download)

DOWNLOAD NOW!


Book Synopsis The Zebrafish: Cellular and Developmental Biology, Part B by :

Download or read book The Zebrafish: Cellular and Developmental Biology, Part B written by and published by Academic Press. This book was released on 2011-06-02 with total page 317 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume of Methods in Cell Biology, the second of two parts on the subject of zebrafish, provides a comprehensive compendium of laboratory protocols and reviews covering all the new methods developed since 1999. - Details state-of-the art zebrafish protocols, delineating critical steps in the procedures as well as potential pitfalls - Illustrates many techiques in full-color - Summarizes the Zebrafish Genome Project

OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 414: Prenatal Developmental Toxicity Study

Download OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 414: Prenatal Developmental Toxicity Study PDF Online Free

Author :
Publisher : OECD Publishing
ISBN 13 : 9264070826
Total Pages : 14 pages
Book Rating : 4.2/5 (64 download)

DOWNLOAD NOW!


Book Synopsis OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 414: Prenatal Developmental Toxicity Study by : OECD

Download or read book OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 414: Prenatal Developmental Toxicity Study written by OECD and published by OECD Publishing. This book was released on 2018-06-27 with total page 14 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Test Guideline for developmental toxicity testing is designed to provide general information concerning the effects of prenatal exposure on the pregnant test animal and on the developing organism. The test substance is normally administered to ...

Model Organisms to Study Biological Activities and Toxicity of Nanoparticles

Download Model Organisms to Study Biological Activities and Toxicity of Nanoparticles PDF Online Free

Author :
Publisher : Springer Nature
ISBN 13 : 9811517029
Total Pages : 466 pages
Book Rating : 4.8/5 (115 download)

DOWNLOAD NOW!


Book Synopsis Model Organisms to Study Biological Activities and Toxicity of Nanoparticles by : Busi Siddhardha

Download or read book Model Organisms to Study Biological Activities and Toxicity of Nanoparticles written by Busi Siddhardha and published by Springer Nature. This book was released on 2020-03-28 with total page 466 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive overview of state-of-the-art applications of nanotechnology in biology and medicine, as well as model organisms that can help us understand the biological activity and associated toxicity of nanoparticles, and devise strategies to minimize toxicity and enhance therapies. Thanks to their high surface-to-volume ratio, nanoparticles are characterized by excellent biocompatibility and bioavailability, a high therapeutic index, and relatively low toxicity, which has led to their widespread application in the early diagnosis of diseases, comprehensive monitoring of disease progression, and improved therapeutics. The book also explores nanoparticle-based insecticides and their mechanisms of action, and provides a comparative analysis of the various model organisms that are used to understand the biological properties of nanoparticles. Further, it describes various in-vivo models that yield important insights into nanomaterial-mediated toxicity, promoting the optimal utilization of nanoparticles. In closing, the book discusses future perspectives and regulatory issues concerning the use of nanomaterials in translational research.

Zebrafish in Biomedical Research

Download Zebrafish in Biomedical Research PDF Online Free

Author :
Publisher :
ISBN 13 : 9781789859850
Total Pages : pages
Book Rating : 4.8/5 (598 download)

DOWNLOAD NOW!


Book Synopsis Zebrafish in Biomedical Research by : Yusuf Bozkurt

Download or read book Zebrafish in Biomedical Research written by Yusuf Bozkurt and published by . This book was released on 2020-03 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Pharmaceutical Toxicology

Download Pharmaceutical Toxicology PDF Online Free

Author :
Publisher :
ISBN 13 :
Total Pages : 284 pages
Book Rating : 4.3/5 (91 download)

DOWNLOAD NOW!


Book Synopsis Pharmaceutical Toxicology by : Gerard J. Mulder

Download or read book Pharmaceutical Toxicology written by Gerard J. Mulder and published by . This book was released on 2006 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt: Toxicology studies are carried out on all drug substances to ensure safety. This book provides an overview of the methodology andrequirements of pre-clinical safety assessments of new medicines. with the focus on medicinal drugs - the most important safety issues of drugs are covered, including registration requirements of new drugs and pharmacovigilance. This is an introductory text for students at BSc, MSc and PhD levels,and will be an excellent companion to pharmacology textbooks, combining a broad treatment of the issues relevant for assessing the safety/efficacy balance of a new drug wit

Fungal Pigments

Download Fungal Pigments PDF Online Free

Author :
Publisher : MDPI
ISBN 13 : 303842787X
Total Pages : 141 pages
Book Rating : 4.0/5 (384 download)

DOWNLOAD NOW!


Book Synopsis Fungal Pigments by : Laurent Dufossé

Download or read book Fungal Pigments written by Laurent Dufossé and published by MDPI. This book was released on 2018-03-23 with total page 141 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a printed edition of the Special Issue "Fungal Pigments" that was published in JoF