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Validation Study Ii
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Book Synopsis Evolution of Translational Omics by : Institute of Medicine
Download or read book Evolution of Translational Omics written by Institute of Medicine and published by National Academies Press. This book was released on 2012-09-13 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: Technologies collectively called omics enable simultaneous measurement of an enormous number of biomolecules; for example, genomics investigates thousands of DNA sequences, and proteomics examines large numbers of proteins. Scientists are using these technologies to develop innovative tests to detect disease and to predict a patient's likelihood of responding to specific drugs. Following a recent case involving premature use of omics-based tests in cancer clinical trials at Duke University, the NCI requested that the IOM establish a committee to recommend ways to strengthen omics-based test development and evaluation. This report identifies best practices to enhance development, evaluation, and translation of omics-based tests while simultaneously reinforcing steps to ensure that these tests are appropriately assessed for scientific validity before they are used to guide patient treatment in clinical trials.
Book Synopsis Improving and Accelerating Therapeutic Development for Nervous System Disorders by : Institute of Medicine
Download or read book Improving and Accelerating Therapeutic Development for Nervous System Disorders written by Institute of Medicine and published by National Academies Press. This book was released on 2014-02-06 with total page 107 pages. Available in PDF, EPUB and Kindle. Book excerpt: Improving and Accelerating Therapeutic Development for Nervous System Disorders is the summary of a workshop convened by the IOM Forum on Neuroscience and Nervous System Disorders to examine opportunities to accelerate early phases of drug development for nervous system drug discovery. Workshop participants discussed challenges in neuroscience research for enabling faster entry of potential treatments into first-in-human trials, explored how new and emerging tools and technologies may improve the efficiency of research, and considered mechanisms to facilitate a more effective and efficient development pipeline. There are several challenges to the current drug development pipeline for nervous system disorders. The fundamental etiology and pathophysiology of many nervous system disorders are unknown and the brain is inaccessible to study, making it difficult to develop accurate models. Patient heterogeneity is high, disease pathology can occur years to decades before becoming clinically apparent, and diagnostic and treatment biomarkers are lacking. In addition, the lack of validated targets, limitations related to the predictive validity of animal models - the extent to which the model predicts clinical efficacy - and regulatory barriers can also impede translation and drug development for nervous system disorders. Improving and Accelerating Therapeutic Development for Nervous System Disorders identifies avenues for moving directly from cellular models to human trials, minimizing the need for animal models to test efficacy, and discusses the potential benefits and risks of such an approach. This report is a timely discussion of opportunities to improve early drug development with a focus toward preclinical trials.
Book Synopsis Test Development and Validation by : Gary Skaggs
Download or read book Test Development and Validation written by Gary Skaggs and published by SAGE Publications. This book was released on 2021-12-31 with total page 409 pages. Available in PDF, EPUB and Kindle. Book excerpt: Test Development and Validation by Gary Skaggs frameworks for test development and validation, and guidance for developing tests in straightforward language in one core text. Covering the changes in testing, technical development of tests and determining validity of tests, this book offers clear explanations within a real-world context.
Book Synopsis Expert System Verification and Validation Study by :
Download or read book Expert System Verification and Validation Study written by and published by . This book was released on 1991 with total page 20 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis MINET Validation Study Using EBR-II Test Data by : Gregory J. Van Tuyle
Download or read book MINET Validation Study Using EBR-II Test Data written by Gregory J. Van Tuyle and published by . This book was released on 1983 with total page 39 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Encyclopedia of Database Systems by : Ling Liu
Download or read book Encyclopedia of Database Systems written by Ling Liu and published by . This book was released on with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Small Clinical Trials by : Institute of Medicine
Download or read book Small Clinical Trials written by Institute of Medicine and published by National Academies Press. This book was released on 2001-01-01 with total page 221 pages. Available in PDF, EPUB and Kindle. Book excerpt: Clinical trials are used to elucidate the most appropriate preventive, diagnostic, or treatment options for individuals with a given medical condition. Perhaps the most essential feature of a clinical trial is that it aims to use results based on a limited sample of research participants to see if the intervention is safe and effective or if it is comparable to a comparison treatment. Sample size is a crucial component of any clinical trial. A trial with a small number of research participants is more prone to variability and carries a considerable risk of failing to demonstrate the effectiveness of a given intervention when one really is present. This may occur in phase I (safety and pharmacologic profiles), II (pilot efficacy evaluation), and III (extensive assessment of safety and efficacy) trials. Although phase I and II studies may have smaller sample sizes, they usually have adequate statistical power, which is the committee's definition of a "large" trial. Sometimes a trial with eight participants may have adequate statistical power, statistical power being the probability of rejecting the null hypothesis when the hypothesis is false. Small Clinical Trials assesses the current methodologies and the appropriate situations for the conduct of clinical trials with small sample sizes. This report assesses the published literature on various strategies such as (1) meta-analysis to combine disparate information from several studies including Bayesian techniques as in the confidence profile method and (2) other alternatives such as assessing therapeutic results in a single treated population (e.g., astronauts) by sequentially measuring whether the intervention is falling above or below a preestablished probability outcome range and meeting predesigned specifications as opposed to incremental improvement.
Book Synopsis A Validation Study of Two Self-concept and Two Attitude Towards School Instruments by : Trinidad N. Garcia
Download or read book A Validation Study of Two Self-concept and Two Attitude Towards School Instruments written by Trinidad N. Garcia and published by . This book was released on 1981 with total page 102 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Finite Element Analysis by : Barna Szabó
Download or read book Finite Element Analysis written by Barna Szabó and published by John Wiley & Sons. This book was released on 2021-06-22 with total page 386 pages. Available in PDF, EPUB and Kindle. Book excerpt: Finite Element Analysis An updated and comprehensive review of the theoretical foundation of the finite element method The revised and updated second edition of Finite Element Analysis: Method, Verification, and Validation offers a comprehensive review of the theoretical foundations of the finite element method and highlights the fundamentals of solution verification, validation, and uncertainty quantification. Written by noted experts on the topic, the book covers the theoretical fundamentals as well as the algorithmic structure of the finite element method. The text contains numerous examples and helpful exercises that clearly illustrate the techniques and procedures needed for accurate estimation of the quantities of interest. In addition, the authors describe the technical requirements for the formulation and application of design rules. Designed as an accessible resource, the book has a companion website that contains a solutions manual, PowerPoint slides for instructors, and a link to finite element software. This important text: Offers a comprehensive review of the theoretical foundations of the finite element method Puts the focus on the fundamentals of solution verification, validation, and uncertainty quantification Presents the techniques and procedures of quality assurance in numerical solutions of mathematical problems Contains numerous examples and exercises Written for students in mechanical and civil engineering, analysts seeking professional certification, and applied mathematicians, Finite Element Analysis: Method, Verification, and Validation, Second Edition includes the tools, concepts, techniques, and procedures that help with an understanding of finite element analysis.
Author :University of Houston--Clear Lake. Research Institute for Computing and Information Systems Publisher : ISBN 13 : Total Pages :50 pages Book Rating :4.:/5 (363 download)
Book Synopsis Expert System Verification and Validation Study by : University of Houston--Clear Lake. Research Institute for Computing and Information Systems
Download or read book Expert System Verification and Validation Study written by University of Houston--Clear Lake. Research Institute for Computing and Information Systems and published by . This book was released on 1990 with total page 50 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis A Validation Study of Two Group Intelligence Tests by : Melvin Carl Schwartz
Download or read book A Validation Study of Two Group Intelligence Tests written by Melvin Carl Schwartz and published by . This book was released on 1964 with total page 80 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Validity and Validation by : Catherine S. Taylor
Download or read book Validity and Validation written by Catherine S. Taylor and published by Oxford University Press. This book was released on 2013-09-03 with total page 217 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Understanding Research series focuses on the process of writing up social research. The series is broken down into three categories: Understanding Statistics, Understanding Measurement, and Understanding Qualitative Research. The books provide researchers with guides to understanding, writing, and evaluating social research. Each volume demonstrates how research should be represented, including how to write up the methodology as well as the research findings. Each volume also reviews how to appropriately evaluate published research. Validity and Validation is an introduction to validity theory and to the methods used to obtain evidence for the validity of research and assessment results. The book pulls together the best thinking from educational and psychological research and assessment over the past 50 years. It briefly describes validity theory's roots in the philosophy of science. It highlights the ways these philosophical perspectives influence concepts of internal and external validity in research methodology, as well as concepts of validity and reliability in educational and psychological tests and measurements. Each chapter provides multiple examples (e.g., research designs and examples of output) to help the readers see how validation work is done in practice, from the ways we design research studies to the ways we interpret research results. Of particular importance is the practical focus on validation of scores from tests and other measures. The book also addresses strategies for investigating the validity of inferences we make about examinees using scores from assessments, as well as how to investigate score uses, the value implications of score interpretations, and the social consequences of score use. With this foundation, the book presents strategies for minimizing threats for validity as well as quantitative and qualitative methods for gathering evidence for the validity of scores.
Book Synopsis Animal Welfare Assessment, Volume II by : Edward Narayan
Download or read book Animal Welfare Assessment, Volume II written by Edward Narayan and published by Frontiers Media SA. This book was released on 2021-09-30 with total page 166 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :Agency for Healthcare Research and Quality/AHRQ Publisher :Government Printing Office ISBN 13 :1587634333 Total Pages :396 pages Book Rating :4.5/5 (876 download)
Book Synopsis Registries for Evaluating Patient Outcomes by : Agency for Healthcare Research and Quality/AHRQ
Download or read book Registries for Evaluating Patient Outcomes written by Agency for Healthcare Research and Quality/AHRQ and published by Government Printing Office. This book was released on 2014-04-01 with total page 396 pages. Available in PDF, EPUB and Kindle. Book excerpt: This User’s Guide is intended to support the design, implementation, analysis, interpretation, and quality evaluation of registries created to increase understanding of patient outcomes. For the purposes of this guide, a patient registry is an organized system that uses observational study methods to collect uniform data (clinical and other) to evaluate specified outcomes for a population defined by a particular disease, condition, or exposure, and that serves one or more predetermined scientific, clinical, or policy purposes. A registry database is a file (or files) derived from the registry. Although registries can serve many purposes, this guide focuses on registries created for one or more of the following purposes: to describe the natural history of disease, to determine clinical effectiveness or cost-effectiveness of health care products and services, to measure or monitor safety and harm, and/or to measure quality of care. Registries are classified according to how their populations are defined. For example, product registries include patients who have been exposed to biopharmaceutical products or medical devices. Health services registries consist of patients who have had a common procedure, clinical encounter, or hospitalization. Disease or condition registries are defined by patients having the same diagnosis, such as cystic fibrosis or heart failure. The User’s Guide was created by researchers affiliated with AHRQ’s Effective Health Care Program, particularly those who participated in AHRQ’s DEcIDE (Developing Evidence to Inform Decisions About Effectiveness) program. Chapters were subject to multiple internal and external independent reviews.
Author :Agency for Health Care Research and Quality (U.S.) Publisher :Government Printing Office ISBN 13 :1587634236 Total Pages :236 pages Book Rating :4.5/5 (876 download)
Book Synopsis Developing a Protocol for Observational Comparative Effectiveness Research: A User's Guide by : Agency for Health Care Research and Quality (U.S.)
Download or read book Developing a Protocol for Observational Comparative Effectiveness Research: A User's Guide written by Agency for Health Care Research and Quality (U.S.) and published by Government Printing Office. This book was released on 2013-02-21 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt: This User’s Guide is a resource for investigators and stakeholders who develop and review observational comparative effectiveness research protocols. It explains how to (1) identify key considerations and best practices for research design; (2) build a protocol based on these standards and best practices; and (3) judge the adequacy and completeness of a protocol. Eleven chapters cover all aspects of research design, including: developing study objectives, defining and refining study questions, addressing the heterogeneity of treatment effect, characterizing exposure, selecting a comparator, defining and measuring outcomes, and identifying optimal data sources. Checklists of guidance and key considerations for protocols are provided at the end of each chapter. The User’s Guide was created by researchers affiliated with AHRQ’s Effective Health Care Program, particularly those who participated in AHRQ’s DEcIDE (Developing Evidence to Inform Decisions About Effectiveness) program. Chapters were subject to multiple internal and external independent reviews. More more information, please consult the Agency website: www.effectivehealthcare.ahrq.gov)
Book Synopsis Validity and Validation in Social, Behavioral, and Health Sciences by : Bruno D. Zumbo
Download or read book Validity and Validation in Social, Behavioral, and Health Sciences written by Bruno D. Zumbo and published by Springer. This book was released on 2014-09-26 with total page 329 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book combines an overview of validity theory, trends in validation practices and a review of standards and guidelines in several international jurisdictions with research synthesis of the validity evidence in different research areas. An overview of theory is both useful and timely, in view of the increased use of tests and measures for decision-making, ranking and policy purposes in large-scale testing, assessment and social indicators and quality of life research. Research synthesis is needed to help us assemble, critically appraise and integrate the overwhelming volume of research on validity in different contexts. Rather than examining whether any given measure is “valid”, the focus is on a critical appraisal of the kinds of validity evidence reported in the published research literature. The five sources of validity evidence discussed are: content-related, response processes, internal structure, associations with other variables and consequences. The 15 syntheses included here, represent a broad sampling of psychosocial, health, medical and educational research settings, giving us an extensive evidential basis to build upon earlier studies. The book concludes with a meta-synthesis of the 15 syntheses and a discussion of the current thinking of validation practices by leading experts in the field.
Book Synopsis Police Validation Study by : John Clancy
Download or read book Police Validation Study written by John Clancy and published by . This book was released on 1974* with total page 49 pages. Available in PDF, EPUB and Kindle. Book excerpt:
