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Author : Ivan Conte
Publisher : Frontiers Media SA
ISBN 13 : 2889713997
Total Pages : 175 pages
Book Rating : 4.8/5 (897 download)
Download or read book With the Eyes on Non-Coding RNAs written by Ivan Conte and published by Frontiers Media SA. This book was released on 2021-09-28 with total page 175 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Gautam Sethi
Publisher : World Scientific
ISBN 13 : 9811267405
Total Pages : 377 pages
Book Rating : 4.8/5 (112 download)
Download or read book Non-coding Rna Transcripts In Cancer Therapy: Pre-clinical And Clinical Implications written by Gautam Sethi and published by World Scientific. This book was released on 2023-03-14 with total page 377 pages. Available in PDF, EPUB and Kindle. Book excerpt: 'Non-coding RNA Transcripts in Cancer Therapy: Pre-clinical and Clinical Implications' provides a new insight towards role of non-coding RNAs molecules including microRNAs, long non-coding RNAs and circular RNAs in cancer. The reason of focusing on cancer is that this malignant disease is responsible for high death around the world and after cardiovascular diseases, it is a leading cause of death. In the current book, the basic information and knowledge about ncRNAs, their biogenesis and their biological functions are covered. It is shown that ncRNAs can regulate expression level of genes at transcriptional and post-transcriptional levels and therefore, ncRNAs are master and key players in molecular pathways. Then, the impact of regulation of molecular pathways by ncRNAs on important molecular mechanisms such as proliferation, metastasis, epithelial-to-mesenchymal transition, apoptosis and autophagy are described. All of these aspects are integrated in cancer and for treatment of this disease. In case of miRNAs, their biogenesis and biological functions in physiological conditions are described. Then, impact of miRNAs on proliferation, metastasis, therapy response (drug resistance and radio-resistance) is described. For lncRNAs and circRNAs, a same way is followed and their biogenesis and functional roles in cells are discussed. At the next step, function of lncRNAs and circRNAs in regulating proliferation, metastasis and therapy response (chemoresistance and radio-resistance) is introduced. These subjects are discussed based on pre-clinical studies and in order to make the book more comprehensive and broaden its scope, the function of exosomal ncRNAs in diagnosis and prognosis of cancer patients is described.
Author : Volker A. Erdmann
Publisher : Springer Science & Business Media
ISBN 13 : 3642194540
Total Pages : 514 pages
Book Rating : 4.6/5 (421 download)
Download or read book Non Coding RNAs in Plants written by Volker A. Erdmann and published by Springer Science & Business Media. This book was released on 2011-07-20 with total page 514 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the most recent years, each of the RNA silencing pathways of plants have appeared to generate ncRNAs with dedicated functions, specialized biological activities and specific functional scopes. RNA silencing plays a crucial role in coordinating the expression, stability, protection and inheritance of eukaryotic genomes. It compromises several mechanisms, that invariably depend on core small non coding RNAs and that achieve dedicated sequence-specific functions. RNA silencing has been recognized to carry critical developmental, stress-response and bodyguard functions be coordinating the expression, protection, stability and inheritance of virtually all eukaryotic genomes. Thus, the ncRNAs encompass a wide set of mechanisms that achieve specialized functions.
Author : M.R.S. Rao
Publisher : Springer
ISBN 13 : 9811052034
Total Pages : 336 pages
Book Rating : 4.8/5 (11 download)
Download or read book Long Non Coding RNA Biology written by M.R.S. Rao and published by Springer. This book was released on 2017-08-16 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: This contributed volume offers a comprehensive and detailed overview of the various aspects of long non-coding RNAs and discusses their emerging significance. Written by leading experts in the field, it motivates young researchers around the globe, and offers graduate and postgraduate students fascinating insights into genes and their regulation in eukaryotes and higher organisms.
Author : Yingqun Huang
Publisher : Frontiers Media SA
ISBN 13 : 2889195716
Total Pages : 78 pages
Book Rating : 4.8/5 (891 download)
Download or read book Emerging Roles of Long Noncoding RNAs in Neurological Diseases and Metabolic Disorders written by Yingqun Huang and published by Frontiers Media SA. This book was released on 2015-07-21 with total page 78 pages. Available in PDF, EPUB and Kindle. Book excerpt: Long noncoding RNAs (lncRNAs) are a new class of transcripts that are in general longer than 200 nucleotides and that have no protein-coding potential. The vast majority of vertebrate genomes encode diverse and complex lncRNAs that play regulatory roles at almost every step of gene expression. Recently, increasing evidence has implicated lncRNAs in the pathogenesis of various human diseases. The purpose of the Research Topic, "Emerging roles of long noncoding RNAs in neurological diseases and metabolic disorders", is to bring together leading researchers in the field who, through contributing to an organized and comprehensive collection of peer-reviewed articles, provide a broad perspective on the latest advances in the field. A number of interesting and cutting-edge areas will be covered as below, but this list is not exclusive: - The methodologies and technologies of identifying and studying lncRNAs - LncRNAs in gene-specific transcription - LncRNAs in epigenetic regulation - LncRNAs in post-transcriptional regulation - LncRNAs in disease - Mapping of noncoding single nucleotide polymorphisms associated with disease.
Author : Stefan Jurga
Publisher : Springer Nature
ISBN 13 : 303044743X
Total Pages : 545 pages
Book Rating : 4.0/5 (34 download)
Download or read book The Chemical Biology of Long Noncoding RNAs written by Stefan Jurga and published by Springer Nature. This book was released on 2020-10-01 with total page 545 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book offers a comprehensive and detailed overview of various aspects of long non-coding RNAs. It discusses their emerging significance in molecular medicine, ranging from human cancers to cardiovascular and metabolic diseases. Transcriptomic studies have demonstrated that the majority of genomes found in complex organisms are expressed in highly dynamic and cell-specific patterns, producing huge numbers of intergenic, antisense and intronic long non-protein-coding RNAs (lncRNAs). Thousands of lncRNAs have been identified, and unlike mRNA, they have no protein-coding capacity. A large repertoire of ncRNAs, actively transcribed from the mammalian genome, control diverse cellular processes, both in terms of development and diseases, through a variety of gene regulatory mechanisms. IncRNAs have emerged as a new paradigm in epigenetic regulation of the genome. Given its scope, the book will be of particular interest to molecular, chemical, cell and developmental biologists, as well as specialists in translational medicine involved in disease-oriented research. It also offers a valuable resource for in silico experts seeking a deeper understanding of lncRNA expression and function through computational analysis of the NGS data.
Author : Ahmad M. Khalil
Publisher : Springer Science & Business Media
ISBN 13 : 1461486211
Total Pages : 232 pages
Book Rating : 4.4/5 (614 download)
Download or read book Molecular Biology of Long Non-coding RNAs written by Ahmad M. Khalil and published by Springer Science & Business Media. This book was released on 2013-09-20 with total page 232 pages. Available in PDF, EPUB and Kindle. Book excerpt: Long non-coding RNAs (lnc)RNAs have emerged as a new paradigm in epigenetic regulation of the genome. Thousands of lncRNAs have been identified and observed in a wide range of organisms. Unlike mRNA, lncRNA have no protein-coding capacity. So, while their function is not entirely clear, they may serve as key organizers of protein complexes that allow for higher order regulatory events. Discovering these functions has been the result of intense research done of the last few years, and lncRNA research has had several critical developments during that time. This book will consolidate these ideas and models to better examine the most important issues in lncRNA biology. This will include critical studies that have led to the discovery and annotation of lncRNAs in numerous species, and the molecular mechanisms for a few lncRNA that have begun to emerge.
Author : Lütfi Tutar
Publisher : BoD – Books on Demand
ISBN 13 : 1803560142
Total Pages : 238 pages
Book Rating : 4.8/5 (35 download)
Download or read book Recent Advances in Noncoding RNAs written by Lütfi Tutar and published by BoD – Books on Demand. This book was released on 2022-11-02 with total page 238 pages. Available in PDF, EPUB and Kindle. Book excerpt: The discovery of noncoding RNAs (ncRNAs) is changed our understanding of genome, transcriptome, and interactions with proteome in a cell. Since the discovery of the first microRNA (miRNA) called lin-4 on Caenorhabditis elegans in 1993, our understanding of gene expression has deepened. Further miRNA discoveries have led to the investigation of new ncRNA families and their function, biogenesis, and interactions with other types of molecules. Recent developments in bioinformatics, public databases, sequencing technologies, and biochemical techniques have increased our understanding of the biogenesis, function, and interactions of ncRNAs. This book provides an overview of current ncRNA research dealing with human diseases and cancer and plant miRNAs.
Author : En-Zhi Jia
Publisher : Frontiers Media SA
ISBN 13 : 2832517307
Total Pages : 156 pages
Book Rating : 4.8/5 (325 download)
Download or read book Non-coding RNA and coronary artery disease written by En-Zhi Jia and published by Frontiers Media SA. This book was released on 2023-04-18 with total page 156 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Philip Meneely
Publisher :
ISBN 13 : 0198809905
Total Pages : 491 pages
Book Rating : 4.1/5 (988 download)
Download or read book Genetic Analysis written by Philip Meneely and published by . This book was released on 2020 with total page 491 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genetic Analysis applies the combined power of molecular biology, genetics, and genomics to explore how the principles of genetics can be used as analytical tools to solve biological problems. This new edition: Illustrates the conceptual basis of key analytical tools with carefully selected examples from a range of model organisms, and encourages the reader to Look beyond the examples to see how these tools can be used to explore a wide range of biological questions, Covers the latest and most powerful experimental tools to provide a state-of-the-art review of the field, giving insights into gene networks and interactions, Includes extended case studies that enable the reader to fully get to grips with how genetic tools can be used to understand biological systems in the real world. New to This Edition: A new chapter on genome editing with focus on the CRISPR-Cas 9 system, New content on the analysis of gene activity using temperature-sensitive mutations and mosaics, Increased coverage of epigenetics, updated with the latest developments in the field, A new Learning feature called "Literature Link," which connects each chapter's content to cutting-edge research. The online resources to accompany Genetic Analysis feature the following material for students and teachers: For students: Practice problems and solutions to test your knowledge of the concepts presented, and help you to master them, Online datasets with which to practise analytic techniques, For registered adopters of the book: Figures from the book in electronic format, ready to download, Journal clubs-suggested papers and discussion questions linked to topics covered in the book. Book jacket.
Author : R. Curtis Bird
Publisher : Elsevier
ISBN 13 : 0080537812
Total Pages : 317 pages
Book Rating : 4.0/5 (85 download)
Download or read book Nuclear Structure and Gene Expression written by R. Curtis Bird and published by Elsevier. This book was released on 1996-11-28 with total page 317 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nuclear Structure and Gene Expression assimilates the contributions of genome organization and of the components of the nuclear matrix to the control of DNA and RNA synthesis. Nuclear domains which accommodate DNA replication and gene expression are considered in relation to short-term developmental and homeostatic requirements as well as to long-term commitments to phenotypic gene expression in differentiated cells. Consideration is given to the involvement of nuclear structure in gene localization as well as to the targeting and concentration of transcription factors. Aberrations in nuclear architecture associated with and potentially functionally related to pathologies are evaluated. Tumor cells are described from the perspective of the striking modifications in both the composition and organization of nuclear components. Nuclear Structure and Gene Expression presents concepts as well as experimental approaches, which define functionality of nuclear morphology.* Mechanisms of interaction between nuclear structure and genes* Gene expression regulation by elements of the nuclear matrix* How nuclear structure exerts a regulatory effect on other aspects of cell function/physiology
Author : Mark Springer
Publisher : Page Publishing Inc
ISBN 13 :
Total Pages : 251 pages
Book Rating : 4.8/5 (879 download)
Download or read book Flesh Becomes Words written by Mark Springer and published by Page Publishing Inc. This book was released on 2023-02-23 with total page 251 pages. Available in PDF, EPUB and Kindle. Book excerpt: In science, not God we trust is the future America in which Jordan McCarty, a professor of seventeenth-century English literature, has just lost his job and is losing his eighteen-year-old son, Brenton, to a "God gang" as belief in the Bible is now against the law. Blessed with a photographic memory but in need of a job, Jordan joins the world of biotechnology kingpin and former colleague Dr. Richard Dickson, who offers him a position as a technology writer at his new life span extension company, BioSpan. After discovering how DNA preserves our thoughts and memories, Dr. Dickson partners with a Las Vegas titan, Armando Bigolosi, and a modern-day biohacker, Daulton Hayes, who has invented a technology capable of translating the genetic language of DNA into the English language, thereby turning flesh into words. With unlimited funding, these three men join forces and aim to apply this technology to translate the written words of great writers of the past into the DNA of their thoughts. They embark on an audacious plan to restore the minds of these writers, bring their souls back to life, and usher in the age of edutainment in Las Vegas. Having memorized the entire contents of the Bible to understand what has led his son astray from science, Jordan develops a belief in God, leading to a climatic confrontation with Dr. Dickson, when Dickson announces that he has translated the entire contents of the Bible into DNA and plans to replace his thoughts with God's thoughts.
Author : Simon Charles Heath
Publisher : Frontiers Media SA
ISBN 13 : 283253645X
Total Pages : 172 pages
Book Rating : 4.8/5 (325 download)
Download or read book Insights in Statistical Genetics and Methodology: 2022 written by Simon Charles Heath and published by Frontiers Media SA. This book was released on 2023-10-24 with total page 172 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Research Topic is part of the Insights in Frontiers in Genetics series.
Author : Gareth W. Roberts
Publisher : Cambridge University Press
ISBN 13 : 9780521425582
Total Pages : 204 pages
Book Rating : 4.4/5 (255 download)
Download or read book Molecular Neuropathology written by Gareth W. Roberts and published by Cambridge University Press. This book was released on 1995-06-08 with total page 204 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides an introduction to the essential techniques required for studying the molecular biology of brain disease. The approaches and strategies for investigations of gene structure and regulation are described with reference to the molecular genetics of prion and Alzheimer's disease. The effects of aberrant gene regulation can also be examined at the protein level by immunocytochemistry and autoradiography. Improved understanding of basic biology has resulted in new approaches to animal models using transgenic techniques and new therapeutic approaches. The volume is structured to illustrate all these approaches and demonstrate the practice and promise of molecular neuropathology.
Author : Chandan K. Sen
Publisher : Elsevier
ISBN 13 : 0124058582
Total Pages : 1305 pages
Book Rating : 4.1/5 (24 download)
Download or read book MicroRNA in Regenerative Medicine written by Chandan K. Sen and published by Elsevier. This book was released on 2014-11-26 with total page 1305 pages. Available in PDF, EPUB and Kindle. Book excerpt: This work encapsulates the uses of miRNA across stem cells, developmental biology, tissue injury and tissue regeneration. In particular contributors provide focused coverage of methodologies, intervention and tissue engineering. Regulating virtually all biological processes, the genome's 1048 encoded microRNAs appear to hold considerable promise for the potential repair and regeneration of tissues and organs in future therapies. In this work, 50 experts address key topics of this fast-emerging field. Concisely summarizing and evaluating key findings emerging from fundamental research into translational application, they point to the current and future significance of clinical research in the miRNA area. Coverage encompasses all major aspects of fundamental stem cell and developmental biology, including the uses of miRNA across repair and regeneration, and special coverage of methodologies and interventions as they point towards organ and tissue engineering - Multi-colour text layout with 150 colour figures to illustrate important findings - Take home messages encapsulate key lessons throughout text - Short chapters offer focused discussion and clear 'voice'
Author : Trygve O Tollefsbol
Publisher : Elsevier
ISBN 13 : 0443218129
Total Pages : 1362 pages
Book Rating : 4.4/5 (432 download)
Download or read book Epigenetics in Human Disease written by Trygve O Tollefsbol and published by Elsevier. This book was released on 2023-10-09 with total page 1362 pages. Available in PDF, EPUB and Kindle. Book excerpt: Epigenetics in Human Disease, Third Edition examines the diseases and conditions on which we have advanced knowledge of epigenetic mechanisms, such as cancer, autoimmune disorders, aging, metabolic disorders, neurobiological disorders and cardiovascular disease. From molecular mechanisms and epigenetic technology to clinical translation of recent research, the nature and applications of the science is presented for those with interests ranging from the fundamental basis of epigenetics to therapeutic interventions for epigenetic-based disorders, with an emphasis throughout on understanding and application of key concepts in new research and clinical practice. Fully revised and up-to-date, this Third Edition discusses topics of current interest in epigenetic disease research, including stem cell epigenetic therapy, bioinformatic analysis of NGS data, epigenetic mechanisms of imprinting disorders, microRNA in cancer, epigenetic approaches to control obesity, epigenetics and airway disease, and epigenetics in cardiovascular disease. Further sections explore online epigenetic tools and datasets; early-life programming of epigenetics in age-related diseases; the epigenetics of addiction and suicide, and epigenetic approaches to regulating and preventing diabetes, cardiac disease, allergic disorders, Alzheimer's disease, respiratory diseases, and many other human maladies. In addition, each chapter now includes chapter summaries, definitions, and vibrant imagery and figures to reinforce understanding, as well as step-by-step methods and disease research case studies. - Includes contributions from leading international investigators involved in translational epigenetic research and therapeutic applications - Integrates methods and applications with fundamental chapters on epigenetics in human disease, along with an evaluation of recent clinical breakthroughs - Presents side-by-side coverage of the basis of epigenetic diseases and treatment pathways - Each chapter updated to include summaries, definitions, and vibrant imagery and figures to reinforce understanding - Features step-by-step methods and disease research case studies to put book concepts into practice
Author : Xiaoyi Raymond Gao
Publisher : Academic Press
ISBN 13 : 0128167270
Total Pages : 386 pages
Book Rating : 4.1/5 (281 download)
Download or read book Genetics and Genomics of Eye Disease written by Xiaoyi Raymond Gao and published by Academic Press. This book was released on 2019-09-12 with total page 386 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genetics and Genomics of Eye Disease: Advancing to Precision Medicine thoroughly examines the latest genomics methods for studying eye disease, including complex eye disorders associated with multiple genes. GWAS, WES, WGS, RNA-sequencing, and transcriptome analysis as employed in ocular genomics are discussed in-depth, as are genomics findings tied to early-onset glaucoma, strabismus, age-related macular degeneration, adult-onset glaucoma, diabetic retinopathy, keratoconus, and leber congenital amaurosis, among other diseases. Research and clinical specialists offer guidance on conducting preventative screenings and counseling patients, as well as the promise of machine learning, computational statistics and artificial intelligence in advancing ocular genomics research. - Offers thorough guidance on conducting genetic and genomic studies of eye disease - Examines the genetic basis of a wide range of complex eye diseases and single-gene and Mendelian disorders - Discusses the application of genetic testing and genetic risk prediction in eye disease diagnosis and patient counseling
