Use Boolean Network to Model and Control Within- and Between-Person Dynamics

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Book Synopsis Use Boolean Network to Model and Control Within- and Between-Person Dynamics by : Xiao Yang

Download or read book Use Boolean Network to Model and Control Within- and Between-Person Dynamics written by Xiao Yang and published by . This book was released on 2020 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This body of work introduces and forwards a Boolean network-based method for studying psychological dynamics, both within-person and between-persons. I outline the Boolean network method, provide a guide for implementation, and illustrate how the method is applied in two empirical settings -- study of children's self-regulation, and study of group-therapy processes. The work highlights the utility of the method for obtaining intuitive descriptions of individual or group processes and deriving strategies for directing the individual or group towards desired outcomes. Developmental science is making use of dynamical system methods to explain the mechanisms of change driving human development and to predict how and when individuals or groups will change. A natural next step is to understand how to intervene when problematic patterns or change arise. Although psychological researchers have proposed and explored use of network methods to design interventions, applications are sparse. My aim is to enrich the repertoire of methods researchers can use to learn about and direct individuals' and groups' psychological functioning, and in doing so to prompt further use of network methods for modeling behavior change. In Chapter 1, I outline the motivation for introducing a Boolean network method that can be used to describe psychological systems and design interventions that may optimize how those systems function. Although a number of researchers have outlined the possibility of using dynamical system methods to guide psychological processes to desired levels, methods for deriving control strategies have remained theoretical. In this chapter, I identify a gap in the research on methods for analysis of developmental and psychological change processes -- specifically, the sparsity of empirical applications of control system design despite its theoretical importance -- and introduce how a Boolean network control method (Kauffman, 1969; 1993) can address this gap. Second, I briefly explain why network control is useful for guiding developmental processes, and how methods at the overlap between dynamical systems methods and network analysis can be used to develop that guidance. Third, I clarify how within- and between-person dynamics are conceptualized in this project, and how the definitions used here are analogous to other terms used in psychology. Fourth, I explain why the same dynamical system method can be used to describe both within- and between-person dynamics. I then briefly outline two empirical studies where I demonstrate how the Boolean network method can be applied to study and control of both within- and between-person dynamics. In Chapter 2, I revisit how dynamical system methods are used to model the nonlinear dynamics of multivariate systems. Despite the interest and advancement of control theory to direct psychological dynamics toward desired goals, control has been less studied and rarely applied in nonlinear psychological systems. We introduce the Boolean network method to address this gap. This method is useful because it can be used to model the nonlinear dynamics in multivariate systems and to develop network control strategies that might be used to manage the system toward a desired state. The Boolean network method is a discrete-time dynamical system method, and we introduce this method in three steps: (1) inference of the temporal relations between multiple binary variables as Boolean functions and construction of Boolean networks in which the binary variables are nodes and the Boolean functions are edges, (2) extraction of attractors based on the inferred dynamics and assignment of desirability for each attractor, and (3) design of network control to direct a psychological system toward a desired attractor by identifying how the Boolean network needs to be updated. To demonstrate how the Boolean network can describe and prescribe control for emotion regulation dynamics, we applied this method to an observational dataset of children's regulation of anger using bidding and/or distraction behavior (N = 120, T = 480 seconds). Network control strategies were designed to move the child into attractors where anger is OFF. The sample shows heterogeneous emotion regulation dynamics across children in 22 distinct Boolean networks, and heterogeneous control strategies regarding which behavior to perturb and how to perturb it. The presentation and illustration forward the Boolean network method as a novel method to describe nonlinear dynamics in multivariate psychological systems and a control method to guide nonlinear psychological systems toward desired goals. In Chapter 3, I revisit theories suggesting group processes can induce desired or undesired behavior change in individuals in a group because they are under social influence. Empirical modeling of group processes often assumes the social influence is assimilative only, and network-based interventions that aim to manage group processes and promote desired behavior change does not apply when the social network is fully connected. We introduce the Boolean network method to address these two gaps because it allows both assimilative and repulsive social influence to be modeled simultaneously, and prescribes network control strategies by changing a few group members' behavior regardless of network topology. The Boolean network method is a dynamical system method that models the group-specific temporal relations between group members' behavior as a Boolean network, and also allows for control theory to design group management strategies and direct the groups toward desired behavior. The Boolean network method is applied to empirical data of individuals' self-disclosure behavior in multi-week therapy groups (N = 155, 18 groups, T = 10~16 weeks), to model and manage group-specific processes of self-disclosure. Results show the method can estimate each group member's self-disclosure with error rate of 0.14 (SD = 0.10). Both assimilative and repulsive social influence are found in 14 out of 18 groups. Group-specific network control strategies were designed to elicit the majority of the group self-disclose by encouraging a few group members' self-disclose behavior. This example illustrates the Boolean network as a flexible method that allows for modeling of assimilative and repulsive social influences that simultaneously operate in a group process and design of strategies that can be used to direct the group process to desired states (without manipulating the social ties). This dissertation introduces and forwards the Boolean network method as a method that can be used to describe and control a system's trajectory. The final chapter, Chapter 4, summarizes the contribution of this dissertation in terms of method innovation, theory, data, and potential applications, and begins to elaborate how the method might be extended further. To our knowledge, this is the first application of the Boolean network method in describing and controlling nonlinear psychological processes. The Boolean network method follows the long-standing tradition of using dynamical system methods to explain, model, and predict how complex psychological systems operate and change over time. This dissertation adds to that literature by providing the methodological steps and empirical examples that will enable control system design for nonlinear within- and between-person dynamics. Our demonstration emphasizes the appeal of this method for both theory and practice -- providing simple descriptions and explanations of system dynamics and system control strategies. Altogether, this dissertation forwards and provides access to a useful tool that can help researchers discover, understand, and shape many different kinds of psychological dynamics.

Analysis and Control of Boolean Networks

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Publisher : Springer Science & Business Media
ISBN 13 : 0857290975
Total Pages : 474 pages
Book Rating : 4.8/5 (572 download)

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Book Synopsis Analysis and Control of Boolean Networks by : Daizhan Cheng

Download or read book Analysis and Control of Boolean Networks written by Daizhan Cheng and published by Springer Science & Business Media. This book was released on 2010-11-23 with total page 474 pages. Available in PDF, EPUB and Kindle. Book excerpt: Analysis and Control of Boolean Networks presents a systematic new approach to the investigation of Boolean control networks. The fundamental tool in this approach is a novel matrix product called the semi-tensor product (STP). Using the STP, a logical function can be expressed as a conventional discrete-time linear system. In the light of this linear expression, certain major issues concerning Boolean network topology – fixed points, cycles, transient times and basins of attractors – can be easily revealed by a set of formulae. This framework renders the state-space approach to dynamic control systems applicable to Boolean control networks. The bilinear-systemic representation of a Boolean control network makes it possible to investigate basic control problems including controllability, observability, stabilization, disturbance decoupling etc.

Probabilistic Boolean Networks

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Publisher : SIAM
ISBN 13 : 0898716926
Total Pages : 276 pages
Book Rating : 4.8/5 (987 download)

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Book Synopsis Probabilistic Boolean Networks by : Ilya Shmulevich

Download or read book Probabilistic Boolean Networks written by Ilya Shmulevich and published by SIAM. This book was released on 2010-01-21 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first comprehensive treatment of probabilistic Boolean networks, unifying different strands of current research and addressing emerging issues.

Modeling and Control of Complex Systems

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Publisher : CRC Press
ISBN 13 : 0849379865
Total Pages : 552 pages
Book Rating : 4.8/5 (493 download)

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Book Synopsis Modeling and Control of Complex Systems by : Petros A. Ioannou

Download or read book Modeling and Control of Complex Systems written by Petros A. Ioannou and published by CRC Press. This book was released on 2007-12-26 with total page 552 pages. Available in PDF, EPUB and Kindle. Book excerpt: Comprehension of complex systems comes from an understanding of not only the behavior of constituent elements but how they act together to form the behavior of the whole. However, given the multidisciplinary nature of complex systems, the scattering of information across different areas creates a chaotic situation for those trying to understand pos

Logical Modeling of Cellular Processes: From Software Development to Network Dynamics

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Publisher : Frontiers Media SA
ISBN 13 : 2889459837
Total Pages : 340 pages
Book Rating : 4.8/5 (894 download)

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Book Synopsis Logical Modeling of Cellular Processes: From Software Development to Network Dynamics by : Matteo Barberis

Download or read book Logical Modeling of Cellular Processes: From Software Development to Network Dynamics written by Matteo Barberis and published by Frontiers Media SA. This book was released on 2019-08-16 with total page 340 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mathematical models have become invaluable tools for understanding the intricate dynamic behavior of complex biochemical and biological systems. Among computational strategies, logical modeling has been recently gaining interest as an alternative approach to address network dynamics. Due to its advantages, including scalability and independence of kinetic parameters, the logical modeling framework is becoming increasingly popular to study the dynamics of highly interconnected systems, such as cell cycle progression, T cell differentiation and gene regulation. Novel tools and standards have been developed to increase the interoperability of logical models, which can now be employ to respond a variety of biological questions. This Research Topic brings together the most recent and cutting-edge approaches in the area of logical modeling including, among others, novel biological applications, software development and model analysis techniques.

Algebraic and Discrete Mathematical Methods for Modern Biology

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Publisher : Academic Press
ISBN 13 : 0128012714
Total Pages : 383 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Algebraic and Discrete Mathematical Methods for Modern Biology by : Raina Robeva

Download or read book Algebraic and Discrete Mathematical Methods for Modern Biology written by Raina Robeva and published by Academic Press. This book was released on 2015-05-09 with total page 383 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by experts in both mathematics and biology, Algebraic and Discrete Mathematical Methods for Modern Biology offers a bridge between math and biology, providing a framework for simulating, analyzing, predicting, and modulating the behavior of complex biological systems. Each chapter begins with a question from modern biology, followed by the description of certain mathematical methods and theory appropriate in the search of answers. Every topic provides a fast-track pathway through the problem by presenting the biological foundation, covering the relevant mathematical theory, and highlighting connections between them. Many of the projects and exercises embedded in each chapter utilize specialized software, providing students with much-needed familiarity and experience with computing applications, critical components of the "modern biology" skill set. This book is appropriate for mathematics courses such as finite mathematics, discrete structures, linear algebra, abstract/modern algebra, graph theory, probability, bioinformatics, statistics, biostatistics, and modeling, as well as for biology courses such as genetics, cell and molecular biology, biochemistry, ecology, and evolution. - Examines significant questions in modern biology and their mathematical treatments - Presents important mathematical concepts and tools in the context of essential biology - Features material of interest to students in both mathematics and biology - Presents chapters in modular format so coverage need not follow the Table of Contents - Introduces projects appropriate for undergraduate research - Utilizes freely accessible software for visualization, simulation, and analysis in modern biology - Requires no calculus as a prerequisite - Provides a complete Solutions Manual - Features a companion website with supplementary resources

On Construction and Control of Probabilistic Boolean Networks

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Publisher : Open Dissertation Press
ISBN 13 : 9781361281581
Total Pages : pages
Book Rating : 4.2/5 (815 download)

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Book Synopsis On Construction and Control of Probabilistic Boolean Networks by : XI Chen, (Ch

Download or read book On Construction and Control of Probabilistic Boolean Networks written by XI Chen, (Ch and published by Open Dissertation Press. This book was released on 2017-01-26 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This dissertation, "On Construction and Control of Probabilistic Boolean Networks" by Xi, Chen, 陈曦, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. Abstract: Modeling gene regulation is an important problem in genomic research. The Boolean network (BN) and its generalization Probabilistic Boolean network (PBN) have been proposed to model genetic regulatory interactions. BN is a deterministic model while PBN is a stochastic model. In a PBN, on one hand, its stationary distribution gives important information about the long-run behavior of the network. On the other hand, one may be interested in system synthesis which requires the construction of networks from the observed stationary distribution. This results in an inverse problem of constructing PBNs from a given stationary distribution and a given set of Boolean Networks (BNs), which is ill-posed and challenging, because there may be many networks or no network having the given properties and the size of the inverse problem is huge. The inverse problem is first formulated as a constrained least squares problem. A heuristic method is then proposed based on the conjugate gradient (CG) algorithm, an iterative method, to solve the resulting least squares problem. An estimation method for the parameters of the PBNs is also discussed. Numerical examples are then given to demonstrate the effectiveness of the proposed methods. However, the PBNs generated by the above algorithm depends on the initial guess and is not unique. A heuristic method is then proposed for generating PBNs from a given transition probability matrix. Unique solution can be obtained in this case. Moreover, these algorithms are able to recover the dominated BNs and therefore the major structure of the network. To further evaluate the feasible solutions, a maximum entropy approach is proposed using entropy as a measure of the fitness. Newton's method in conjunction with the CG method is then applied to solving the inverse problem. The convergence rate of the proposed method is demonstrated. Numerical examples are also given to demonstrate the effectiveness of our proposed method. Another important problem is to find the optimal control policy for a PBN so as to avoid the network from entering into undesirable states. By applying external control, the network is desired to enter into some state within a few time steps. For PBN CONTROL, people propose to find a control sequence such that the network will terminate in the desired state with a maximum probability. Also, the problem of minimizing the maximum cost is considered. Integer linear programming (ILP) and dynamic programming (DP) in conjunction with hard constraints are then employed to solve the above problems. Numerical experiments are given to demonstrate the effectiveness of our algorithms. A hardness result is demonstrated and suggests that PBN CONTROL is harder than BN CONTROL. In addition, deciding the steady state probability in PBN for a specified global state is demonstrated to be NP-hard. However, due to the high computational complexity of PBNs, DP method is computationally inefficient for a large size network. Inspired by the state reduction strategies studied in [86], the DP method in conjunction with state reduction approach is then proposed to reduce the computational cost of the DP method. Numerical examples are given to demonstrate both the effectiveness and the efficiency of our proposed method. DOI: 10.5353/th_b4832960 Subjects: Genetic regulation - Mathematical models Algebra, Boo

Understanding the Dynamics of Biological Systems

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Publisher : Springer Science & Business Media
ISBN 13 : 1441979646
Total Pages : 249 pages
Book Rating : 4.4/5 (419 download)

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Book Synopsis Understanding the Dynamics of Biological Systems by : Werner Dubitzky

Download or read book Understanding the Dynamics of Biological Systems written by Werner Dubitzky and published by Springer Science & Business Media. This book was released on 2011-01-07 with total page 249 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is intended as a communication platform to bridge the cultural, conceptual, and technological gap among the key systems biology disciplines of biology, mathematics, and information technology. To support this goal, contributors were asked to adopts an approach that appeals to audiences from different backgrounds.

Discrete-Time and Discrete-Space Dynamical Systems

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Publisher : Springer
ISBN 13 : 3030259722
Total Pages : 222 pages
Book Rating : 4.0/5 (32 download)

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Book Synopsis Discrete-Time and Discrete-Space Dynamical Systems by : Kuize Zhang

Download or read book Discrete-Time and Discrete-Space Dynamical Systems written by Kuize Zhang and published by Springer. This book was released on 2019-08-06 with total page 222 pages. Available in PDF, EPUB and Kindle. Book excerpt: Discrete-Time and Discrete-Space Dynamical Systems provides a systematic characterization of the similarities and differences of several types of discrete-time and discrete-space dynamical systems, including: Boolean control networks; nondeterministic finite-transition systems; finite automata; labelled Petri nets; and cellular automata. The book's perspective is primarily based on topological properties though it also employs semitensor-product and graph-theoretic methods where appropriate. It presents a series of fundamental results: invertibility, observability, detectability, reversiblity, etc., with applications to systems biology. Academic researchers with backgrounds in applied mathematics, engineering or computer science and practising engineers working with discrete-time and discrete-space systems will find this book a helpful source of new understanding for this increasingly important class of systems. The basic results to be found within are of fundamental importance for further study of related problems such as automated synthesis and safety control in cyber-physical systems using formal methods.

Computational Intelligence in Music, Sound, Art and Design

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Publisher : Springer
ISBN 13 : 3319775839
Total Pages : 326 pages
Book Rating : 4.3/5 (197 download)

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Book Synopsis Computational Intelligence in Music, Sound, Art and Design by : Antonios Liapis

Download or read book Computational Intelligence in Music, Sound, Art and Design written by Antonios Liapis and published by Springer. This book was released on 2018-03-24 with total page 326 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book constitutes the refereed proceedings of the 7th International Conference on Evolutionary Computation in Combinatorial Optimization, EvoMUSART 2018, held in Parma, Italy, in April 2018, co-located with the Evo*2017 events EuroGP, EvoCOP and EvoApplications. The 21 revised full papers presented were carefully reviewed and selected from 33 submissions. The papers cover a wide range of topics and application areas, including: generative approaches to music and visual art; medical art therapy; visualization in virtual reality; jewellery design; interactive evolutionary computation; and the art theory of evolutionary computation.

Systems Biology of Cell Signaling

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Publisher : Frontiers Media SA
ISBN 13 : 2889742814
Total Pages : 224 pages
Book Rating : 4.8/5 (897 download)

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Book Synopsis Systems Biology of Cell Signaling by : Zhike Zi

Download or read book Systems Biology of Cell Signaling written by Zhike Zi and published by Frontiers Media SA. This book was released on 2022-02-17 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt: Topic Editor Prof. Xing is in collaboration with ATCC (https://www.atcc.org/) on testing some of their cell lines in research. All other Topic Editors declare no competing interests with regards to the Research Topic subject.

Genomic Control Process

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Publisher : Academic Press
ISBN 13 : 0124047467
Total Pages : 461 pages
Book Rating : 4.1/5 (24 download)

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Book Synopsis Genomic Control Process by : Isabelle S. Peter

Download or read book Genomic Control Process written by Isabelle S. Peter and published by Academic Press. This book was released on 2015-01-21 with total page 461 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genomic Control Process explores the biological phenomena around genomic regulatory systems that control and shape animal development processes, and which determine the nature of evolutionary processes that affect body plan. Unifying and simplifying the descriptions of development and evolution by focusing on the causality in these processes, it provides a comprehensive method of considering genomic control across diverse biological processes. This book is essential for graduate researchers in genomics, systems biology and molecular biology seeking to understand deep biological processes which regulate the structure of animals during development. - Covers a vast area of current biological research to produce a genome oriented regulatory bioscience of animal life - Places gene regulation, embryonic and postembryonic development, and evolution of the body plan in a unified conceptual framework - Provides the conceptual keys to interpret a broad developmental and evolutionary landscape with precise experimental illustrations drawn from contemporary literature - Includes a range of material, from developmental phenomenology to quantitative and logic models, from phylogenetics to the molecular biology of gene regulation, from animal models of all kinds to evidence of every relevant type - Demonstrates the causal power of system-level understanding of genomic control process - Conceptually organizes a constellation of complex and diverse biological phenomena - Investigates fundamental developmental control system logic in diverse circumstances and expresses these in conceptual models - Explores mechanistic evolutionary processes, illuminating the evolutionary consequences of developmental control systems as they are encoded in the genome

Fractal and Multifractal Facets in the Structure and Dynamics of Physiological Systems and Applications to Homeostatic Control, Disease Diagnosis and Integrated Cyber-Physical Platforms

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Publisher : Frontiers Media SA
ISBN 13 : 2889635317
Total Pages : 180 pages
Book Rating : 4.8/5 (896 download)

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Book Synopsis Fractal and Multifractal Facets in the Structure and Dynamics of Physiological Systems and Applications to Homeostatic Control, Disease Diagnosis and Integrated Cyber-Physical Platforms by : Paul Bogdan

Download or read book Fractal and Multifractal Facets in the Structure and Dynamics of Physiological Systems and Applications to Homeostatic Control, Disease Diagnosis and Integrated Cyber-Physical Platforms written by Paul Bogdan and published by Frontiers Media SA. This book was released on 2020-06-25 with total page 180 pages. Available in PDF, EPUB and Kindle. Book excerpt: Widespread chronic diseases (e.g., heart diseases, diabetes and its complications, stroke, cancer, brain diseases) constitute a significant cause of rising healthcare costs and pose a significant burden on quality-of-life for many individuals. Despite the increased need for smart healthcare sensing systems that monitor / measure patients’ body balance, there is no coherent theory that facilitates the modeling of human physiological processes and the design and optimization of future healthcare cyber-physical systems (HCPS). The HCPS are expected to mine the patient’s physiological state based on available continuous sensing, quantify risk indices corresponding to the onset of abnormality, signal the need for critical medical intervention in real-time by communicating patient’s medical information via a network from individual to hospital, and most importantly control (actuate) vital health signals (e.g., cardiac pacing, insulin level, blood pressure) within personalized homeostasis. To prevent health complications, maintain good health and/or avoid fatal conditions calls for a cross-disciplinary approach to HCPS design where recent statistical-physics inspired discoveries done by collaborations between physicists and physicians are shared and enriched by applied mathematicians, control theorists and bioengineers. This critical and urgent multi-disciplinary approach has to unify the current state of knowledge and address the following fundamental challenges: One fundamental challenge is represented by the need to mine and understand the complexity of the structure and dynamics of the physiological systems in healthy homeostasis and associated with a disease (such as diabetes). Along the same lines, we need rigorous mathematical techniques for identifying the interactions between integrated physiologic systems and understanding their role within the overall networking architecture of healthy dynamics. Another fundamental challenge calls for a deeper understanding of stochastic feedback and variability in biological systems and physiological processes, in particular, and for deciphering their implications not only on how to mathematically characterize homeostasis, but also on defining new control strategies that are accounting for intra- and inter-patient specificity – a truly mathematical approach to personalized medicine. Numerous recent studies have demonstrated that heart rate variability, blood glucose, neural signals and other interdependent physiological processes demonstrate fractal and non-stationary characteristics. Exploiting statistical physics concepts, numerous recent research studies demonstrated that healthy human physiological processes exhibit complex critical phenomena with deep implications for how homeostasis should be defined and how control strategies should be developed when prolonged abnormal deviations are observed. In addition, several efforts have tried to connect these fractal characteristics with new optimal control strategies that implemented in medical devices such as pacemakers and artificial pancreas could improve the efficiency of medical therapies and the quality-of-life of patients but neglecting the overall networking architecture of human physiology. Consequently, rigorously analyzing the complexity and dynamics of physiological processes (e.g., blood glucose and its associated implications and interdependencies with other physiological processes) represents a fundamental step towards providing a quantifiable (mathematical) definition of homeostasis in the context of critical phenomena, understanding the onset of chronic diseases, predicting deviations from healthy homeostasis and developing new more efficient medical therapies that carefully account for the physiological complexity, intra- and inter-patient variability, rather than ignoring it. This Research Topic aims to open a synergetic and timely effort between physicians, physicists, applied mathematicians, signal processing, bioengineering and biomedical experts to organize the state of knowledge in mining the complexity of physiological systems and their implications for constructing more accurate mathematical models and designing QoL-aware control strategies implemented in the new generation of HCPS devices. By bringing together multi-disciplinary researchers seeking to understand the many aspects of human physiology and its complexity, we aim at enabling a paradigm shift in designing future medical devices that translates mathematical characteristics in predictable mathematical models quantifying not only the degree of homeostasis, but also providing fundamentally new control strategies within the personalized medicine era.

Environmental Health Perspectives

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Publisher :
ISBN 13 :
Total Pages : 1724 pages
Book Rating : 4.E/5 ( download)

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Book Synopsis Environmental Health Perspectives by :

Download or read book Environmental Health Perspectives written by and published by . This book was released on 2000 with total page 1724 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Computational Biology for Stem Cell Research

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Publisher : Elsevier
ISBN 13 : 0443132216
Total Pages : 568 pages
Book Rating : 4.4/5 (431 download)

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Book Synopsis Computational Biology for Stem Cell Research by : Pawan Raghav

Download or read book Computational Biology for Stem Cell Research written by Pawan Raghav and published by Elsevier. This book was released on 2024-01-12 with total page 568 pages. Available in PDF, EPUB and Kindle. Book excerpt: Computational Biology for Stem Cell Research is an invaluable guide for researchers as they explore HSCs and MSCs in computational biology. With the growing advancement of technology in the field of biomedical sciences, computational approaches have reduced the financial and experimental burden of the experimental process. In the shortest span, it has established itself as an integral component of any biological research activity. HSC informatics (in silico) techniques such as machine learning, genome network analysis, data mining, complex genome structures, docking, system biology, mathematical modeling, programming (R, Python, Perl, etc.) help to analyze, visualize, network constructions, and protein-ligand or protein-protein interactions. This book is aimed at beginners with an exact correlation between the biomedical sciences and in silico computational methods for HSCs transplantation and translational research and provides insights into methods targeting HSCs properties like proliferation, self-renewal, differentiation, and apoptosis. Modeling Stem Cell Behavior: Explore stem cell behavior through animal models, bridging laboratory studies to real-world clinical allogeneic HSC transplantation (HSCT) scenarios. Bioinformatics-Driven Translational Research: Navigate a path from bench to bedside with cutting-edge bioinformatics approaches, translating computational insights into tangible advancements in stem cell research and medical applications. Interdisciplinary Resource: Discover a single comprehensive resource catering to biomedical sciences, life sciences, and chemistry fields, offering essential insights into computational tools vital for modern research.

Computational Methods for Understanding Complexity: The Use of Formal Methods in Biology

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Publisher : Frontiers Media SA
ISBN 13 : 2889450422
Total Pages : 115 pages
Book Rating : 4.8/5 (894 download)

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Book Synopsis Computational Methods for Understanding Complexity: The Use of Formal Methods in Biology by : David A. Rosenblueth,

Download or read book Computational Methods for Understanding Complexity: The Use of Formal Methods in Biology written by David A. Rosenblueth, and published by Frontiers Media SA. This book was released on 2016-11-21 with total page 115 pages. Available in PDF, EPUB and Kindle. Book excerpt: The complexity of living organisms surpasses our unaided habilities of analysis. Hence, computational and mathematical methods are necessary for increasing our understanding of biological systems. At the same time, there has been a phenomenal recent progress allowing the application of novel formal methods to new domains. This progress has spurred a conspicuous optimism in computational biology. This optimism, in turn, has promoted a rapid increase in collaboration between specialists of biology with specialists of computer science. Through sheer complexity, however, many important biological problems are at present intractable, and it is not clear whether we will ever be able to solve such problems. We are in the process of learning what kind of model and what kind of analysis and synthesis techniques to use for a particular problem. Some existing formalisms have been readily used in biological problems, others have been adapted to biological needs, and still others have been especially developed for biological systems. This Research Topic has examples of cases (1) employing existing methods, (2) adapting methods to biology, and (3) developing new methods. We can also see discrete and Boolean models, and the use of both simulators and model checkers. Synthesis is exemplified by manual and by machine-learning methods. We hope that the articles collected in this Research Topic will stimulate new research.

Scientific and Technical Aerospace Reports

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Publisher :
ISBN 13 :
Total Pages : 1572 pages
Book Rating : 4.:/5 (31 download)

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Book Synopsis Scientific and Technical Aerospace Reports by :

Download or read book Scientific and Technical Aerospace Reports written by and published by . This book was released on 1992 with total page 1572 pages. Available in PDF, EPUB and Kindle. Book excerpt: