Vascular Endothelial Growth Factor Expression In The Murine Dental Pulp During Aging And Dentin Regeneration

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Vascular Endothelial Growth Factor Expression in the Murine Dental Pulp During Aging and Dentin Regeneration

Author : Sara N. Parent
Publisher :
ISBN 13 :
Total Pages : 58 pages
Book Rating : 4.:/5 (91 download)

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Book Synopsis Vascular Endothelial Growth Factor Expression in the Murine Dental Pulp During Aging and Dentin Regeneration by : Sara N. Parent

Download or read book Vascular Endothelial Growth Factor Expression in the Murine Dental Pulp During Aging and Dentin Regeneration written by Sara N. Parent and published by . This book was released on 2014 with total page 58 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vascular endothelial growth factor (VEGF) is an important pro-angiogenic growth factor that is essential for maintenance of vascular networks throughout the body, including those in the dental pulp. In addition, it has been suggested that VEGF may play a role in dentin regeneration and mineralization. As well studied as VEGF is, currently there are no studies looking at the effects of aging on VEGF expression in the dental pulp. We proposed a study of the expression levels of VEGF in the dental pulp during aging using a mouse model to test whether VEGF expression decreases with age and whether this decrease causes a decrease in pulpal vascular density and tertiary dentin formation. Tertiary dentin is formed as an internal reparative response to injury to the tooth, which can involve stem cell recruitment from the dental pulp. However, better understanding of this process is needed to develop stem cell and tissue regeneration applications to improve the organization and formation of tertiary dentin following injury. Mandibles from mice in six separate age groups were collected and histological analysis was performed. Mandibular molar sections were stained for antibodies for VEGFR-2, VEGFR-3, VEGF-A, VEGF-C, LYVE-1 (a lymphatic marker) and BS-1 (a vascular marker). Mandibular molars were also isolated from three separate age groups and collected for gene expression analysis using Q-RT-PCR. The immunofluorescence results from the vascularity study showed a significant decrease in blood vessel density with the highest levels found in the neonate and the lowest found in the most aged samples. There was also a distinct qualitative difference in the expression of VEGF-A in the dental pulp and odontoblast layers of samples from each age group that followed the same trend as the vasculature. Lymphatics were not detected in any of the age groups. Q-RT-PCR results showed that there was a decrease in gene expression in vWF (a blood vessel marker), VE-cadherin (a blood vessel marker), VEGFR-3, VEGF-A and VEGF-C from the neonatal to senescent age groups. VEGFR-1 and -2 were only detected at low levels in the neonatal age group. Surprisingly VEGF-C and VEGFR-3 were highly expressed in the dental pulp and although their expressions also decrease with aging, they were the only VEGF ligand and receptor detectable in the uninjured adult mouse molar. For the second part of the study, to determine if VEGF played a role in dentin regeneration, the first maxillary molars of nine mice were drilled to induce a wound healing response in the tooth. They were allowed time to heal and then the maxillae were collected and stained with 3,3'-diaminobenzidine for VEGF-A and VEGFR-2 expression at three time points post-injury. The histological sections from injured molars showed a dramatic increase in VEGF-A expression fifteen minutes after injury that dissipated with time and returned to near normal levels after four weeks post-injury. VEGFR-2 expression was also elevated soon after injury and then gradually returned to pre-injury levels. Current findings of this study suggest that although the expression of VEGF-A and its receptor VEGFR-2, which has been traditionally viewed as the most potent pro- angiogenic signaling pathway, does decrease with age, this ligand and receptor may play a more important role in regulating the response to tooth injury and dental regeneration. In contrast, VEGFR-3 and its ligand VEGF-C, which have traditionally been associated with only lymphangiogenesis, may be contributing to the regulation of angiogenesis in the dental pulp.

Characterization of Dental Pulp Stem Cells and Their Potential Clinical Applications

Author : Kajohnkiart Janebodin
Publisher :
ISBN 13 :
Total Pages : 238 pages
Book Rating : 4.:/5 (876 download)

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Book Synopsis Characterization of Dental Pulp Stem Cells and Their Potential Clinical Applications by : Kajohnkiart Janebodin

Download or read book Characterization of Dental Pulp Stem Cells and Their Potential Clinical Applications written by Kajohnkiart Janebodin and published by . This book was released on 2013 with total page 238 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dental pulp stem cells (DPSCs) were first isolated and characterized from human teeth and most studies have focused on using human DPSCs for dentin regeneration. However, mouse DPSCs have not been well characterized and their origin(s) have not yet been elucidated. I examined if murine DPSCs are neural crest derived and determined their in vitro and in vivo capacity. DPSCs from neonatal mice expressed embryonic stem cell and neural crest genes, but lacked expression of mesodermal genes. Cells isolated from the Wnt1-Cre/R26R-LacZ mouse, a reporter of neural crest-derived tissues, indicated that DPSCs were Wnt1-marked and therefore of neural crest origin. Clonal DPSCs showed multi-differentiation in neural crest lineage for odontoblasts, chondrocytes, adipocytes, neurons, and smooth muscles. In vivo subcutaneous transplantation with hydroxyapatite/tricalcium phosphate, based on tissue/cell morphology and specific antibody staining, revealed that the clones differentiated into odontoblast-like cells and produced dentin/pulp-like structure. Conversely, femur-derived bone marrow stromal cells (BMSCs) gave rise to osteoblast-like cells and generated bone-like structure. Interestingly, the capillary distribution in the DPSC transplants showed close proximity to odontoblasts whereas in the BMSC transplants bone condensations were distant to capillaries resembling dentinogenesis in the former vs. osteogenesis in the latter. Loss of functional salivary gland causes patients' moribidities from difficulties in swallowing and speech, as well as oral diseases. Stem cell therapy is considered a potential therapeutic alternative. However, combinatory approaches including not only salivary gland stem cells but also supportive cells and appropriate extracellular matrix are necessary to form a functional salivary gland. Like tooth formation, the development of salivary gland requires epithelium interacting with neural crest-derived mesenchyme. I used the human salivary gland (HSG) cell line as a model to study the effects of DPSCs on salivary gland differentiation. In vitro differentiation on matrigel showed that HSG alone and HSG co-cultured with Wnt1-Cre/R26R-LacZ derived DPSCs (HSG+DPSC) differentiated into acinar-like structures. However, HSG formed more mature (higher expression of LAMP-1 and CD44), larger and increased numbers of acini in HSG+DPSC. Subcutaneous co-transplantation of HSG and DPSCs with hyaluronic acid (HA) hydrogels after 2 weeks was evaluated by Q-RT-PCR, morphology and immunohistology. Compared to HSG transplants which only showed undifferentiated tumor-like cells, HSG+DPSC demonstrated (1) higher expression of murine mesenchymal marker Fgf-7, (2) higher expression of mature human salivary gland differentiation marker alpha-amylase-1 (AMY-1), (3) higher expression of murine endothelial, vWF, neuronal, NF-200, and angiogenic markers, Vegfr-3 and Vegf-c, (4) mucin-secreting acinar- and duct-like structures with abundant blood vessels at the interface with DPSCs, and (5) more mature glandular structures double-positive for salivary gland differentiation markers CD44 and LAMP-1. These results indicate that DPSCs supported and enhanced HSG differentiation into functional salivary gland tissue. In addition, DPSCs have previously demonstrated potential pericyte-like topography and function. However, the mechanisms regulating their pericyte function are still yet to be elucidated. DPSC angiogenic and pericyte function were investigated Tie2-GFP derived dental pulp cells were negative for GFP driven by the endothelial Tie2 transgene, indicating an absence of endothelial cells. Endothelial cells co-cultured with DPSCs formed more mature in vitro tube-like structures as compared to those co-cultured with BMSCs. Many DPSCs were located adjacent to vascular tubes, suggesting a pericyte location and function. In vivo DPSCs subcutaneously transplanted in matrigel (MG) (DPSC-MG) induced more vessel formation than BMSC-MG. DPSCs expressed higher Vegfd, Vegfr3, EphrinB2 levels. Soluble Flt (sFlt), an angiogenic inhibitor that binds VEGF-A, significantly decreased the amount of blood vessels in DPSC-MG, but not in BMSC-MG. sFlt inhibited VEGFR2 and downstream ERK signaling and down-regulated Vegfa, Vegf receptors and EphrinB2 expression in DPSCs. Therefore, DPSC-induced angiogenesis is VEGF-dependent. DPSCs enhance angiogenesis by secreting VEGF-A, -C, -D and forming tight associations with vessels, resembling pericyte-like cells. Taken together, I demonstrate the existence of neural crest-derived DPSCs with differentiation capacity into cranial mesenchymal tissues and other neural crest-derived tissues. I also illustrate the potential of DPSCs as inductive mesenchyme for salivary gland regeneration, repair, and tissue engineering, and provide first insights into the mechanism(s) of DPSC angiogenic capacity and their function as pericytes. DPSCs hold promise as a stem cell source for regenerating neural crest derived tissues, and the trophic and angiogenic properties of DPSCs also highlight this stem cell source useful for tissue regeneration.

Regenerative Dentistry

Author : Mona Marei
Publisher : Springer Nature
ISBN 13 : 3031025814
Total Pages : 164 pages
Book Rating : 4.0/5 (31 download)

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Book Synopsis Regenerative Dentistry by : Mona Marei

Download or read book Regenerative Dentistry written by Mona Marei and published by Springer Nature. This book was released on 2022-06-01 with total page 164 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dental caries, periodontitis, tooth loss, and bone resorption are considered prevalent health problems that have direct affect on the quality of life. While, advances in stem cell biology and biotechnology have sparked hope for devastating maladies, such as diabetes, cardiovascular diseases, etc., it also provides a strategy of regenerative therapy for dental tissues. From the prospective of tissue engineering, it is of utmost importance to understand and emulate the complex cell interactions that make up a tissue or organ. Unlike other tissues in the body, dental tissues are unique in their development, function, and even in their maintenance throughout life. The harmonized stimulations of biology and mechanical regulators to promote cellular activities have matured our understanding of the value of regenerative therapy of dental tissue versus the reparative treatment. In this book, we review the current knowledge available to regenerate alveolar bone, periodontal structure, and pulp/dentin complex. The book provides researchers with detailed information about development and functional characteristics of the dental unit with detailed protocols covering a comprehensive range of various approaches to engineer dental tissues: to use isolated cells or cell substitutes as cellular replacement, to use acellular biomaterials capable of inducing tissue regeneration, and/or to use a combination of cells, biomaterial and growth factors. We are well aware, with the concept changes in the field toward in-vitro biomimetics of in-vivo tissue development. The theoretical frame work integrating these concepts of developmental biology and developmental engineering is yet to be emphasized and implemented. Until this happens, we consider this book of regenerative dentistry as a call for scientists to achieve, researchers to innovate, practitioners to apply, and students to learn the art and science of regenerative therapy in dentistry. Table of Contents: Introduction to Regenerative Dentistry / Tissue Engineering Alveolar Bone / Tissue Engineering of the Periodontal Tissues / Dynamics for Pulp-Dentin Tissue Engineering in Operative Dentistry

The Cell Cycle in the Central Nervous System

Author : Damir Janigro
Publisher : Springer Science & Business Media
ISBN 13 : 1597450219
Total Pages : 555 pages
Book Rating : 4.5/5 (974 download)

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Book Synopsis The Cell Cycle in the Central Nervous System by : Damir Janigro

Download or read book The Cell Cycle in the Central Nervous System written by Damir Janigro and published by Springer Science & Business Media. This book was released on 2008-01-23 with total page 555 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cell Cycle in the Central Nervous System overviews the changes in cell cycle as they relate to prenatal and post natal brain development, progression to neurological disease or tumor formation.Topics covered range from the cell cycle during the prenatal development of the mammalian central nervous system to future directions in postnatal neurogenesis through gene transfer, electrical stimulation, and stem cell introduction. Additional chapters examine the postnatal development of neurons and glia, the regulation of cell cycle in glia, and how that regulation may fail in pretumor conditions or following a nonneoplastic CNS response to injury. Highlights include treatments of the effects of deep brain stimulation on brain development and repair; the connection between the electrophysiological properties of neuroglia, cell cycle, and tumor progression; and the varied immunological responses and their regulation by cell cycle.

Dentin/Pulp Complex

Author : Tatsuya Ishikawa
Publisher : Quintessence Publishing (IL)
ISBN 13 :
Total Pages : 206 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Dentin/Pulp Complex by : Tatsuya Ishikawa

Download or read book Dentin/Pulp Complex written by Tatsuya Ishikawa and published by Quintessence Publishing (IL). This book was released on 2002 with total page 206 pages. Available in PDF, EPUB and Kindle. Book excerpt:

The Dental Pulp

Author : Michel Goldberg
Publisher : Springer
ISBN 13 : 3642551602
Total Pages : 281 pages
Book Rating : 4.6/5 (425 download)

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Book Synopsis The Dental Pulp by : Michel Goldberg

Download or read book The Dental Pulp written by Michel Goldberg and published by Springer. This book was released on 2014-07-30 with total page 281 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a detailed update on our knowledge of dental pulp and regenerative approaches to therapy. It is divided into three parts. The pulp components are first described, covering pulp cells, extracellular matrix, vascularization and innervation as well as pulp development and aging. The second part is devoted to pulp pathology and includes descriptions of the differences between reactionary and reparative dentin, the genetic alterations leading to dentinogenesis imperfecta and dentin dysplasia, the pulp reaction to dental materials, adverse impacts of bisphenol A and the effects of fluorosis, dioxin and other toxic agents. The final part of the book focuses on pulp repair and regeneration. It includes descriptions of various in vitro and in vivo (animal) experimental approaches, definition of the pulp stem cells with special focus on the stem cell niches, discussion of the regeneration of a living pulp and information on new strategies that induce pulp mineralization.

Dental Pulp Stem Cells

Author : Sibel Yildirim
Publisher : Springer Science & Business Media
ISBN 13 : 146145686X
Total Pages : 89 pages
Book Rating : 4.4/5 (614 download)

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Book Synopsis Dental Pulp Stem Cells by : Sibel Yildirim

Download or read book Dental Pulp Stem Cells written by Sibel Yildirim and published by Springer Science & Business Media. This book was released on 2012-10-15 with total page 89 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stem cell technology is moving forward at a tremendous rate. Recent discoveries have surprised even the most expert researchers. While every piece of new data broadens the current knowledge and contributes to this moving forward, the new data also serve as paradigm shifters of fundamental knowledge of cell biology. While the question ‘What is a Stem Cell’ may now seem to basic to even discuss, there are still some discrepancies, however, between groups in terms of their functional roles. Teeth develop from the ectoderm of the first branchial arch and the ectomesenchyme of the neural crest. Deciduous teeth start to form between the sixth and eighth weeks, and permanent teeth begin to form in the twentieth weeks. Several studies have demonstrated that the pulp from both adult teeth and deciduous teeth contains dental pulp stem cells. Several factors have made them very attractive as a model system for many researchers; they are multipotent, ethically and non-controversially available in large numbers, immuno-compatible, developmentally primitive, easy to isolate and have high expansion potential in vitro. However, many controversies still exist in the field. There are several unanswered questions in the biology of dental pulp and odontoblasts. This new volume in the SpringerBriefs in Stem Cells series presents an evaluation of stem cells from human dental pulp as a reliable stem cell source for cell-based therapy to stimulate tissue regeneration.

BiodentineTM

Author : Imad About
Publisher : Springer Nature
ISBN 13 : 3030809323
Total Pages : 233 pages
Book Rating : 4.0/5 (38 download)

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Book Synopsis BiodentineTM by : Imad About

Download or read book BiodentineTM written by Imad About and published by Springer Nature. This book was released on 2021-10-20 with total page 233 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a comprehensive guide to BiodentineTM, an innovative biocompatible and bioactive material based on pure tricalcium silicate that can permanently replace dentin and can also serve as a temporary enamel substitute. Although BiodentineTM has been widely used across the world for the past decade, this is the first book to be devoted to its properties, interactions with the soft and hard tissues, and its multiple clinical applications. The coverage encompasses applications in primary and permanent teeth, in specialties as diverse as restorative dentistry, endodontics, paediatric dentistry, dental traumatology, and prosthetic dentistry. BiodentineTM application both in vital pulp therapy and endodontic procedures is illustrated and clinical step by step protocols are provided. The book provides a detailed update on BiodentineTM use to preserve the pulp vitality in direct/indirect pulp capping, pulpotomy and irreversible pulpitis treatment. It also details BiodentineTM use for non-vital teeth treatment in indications such as root/furcation perforation repair, apexification as well as in regenerative endodontic procedures. BiodentineTM: Properties and Clinical Applications will be a rich source of guidance and information for all dentists as well as dental students and academics.

Dental and Periodontal Tissues Formation and Regeneration: Current Approaches and Future Challenges

Author : Giovanna Orsini
Publisher : Frontiers Media SA
ISBN 13 : 2889199843
Total Pages : 248 pages
Book Rating : 4.8/5 (891 download)

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Book Synopsis Dental and Periodontal Tissues Formation and Regeneration: Current Approaches and Future Challenges by : Giovanna Orsini

Download or read book Dental and Periodontal Tissues Formation and Regeneration: Current Approaches and Future Challenges written by Giovanna Orsini and published by Frontiers Media SA. This book was released on 2016-10-07 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sequential and reciprocal interactions between oral epithelial and cranial neural crest-derived mesenchymal cells give rise to the teeth and periodontium. Teeth are vital organs containing a rich number of blood vessels and nerve fibers within the dental pulp and periodontium. Teeth are composed by unique and specific collagenous (dentin, fibrillar cementum) and non-collagenous (enamel) highly mineralized extracellular matrices. Alveolar bone is another collagenous hard tissue that supports tooth stability and function through its close interaction with the periodontal ligament. Dental hard tissues are often damaged after infection or traumatic injuries that lead to the partial or complete destruction of the functional dental and supportive tissues. Well-established protocols are routinely used in dental clinics for the restoration or replacement of the damaged tooth and alveolar bone areas. Recent progress in the fields of cell biology, tissue engineering, and nanotechnology offers promising opportunities to repair damaged or missing dental tissues. Indeed, pulp and periodontal tissue regeneration is progressing rapidly with the application of stem cells, biodegradable scaffolds, and growth factors. Furthermore, methods that enable partial dental hard tissue repair and regeneration are being evaluated with variable degrees of success. However, these cell-based therapies are still incipient and many issues need to be addressed before any clinical application. The understanding of tooth and periodontal tissues formation would be beneficial for improving regenerative attempts in dental clinics. In the present e-book we have covered the various aspects dealing with dental and periodontal tissues physiology and regeneration in 6 chapters: 1. General principles on the use of stem cells for regenerating craniofacial and dental tissues 2. The roles of nerves, vessels and stem cell niches in tissue regeneration 3. Dental pulp regeneration and mechanisms of various odontoblast functions 4. Dental root and periodontal physiology, pathology and regeneration 5. Physiology and regeneration of the bone using various scaffolds and stem cell populations 6. Physiology, pathology and regeneration of enamel using dental epithelial stem cells

Index Medicus

Author :
Publisher :
ISBN 13 :
Total Pages : 1940 pages
Book Rating : 4.:/5 (319 download)

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Book Synopsis Index Medicus by :

Download or read book Index Medicus written by and published by . This book was released on 2004 with total page 1940 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.

Bone Tissue Engineering

Author : Jeffrey O. Hollinger
Publisher : CRC Press
ISBN 13 : 1135501912
Total Pages : 500 pages
Book Rating : 4.1/5 (355 download)

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Book Synopsis Bone Tissue Engineering by : Jeffrey O. Hollinger

Download or read book Bone Tissue Engineering written by Jeffrey O. Hollinger and published by CRC Press. This book was released on 2004-10-14 with total page 500 pages. Available in PDF, EPUB and Kindle. Book excerpt: Focusing on bone biology, Bone Tissue Engineering integrates basic sciences with tissue engineering. It includes contributions from world-renowned researchers and clinicians who discuss key topics such as different models and approaches to bone tissue engineering, as well as exciting clinical applications for patients. Divided into four sections, t

Oral Wound Healing

Author : Hannu Larjava
Publisher : John Wiley & Sons
ISBN 13 : 0813804817
Total Pages : 433 pages
Book Rating : 4.8/5 (138 download)

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Book Synopsis Oral Wound Healing by : Hannu Larjava

Download or read book Oral Wound Healing written by Hannu Larjava and published by John Wiley & Sons. This book was released on 2012-05-15 with total page 433 pages. Available in PDF, EPUB and Kindle. Book excerpt: Oral Wound Healing: Cell Biology and Clinical Management brings experts from around the world together to provide an authoritative reference on the processes, principles and clinical management of wound healing in the oral mucosa. Promoting a thorough understanding of current research on the topic, this new resource draws together thinking on the basic biological processes of wound healing in the oral environment, as well as providing more detailed information and discussion on processes such as inflammation, reepithelialization and angiogenesis. Beyond this, the book goes on to examine topics pertinent to the effective clinical management of oral wound healing, bringing together chapters on large dento-facial defects, dental implants, periodontal regeneration, and pulp healing.An essential synthesis of current research and clinical applications, Oral Wound Healing will be an indispensable resource for dental specialists, oral and maxillofacial surgeons as well as researchers in oral medicine and biology.

Essential Endodontology

Author : Dag Orstavik
Publisher : John Wiley & Sons
ISBN 13 : 1119271959
Total Pages : 407 pages
Book Rating : 4.1/5 (192 download)

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Book Synopsis Essential Endodontology by : Dag Orstavik

Download or read book Essential Endodontology written by Dag Orstavik and published by John Wiley & Sons. This book was released on 2020-01-21 with total page 407 pages. Available in PDF, EPUB and Kindle. Book excerpt: The authoritative reference that continues to present a systematic analysis of the scientific basis of endodontology The third edition of Essential Endodontology: Prevention and Treatment of Apical Periodontitis has been revised and updated to include the most recent developments in the field, maintaining its position as the major scientific treatise of apical periodontitis. Making an often-complex subject more digestible, the book explores the scientific basis of endodontology, adopting a systematic analysis of the available clinical and laboratory evidence. Promoting apical periodontitis as a disease entity, the comprehensive third edition focuses on its biology and clinical features, enabling the reader to have a better understanding of its diagnosis, prevention and treatment. In addition to thorough updates and full colour illustrations throughout, a new chapter on regenerative endodontics has been added to this edition. Written with a focus on the scientific basis of endodontology Includes a new chapter on regenerative endodontics Presents the most current information and major developments in this fast-moving field Provides helpful learning outcomes in each chapter Contains full colour illustrations, enriching the text Features contributions from a noted panel of international experts, including new contributors from across the globe Regarded as a vital companion to the pursuit of excellence in postgraduate and specialist education, Essential Endodontology is an indispensable and accessible resource for practicing endodontists, postgraduate students of endodontology and those seeking professional certification in endodontology.

Geriatric Gastroenterology

Author : C. S. Pitchumoni
Publisher : Springer Science & Business Media
ISBN 13 : 1441916237
Total Pages : 660 pages
Book Rating : 4.4/5 (419 download)

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Book Synopsis Geriatric Gastroenterology by : C. S. Pitchumoni

Download or read book Geriatric Gastroenterology written by C. S. Pitchumoni and published by Springer Science & Business Media. This book was released on 2012-07-26 with total page 660 pages. Available in PDF, EPUB and Kindle. Book excerpt: As aging trends in the United States and Europe in particular are strongly suggestive of increasingly older society, it would be prudent for health care providers to better prepare for such changes. By including physiology, disease, nutrition, pharmacology, pathology, radiology and other relevant associated topics, Geriatric Gastroenterology fills the void in the literature for a volume devoted specifically to gastrointestinal illness in the elderly. This unique volume includes provision of training for current and future generations of physicians to deal with the health problems of older adults. It will also serve as a comprehensive guide to practicing physicians for ease of reference. Relevant to the geriatric age group, the volume covers epidemiology, physiology of aging, gastrointestinal physiology, pharmacology, radiology, pathology, motility disorders, luminal disorders, hepato-biliary disease, systemic manifestations, neoplastic disorders, gastrointestinal bleeding, cancer and medication related interactions and adverse events, all extremely common in older adults; these are often hard to evaluate and judge, especially considering the complex aging physiology. All have become important components of modern medicine. Special emphasis is be given to nutrition and related disorders. Capsule endoscopy and its utility in the geriatric population is also covered. Presented in simple, easy to read style, the volume includes numerous tables, figures and key points enabling ease of understanding. Chapters on imaging and pathology are profusely illustrated. All chapters are written by specialists and include up to date scientific information. Geriatric Gastroenterology is of great utility to residents in internal medicine, fellows in gastroenterology and geriatric medicine as well as gastroenterologists, geriatricians and practicing physicians including primary care physicians caring for older adults.

Nanotechnology in Endodontics

Author : Anil Kishen
Publisher : Springer
ISBN 13 : 3319135759
Total Pages : 206 pages
Book Rating : 4.3/5 (191 download)

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Book Synopsis Nanotechnology in Endodontics by : Anil Kishen

Download or read book Nanotechnology in Endodontics written by Anil Kishen and published by Springer. This book was released on 2015-03-18 with total page 206 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides detailed information on the emerging applications of nanomaterials and nanoparticles within endodontics, highlighting the exciting potential clinical impact of nanotechnology in the field. The range of applications covered is diverse, encompassing drug and gene delivery, tissue engineering, antibacterial strategies, dentin tissue stabilization, dentin pulp regeneration and use in restorative and endodontic materials. Important scientific background information relating to each application is provided, with clear coverage of basic principles. In addition, potential pitfalls are identified and explained. The cytotoxicity of nanomaterials and nanoparticles is also addressed in a separate chapter. The book will be of value both for endodontic practitioners and for all scientists and graduate students who are interested in the application of nanotechnology in endodontics.

Clinical Concepts and Practical Management Techniques in Dentistry

Author :
Publisher : BoD – Books on Demand
ISBN 13 : 1839628421
Total Pages : 262 pages
Book Rating : 4.8/5 (396 download)

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Book Synopsis Clinical Concepts and Practical Management Techniques in Dentistry by :

Download or read book Clinical Concepts and Practical Management Techniques in Dentistry written by and published by BoD – Books on Demand. This book was released on 2022-02-09 with total page 262 pages. Available in PDF, EPUB and Kindle. Book excerpt: Oral healthcare deals with complete oral health, including prevention, treatment, and cure. This book provides readers with the latest updates on dental clinical concepts and practical management techniques. It is divided into four sections that contain in-depth chapters with concepts and techniques from the fields of oral medicine, periodontology, radiology, endodontics, restorative dentistry, dental trauma, and probability and sampling. It is a compendium of work by internationally recognized oral clinicians and public healthcare leaders in dentistry. It presents updates on some of the most pertinent issues within the practice of dentistry, such as regenerative endodontic procedures, the unique role of radiographs, recognition of child abuse, and dental statistics.

Stem Cells in Aesthetic Procedures

Author : Melvin A. Shiffman
Publisher : Springer
ISBN 13 : 3642452078
Total Pages : 815 pages
Book Rating : 4.6/5 (424 download)

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Book Synopsis Stem Cells in Aesthetic Procedures by : Melvin A. Shiffman

Download or read book Stem Cells in Aesthetic Procedures written by Melvin A. Shiffman and published by Springer. This book was released on 2014-07-21 with total page 815 pages. Available in PDF, EPUB and Kindle. Book excerpt: Interest in the use of stem cells in aesthetic procedures has been increasing rapidly, reflecting the widespread acknowledgment of the tremendous potential of stem cell fat transfer. This is, however, the first book to be devoted entirely to the subject. The book opens by reviewing the history of the development of pluripotent stem cells and the results of research into the biochemistry and physiology of stem cells. Adipose tissue anatomy and survival are discussed and the wide range of aesthetic procedures involving stem cell fat transfer are then described in detail. These procedures relate to the face, breast, buttocks, legs, hands, penis and Poland syndrome. In addition, potential risks and complications are identified. The book has been written by leading experts and will be an invaluable source of information for students, beginners and experienced surgeons in a range of specialties.