Vaccine Technology In The 21st Century

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Vaccines for the 21st Century

Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 0309174988
Total Pages : 472 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Vaccines for the 21st Century by : Institute of Medicine

Download or read book Vaccines for the 21st Century written by Institute of Medicine and published by National Academies Press. This book was released on 2001-02-21 with total page 472 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vaccines have made it possible to eradicate the scourge of smallpox, promise the same for polio, and have profoundly reduced the threat posed by other diseases such as whooping cough, measles, and meningitis. What is next? There are many pathogens, autoimmune diseases, and cancers that may be promising targets for vaccine research and development. This volume provides an analytic framework and quantitative model for evaluating disease conditions that can be applied by those setting priorities for vaccine development over the coming decades. The committee describes an approach for comparing potential new vaccines based on their impact on morbidity and mortality and on the costs of both health care and vaccine development. The book examines: Lessons to be learned from the polio experience. Scientific advances that set the stage for new vaccines. Factors that affect how vaccines are used in the population. Value judgments and ethical questions raised by comparison of health needs and benefits. The committee provides a way to compare different forms of illness and set vaccine priorities without assigning a monetary value to lives. Their recommendations will be important to anyone involved in science policy and public health planning: policymakers, regulators, health care providers, vaccine manufacturers, and researchers.

Priorities for the National Vaccine Plan

Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 0309156203
Total Pages : 368 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Priorities for the National Vaccine Plan by : Institute of Medicine

Download or read book Priorities for the National Vaccine Plan written by Institute of Medicine and published by National Academies Press. This book was released on 2010-05-17 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vaccination is a fundamental component of preventive medicine and public health. The use of vaccines to prevent infectious diseases has resulted in dramatic decreases in disease, disability, and death in the United States and around the world. The current political, economic, and social environment presents both opportunities for and challenges to strengthening the U.S. system for developing, manufacturing, regulating, distributing, funding, and administering safe and effective vaccines for all people. Priorities for the National Vaccine Plan examines the extraordinarily complex vaccine enterprise, from research and development of new vaccines to financing and reimbursement of immunization services. Priorities for the National Vaccine Plan examines the extraordinarily complex vaccine enterprise, from research and development of new vaccines to financing and reimbursement of immunization services. The book makes recommendations about priority actions in the update to the National Vaccine Plan that are intended to achieve the objectives of disease prevention and enhancement of vaccine safety. It is centered on the plan's five goals in the areas of vaccine development, safety, communication, supply and use, and global health.

Pandemic Outbreaks in the 21st Century

Author : Viswanath Buddolla
Publisher : Elsevier
ISBN 13 : 0323900011
Total Pages : 328 pages
Book Rating : 4.3/5 (239 download)

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Book Synopsis Pandemic Outbreaks in the 21st Century by : Viswanath Buddolla

Download or read book Pandemic Outbreaks in the 21st Century written by Viswanath Buddolla and published by Elsevier. This book was released on 2021-08-24 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the past two decades, several pandemics have ravaged the globe, giving us several lessons on infectious disease epidemiology, the importance of initial detection and characterization of outbreak viruses, the importance of viral epidemic prevention steps, and the importance of modern vaccines. Pandemic Outbreaks in the Twenty-First Century: Epidemiology, Pathogenesis, Prevention, and Treatment summarizes the improvements in the 21st century to overcome / prevent / treat global pandemic with future prospective. Divided into 9 chapters, the book begins with an in-depth introduction to the lessons learned from the first pandemic of the 21st century. It describes the history, present and future in terms of detection, prevention and treatment. Followed by chapters on the outbreak, treatment strategies and clinical management of several infectious diseases like MERS, SARD and COVID 19, Pandemic Outbreaks in the Twenty-First Century: Epidemiology, Pathogenesis, Prevention, and Treatment, presents chapters on immunotherapies and vaccine technologies to combat pandemic outbreak and challenges. The book finishes with a chapter on the current knowledge and technology to control pandemic outbreaks. All are presented in a practical short format, making this volume a valuable resource for very broad academic audience. Provides insight to the lessons learned from past pandemics Gives recommendations, future direction in terms of detection, prevention and treatment of pandemics Guides readers through the status and recent developments of vaccines to overcome or prevent pandemics Shows how to enhance the host innate immunity in infectious diseases Includes a chapter on immunotherapies to combat pandemic outbreaks

Ranking Vaccines

Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 0309255252
Total Pages : 188 pages
Book Rating : 4.3/5 (92 download)

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Book Synopsis Ranking Vaccines by : Institute of Medicine

Download or read book Ranking Vaccines written by Institute of Medicine and published by National Academies Press. This book was released on 2012-10-11 with total page 188 pages. Available in PDF, EPUB and Kindle. Book excerpt: As a number of diseases emerge or reemerge thus stimulating new vaccine development opportunities to help prevent those diseases, it can be especially difficult for decision makers to know where to invest their limited resources. Therefore, it is increasingly important for decision makers to have the tools that can assist and inform their vaccine prioritization efforts. In this first phase report, the IOM offers a framework and proof of concept to account for various factors influencing vaccine prioritization-demographic, economic, health, scientific, business, programmatic, social, policy factors and public concerns. Ranking Vaccines: A Prioritization Framework describes a decision-support model and the blueprint of a software-called Strategic Multi-Attribute Ranking Tool for Vaccines or SMART Vaccines. SMART Vaccines should be of help to decision makers. SMART Vaccines Beta is not available for public use, but SMART Vaccines 1.0 is expected to be released at the end of the second phase of this study, when it will be fully operational and capable of guiding discussions about prioritizing the development and introduction of new vaccines.

The Critical Public Health Value of Vaccines

Author : National Academies of Sciences, Engineering, and Medicine
Publisher :
ISBN 13 : 9780309461566
Total Pages : 230 pages
Book Rating : 4.4/5 (615 download)

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Book Synopsis The Critical Public Health Value of Vaccines by : National Academies of Sciences, Engineering, and Medicine

Download or read book The Critical Public Health Value of Vaccines written by National Academies of Sciences, Engineering, and Medicine and published by . This book was released on 2022-01-29 with total page 230 pages. Available in PDF, EPUB and Kindle. Book excerpt: Immunization against disease is among the most successful global health efforts of the modern era, and substantial gains in vaccination coverage rates have been achieved worldwide. However, that progress has stagnated in recent years, leaving an estimated 20 million children worldwide either undervaccinated or completely unvaccinated. The determinants of vaccination uptake are complex, mutable, and context specific. A primary driver is vaccine hesitancy - defined as a "delay in acceptance or refusal of vaccines despite availability of vaccination services". The majority of vaccine-hesitant people fall somewhere on a spectrum from vaccine acceptance to vaccine denial. Vaccine uptake is also hampered by socioeconomic or structural barriers to access. On August 17-20, 2020, the Forum on Microbial Threats at the National Academies of Sciences, Engineering, and Medicine held a 4-day virtual workshop titled The Critical Public Health Value of Vaccines: Tackling Issues of Access and Hesitancy. The workshop focused on two main areas (vaccine access and vaccine confidence) and gave particular consideration to health systems, research opportunities, communication strategies, and policies that could be considered to address access, perception, attitudes, and behaviors toward vaccination. This publication summarizes the presentations and discussion of the workshop.

Stuck

Author : Heidi J. Larson
Publisher : Oxford University Press
ISBN 13 : 0190077255
Total Pages : 224 pages
Book Rating : 4.1/5 (9 download)

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Book Synopsis Stuck by : Heidi J. Larson

Download or read book Stuck written by Heidi J. Larson and published by Oxford University Press. This book was released on 2020-07-01 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vaccine reluctance and refusal are no longer limited to the margins of society. Debates around vaccines' necessity -- along with quesitons around their side effects -- have gone mainstream, blending with geopolitical conflicts, political campaigns, celebrity causes, and "natural" lifestyles to win a growing number of hearts and minds. Today's anti-vaccine positions find audiences where they've never existed previously. Stuck examines how the issues surrounding vaccine hesitancy are, more than anything, about people feeling left out of the conversation. A new dialogue is long overdue, one that addresses the many types of vaccine hesitancy and the social factors that perpetuate them. To do this, Stuck provides a clear-eyed examination of the social vectors that transmit vaccine rumors, their manifestations around the globe, and how these individual threads are all connected.

The Vaccine Book

Author : Barry R. Bloom
Publisher : Academic Press
ISBN 13 : 012805400X
Total Pages : 666 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis The Vaccine Book by : Barry R. Bloom

Download or read book The Vaccine Book written by Barry R. Bloom and published by Academic Press. This book was released on 2016-06-23 with total page 666 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Vaccine Book, Second Edition provides comprehensive information on the current and future state of vaccines. It reveals the scientific opportunities and potential impact of vaccines, including economic and ethical challenges, problems encountered when producing vaccines, how clinical vaccine trials are designed, and how to introduce vaccines into widespread use. Although vaccines are now available for many diseases, there are still challenges ahead for major diseases, such as AIDS, tuberculosis, and malaria. This book is designed for students, researchers, public health officials, and all others interested in increasing their understanding of vaccines. It answers common questions regarding the use of vaccines in the context of a rapidly expanding anti-vaccine environment. This new edition is completely updated and revised with new and unique topics, including new vaccines, problems of declining immunization rates, trust in vaccines, the vaccine hesitancy, and the social value of vaccines for the community vs. the individual child's risk. - Provides insights into diseases that could be prevented, along with the challenges facing research scientists in the world of vaccines - Gives new ideas about future vaccines and concepts - Introduces new vaccines and concepts - Gives ideas about challenges facing public and private industrial investors in the vaccine area - Discusses the problem of declining immunization rates and vaccine hesitancy

Novel Technologies for Vaccine Development

Author : Igor S Lukashevich
Publisher : Springer
ISBN 13 : 3709118182
Total Pages : 393 pages
Book Rating : 4.7/5 (91 download)

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Book Synopsis Novel Technologies for Vaccine Development by : Igor S Lukashevich

Download or read book Novel Technologies for Vaccine Development written by Igor S Lukashevich and published by Springer. This book was released on 2014-11-13 with total page 393 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents a detailed overview of the development of new viral vector-based vaccines before discussing two major applications: preventive vaccines for infectious diseases and therapeutic cancer vaccines. Viral vector-based vaccines hold a great potential for development into successful pharmaceutical products and several examples at the advanced pre-clinical or clinical stage are presented. Nevertheless, the most efforts were focused on novel and very innovative technologies for new generation of vector-based vaccines. Furthermore, specific topics such as delivery and adjuvant and protection strategies for cell-mediated-based vaccines are presented. Given its scope, the book is a “must read” for all those involved in vaccine development, both in academia and industrial vaccine development.

System Vaccinology

Author : Vijay Kumar Prajapati
Publisher : Elsevier
ISBN 13 : 0323859410
Total Pages : 436 pages
Book Rating : 4.3/5 (238 download)

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Book Synopsis System Vaccinology by : Vijay Kumar Prajapati

Download or read book System Vaccinology written by Vijay Kumar Prajapati and published by Elsevier. This book was released on 2022-08-15 with total page 436 pages. Available in PDF, EPUB and Kindle. Book excerpt: Emergence of new and deadly infectious diseases is significantly deteriorating the human health. Development of vaccine by the scientist has become an important weapon to control the spread of infectious diseases as well as to improve the life expectancy at global level in 20th-21st Century. This book will provide the in-depth knowledge of vaccine history, and development of new strategies to design efficacious and safe vaccine molecule. This book will cover the development of system vaccinology and their applications revolutionize the vaccine discovery. This will provide a resource for the basic and clinical researcher working to human life expectancy by their vaccine experiments and clinical trials. My purpose to write this book to educate the students and researchers with modern development in the field of vaccinology and empowering the researcher with new tools and methodology for developing potential and immunogenic vaccines. This book will be helpful to solve the curiosity of science and medical background students related with vaccinology and will be helpful to devise a new vaccine molecule to control the spread of new and emerging pathogens. Systems biology is a rapidly expanding research discipline aiming to integrate multifaceted datasets generated using state-of-the-art high- throughput technologies such as arrays and next-generation sequencing. Combined with sophisticated computational analysis we are able to interrogate host responses to infections and vaccination on a systems level, thus generating important new hypotheses and discovering unknown associations between immunological parameters. Provides in-depth knowledge of vaccine history Covers the development of system vaccinology and their applications revolutionize the vaccine discovery Gives insights to the development of new strategies to design efficacious and safe vaccine molecule Provides a resource for the basic and clinical researcher working to human life expectancy by their vaccine experiments and clinical trials Highlights the importance of differential miRNA expression, microbiome after vaccination for human health Serves the need of students and researcher for applying computational tools and quick designing of potential molecule which may be proposed for vaccine trial Take the decisions to perform the kind of experiments for assessment of vaccine immunogenicity Aims to understand disease pathogenesis and host responses to infection and vaccination Offers a seamless continuum of scientific discovery and vaccine invention

Global Virology III: Virology in the 21st Century

Author : Paul Shapshak
Publisher : Springer Nature
ISBN 13 : 3030290220
Total Pages : 671 pages
Book Rating : 4.0/5 (32 download)

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Book Synopsis Global Virology III: Virology in the 21st Century by : Paul Shapshak

Download or read book Global Virology III: Virology in the 21st Century written by Paul Shapshak and published by Springer Nature. This book was released on 2019-11-22 with total page 671 pages. Available in PDF, EPUB and Kindle. Book excerpt: Global Virology, Volume III: Virology in the 21st Century examines work that has been undertaken, or is planned, in several fields of virology, in an effort to promote current and future work, research, and health. Fields and methods addressed include virology, immunology, space research, astrovirology/astrobiology, plasmids, swarm intelligence, bioinformatics, data-mining, machine learning, neural networks, critical equations, and advances in biohazard biocontainment. Novel and forward-looking methods, techniques, and approaches in research and development are presented by experts in the field.

Vaccines for the 21st Century

Author : Committee to Study Priorities for Vaccine Development
Publisher : National Academies Press
ISBN 13 : 0309564433
Total Pages : 473 pages
Book Rating : 4.3/5 (95 download)

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Book Synopsis Vaccines for the 21st Century by : Committee to Study Priorities for Vaccine Development

Download or read book Vaccines for the 21st Century written by Committee to Study Priorities for Vaccine Development and published by National Academies Press. This book was released on 2001-03-07 with total page 473 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vaccines have made it possible to eradicate the scourge of smallpox, promise the same for polio, and have profoundly reduced the threat posed by other diseases such as whooping cough, measles, and meningitis. What is next? There are many pathogens, autoimmune diseases, and cancers that may be promising targets for vaccine research and development. This volume provides an analytic framework and quantitative model for evaluating disease conditions that can be applied by those setting priorities for vaccine development over the coming decades. The committee describes an approach for comparing potential new vaccines based on their impact on morbidity and mortality and on the costs of both health care and vaccine development. The book examines: Lessons to be learned from the polio experience. Scientific advances that set the stage for new vaccines. Factors that affect how vaccines are used in the population. Value judgments and ethical questions raised by comparison of health needs and benefits. The committee provides a way to compare different forms of illness and set vaccine priorities without assigning a monetary value to lives. Their recommendations will be important to anyone involved in science policy and public health planning: policymakers, regulators, health care providers, vaccine manufacturers, and researchers.

Vaccine Design

Author : Rino Rappuoli
Publisher : Caister Academic Press Limited
ISBN 13 : 9781904455745
Total Pages : 0 pages
Book Rating : 4.4/5 (557 download)

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Book Synopsis Vaccine Design by : Rino Rappuoli

Download or read book Vaccine Design written by Rino Rappuoli and published by Caister Academic Press Limited. This book was released on 2011 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this book, expert international authors critically review the current cutting-edge research in vaccine design and development. Particular emphasis is given to new approaches and technologies.

A Shot to Save the World

Author : Gregory Zuckerman
Publisher : Penguin
ISBN 13 : 0593420403
Total Pages : 384 pages
Book Rating : 4.5/5 (934 download)

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Book Synopsis A Shot to Save the World by : Gregory Zuckerman

Download or read book A Shot to Save the World written by Gregory Zuckerman and published by Penguin. This book was released on 2021-10-26 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt: "An inspiring and informative page-turner." –Walter Isaacson Longlisted for the FT/McKinsey Business Book of the Year Award The authoritative account of the race to produce the vaccines that are saving us all, from the #1 New York Times bestselling author of The Man Who Solved the Market Few were ready when a mysterious respiratory illness emerged in Wuhan, China in January 2020. Politicians, government officials, business leaders, and public-health professionals were unprepared for the most devastating pandemic in a century. Many of the world’s biggest drug and vaccine makers were slow to react or couldn’t muster an effective response. It was up to a small group of unlikely and untested scientists and executives to save civilization. A French businessman dismissed by many as a fabulist. A Turkish immigrant with little virus experience. A quirky Midwesterner obsessed with insect cells. A Boston scientist employing questionable techniques. A British scientist despised by his peers. Far from the limelight, each had spent years developing innovative vaccine approaches. Their work was met with skepticism and scorn. By 2020, these individuals had little proof of progress. Yet they and their colleagues wanted to be the ones to stop the virus holding the world hostage. They scrambled to turn their life’s work into life-saving vaccines in a matter of months, each gunning to make the big breakthrough—and to beat each other for the glory that a vaccine guaranteed. A #1 New York Times bestselling author and award-winning Wall Street Journal investigative journalist lauded for his “bravura storytelling” (Gary Shteyngart) and “first-rate” reporting (The New York Times), Zuckerman takes us inside the top-secret laboratories, corporate clashes, and high-stakes government negotiations that led to effective shots. Deeply reported and endlessly gripping, this is a dazzling, blow-by-blow chronicle of the most consequential scientific breakthrough of our time. It’s a story of courage, genius, and heroism. It’s also a tale of heated rivalries, unbridled ambitions, crippling insecurities, and unexpected drama. A Shot to Save the World is the story of how science saved the world.

The Messenger

Author : Peter Loftus
Publisher : Harvard Business Press
ISBN 13 : 164782320X
Total Pages : 299 pages
Book Rating : 4.6/5 (478 download)

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Book Synopsis The Messenger by : Peter Loftus

Download or read book The Messenger written by Peter Loftus and published by Harvard Business Press. This book was released on 2022-07-26 with total page 299 pages. Available in PDF, EPUB and Kindle. Book excerpt: The inside story of an unprecedented feat of science and business. At the start of 2020, Moderna was a biotech unicorn with dim prospects. Yes, there was the promise of its disruptive innovation that could transform medicine by using something called messenger RNA, one of the body's building blocks of life, to combat disease. But its stock was under water. There were reports of a toxic work culture. And despite ten years of work, the company was still years away from delivering its first product. Investors were getting antsy, or worse, skeptical. Then the pandemic hit, and Moderna, at first reluctantly, became a central player in a global drama—a David to Big Pharma's Goliaths—turning its technology toward breaking the global grip of the terrible disease. By year's end, with the virus raging, Moderna delivered one of the world's first Covid-19 vaccines, with a stunningly high rate of protection. The achievement gave the world a way out of a crippling pandemic while validating Moderna's technology, transforming the company into a global industry power. Biotech, and the venture capital community that fuels it, will never be the same. Wall Street Journal reporter Peter Loftus, veteran reporter covering the pharmaceutical and biotech industries and part of a Pulitzer Prize–finalist team, brings the inside story of Moderna, from its humble start at a casual lunch through its heady startup days, into the heart of the pandemic and beyond. With deep access to all of the major players, Loftus weaves a tale of science and business that brings to life Moderna's monumental feat of creating a vaccine that beat back a deadly virus and changed the business of medicine forever. The Messenger spans a decade and is full of heroic efforts by ordinary people, lucky breaks, and life-and-death decisions. It's the story of a revolutionary idea, the evolution of a cutting-edge American industry, and one of the great achievements of this century.

Making Markets for Vaccines

Author : Owen Barder
Publisher :
ISBN 13 :
Total Pages : 132 pages
Book Rating : 4.:/5 (321 download)

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Book Synopsis Making Markets for Vaccines by : Owen Barder

Download or read book Making Markets for Vaccines written by Owen Barder and published by . This book was released on 2005 with total page 132 pages. Available in PDF, EPUB and Kindle. Book excerpt: A legacy of our generation -- Ch. 1. We need to invest more in vaccines -- Ch. 2. Promoting private investment in vaccine development -- Ch. 3. A market not a prize -- Ch. 4. Design choices -- Ch. 5. $3 billion per disease -- Ch. 6. Meeting industry requirements -- Ch. 7. How sponsors can do it.

Micro- and Nanotechnology in Vaccine Development

Author : Mariusz Skwarczynski
Publisher : William Andrew
ISBN 13 : 0323400299
Total Pages : 462 pages
Book Rating : 4.3/5 (234 download)

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Book Synopsis Micro- and Nanotechnology in Vaccine Development by : Mariusz Skwarczynski

Download or read book Micro- and Nanotechnology in Vaccine Development written by Mariusz Skwarczynski and published by William Andrew. This book was released on 2016-09-20 with total page 462 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive overview of how use of micro- and nanotechnology (MNT) has allowed major new advance in vaccine development research, and the challenges that immunologists face in making further progress. MNT allows the creation of particles that exploit the inherent ability of the human immune system to recognize small particles such as viruses and toxins. In combination with minimal protective epitope design, this permits the creation of immunogenic particles that stimulate a response against the targeted pathogen. The finely tuned response of the human immune system to small particles makes it unsurprising that many of the lead adjuvants and vaccine delivery systems currently under investigation are based on nanoparticles. - Provides a comprehensive and unparalleled overview of the role of micro- and nanotechnology in vaccine development - Allows researchers to quickly familiarize themselves with the broad spectrum of vaccines and how micro- and nanotechnologies are applied to their development - Includes a combination of overview chapters setting out general principles, and focused content dealing with specific vaccines, making it useful to readers from a variety of disciplines

Promoting Access to Medical Technologies and Innovation - Intersections between Public Health, Intellectual Property and Trade

Author : World Intellectual Property Organization
Publisher : WIPO
ISBN 13 : 9280523082
Total Pages : 259 pages
Book Rating : 4.2/5 (85 download)

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Book Synopsis Promoting Access to Medical Technologies and Innovation - Intersections between Public Health, Intellectual Property and Trade by : World Intellectual Property Organization

Download or read book Promoting Access to Medical Technologies and Innovation - Intersections between Public Health, Intellectual Property and Trade written by World Intellectual Property Organization and published by WIPO. This book was released on 2013 with total page 259 pages. Available in PDF, EPUB and Kindle. Book excerpt: This study has emerged from an ongoing program of trilateral cooperation between WHO, WTO and WIPO. It responds to an increasing demand, particularly in developing countries, for strengthened capacity for informed policy-making in areas of intersection between health, trade and IP, focusing on access to and innovation of medicines and other medical technologies.