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Xenobiotica
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Download or read book Xenobiotica written by and published by . This book was released on 1996 with total page 898 pages. Available in PDF, EPUB and Kindle. Book excerpt: Covers three main areas: general xenobiochemistry, including the metabolism and disposition of drugs and environmental chemicals in animals, plants and micro-organisms, and the related methodology; molecular toxicology, concerning mechanisms of toxicity and the study of toxicology at the molecular level; and clinical pharmacokinetics and metabolism, focusing on the pharmacokinetic behavior of foreign compounds in man.
Book Synopsis Handbook of Biotransformations of Aromatic Compounds by : B.L. Goodwin
Download or read book Handbook of Biotransformations of Aromatic Compounds written by B.L. Goodwin and published by CRC Press. This book was released on 2004-11-10 with total page 2126 pages. Available in PDF, EPUB and Kindle. Book excerpt: Understanding the biotransformations of aromatic compounds and how they metabolize in animals, plants, and microbes, is central to the applications in a wide range of industries, such as the design and testing of natural and synthetic pharmaceuticals, oil refining, the development of agrochemicals, bioremediation, and for use in functional genomics
Book Synopsis Human-based Systems for Translational Research by : Robert Coleman
Download or read book Human-based Systems for Translational Research written by Robert Coleman and published by Royal Society of Chemistry. This book was released on 2014-12-08 with total page 297 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a history and discussion of the use of human tissues as an alternative to animal-based testing for assessing the efficacy and safety of new medicines. Beginning by providing a historical background to animal-based testing, this text then describes in detail the issues relating to access to human cells and tissue and the rules and regulations governing their use. The book illustrates what is currently possible in humanising medicines research and development, and suggests more rational and reliable means of developing safe and effective drugs for the future than those on which we currently rely. Early chapters establish the need to generate more data in human-derived test systems, and the need for resources such as tissue banks and standardised processes whilst highlighting the barriers that have prevented such developments so far. Subsequent chapters explore the alternatives to current animal toxicology studies, including stem cells and computational models, with balanced views of the technical challenges and opportunities these offer. In addition, useful information on computational methods and pharmacokinetics are included. This book is an essential read for anyone engaged in translational drug discovery who wishes to consolidate their understanding and broaden their awareness of the key issues involved in accessing primary human tissue and the advantages of doing so.
Download or read book Cumulated Index Medicus written by and published by . This book was released on 1974 with total page 1260 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Pharmacology and Toxicology of Cytochrome P450 - 60th Anniversary by :
Download or read book Pharmacology and Toxicology of Cytochrome P450 - 60th Anniversary written by and published by Academic Press. This book was released on 2022-08-09 with total page 436 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pharmacology and Toxicology of Cytochrome P450 - 60th Anniversary, Volume 95 highlights the extensive contributions by worldwide researchers in the cytochrome P450 (P450) field over the past six decades, and since the first article on P450 was published in 1962. Chapters in this new release include Multiple conformations of cytochromes P450 and the relevance to predicting SAR, Pharmacogenetics of the cytochromes P450 and relevance to drug metabolism, Cytochromes P450 drug metabolism within the brain, Mammalian cytochrome P450 biodiversity: Physiological importance, function, and protein and genomic structures of cytochromes P4502B in multiple species of woodrats with different dietary preferences, and more. Additional section cover Atypical kinetics of cytochrome P450 enzymes in drug metabolism, Biosynthesis using cytochrome P450 Enzymes: focus on synthesis of drug metabolites, Use of engineered cytochrome P450s for accelerating drug discovery and development, Assessing cytochrome P450 function using genetically engineered mouse models, Use of the biologicals with sustainable reproducibility for phenotyping study of cytochrome P450 enzymes involved in the biotransformation of test compounds and calculating the fraction unbound parameter, for anticipating drug Interactions, and much more. Research on many forms of P450s has been extended into different fields, from molecules to in vivo situations because pharmacologists and toxicologists appreciate and are attracted to the potential therapeutics. The purpose of this volume is to collect a comprehensive description of major progress to date, to discuss possible future directions, and to invite young researchers to join this important and exciting world of P450. - Comprehensive coverage of major progress in the last 60 years on the P450 research in pharmacology and toxicology - Discussion of possible future directions of the research on P450s, especially for improved pharmacotherapy in humans - Encouragement to young scientists to join this important and exciting basic, translational, and advanced world of P450
Book Synopsis Evaluation of Toxic and Genotoxic Effects of Xenobiotica by Means of a Liver Perfusion System by : Brita Beije
Download or read book Evaluation of Toxic and Genotoxic Effects of Xenobiotica by Means of a Liver Perfusion System written by Brita Beije and published by . This book was released on 1983 with total page 48 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Handbook of Mammalian Metabolism of Plant Compounds (1991) by : Ronald R. Scheline
Download or read book Handbook of Mammalian Metabolism of Plant Compounds (1991) written by Ronald R. Scheline and published by CRC Press. This book was released on 2017-12-14 with total page 868 pages. Available in PDF, EPUB and Kindle. Book excerpt: Handbook of Mammalian Metabolism of Plant Compounds provides an extensive survey of how mammals metabolize compounds found in higher plants. Information about these compounds is important to researchers in pharmacology, toxicology, medical and natural products chemistry, and food sciences. Although there is plenty of literature about mammalian metabolism of plant compounds, it is scattered, and summaries of specific plant compounds are often difficult to obtain. This book contains 11 chapters discussing the metabolic fate of individual plant compounds grouped according to chemical class. It also features structural formulas of the compounds and their metabolites, including probable pathways of metabolism. This book provides a convenient single-volume reference source that will benefit all researchers requiring this type of information.
Book Synopsis Mass Spectrometry by : R A W Johnstone
Download or read book Mass Spectrometry written by R A W Johnstone and published by Royal Society of Chemistry. This book was released on 2007-10-31 with total page 442 pages. Available in PDF, EPUB and Kindle. Book excerpt: Specialist Periodical Reports provide systematic and detailed review coverage of progress in the major areas of chemical research. Written by experts in their specialist fields the series creates a unique service for the active research chemist, supplying regular critical in-depth accounts of progress in particular areas of chemistry. For over 80 years the Royal Society of Chemistry and its predecessor, the Chemical Society, have been publishing reports charting developments in chemistry, which originally took the form of Annual Reports. However, by 1967 the whole spectrum of chemistry could no longer be contained within one volume and the series Specialist Periodical Reports was born. The Annual Reports themselves still existed but were divided into two, and subsequently three, volumes covering Inorganic, Organic and Physical Chemistry. For more general coverage of the highlights in chemistry they remain a 'must'. Since that time the SPR series has altered according to the fluctuating degree of activity in various fields of chemistry. Some titles have remained unchanged, while others have altered their emphasis along with their titles; some have been combined under a new name whereas others have had to be discontinued. The current list of Specialist Periodical Reports can be seen on the inside flap of this volume.
Book Synopsis Issues in Global Environment: Biodiversity, Resources, and Conservation: 2011 Edition by :
Download or read book Issues in Global Environment: Biodiversity, Resources, and Conservation: 2011 Edition written by and published by ScholarlyEditions. This book was released on 2012-01-09 with total page 1175 pages. Available in PDF, EPUB and Kindle. Book excerpt: Issues in Global Environment: Biodiversity, Resources, and Conservation: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Global Environment—Biodiversity, Resources, and Conservation. The editors have built Issues in Global Environment: Biodiversity, Resources, and Conservation: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Global Environment—Biodiversity, Resources, and Conservation in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Global Environment: Biodiversity, Resources, and Conservation: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Download or read book Mass Spectrometry written by M E Rose and published by Royal Society of Chemistry. This book was released on 2007-10-31 with total page 450 pages. Available in PDF, EPUB and Kindle. Book excerpt: Specialist Periodical Reports provide systematic and detailed review coverage of progress in the major areas of chemical research. Written by experts in their specialist fields the series creates a unique service for the active research chemist, supplying regular critical in-depth accounts of progress in particular areas of chemistry. For over 80 years the Royal Society of Chemistry and its predecessor, the Chemical Society, have been publishing reports charting developments in chemistry, which originally took the form of Annual Reports. However, by 1967 the whole spectrum of chemistry could no longer be contained within one volume and the series Specialist Periodical Reports was born. The Annual Reports themselves still existed but were divided into two, and subsequently three, volumes covering Inorganic, Organic and Physical Chemistry. For more general coverage of the highlights in chemistry they remain a 'must'. Since that time the SPR series has altered according to the fluctuating degree of activity in various fields of chemistry. Some titles have remained unchanged, while others have altered their emphasis along with their titles; some have been combined under a new name whereas others have had to be discontinued. The current list of Specialist Periodical Reports can be seen on the inside flap of this volume.
Book Synopsis Pharmacokinetic Analysis by : I-Der Lee
Download or read book Pharmacokinetic Analysis written by I-Der Lee and published by CRC Press. This book was released on 1996-06-07 with total page 582 pages. Available in PDF, EPUB and Kindle. Book excerpt: This insightful work provides a useful introduction to the very large and important field of pharmacokinetics. The authors have selected the Time Constant Approach as a unifying view within which to present important application areas. In addition to providing consistency, their approach provides the novice with an intuitive time view that is meaningful from the outset. This approach allows one to get a "feel" for the data and to relate it to other data in a direct and accessible manner. The Time Constant Approach provides a synthesis of the noncompartmental and compartmental methods, with the advantages of both. It starts by defining a physiologically meaningful model based on the pharmacokinetic processes involved. The Time Constant Approach recognizes pharmacokinetics as a number of processes that move drugs between physiological compartments, each process occurring at its own characteristic length of time, to correlate descriptive pharmacokinetic events with time constants of pharmacokinetic processes. While analogous to the three most common testing approaches for pharmacokinetics (the noncompartmental, compartmental and statistical moment approaches) the Time Constant Approach possesses many advantages.
Book Synopsis Chemical Warfare Agents by : Timothy T. Marrs
Download or read book Chemical Warfare Agents written by Timothy T. Marrs and published by John Wiley & Sons. This book was released on 2007-04-04 with total page 750 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chemical Warfare Agents, Second Edition has been totally revised since the successful first edition and expanded to about three times the length, with many new chapters and much more in-depth consideration of all the topics. The chapters have been written by distinguished international experts in various aspects of chemical warfare agents and edited by an experienced team to produce a clear review of the field. The book now contains a wealth of material on the mechanisms of action of the major chemical warfare agents, including the nerve agent cyclosarin, formally considered to be of secondary importance, as well as ricin and abrin. Chemical Warfare Agents, Second Edition discusses the physico-chemical properties of chemical warfare agents, their dispersion and fate in the environment, their toxicology and management of their effects on humans, decontamination and protective equipment. New chapters cover the experience gained after the use of sarin to attack travellers on the Tokyo subway and how to deal with the outcome of the deployment of riot control agents such as CS gas. This book provides a comprehensive review of chemical warfare agents, assessing all available evidence regarding the medical, technical and legal aspects of their use. It is an invaluable reference work for physicians, public health planners, regulators and any other professionals involved in this field. Review of the First Edition: "What more appropriate time for a title of this scope than in the post 9/11 era? ...a timely, scholarly, and well-written volume which offers much information of immense current and...future benefit." —VETERINARY AND HUMAN TOXICOLOGY
Book Synopsis Environment and Skin by : Jean Krutmann
Download or read book Environment and Skin written by Jean Krutmann and published by Springer. This book was released on 2017-11-20 with total page 128 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a rich source of information on skin disorders due to toxicants in the environment. State of the art knowledge is summarized concerning the molecular basis of skin damage caused by well-appreciated environmental noxae. The book also provides a uniquely comprehensive overview of the detrimental dermatological effects of exposure to air pollution and global climate change. A special focus is contact allergy, which, beyond representing a major problem in dermatotoxicology, serves as a prime example for the development of toxicological approaches to risk assessment. A further chapter is devoted to contact urticaria, a condition that can progress to life-threatening anaphylactic reactions. The novel information offered in this book will enable the reader to go beyond the traditional thinking of dermatotoxicology and achieve a modern appreciation of the highly complex interplay between skin and environment.
Book Synopsis Metabolic Basis of Detoxication by : William B. Jakoby
Download or read book Metabolic Basis of Detoxication written by William B. Jakoby and published by Elsevier. This book was released on 2012-12-02 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt: Metabolic Basis of Detoxication: Metabolism of Functional Groups considers the possible fates of the relatively circumscribed number of functional groups that xenobiotics bear. An understanding of the possible reactions, and the chemical and biological factors influencing them, will contribute to the overall predictability of the fate of "real" molecules. This approach attempts to knit together the understanding of metabolic pathways with that of the enzymes that catalyze the specific steps. The book contains 18 chapters and begins with a discussion of the biological oxidation of carbon atoms. This is followed by separate chapters on the metabolism of halogenated aliphatic hydrocarbons, aryl halides, heterocyclic rings, alcohols, aldehydes, and ketones. Subsequent chapters cover oxidative processes such as metabolic dealkylations and biological oxidation at nitrogen centers; the reduction of nitro and azo compounds and tertiary amine N-oxides; the oxidation, alkylation, acylation, and glycosylation of mercaptans; epoxide metabolism; and conjugation of phenols. The book aims to inform and interest the pharmacologist and toxicologist concerning the biochemical aspects and to orient the biochemist to the pharmacological insights required in dealing with the metabolism of xenobiotics.
Book Synopsis Annual Reports in Medicinal Chemistry by :
Download or read book Annual Reports in Medicinal Chemistry written by and published by Academic Press. This book was released on 1979-11-14 with total page 370 pages. Available in PDF, EPUB and Kindle. Book excerpt: Annual Reports in Medicinal Chemistry
Book Synopsis Chocolate in Health and Nutrition by : Ronald Ross Watson
Download or read book Chocolate in Health and Nutrition written by Ronald Ross Watson and published by Springer Science & Business Media. This book was released on 2012-08-04 with total page 542 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chocolate in Health and Nutrition represents the first comprehensive compilation of the newest data on the actions of the flavonoids and microorganisms associated with the beneficial effects of chocolate. This unique text provides practical, data-driven resources based upon the totality of the evidence to help the reader understand the basics, treatments and preventive strategies that are involved in the understanding of the role chocolate may play in healthy individuals as well as those with cardiovascular disease, diabetes or neurocognitive declines. Of equal importance, critical issues that involve patient concerns, such as dental caries and food preferences in children, potential effects on weight gain, addiction and withdrawal are included in well-referenced, informative chapters. The latest research on the role of chocolate in normal health areas including mood, pain and weight management, cardiovascular disease and related conditions are presented. Chocolate in Health and Nutrition provides health professionals in many areas of research and practice with the most up-to-date, well referenced and comprehensive volume on the current state of the science and medical uses of chocolate.
Download or read book Metabolic Maps written by Hiroyasu Aizawa and published by Elsevier. This book was released on 2001-05-31 with total page 346 pages. Available in PDF, EPUB and Kindle. Book excerpt: People working in development of drugs, pesticides, washing detergents, etc., are obliged by law to conduct analyses of the "metabolic pathways" or "maps" for the chemical compounds that they are using or proposing. Everyone in these industries or carrying out research toward such products is therefore interested in having a reference on these compounds. - Covers literature relating to degradation and metabolic profiles of molecules - Draws together the literature on degradation and metabolism patterns with that on diversified conditions of the environmental systems - Indicates 3D chemical structures, predicted physico-chemical parameters, logP and the SMILES chemical notations of the parent compounds to assist scientists design the lead compounds for new discovery using computer-aided technology
