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X Ray Crystallographic Studies Of Cellular Retinoic Acid Binding Protein Ii Mutants Designed As Rhodopsin Mimics
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Book Synopsis X-ray Crystallographic Studies of Cellular Retinoic Acid-binding Protein II Mutants Designed as Rhodopsin Mimics by : Xiaofei Jia
Download or read book X-ray Crystallographic Studies of Cellular Retinoic Acid-binding Protein II Mutants Designed as Rhodopsin Mimics written by Xiaofei Jia and published by . This book was released on 2008 with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis X-ray Crystallographic Studies of Mutants of Cellular Retinoic Acid Binding Protein (II) Toward Designing a Mimic of Rhodopsin by : Soheila Vaezeslami
Download or read book X-ray Crystallographic Studies of Mutants of Cellular Retinoic Acid Binding Protein (II) Toward Designing a Mimic of Rhodopsin written by Soheila Vaezeslami and published by . This book was released on 2006 with total page 530 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Dissertation Abstracts International by :
Download or read book Dissertation Abstracts International written by and published by . This book was released on 2006 with total page 846 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis X-ray Crystallographic Studies Of Designed Peptides, Self Assembling Pseudopeptides And Molecular Modeling by :
Download or read book X-ray Crystallographic Studies Of Designed Peptides, Self Assembling Pseudopeptides And Molecular Modeling written by and published by . This book was released on 2003 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Structural studies of peptides has relevance for various applications, like, in de novo design of proteins, in designing better catalysts for organic synthesis, in structure based drug design, in the design and construction of synthetic protein mimics and in building novel materials via supramolecular self assembly. Crystal structure determination of peptides is expected to provide information about their static structure, mode of aggregation, solvation and hydrogen bond interactions of the sequences in the solid state. Comparison and analysis of the related structures from the database analysis could provide information about sequence dependent conformational features, which eventually would act as precursor for de novo protein design. Self assembling processes are common throughout nature and technology. Living cells self assemble, and understanding life will therefore require an understanding of self assembly. Supramolecular chemistry has become an area of intense research, partly inspired by biological ensembles in nature, such as collagen and enzymes or protein assemblies in general. Understanding, inducing, and directing such self assembling processes are key to unraveling the progressive emergence of complex matter. Most of the drugs available today have a broad spectrum of action in that they can act on more than one receptor and the mechanism of action of these drugs are poorly understood. Homology modeling of receptors and docking studies with drug molecules (both peptides and non-peptides) would result in a better understanding of the mechanism of drug-receptor binding thus resulting in the design of more specific and effective drugs. This thesis reports the results of X-ray crystallographic studies of ten molecules listed below (Ter: terephthalic acid) and the molecular model of cholecystokinin type 1 receptor (CCK1R). The abbreviations used for the sequences are given in parenthesis. Boc-Gly-Dpg-Gly-Leu-OMe (GDGL), C24H44N4O7 Boc-Val-Ala-Leu-Dpg-Val-Ala.
Book Synopsis X-ray Crystallographic Studies of Three Nucleic Acid Binding Proteins by : Bart L. Staker
Download or read book X-ray Crystallographic Studies of Three Nucleic Acid Binding Proteins written by Bart L. Staker and published by . This book was released on 2000 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis X-ray Crystallographic Studies of the Nucleotide Binding Sites on Adenylosuccinate Synthetase Mutants from Escherichia Coli by : Jun-yong Choe
Download or read book X-ray Crystallographic Studies of the Nucleotide Binding Sites on Adenylosuccinate Synthetase Mutants from Escherichia Coli written by Jun-yong Choe and published by . This book was released on 1997 with total page 112 pages. Available in PDF, EPUB and Kindle. Book excerpt: Crystal structures of mutant adenylosuccinate synthetase, in space group P3221, have been refined to R factors of 0.167 (Kl6Q), 0.150 (R143L) and 0.194 (R303L) against data to 2.5 A resolution. All the crystal structures presented in this work contain 6-phosphoryl-IMP, GDP, and Mg2. The K16Q and R143L mutants have hadacidin bound, whereas R303L has only water molecules in the putative aspartate binding site. As a consequence the 300's loop is disordered in the R303L structure. In the K16Q structure, NE2 of Gln 16 is in approximately the same position as NZ of Lys 16 of the wild-type enzyme. The void created by the elimination of the guanidinium group in the R143L mutant is filled by water molecules. In all three structures OD1 of Asp 13 coordinates Mg2, as well as hydrogen bonds with N1 of 6 -phosphoryl-IMP. In addition, distances between Asp 13 and 6-phosphoryl-IMP decrease as distances between His 41 and 6-phosphoryl-IMP increase; the relative separation of Asp 13 and His 41 from 6-phosphoryl-IMP is correlated with k[subscript cat].
Download or read book Cumulated Index Medicus written by and published by . This book was released on 1998 with total page 1874 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :Jacqueline M. Matthews Publisher :Springer Science & Business Media ISBN 13 :1461432294 Total Pages :184 pages Book Rating :4.4/5 (614 download)
Book Synopsis Protein Dimerization and Oligomerization in Biology by : Jacqueline M. Matthews
Download or read book Protein Dimerization and Oligomerization in Biology written by Jacqueline M. Matthews and published by Springer Science & Business Media. This book was released on 2012-09-04 with total page 184 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume has a strong focus on homo-oligomerization, which is surprisingly common. However, protein function is so often linked to both homo- and hetero-oligomerization and many heterologous interactions likely evolved from homologous interaction, so this volume also covers many aspects of hetero-oligomerization.
Book Synopsis Cambridge Scientific Biochemistry Abstracts by :
Download or read book Cambridge Scientific Biochemistry Abstracts written by and published by . This book was released on 1993-07 with total page 1498 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Molecular Biology of The Cell by : Bruce Alberts
Download or read book Molecular Biology of The Cell written by Bruce Alberts and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Tolerable upper intake levels for vitamins and minerals by : European Commission. Scientific Committee on Food
Download or read book Tolerable upper intake levels for vitamins and minerals written by European Commission. Scientific Committee on Food and published by . This book was released on 2006 with total page 478 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Computational Design of Ligand Binding Proteins by : Barry L. Stoddard
Download or read book Computational Design of Ligand Binding Proteins written by Barry L. Stoddard and published by Humana. This book was released on 2016-04-20 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides a collection of protocols and approaches for the creation of novel ligand binding proteins, compiled and described by many of today's leaders in the field of protein engineering. Chapters focus on modeling protein ligand binding sites, accurate modeling of protein-ligand conformational sampling, scoring of individual docked solutions, structure-based design program such as ROSETTA, protein engineering, and additional methodological approaches. Examples of applications include the design of metal-binding proteins and light-induced ligand binding proteins, the creation of binding proteins that also display catalytic activity, and the binding of larger peptide, protein, DNA and RNA ligands. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Book Synopsis Make Life Visible by : Yoshiaki Toyama
Download or read book Make Life Visible written by Yoshiaki Toyama and published by Springer Nature. This book was released on 2019-10-02 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access book describes marked advances in imaging technology that have enabled the visualization of phenomena in ways formerly believed to be completelyimpossible. These technologies have made major contributions to the elucidation of the pathology of diseases as well as to their diagnosis and therapy. The volume presents various studies from molecular imaging to clinical imaging. It also focuses on innovative, creative, advanced research that gives full play to imaging technology inthe broad sense, while exploring cross-disciplinary areas in which individual research fields interact and pursuing the development of new techniques where they fuse together. The book is separated into three parts, the first of which addresses the topic of visualizing and controlling molecules for life. Th e second part is devoted to imaging of disease mechanisms, while the final part comprises studies on the application of imaging technologies to diagnosis and therapy. Th e book contains the proceedings of the 12th Uehara International Symposium 2017, “Make Life Visible” sponsored by the Uehara Memorial Foundation and held from June 12 to 14, 2017. It is written by leading scientists in the field and is an open access publication under a CC BY 4.0 license.
Book Synopsis Biological & Agricultural Index by :
Download or read book Biological & Agricultural Index written by and published by . This book was released on 1997 with total page 2984 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Molecular Pharmacology by : John Dickenson
Download or read book Molecular Pharmacology written by John Dickenson and published by John Wiley & Sons. This book was released on 2012-11-30 with total page 675 pages. Available in PDF, EPUB and Kindle. Book excerpt: This textbook provides a fresh, comprehensive and accessible introduction to the rapidly expanding field of molecular pharmacology. Adopting a drug target-based, rather than the traditional organ/system based, approach this innovative guide reflects the current advances and research trend towards molecular based drug design, derived from a detailed understanding of chemical responses in the body. Drugs are then tailored to fit a treatment profile, rather than the traditional method of ‘trial and error’ drug discovery which focuses on testing chemicals on animals or cell cultures and matching their effects to treatments. Providing an invaluable resource for advanced under-graduate and MSc/PhD students, new researchers to the field and practitioners for continuing professional development, Molecular Pharmacology explores; recent advances and developments in the four major human drug target families (G-protein coupled receptors, ion channels, nuclear receptors and transporters), cloning of drug targets, transgenic animal technology, gene therapy, pharmacogenomics and looks at the role of calcium in the cell. Current - focuses on cutting edge techniques and approaches, including new methods to quantify biological activities in different systems and ways to interpret and understand pharmacological data. Cutting Edge - highlights advances in pharmacogenomics and explores how an individual’s genetic makeup influences their response to therapeutic drugs and the potential for harmful side effects. Applied - includes numerous, real-world examples and a detailed case-study based chapter which looks at current and possible future treatment strategies for cystic fibrosis. This case study considers the relative merits of both drug therapy for specific classes of mutation and gene therapy to correct the underlying defect. Accessible - contains a comprehensive glossary, suggestions for further reading at the end of each chapter and an associated website that provides a complete set of figures from within the book.
Download or read book Carotenoids written by John T. Landrum and published by CRC Press. This book was released on 2009-12-21 with total page 562 pages. Available in PDF, EPUB and Kindle. Book excerpt: Carotenoids are of great interest due to their essential biological functions in both plants and animals. However, the properties and functions of carotenoids in natural systems are surprisingly complex. With an emphasis on the chemical aspects of these compounds, Carotenoids: Physical, Chemical, and Biological Functions and Properties presents a b
Book Synopsis Pediatric Retina by : James D. Reynolds
Download or read book Pediatric Retina written by James D. Reynolds and published by Springer Science & Business Media. This book was released on 2010-09-14 with total page 459 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pediatric retinal diseases are not simply retinal diseases that occur in children; rather, they are unique disorders that often are not found in adults. This textbook of the pediatric retina offers in-depth guidance on congenital and acquired diseases of the retina in the pediatric population. It is organized according to disease onset and timing, as well as anatomy. All chapters are written by leading authorities in the field from both the pediatric and the retinal perspective. A multidisciplinary approach to the topic is adopted, and critical information is included on disease classification and diagnosis, pathophysiology, genetics, complications, and prognosis. Pediatric Retina will be a useful source of information for pediatric ophthalmologists, retina specialists, and other eye care providers who care for children.