Uncertainty In Pharmacology

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Uncertainty in Pharmacology

Author : Adam LaCaze
Publisher : Springer Nature
ISBN 13 : 3030291790
Total Pages : 475 pages
Book Rating : 4.0/5 (32 download)

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Book Synopsis Uncertainty in Pharmacology by : Adam LaCaze

Download or read book Uncertainty in Pharmacology written by Adam LaCaze and published by Springer Nature. This book was released on 2020-02-20 with total page 475 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume covers a wide range of topics concerning methodological, epistemological, and regulatory-ethical issues around pharmacology. The book focuses in particular on the diverse sources of uncertainty, the different kinds of uncertainty that there are, and the diverse ways in which these uncertainties are (or could be) addressed. Compared with the more basic sciences, such as chemistry or biology, pharmacology works across diverse observable levels of reality: although the first step in the causal chain leading to the therapeutic outcome takes place at the biochemical level, the end-effect is a clinically observable result—which is influenced not only by biological actions, but also psychological and social phenomena. Issues of causality and evidence must be treated with these specific aspects in mind. In covering these issues, the book opens up a common domain of investigation which intersects the deeply intertwined dimensions of pharmacological research, pharmaceutical regulation and the related economic environment. The book is a collective endeavour with in-depth contributions from experts in pharmacology, philosophy of medicine, statistics, scientific methodology, formal and social epistemology, working in constant dialogue across disciplinary boundaries.

Uncertainty in Medicine

Author : Paul K. J. Han
Publisher : Oxford University Press
ISBN 13 : 0190270586
Total Pages : 193 pages
Book Rating : 4.1/5 (92 download)

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Book Synopsis Uncertainty in Medicine by : Paul K. J. Han

Download or read book Uncertainty in Medicine written by Paul K. J. Han and published by Oxford University Press. This book was released on 2021 with total page 193 pages. Available in PDF, EPUB and Kindle. Book excerpt: Introduction : The Challenge of Uncertainty in Medicine -- The Nature and Etiology of Uncertainty -- The Anatomy of Uncertainty -- The Natural History of Uncertainty -- The Management of Uncertainty -- A Way Forward : Systematizing Uncertainty Tolerance.

Testing Treatments

Author : Imogen Evans
Publisher : Pinter & Martin Publishers
ISBN 13 : 1905177488
Total Pages : 187 pages
Book Rating : 4.9/5 (51 download)

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Book Synopsis Testing Treatments by : Imogen Evans

Download or read book Testing Treatments written by Imogen Evans and published by Pinter & Martin Publishers. This book was released on 2011 with total page 187 pages. Available in PDF, EPUB and Kindle. Book excerpt: This work provides a thought-provoking account of how medical treatments can be tested with unbiased or 'fair' trials and explains how patients can work with doctors to achieve this vital goal. It spans the gamut of therapy from mastectomy to thalidomide and explores a vast range of case studies.

Mapping Uncertainty in Medicne

Author : Avril Danczak
Publisher : Royal College of General Practitioners
ISBN 13 : 0850844185
Total Pages : 342 pages
Book Rating : 4.8/5 (58 download)

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Book Synopsis Mapping Uncertainty in Medicne by : Avril Danczak

Download or read book Mapping Uncertainty in Medicne written by Avril Danczak and published by Royal College of General Practitioners. This book was released on 2016-02-28 with total page 342 pages. Available in PDF, EPUB and Kindle. Book excerpt: Uncertainty is the norm in medical practice, yet often gives rise to distress in clinicians, who fear they will make shameful or guilt inducing errors. This book offers a succinct method to clinicians for classifying uncertainty and finding the right skills to manage different types of uncertainty successfully. Every clinician experiences moments when 'they don't know what to do'. Modern medicine is increasingly complex and training has also become more complicated. The days of 'see one, do one, teach one' are over. Yet, both younger clinicians and senior practitioners describe uncertainty as one of the most challenging and stressful aspects of clinical work. If uncertainty is uncomfortable or threatening to individual practitioners, it also provides complex educational challenges. How can we learn to cope with uncertainty effectively ourselves? How can we teach others to understand and manage uncertainty? In this ground breaking book, the authors propose ways to cut through uncertainty, which is explored as an inevitable (and even desirable) component of clinical practice. A Map of Uncertainty in Medicine (MUM) is used to classify uncertainty and to define the skills that will help find a way though practical difficulties. It is always good to have your MUM with you in a tricky situation!

Risky Medicine

Author : Robert Aronowitz
Publisher : University of Chicago Press
ISBN 13 : 022604971X
Total Pages : 285 pages
Book Rating : 4.2/5 (26 download)

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Book Synopsis Risky Medicine by : Robert Aronowitz

Download or read book Risky Medicine written by Robert Aronowitz and published by University of Chicago Press. This book was released on 2015-09-16 with total page 285 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Will ever-more sensitive screening tests for cancer lead to longer, better lives? Will anticipating and trying to prevent the future complications of chronic disease lead to better health? Not always, says Robert Aronowitz. In fact, it often is hurting us... Drawing on such controversial examples as HPV vaccines, cancer screening programs, and the cancer survivorship movement, Aronowitz demonstrates that patients and their doctors have come to believe, perilously, that far too many medical interventions are worthwhile because they promise to control our fears and reduce uncertainty." -- Taken from book flyleaf.

The Good Doctor

Author : Kenneth Brigham
Publisher : Seven Stories Press
ISBN 13 : 1609809971
Total Pages : 181 pages
Book Rating : 4.6/5 (98 download)

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Book Synopsis The Good Doctor by : Kenneth Brigham

Download or read book The Good Doctor written by Kenneth Brigham and published by Seven Stories Press. This book was released on 2020-07-07 with total page 181 pages. Available in PDF, EPUB and Kindle. Book excerpt: What makes a good doctor? It's not what you think. A doctor willing to face their own uncertainty in the face of illness and treatment might just be the best medicine. Too often we choose the wrong doctor for the wrong reasons. It doesn't have to be that way. In The Good Doctor, Ken Brigham, MD, and Michael M.E. Johns, MD, argue that we need to change the way we think about health care if we want to be the healthiest we can be. Counterintuitive as it may seem, uncertainty is integral to medicine, and you want a doctor who knows that: someone who sees you as the unique case you are, someone who knows that data isn't everything, someone who is able to change her mind as the information changes. For too long we've clung to the myth of the infallible doctor--one who assuredly tells us this is what's wrong and here is how I will cure you--and our health has suffered for it. Brigham and Johns propose a new model of medicine, one that is comfortable with ambiguity and that centers on an equal partnership between patient and doctor. Uncertainty, properly embraced, opens a new universe of possibilities.

The Laws of Medicine

Author : Siddhartha Mukherjee
Publisher : Simon and Schuster
ISBN 13 : 147678485X
Total Pages : 96 pages
Book Rating : 4.4/5 (767 download)

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Book Synopsis The Laws of Medicine by : Siddhartha Mukherjee

Download or read book The Laws of Medicine written by Siddhartha Mukherjee and published by Simon and Schuster. This book was released on 2015-10-13 with total page 96 pages. Available in PDF, EPUB and Kindle. Book excerpt: Essential, required reading for doctors and patients alike: A Pulitzer Prize-winning author and one of the world’s premiere cancer researchers reveals an urgent philosophy on the little-known principles that govern medicine—and how understanding these principles can empower us all. Over a decade ago, when Siddhartha Mukherjee was a young, exhausted, and isolated medical resident, he discovered a book that would forever change the way he understood the medical profession. The book, The Youngest Science, forced Dr. Mukherjee to ask himself an urgent, fundamental question: Is medicine a “science”? Sciences must have laws—statements of truth based on repeated experiments that describe some universal attribute of nature. But does medicine have laws like other sciences? Dr. Mukherjee has spent his career pondering this question—a question that would ultimately produce some of most serious thinking he would do around the tenets of his discipline—culminating in The Laws of Medicine. In this important treatise, he investigates the most perplexing and illuminating cases of his career that ultimately led him to identify the three key principles that govern medicine. Brimming with fascinating historical details and modern medical wonders, this important book is a fascinating glimpse into the struggles and Eureka! moments that people outside of the medical profession rarely see. Written with Dr. Mukherjee’s signature eloquence and passionate prose, The Laws of Medicine is a critical read, not just for those in the medical profession, but for everyone who is moved to better understand how their health and well-being is being treated. Ultimately, this book lays the groundwork for a new way of understanding medicine, now and into the future.

Clinical Reasoning: Knowledge, Uncertainty, and Values in Health Care

Author : Daniele Chiffi
Publisher : Springer Nature
ISBN 13 : 3030590941
Total Pages : 168 pages
Book Rating : 4.0/5 (35 download)

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Book Synopsis Clinical Reasoning: Knowledge, Uncertainty, and Values in Health Care by : Daniele Chiffi

Download or read book Clinical Reasoning: Knowledge, Uncertainty, and Values in Health Care written by Daniele Chiffi and published by Springer Nature. This book was released on 2020 with total page 168 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book offers a philosophically-based, yet clinically-oriented perspective on current medical reasoning aiming at 1) identifying important forms of uncertainty permeating current clinical reasoning and practice 2) promoting the application of an abductive methodology in the health context in order to deal with those clinical uncertainties 3) bridging the gap between biomedical knowledge, clinical practice, and research and values in both clinical and philosophical literature. With a clear philosophical emphasis, the book investigates themes lying at the border between several disciplines, such as medicine, nursing, logic, epistemology, and philosophy of science; but also ethics, epidemiology, and statistics. At the same time, it critically discusses and compares several professional approaches to clinical practice such as the one of medical doctors, nurses and other clinical practitioners, showing the need for developing a unified framework of reasoning, which merges methods and resources from many different clinical but also non-clinical disciplines. In particular, this book shows how to leverage nursing knowledge and practice, which has been considerably neglected so far, to further shape the interdisciplinary nature of clinical reasoning. Furthermore, a thorough philosophical investigation on the values involved in health care is provided, based on both the clinical and philosophical literature. The book concludes by proposing an integrative approach to health and disease going beyond the so-called "classical biomedical model of care".

The Ethics of Uncertainty

Author : L. Syd M. Johnson
Publisher : Oxford University Press
ISBN 13 : 0190943645
Total Pages : 305 pages
Book Rating : 4.1/5 (99 download)

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Book Synopsis The Ethics of Uncertainty by : L. Syd M. Johnson

Download or read book The Ethics of Uncertainty written by L. Syd M. Johnson and published by Oxford University Press. This book was released on 2022 with total page 305 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Consciousness isn't a thing you can poke a stick at. It's not a natural kind, like a bit of quartz, or quarks, or water. Like "life," which can be attributed to many entities, but is not a thing with reality apart from living entities, consciousness can be attributed to conscious entities without being some further thing or fact, some mysterious, mentalizing "force" that can exist without conscious entities. It is manifested in conscious states and creatures, but isn't a thing in and of itself. One of the enduring puzzles about consciousness and conscious states is how they, as apparently mental, nonphysical states, can manifest in a physical entity like a brain. We can point to a physical bit of brain, to a neuron, or a structure like the thalamus, but we can't locate the consciousness within that bit of brain or its neural cells"--

Managing Project Uncertainty

Author : David Cleden
Publisher : Routledge
ISBN 13 : 1351920413
Total Pages : 131 pages
Book Rating : 4.3/5 (519 download)

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Book Synopsis Managing Project Uncertainty by : David Cleden

Download or read book Managing Project Uncertainty written by David Cleden and published by Routledge. This book was released on 2017-03-02 with total page 131 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dealing effectively with uncertainty requires today's project manager to be familiar with a broad spectrum of strategies, encompassing both 'hard' and 'soft' methods. This theme of unified thinking (i.e. the need to selectively draw upon a wide range of strategies in any given situation) will differentiate the book from its contemporaries. By picking up where traditional risk management techniques begin to fail, it brings together leading-edge thinking from a variety of disciplines and shows how these techniques can be used to conquer uncertainty in projects. The ability to make good decisions when faced with uncertainty is the real challenge. It is a universal truth that a decision is only as good as the information it is based on. But good information is often hard to come by, and all projects are vulnerable to the unknown and the unknowable. Thus, uncertainty becomes the sworn enemy of the project manager. Wherever we try to analyse, quantify, plan and act, uncertainty lies in wait to surprise us with its ambiguity and unpredictability. It lurks in every stage of the project lifecycle: in the planning (how long will this really take?), the initiation (this isn't the situation I expected!), the execution (who could have foreseen that happening?), and even the completion of a project (where are the expected benefits?). But managing uncertainty is a lot more than just applying risk management techniques. It requires a deep appreciation of how uncertainty arises and, by recognising its different guises, the appropriate strategies can be formulated. If we can learn how to reduce uncertainty, we can make better management decisions and increase the chances of the project succeeding. This book addresses five key questions: ¢ Why is there uncertainty in projects? ¢ How do you spot the symptoms of uncertainty, preferably at an early stage? ¢ What can be done to avoid uncertainty? ¢ What strategies can be used to deal with project uncertainty? ¢ How can both the individual and the organisation learn to cope more effectively in the future? The reader is assumed to be a either a project management professional, or a senior manager looking for ways to improve project management strategy within their organisation. As such, a foundation in project management basics is assumed, although not essential. The book then builds on this by exposing new ideas and concepts, and shows how these can be harnessed to tackle uncertainty in its many guises.

Improving and Accelerating Therapeutic Development for Nervous System Disorders

Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 0309292492
Total Pages : 107 pages
Book Rating : 4.3/5 (92 download)

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Book Synopsis Improving and Accelerating Therapeutic Development for Nervous System Disorders by : Institute of Medicine

Download or read book Improving and Accelerating Therapeutic Development for Nervous System Disorders written by Institute of Medicine and published by National Academies Press. This book was released on 2014-02-06 with total page 107 pages. Available in PDF, EPUB and Kindle. Book excerpt: Improving and Accelerating Therapeutic Development for Nervous System Disorders is the summary of a workshop convened by the IOM Forum on Neuroscience and Nervous System Disorders to examine opportunities to accelerate early phases of drug development for nervous system drug discovery. Workshop participants discussed challenges in neuroscience research for enabling faster entry of potential treatments into first-in-human trials, explored how new and emerging tools and technologies may improve the efficiency of research, and considered mechanisms to facilitate a more effective and efficient development pipeline. There are several challenges to the current drug development pipeline for nervous system disorders. The fundamental etiology and pathophysiology of many nervous system disorders are unknown and the brain is inaccessible to study, making it difficult to develop accurate models. Patient heterogeneity is high, disease pathology can occur years to decades before becoming clinically apparent, and diagnostic and treatment biomarkers are lacking. In addition, the lack of validated targets, limitations related to the predictive validity of animal models - the extent to which the model predicts clinical efficacy - and regulatory barriers can also impede translation and drug development for nervous system disorders. Improving and Accelerating Therapeutic Development for Nervous System Disorders identifies avenues for moving directly from cellular models to human trials, minimizing the need for animal models to test efficacy, and discusses the potential benefits and risks of such an approach. This report is a timely discussion of opportunities to improve early drug development with a focus toward preclinical trials.

Error and Uncertainty in Diagnostic Radiology

Author : Michael A. Bruno
Publisher : Oxford University Press
ISBN 13 : 0190665416
Total Pages : 270 pages
Book Rating : 4.1/5 (96 download)

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Book Synopsis Error and Uncertainty in Diagnostic Radiology by : Michael A. Bruno

Download or read book Error and Uncertainty in Diagnostic Radiology written by Michael A. Bruno and published by Oxford University Press. This book was released on 2018-02-08 with total page 270 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the past decade, radiological imaging tests - including CT scanning, MRI, PET, X-rays, ultrasound, fluoroscopy and other modalities - have become essential to the routine diagnostic process. While these modern advanced medical images and their striking anatomic detail have discovered underlying issues, they have also contributed to a false impression of infallibility. Unlike other straightforward diagnostic tests, such as the EKG or blood chemistry panel, radiological imaging tests are highly variable and complex, often yielding uncertain results, as well as frequent false-negatives and false-positives. The experts who interpret the images (the diagnostic radiologists) sometimes make mistakes: the practice of diagnostic radiology is a fallible, human endeavour, one involving complex perceptual, neuro-physiological and cognitive processes employed under a wide range of circumstances, and with a great deal of variability. Error and Uncertainty in Diagnostic Radiology opens the 'black box,' of medical imaging, exposing the remarkable inner workings of the process of diagnostic radiology-including how and why it can sometimes go tragically wrong. The occurrence of radiological error is shown to be fundamentally intertwined with the underlying high level of uncertainty known to be present in the diagnostic process. As a foremost expert on radiology quality and safety, Dr. Bruno provides insight into the various types of radiologist error, along with a conceptual framework for understanding error and uncertainty in radiology, leading to practical strategies for error prevention and for reducing the risk of harm to patients when errors inevitably occur. This book is essential for radiologists, members of the Society to Improve Diagnosis in Medicine, emergency physicians, medical educators, medical and hospice administrators, especially quality and safety officers, as well as malpractice insurance carriers.

Improving Diagnosis in Health Care

Author : National Academies of Sciences, Engineering, and Medicine
Publisher : National Academies Press
ISBN 13 : 0309377722
Total Pages : 473 pages
Book Rating : 4.3/5 (93 download)

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Book Synopsis Improving Diagnosis in Health Care by : National Academies of Sciences, Engineering, and Medicine

Download or read book Improving Diagnosis in Health Care written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2015-12-29 with total page 473 pages. Available in PDF, EPUB and Kindle. Book excerpt: Getting the right diagnosis is a key aspect of health care - it provides an explanation of a patient's health problem and informs subsequent health care decisions. The diagnostic process is a complex, collaborative activity that involves clinical reasoning and information gathering to determine a patient's health problem. According to Improving Diagnosis in Health Care, diagnostic errors-inaccurate or delayed diagnoses-persist throughout all settings of care and continue to harm an unacceptable number of patients. It is likely that most people will experience at least one diagnostic error in their lifetime, sometimes with devastating consequences. Diagnostic errors may cause harm to patients by preventing or delaying appropriate treatment, providing unnecessary or harmful treatment, or resulting in psychological or financial repercussions. The committee concluded that improving the diagnostic process is not only possible, but also represents a moral, professional, and public health imperative. Improving Diagnosis in Health Care, a continuation of the landmark Institute of Medicine reports To Err Is Human (2000) and Crossing the Quality Chasm (2001), finds that diagnosis-and, in particular, the occurrence of diagnostic errorsâ€"has been largely unappreciated in efforts to improve the quality and safety of health care. Without a dedicated focus on improving diagnosis, diagnostic errors will likely worsen as the delivery of health care and the diagnostic process continue to increase in complexity. Just as the diagnostic process is a collaborative activity, improving diagnosis will require collaboration and a widespread commitment to change among health care professionals, health care organizations, patients and their families, researchers, and policy makers. The recommendations of Improving Diagnosis in Health Care contribute to the growing momentum for change in this crucial area of health care quality and safety.

Snowball in a Blizzard

Author : Steven Hatch
Publisher : Basic Books
ISBN 13 : 0465098576
Total Pages : 313 pages
Book Rating : 4.4/5 (65 download)

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Book Synopsis Snowball in a Blizzard by : Steven Hatch

Download or read book Snowball in a Blizzard written by Steven Hatch and published by Basic Books. This book was released on 2016-02-23 with total page 313 pages. Available in PDF, EPUB and Kindle. Book excerpt: There's a running joke among radiologists: finding a tumor in a mammogram is akin to finding a snowball in a blizzard. A bit of medical gallows humor, this simile illustrates the difficulties of finding signals (the snowball) against a background of noise (the blizzard). Doctors are faced with similar difficulties every day when sifting through piles of data from blood tests to X-rays to endless lists of patient symptoms. Diagnoses are often just educated guesses, and prognoses less certain still. There is a significant amount of uncertainty in the daily practice of medicine, resulting in confusion and potentially deadly complications. Dr. Steven Hatch argues that instead of ignoring this uncertainty, we should embrace it. By digging deeply into a number of rancorous controversies, from breast cancer screening to blood pressure management, Hatch shows us how medicine can fail-sometimes spectacularly-when patients and doctors alike place too much faith in modern medical technology. The key to good health might lie in the ability to recognize the hype created by so many medical reports, sense when to push a physician for more testing, or resist a physician's enthusiasm when unnecessary tests or treatments are being offered. Both humbling and empowering, Snowball in a Blizzard lays bare the inescapable murkiness that permeates the theory and practice of modern medicine. Essential reading for physicians and patients alike, this book shows how, by recognizing rather than denying that uncertainty, we can all make better health decisions.

The Ethics of Ambiguity

Author : Simone de Beauvoir
Publisher : Open Road Media
ISBN 13 : 1504054210
Total Pages : 98 pages
Book Rating : 4.5/5 (4 download)

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Book Synopsis The Ethics of Ambiguity by : Simone de Beauvoir

Download or read book The Ethics of Ambiguity written by Simone de Beauvoir and published by Open Road Media. This book was released on 2018-05-08 with total page 98 pages. Available in PDF, EPUB and Kindle. Book excerpt: From the groundbreaking author of The Second Sex comes a radical argument for ethical responsibility and freedom. In this classic introduction to existentialist thought, French philosopher Simone de Beauvoir’s The Ethics of Ambiguity simultaneously pays homage to and grapples with her French contemporaries, philosophers Jean-Paul Sartre and Maurice Merleau-Ponty, by arguing that the freedoms in existentialism carry with them certain ethical responsibilities. De Beauvoir outlines a series of “ways of being” (the adventurer, the passionate person, the lover, the artist, and the intellectual), each of which overcomes the former’s deficiencies, and therefore can live up to the responsibilities of freedom. Ultimately, de Beauvoir argues that in order to achieve true freedom, one must battle against the choices and activities of those who suppress it. The Ethics of Ambiguity is the book that launched Simone de Beauvoir’s feminist and existential philosophy. It remains a concise yet thorough examination of existence and what it means to be human.

The Handbook of Applied Communication Research

Author : H. Dan O'Hair
Publisher : John Wiley & Sons
ISBN 13 : 1119399874
Total Pages : 1043 pages
Book Rating : 4.1/5 (193 download)

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Book Synopsis The Handbook of Applied Communication Research by : H. Dan O'Hair

Download or read book The Handbook of Applied Communication Research written by H. Dan O'Hair and published by John Wiley & Sons. This book was released on 2020-04-24 with total page 1043 pages. Available in PDF, EPUB and Kindle. Book excerpt: An authoritative survey of different contexts, methodologies, and theories of applied communication The field of Applied Communication Research (ACR) has made substantial progress over the past five decades in studying communication problems, and in making contributions to help solve them. Changes in society, human relationships, climate and the environment, and digital media have presented myriad contexts in which to apply communication theory. The Handbook of Applied Communication Research addresses a wide array of contemporary communication issues, their research implications in various contexts, and the challenges and opportunities for using communication to manage problems. This innovative work brings together the diverse perspectives of a team of notable international scholars from across disciplines. The Handbook of Applied Communication Research includes discussion and analysis spread across two comprehensive volumes. Volume one introduces ACR, explores what is possible in the field, and examines theoretical perspectives, organizational communication, risk and crisis communication, and media, data, design, and technology. The second volume focuses on real-world communication topics such as health and education communication, legal, ethical, and policy issues, and volunteerism, social justice, and communication activism. Each chapter addresses a specific issue or concern, and discusses the choices faced by participants in the communication process. This important contribution to communication research: Explores how various communication contexts are best approached Addresses balancing scientific findings with social and cultural issues Discusses how and to what extent media can mitigate the effects of adverse events Features original findings from ongoing research programs and original communication models and frameworks Presents the best available research and insights on where current research and best practices should move in the future A major addition to the body of knowledge in the field, The Handbook of Applied Communication Research is an invaluable work for advanced undergraduate students, graduate students, and scholars.

Bodies in Flux

Author : Christa Teston
Publisher : University of Chicago Press
ISBN 13 : 022645083X
Total Pages : 254 pages
Book Rating : 4.2/5 (264 download)

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Book Synopsis Bodies in Flux by : Christa Teston

Download or read book Bodies in Flux written by Christa Teston and published by University of Chicago Press. This book was released on 2017-05-05 with total page 254 pages. Available in PDF, EPUB and Kindle. Book excerpt: Doctors, scientists, and patients have long grappled with the dubious nature of “certainty” in medical practice. To help navigate the chaos caused by ongoing bodily change we rely on scientific reductions and deductions. We take what we know now and make best guesses about what will be. But bodies in flux always outpace the human gaze. Particularly in cancer care, processes deep within our bodies are at work long before we even know where to look. In the face of constant biological and technological change, how do medical professionals ultimately make decisions about care? Bodies in Flux explores the inventive ways humans and nonhumans work together to manufacture medical evidence. Each chapter draws on rhetorical theory to investigate a specific scientific method for negotiating medical uncertainty in cancer care, including evidential visualization, assessment, synthesis, and computation. Case studies unveil how doctors rely on visuals when deliberating about a patient’s treatment options, how members of the FDA use inferential statistics to predict a drug’s effectiveness, how researchers synthesize hundreds of clinical trials into a single evidence-based recommendation, and how genetic testing companies compute and commoditize human health. Teston concludes by advocating for an ethic of care that pushes back against the fetishization of certainty—an ethic of care that honors human fragility and bodily flux.