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Utilization Of Mammalian Specific Locus Studies In Hazard Evaluation And Estimation Of Genetic Risk
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Book Synopsis Utilization of Mammalian Specific Locus Studies in Hazard Evaluation and Estimation of Genetic Risk by : F.J. De Serres
Download or read book Utilization of Mammalian Specific Locus Studies in Hazard Evaluation and Estimation of Genetic Risk written by F.J. De Serres and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 343 pages. Available in PDF, EPUB and Kindle. Book excerpt: The magnitude of the threat to the human genetic material posed by environmental agents has not as yet been fully determined. Never theless, the potential hazards of many chemicals have been identi fied by studies on lower organisms. However, too little is known regarding the comparability or lack of it between the metabolic pathways available in such organisms and those in man. Although at present there is great public concern for what is considered by some as the excessive use of laboratory animals in toxicological testing, it seems clear that the usage of mammalian systems may be deemed necessary. It has been proposed that cell culture systems might suffice to meet this need, however, such approaches cannot match the complexity of physiological occurances that are present in the intact animal. For studies of genetic effects, some non-invasive human test systems are presently available. These do not, however, meet the re quirements for extensive laboratory studies. In order to assess the risks to humans of environmental factors such laboratory investiga tions are essential. Therefore, for the forseeable future reliance on experiments using laboratory animals will be necessary. This Volume, which contains the proceedings of a workshop which was held at the National Institute of Environmental Health Sciences, March 29-31, 1982, explores the existing methodologies and their utility for risk estimations. It covers the most well developed human systems, as well as the most widely used animal tests.
Book Synopsis National Toxicology Program Annual Report for Fiscal Year ... by : National Toxicology Program (U.S.)
Download or read book National Toxicology Program Annual Report for Fiscal Year ... written by National Toxicology Program (U.S.) and published by . This book was released on 1991 with total page 512 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :Frederick J. De Serres Publisher :Springer Science & Business Media ISBN 13 :1461327652 Total Pages :511 pages Book Rating :4.4/5 (613 download)
Book Synopsis Individual Susceptibility to Genotoxic Agents in the Human Population by : Frederick J. De Serres
Download or read book Individual Susceptibility to Genotoxic Agents in the Human Population written by Frederick J. De Serres and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 511 pages. Available in PDF, EPUB and Kindle. Book excerpt: As a result of the industrial revolution, man's technological achievements have been truly great, increasing the quality of life to almost unimagined proportions; but all this progress has not been accomplished without equally un imagined health risks. Sufficiently diagnostic short-term assay procedures have been developed in recent years for us to determine that there are mutagenic agents among thou sands of chemicals to which the human population is exposed today. These chemicals were not significantly present prior to the indus trial revolution. As of today, there are no procedures available which have been adequately demonstrated to assess individual sus ceptibility to genotoxic exposures, and as a result we have had to rely on extrapolating toxicological data from animal model systems. The question is can we afford to allow such an increased environ mental selection pressure via mutagenic exposures to occur without expecting adverse long-term effects on our health. It is apparent from this line of reasoning that what is lacking and immediately needed are test procedures that can be applied to humans to assess genotoxic exposure as well as individual susceptibility to it. There have already been two conferences which have focused at tention on this research area. "Guidelines for studies of human populations exposed to mutagenic and reproductive hazards" (A. D. Bloom, ed., March of Dimes Birth Defects Foundation, White Plains, New York, 1981) and "Indicators of genotoxic exposure in humans" (Banbury Report 13, B. A. Bridges, B. E. Butterworth, and I. B.
Book Synopsis Current Catalog by : National Library of Medicine (U.S.)
Download or read book Current Catalog written by National Library of Medicine (U.S.) and published by . This book was released on with total page 1956 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book NIH Publication written by and published by . This book was released on 1983 with total page 140 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Degenerative Diseases of the Retina by : Robert E. Anderson
Download or read book Degenerative Diseases of the Retina written by Robert E. Anderson and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 409 pages. Available in PDF, EPUB and Kindle. Book excerpt: In 1984, we organized a two-day symposium on retinal degenerations as part of the biennial meeting of the VI International Society for Eye Research, held in Alicante, Spain. The success of this first meeting led to the second held, two years later in Sendai, Japan, organized as a satellite of the VII ISER. We were fortunate that these meetings began at a time of vigorous research activity in the area of retinal degenerations, thanks to the financial support of the Retinitis Pigmentosa Foundation and the strong encouragement of its scientific director, Dr. Alan Laties. Significant advances were made so that every two years scientists were eager to meet to share their findings. The programs included presentations by both basic and clinical researchers with ample time for informal discussions in a relaxed atmos phere. Many investigators met for the first time at these symposia and a number of fruitful collaborations were established. This book contains the proceedings of the VI International Symposium on Retinal Degenerations held November 6-10, 1994, in Jerusalem. As with the other meetings, some new areas were covered. One session was devoted to apoptosis, an important process involved in cell death in inherited retinal degenerations. Another session was on invertebrate photoreceptors, where numerous mutations have now been identified that lead to altered function or degeneration of the retina. All participants were invited to submit chapters and most complied. We thank them for their contributions.
Book Synopsis National Library of Medicine Current Catalog by : National Library of Medicine (U.S.)
Download or read book National Library of Medicine Current Catalog written by National Library of Medicine (U.S.) and published by . This book was released on with total page 988 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Children of Atomic Bomb Survivors by : National Research Council
Download or read book The Children of Atomic Bomb Survivors written by National Research Council and published by National Academies Press. This book was released on 1991-02-01 with total page 524 pages. Available in PDF, EPUB and Kindle. Book excerpt: Do persons exposed to radiation suffer genetic effects that threaten their yet-to-be-born children? Researchers are concluding that the genetic risks of radiation are less than previously thought. This finding is explored in this volume about the children of atomic bomb survivors in Hiroshima and Nagasakiâ€"the population that can provide the greatest insight into this critical issue. Assembled here for the first time are papers representing more than 40 years of research. These documents reveal key results related to radiation's effects on pregnancy termination, sex ratio, congenital defects, and early mortality of children. Edited by two of the principal architects of the studies, J. V. Neel and W. J. Schull, the volume also offers an important comparison with studies of the genetic effects of radiation on mice. The wealth of technical details will be immediately useful to geneticists and other specialists. Policymakers will be interested in the overall conclusions and discussion of future studies.
Book Synopsis Physiology and Toxicology of Male Reproduction by : James C. Lamb
Download or read book Physiology and Toxicology of Male Reproduction written by James C. Lamb and published by Elsevier. This book was released on 2013-10-22 with total page 283 pages. Available in PDF, EPUB and Kindle. Book excerpt: Physiology and Toxicology of Male Reproduction is a collection of papers that deals with general reproductive biology and specific aspects of reproductive toxicology, pertaining to the male sex. Some papers discuss testicular organization, reproductive toxicity testing systems, and germ-cell genetic toxicology. The use of in vitro systems by investigators to dissect the male reproductive toxicants can lead to a more scientific approach toward hazard assessment and the development of safer drugs and chemicals. Other papers explain the fundamental reproductive biology of the testis, the neuroendocrine system, the epididymis and accessory sex organs, and spermatozoal evaluation. Toxicological aspects cover the toxicological evaluation of the complete reproductive system, testicular morphology, sperm assessment, and germ-cell mutagenesis. One paper describes alternative methods in toxicology—by using new in vitro systems that should reduce or eliminate the need for tests conducted on animals. In vitro methodology embraces other systems such as from subcellular fractions to isolated intact organs. In relation to target-organ toxicity, the researcher can focus using primary cell cultures. This collection will prove helpful to toxicologists, graduate students and researchers in biology, particularly in male reproductive toxicology and fertility testing.
Book Synopsis Health Effects of Exposure to Low Levels of Ionizing Radiation by : National Research Council
Download or read book Health Effects of Exposure to Low Levels of Ionizing Radiation written by National Research Council and published by National Academies. This book was released on 1990-02-01 with total page 436 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reevaluates the health risks of ionizing radiation in light of data that have become available since the 1980 report on this subject was published. The data include new, much more reliable dose estimates for the A-bomb survivors, the results of an additional 14 years of follow-up of the survivors for cancer mortality, recent results of follow-up studies of persons irradiated for medical purposes, and results of relevant experiments with laboratory animals and cultured cells. It analyzes the data in terms of risk estimates for specific organs in relation to dose and time after exposure, and compares radiation effects between Japanese and Western populations.
Author :Third Task Force for Research Planning in Environmental Health Science Publisher : ISBN 13 : Total Pages :422 pages Book Rating :4.:/5 (47 download)
Book Synopsis Human Health and the Environment by : Third Task Force for Research Planning in Environmental Health Science
Download or read book Human Health and the Environment written by Third Task Force for Research Planning in Environmental Health Science and published by . This book was released on 1984 with total page 422 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :Third Task Force for Research Planning in Environmental Health Science (U.S.) Publisher : ISBN 13 : Total Pages :420 pages Book Rating :4.:/5 (2 download)
Book Synopsis Human Health and the Environment by : Third Task Force for Research Planning in Environmental Health Science (U.S.)
Download or read book Human Health and the Environment written by Third Task Force for Research Planning in Environmental Health Science (U.S.) and published by . This book was released on 1986 with total page 420 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Short-Term Bioassays in the Analysis of Complex Environmental Mixtures IV by : Michael Waters
Download or read book Short-Term Bioassays in the Analysis of Complex Environmental Mixtures IV written by Michael Waters and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 377 pages. Available in PDF, EPUB and Kindle. Book excerpt: With this proceedings of the fourth symposium on complex mixtures, we continue to revise and extend our knowledge of genetic methods for the evaluation of chemical mixtures in the environment. The early chapters of this volume are devoted to new bioassay techniques that are directly applicable to the monitoring of environments contaminated with genotoxic chemicals. Microbiological methods have been further refined to meet the special needs of atmospheric monitoring so that very small samples may now be efficiently tested. New in situ methods utilizing green plants actually avoid many of the usual difficulties of sample collection and preparation and offer special advantages in monitoring wastewater, sludges, and hazardous wastes. Insects also are being employed very effectively in the evaluation of gaseous air pollutants in controlled laboratory investigations. Increased emphasis has been placed on a comprehensive assessment of the potential of complex mixtures t9 cause various kinds of genetic damage. New assays for chromosome structural and numerical aberrations in mammalian cells in vitro have been developed and are being applied in laboratory studies. Efforts to link tests for gene mutation and cell transformation in vitro with assays for tumorigenesis in vivo are contributing to the validation of the short-term testing approach. Studies comparing in vitro and in vivo data on a coal conversion by-product, on polycyclic aromatic hydrocarbons, and on mineral fibers are reported in separate papers. Later chapters are devoted to investigations on the fractionation and biological evaluation of specific chemical components within complex mixtures.
Book Synopsis Technologies for Detecting Heritable Mutations in Human Beings by : Michael Gough
Download or read book Technologies for Detecting Heritable Mutations in Human Beings written by Michael Gough and published by . This book was released on 1988 with total page 160 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Fundamentals of Genetic Epidemiology by : Muin J. Khoury
Download or read book Fundamentals of Genetic Epidemiology written by Muin J. Khoury and published by Monographs in Epidemiology and. This book was released on 1993 with total page 394 pages. Available in PDF, EPUB and Kindle. Book excerpt: This text integrates the principles, methods and approaches of epidemiology and genetics in the study of disease aetiology. The authors define the central theme of genetic epidemiology as the study of the role of genetic factors and their interaction with environmental factors in the occurrence of disease in populations.
Book Synopsis Acid Rain Economic Assessment by : Paulette Mandelbaum
Download or read book Acid Rain Economic Assessment written by Paulette Mandelbaum and published by Springer Science & Business Media. This book was released on 2013-11-21 with total page 279 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume, Proceedings of the Conference ACID RAIN: Economic Assessment, is meant to present the areas of agreement which economists have established and the uncertainties which they have discovered in their attempts to use the methodology of economics to better understand the nature of the acid rain issue. Scientific articles about acid rain initially appeared in 1972. The public turned its attention to the issue in the mid-1970s. In April 1979, the first acid rain bill was introduced in the Senate, authored by New York's Senator Daniel P. Moynihan. The bill sought to establish a federal research program dedicated to filling the gaps in understanding of the phenomena of long-range transport of air pollutants and their environmental, health and economic impacts. 'The bill was passed into law in 1980. Since then, tens of bills have been proposed to control emissions of S02 and NO , x thought to be the precursors of acid rain. And yet, in contrast with the pattern set by the majority of environmental issues, where legislation followed very quickly on the heels of public anxiety and involvement, by July 1985 not a single federal acid rain control bill had been passed.
Book Synopsis Perspectives on Genetics by : James Franklin Crow
Download or read book Perspectives on Genetics written by James Franklin Crow and published by Univ of Wisconsin Press. This book was released on 2000 with total page 748 pages. Available in PDF, EPUB and Kindle. Book excerpt: For more than ten years, the distinguished geneticists James F. Crow and William F. Dove have edited the popular "Perspectives" column in Genetics, the journal of the Genetics Society of America. This book, Perspectives on Genetics, collects more than 100 of these essays, which cumulatively are a history of modern genetics research and its continuing evolution.
