Unfolding The Intracellular Lifestyle Of Brucella

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Unfolding the Intracellular Lifestyle of Brucella

Author : Mike Khan
Publisher :
ISBN 13 :
Total Pages : 188 pages
Book Rating : 4.:/5 (11 download)

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Book Synopsis Unfolding the Intracellular Lifestyle of Brucella by : Mike Khan

Download or read book Unfolding the Intracellular Lifestyle of Brucella written by Mike Khan and published by . This book was released on 2017 with total page 188 pages. Available in PDF, EPUB and Kindle. Book excerpt: Brucella species are Gram-negative, intracellular pathogens which cause brucellosis, the most common zoonosis worldwide. Human brucellosis is a severely debilitating disease with a major socioeconomic impact. Brucellosis has eluded systematic attempts at eradication for more than a century in even the most developed countries. Currently, no human vaccine exists and vaccines used on animals present many difficulties. Brucella spp. invade many cell and tissue types including reproductive tissues, neurons, epithelial, and non-professional and professional phagocytes. The intracellular lifestyle of Brucella limits exposure to the host innate and adaptive immune responses and sequesters the organisms from the effects of antibiotics. The mechanisms by which Brucella subverts the host to enable chronic infection remain unclear. To better design future vaccines, further knowledge of these mechanisms is critical. The goal of this thesis was to elucidate mechanisms from both the host and the pathogen that contribute to the intracellular lifestyle of Brucella. In Chapter II, we describe how Brucella triggers the host Unfolded Protein Response, which supports its intracellular survival. In Chapter III, we describe the effects of the ubiquitous bacterial second messenger, cyclic-di-GMP, on Brucella virulence and host immune pathways. Finally, in Chapter IV, we describe the active evasion of innate immunity by Brucella through the up-regulation of microRNA 24. Taken together, these data identify novel host and bacterial mechanisms that contribute to the long-term survival of Brucella as well as provide novel targets for future vaccines and therapeutics.

Unfolding the Intracellular Lifestyle of Brucella

Author : Mike Khan
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (12 download)

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Book Synopsis Unfolding the Intracellular Lifestyle of Brucella by : Mike Khan

Download or read book Unfolding the Intracellular Lifestyle of Brucella written by Mike Khan and published by . This book was released on 2017 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Brucella species are Gram-negative, intracellular pathogens which cause brucellosis, the most common zoonosis worldwide. Human brucellosis is a severely debilitating disease with a major socioeconomic impact. Brucellosis has eluded systematic attempts at eradication for more than a century in even the most developed countries. Currently, no human vaccine exists and vaccines used on animals present many difficulties. Brucella spp. invade many cell and tissue types including reproductive tissues, neurons, epithelial, and non-professional and professional phagocytes. The intracellular lifestyle of Brucella limits exposure to the host innate and adaptive immune responses and sequesters the organisms from the effects of antibiotics. The mechanisms by which Brucella subverts the host to enable chronic infection remain unclear. To better design future vaccines, further knowledge of these mechanisms is critical. The goal of this thesis was to elucidate mechanisms from both the host and the pathogen that contribute to the intracellular lifestyle of Brucella. In Chapter II, we describe how Brucella triggers the host Unfolded Protein Response, which supports its intracellular survival. In Chapter III, we describe the effects of the ubiquitous bacterial second messenger, cyclic-di-GMP, on Brucella virulence and host immune pathways. Finally, in Chapter IV, we describe the active evasion of innate immunity by Brucella through the up-regulation of microRNA 24. Taken together, these data identify novel host and bacterial mechanisms that contribute to the long-term survival of Brucella as well as provide novel targets for future vaccines and therapeutics.

Importance of Intracellular Lifestyle of Brucella Melitensis on Immunity and Pathogenesis

Author : Diogo Magnani
Publisher :
ISBN 13 :
Total Pages : 150 pages
Book Rating : 4.:/5 (794 download)

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Book Synopsis Importance of Intracellular Lifestyle of Brucella Melitensis on Immunity and Pathogenesis by : Diogo Magnani

Download or read book Importance of Intracellular Lifestyle of Brucella Melitensis on Immunity and Pathogenesis written by Diogo Magnani and published by . This book was released on 2011 with total page 150 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Pathogenomics of the Genus Brucella and Beyond

Author : Axel Cloeckaert
Publisher : Frontiers Media SA
ISBN 13 : 2889712850
Total Pages : 367 pages
Book Rating : 4.8/5 (897 download)

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Book Synopsis Pathogenomics of the Genus Brucella and Beyond by : Axel Cloeckaert

Download or read book Pathogenomics of the Genus Brucella and Beyond written by Axel Cloeckaert and published by Frontiers Media SA. This book was released on 2021-09-13 with total page 367 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Revisiting Brucellosis in the Greater Yellowstone Area

Author : National Academies of Sciences, Engineering, and Medicine
Publisher : National Academies Press
ISBN 13 : 0309458315
Total Pages : 211 pages
Book Rating : 4.3/5 (94 download)

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Book Synopsis Revisiting Brucellosis in the Greater Yellowstone Area by : National Academies of Sciences, Engineering, and Medicine

Download or read book Revisiting Brucellosis in the Greater Yellowstone Area written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2021-01-30 with total page 211 pages. Available in PDF, EPUB and Kindle. Book excerpt: Brucellosis is a nationally and internationally regulated disease of livestock with significant consequences for animal health, public health, and international trade. In cattle, the primary cause of brucellosis is Brucella abortus, a zoonotic bacterial pathogen that also affects wildlife, including bison and elk. As a result of the Brucellosis Eradication Program that began in 1934, most of the country is now free of bovine brucellosis. The Greater Yellowstone Area (GYA), where brucellosis is endemic in bison and elk, is the last known B. abortus reservoir in the United States. The GYA is home to more than 5,500 bison that are the genetic descendants of the original free-ranging bison herds that survived in the early 1900s, and home to more than 125,000 elk whose habitats are managed through interagency efforts, including the National Elk Refuge and 22 supplemental winter feedgrounds maintained in Wyoming. In 1998 the National Research Council (NRC) issued a report, Brucellosis in the Greater Yellowstone Area, that reviewed the scientific knowledge regarding B. abortus transmission among wildlifeâ€"particularly bison and elkâ€"and cattle in the GYA. Since the release of the 1998 report, brucellosis has re-emerged in domestic cattle and bison herds in that area. Given the scientific and technological advances in two decades since that first report, Revisiting Brucellosis in the Greater Yellowstone Area explores the factors associated with the increased transmission of brucellosis from wildlife to livestock, the recent apparent expansion of brucellosis in non-feedground elk, and the desire to have science inform the course of any future actions in addressing brucellosis in the GYA.

Type IV Secretion in Gram-Negative and Gram-Positive Bacteria

Author : Steffen Backert
Publisher : Springer
ISBN 13 : 3319752413
Total Pages : 364 pages
Book Rating : 4.3/5 (197 download)

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Book Synopsis Type IV Secretion in Gram-Negative and Gram-Positive Bacteria by : Steffen Backert

Download or read book Type IV Secretion in Gram-Negative and Gram-Positive Bacteria written by Steffen Backert and published by Springer. This book was released on 2018-03-13 with total page 364 pages. Available in PDF, EPUB and Kindle. Book excerpt: Type IV secretion systems (T4SSs) are highly versatile membrane-associated transporter machines used by Gram-negative and Gram-positive bacteria to deliver substrate molecules to a large variety of target cells. This volume summarizes our current knowledge of the large variety and structural diversity of T4SSs in pathogenic Escherichia, Agrobacterium, Legionella, Coxiella, Bartonella, Helicobacter, Enterococcus and other species. Divided into 13 chapters contributed by leading experts, it presents findings that significantly enhance our understanding of how various pathogens manipulate host cell functions to trigger bacterial uptake, promote intracellular growth, suppress defense mechanisms and of how bacteria spread antibiotic resistances, thus facilitating bacterial colonization and disease development. The book is an invaluable source of information for researchers and clinicians.

Wildlife Disease Ecology

Author : Kenneth Wilson
Publisher : Cambridge University Press
ISBN 13 : 1107136563
Total Pages : 693 pages
Book Rating : 4.1/5 (71 download)

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Book Synopsis Wildlife Disease Ecology by : Kenneth Wilson

Download or read book Wildlife Disease Ecology written by Kenneth Wilson and published by Cambridge University Press. This book was released on 2019-11-14 with total page 693 pages. Available in PDF, EPUB and Kindle. Book excerpt: Introduces readers to key case studies that illustrate how theory and data can be integrated to understand wildlife disease ecology.

Virulence Mechanisms of Bacterial Pathogens

Author : Indira T. Kudva
Publisher : John Wiley & Sons
ISBN 13 : 1555819281
Total Pages : 871 pages
Book Rating : 4.5/5 (558 download)

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Book Synopsis Virulence Mechanisms of Bacterial Pathogens by : Indira T. Kudva

Download or read book Virulence Mechanisms of Bacterial Pathogens written by Indira T. Kudva and published by John Wiley & Sons. This book was released on 2020-07-10 with total page 871 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ground-breaking overview of an enduring topic Despite the use of antibiotics, bacterial diseases continue to be a critical issue in public health, and bacterial pathogenesis remains a tantalizing problem for research microbiologists. This new edition of Virulence Mechanisms of Bacterial Pathogens broadly covers the knowledge base surrounding this topic and presents recently unraveled bacterial virulence strategies and cutting-edge therapies. A team of editors, led by USDA scientist Indira Kudva, compiled perspectives from experts to explain the wide variety of mechanisms through which bacterial pathogens cause disease: the host interface, host cell enslavement, and bacterial communication, secretion, defenses, and persistence. A collection of reviews on targeted therapies rounds out the seven sections of this unique book. The new edition provides insights into some of the most recent advances in the area of bacterial pathogenesis, including how metabolism shapes the host-pathogen interface interactions across species and genera mechanisms of the secretion systems evasion, survival, and persistence mechanisms new therapies targeting various adaptive and virulence mechanisms of bacterial pathogens Written to promote discussion, extrapolation, exploration, and multidimensional thinking, Virulence Mechanisms of Bacterial Pathogens serves as a textbook for graduate courses on bacterial pathogenesis and a resource for specialists in bacterial pathogenicity, such as molecular biologists, physician scientists, infectious disease clinicians, dental scientists, veterinarians, molecular biologists, industry researchers, and technicians.

Modulation of the immune system by bacteria: from evasion to therapy

Author : Marina De Bernard
Publisher : Frontiers Media SA
ISBN 13 : 2832520227
Total Pages : 227 pages
Book Rating : 4.8/5 (325 download)

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Book Synopsis Modulation of the immune system by bacteria: from evasion to therapy by : Marina De Bernard

Download or read book Modulation of the immune system by bacteria: from evasion to therapy written by Marina De Bernard and published by Frontiers Media SA. This book was released on 2023-04-10 with total page 227 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Desk Encyclopedia of Microbiology

Author : Moselio Schaechter
Publisher : Academic Press
ISBN 13 : 0080961282
Total Pages : 1277 pages
Book Rating : 4.0/5 (89 download)

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Book Synopsis Desk Encyclopedia of Microbiology by : Moselio Schaechter

Download or read book Desk Encyclopedia of Microbiology written by Moselio Schaechter and published by Academic Press. This book was released on 2010-04-19 with total page 1277 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Desk Encyclopedia of Microbiology, Second Edition is a single-volume comprehensive guide to microbiology for the advanced reader. Derived from the six volume e-only Encyclopedia of Microbiology, Third Edition, it bridges the gap between introductory texts and specialized reviews. Covering topics ranging from the basic science of microbiology to the current "hot" topics in the field, it will be invaluable for obtaining background information on a broad range of microbiological topics, preparing lectures and preparing grant applications and reports. - The most comprehensive single-volume source providing an overview of microbiology to non-specialists - Bridges the gap between introductory texts and specialized reviews - Provides concise and general overviews of important topics within the field making it a helpful resource when preparing for lectures, writing reports, or drafting grant applications

Encyclopedia of Infectious Diseases

Author : Michel Tibayrenc
Publisher : John Wiley & Sons
ISBN 13 : 0470114193
Total Pages : 807 pages
Book Rating : 4.4/5 (71 download)

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Book Synopsis Encyclopedia of Infectious Diseases by : Michel Tibayrenc

Download or read book Encyclopedia of Infectious Diseases written by Michel Tibayrenc and published by John Wiley & Sons. This book was released on 2007-07-31 with total page 807 pages. Available in PDF, EPUB and Kindle. Book excerpt: Discover how the application of novel multidisciplinary, integrative approaches and technologies are dramatically changing our understanding of the pathogenesis of infectious diseases and their treatments. Each article presents the state of the science, with a strong emphasis on new and emerging medical applications. The Encyclopedia of Infectious Diseases is organized into five parts. The first part examines current threats such as AIDS, malaria, SARS, and influenza. The second part addresses the evolution of pathogens and the relationship between human genetic diversity and the spread of infectious diseases. The next two parts highlight the most promising uses of molecular identification, vector control, satellite detection, surveillance, modeling, and high-throughput technologies. The final part explores specialized topics of current concern, including bioterrorism, world market and infectious diseases, and antibiotics for public health. Each article is written by one or more leading experts in the field of infectious diseases. These experts place all the latest findings from various disciplines in context, helping readers understand what is currently known, what the next generation of breakthroughs is likely to be, and where more research is needed. Several features facilitate research and deepen readers' understanding of infectious diseases: Illustrations help readers understand the pathogenesis and diagnosis of infectious diseases Lists of Web resources serve as a gateway to important research centers, government agencies, and other sources of information from around the world Information boxes highlight basic principles and specialized terminology International contributions offer perspectives on how infectious diseases are viewed by different cultures A special chapter discusses the representation of infectious diseases in art With its multidisciplinary approach, this encyclopedia helps point researchers in new promising directions and helps health professionals better understand the nature and treatment of infectious diseases.

Regulated Proteolysis in Microorganisms

Author : David A. Dougan
Publisher : Springer Science & Business Media
ISBN 13 : 9400759401
Total Pages : 338 pages
Book Rating : 4.4/5 (7 download)

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Book Synopsis Regulated Proteolysis in Microorganisms by : David A. Dougan

Download or read book Regulated Proteolysis in Microorganisms written by David A. Dougan and published by Springer Science & Business Media. This book was released on 2013-03-12 with total page 338 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book contains an extensive collection of critical reviews, from leading researchers in the field of regulated protein degradation. It covers the role of regulated proteolysis in a range of microorganisms (from Gram positive, Gram negative and pathogenic bacteria to Archaea and the Baker’s yeast Saccharomyces cerevisiae).

Model Organisms for Microbial Pathogenesis, Biofilm Formation and Antimicrobial Drug Discovery

Author : Busi Siddhardha
Publisher : Springer Nature
ISBN 13 : 9811516952
Total Pages : 685 pages
Book Rating : 4.8/5 (115 download)

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Book Synopsis Model Organisms for Microbial Pathogenesis, Biofilm Formation and Antimicrobial Drug Discovery by : Busi Siddhardha

Download or read book Model Organisms for Microbial Pathogenesis, Biofilm Formation and Antimicrobial Drug Discovery written by Busi Siddhardha and published by Springer Nature. This book was released on 2020-03-28 with total page 685 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides essential insights into microbial pathogenesis, host-pathogen interactions, and the anti-microbial drug resistance of various human pathogens on the basis of various model organisms. The initial sections of the book introduce readers to the mechanisms of microbial pathogenesis, host-pathogen interactions, anti-microbial drug resistance, and the dynamics of biofilm formation. Due to the emergence of various microbial resistant strains, it is especially important to understand the prognosis for microbial infections, disease progression profiles, and mechanisms of resistance to antibiotic therapy in order to develop novel therapeutic strategies. In turn, the second part of the book presents a comparative analysis of various animal models to help readers understand microbial pathogenesis, host-pathogen interactions, anti-microbial drug discovery, anti-biofilm therapeutics, and treatment regimes. Given its scope, the book represents a valuable asset for microbiologists, biotechnologists, medical professionals, drug development researchers, and pharmacologists alike.

Metabolic Interaction in Infection

Author : Ricardo Silvestre
Publisher : Springer
ISBN 13 : 3319749323
Total Pages : 478 pages
Book Rating : 4.3/5 (197 download)

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Book Synopsis Metabolic Interaction in Infection by : Ricardo Silvestre

Download or read book Metabolic Interaction in Infection written by Ricardo Silvestre and published by Springer. This book was released on 2018-04-06 with total page 478 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on host–pathogen interactions at the metabolic level. It explores the metabolic requirements of the infectious agents, the microbial metabolic pathways that are dedicated to circumvent host immune mechanisms as well as the molecular mechanisms by which pathogens hijack host cell metabolism for their own benefit. Finally, it provides insights on the possible clinical and immunotherapeutic applications, as well as on the available experimental and analytical methods. The contributions break new ground in understanding the metabolic crosstalk between host and pathogen.

Bacterial Virulence Factors and Rho GTPases

Author : Patrice Boquet
Publisher : Springer Science & Business Media
ISBN 13 : 9783540238652
Total Pages : 216 pages
Book Rating : 4.2/5 (386 download)

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Book Synopsis Bacterial Virulence Factors and Rho GTPases by : Patrice Boquet

Download or read book Bacterial Virulence Factors and Rho GTPases written by Patrice Boquet and published by Springer Science & Business Media. This book was released on 2005-04-01 with total page 216 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pathogenic bacteria for human and animals have developed sophisticated weapons, termed virulence factors, to ensure their replication and persistence into their hosts. The authors in this volume show a synthesis on how the various host cellular Rho GTPases activities are manipulated by bacteria to fulfil their virulence.

The Genus Yersinia:

Author : Robert D. Perry
Publisher : Springer Science & Business Media
ISBN 13 : 0387721231
Total Pages : 454 pages
Book Rating : 4.3/5 (877 download)

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Book Synopsis The Genus Yersinia: by : Robert D. Perry

Download or read book The Genus Yersinia: written by Robert D. Perry and published by Springer Science & Business Media. This book was released on 2007-09-25 with total page 454 pages. Available in PDF, EPUB and Kindle. Book excerpt: The 9th International Symposium on Yersinia was held in Lexington, Kentucky, USA on October 10-14, 2006. Over 250 Yersinia researchers from 18 countries gathered to present and discuss their research. In addition to 37 oral presentations, there were 150 poster presentations. This Symposium volume is based on selected presentations from the meeting and contains both reviews and research articles. It is divided into six topic areas: 1) genomics; 2) structure and metabolism; 3) regulatory mechanisms; 4) pathogenesis and host interactions; 5) molecular epidemiology and detection; and 6) vaccine and antimicrobial therapy development. Consequently, this volume covers a wide range of current research areas in the Yersinia field.

Targeted Intracellular Drug Delivery by Receptor Mediated Endocytosis

Author : Padma V. Devarajan
Publisher : Springer Nature
ISBN 13 : 3030291685
Total Pages : 560 pages
Book Rating : 4.0/5 (32 download)

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Book Synopsis Targeted Intracellular Drug Delivery by Receptor Mediated Endocytosis by : Padma V. Devarajan

Download or read book Targeted Intracellular Drug Delivery by Receptor Mediated Endocytosis written by Padma V. Devarajan and published by Springer Nature. This book was released on 2019-11-09 with total page 560 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book elaborates on drug delivery targeting via intracellular delivery, specifically through the Receptor Mediated Endocytosis (RME) approach, due to the involvement of cellular receptors in various grave diseases. Targeted delivery relies on two basic approaches, passive and active targeting. While passive targeting approaches have shown great promise, the improved selectivity achieved with active targeting approaches has resulted in significantly higher efficacy. Interestingly there are numerous strategies for active targeting, many of which are already highlighted in , Targeted Drug Delivery: Concepts and Applications. Nevertheless an exciting and practical strategy for active targeting, which could enable high intracellular delivery, is through exploitation of RME. Cells in the body express receptors to enable various physiological and biochemical processes. As a result, many of these receptors are overexpressed in pathological conditions, or newer receptors expressed due to defective cellular functioning. RME is based on exploitation of such receptors to achieve intracellular delivery. While targeted delivery can have manifold applications, in this book we focus on two major and challenging therapeutic areas; i) Cancer and ii) Infectious Diseases. Targeted Intracellular Drug Delivery by Receptor Medicated Endocytosis discusses the major receptors that are useful for targeted delivery for these afflictions. A major section of this book is dedicated to details regarding their occurrence and location, the recognition domain of the receptor, structure activity relationship of substrate /ligand for selective binding, ligands explored, antagonists for ligand binding and relevance of these aspects for therapy of cancer and infectious diseases. These facets are elucidated with the help of specific examples from academic research and also emphasize commercial products, wherever relevant. In vitro cellular models relied on for assessing receptor mediated cellular targeting and in vivo models depicting clinical efficacy are focused on in a separate section. Finally, we briefly discuss the regulatory and toxicity issues that may be associated specifically with the RME approach of intracellular drug delivery.