Ubiquitination In Health And Diseases

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Ubiquitination in Health and Diseases

Author : Tomoaki Ishigami
Publisher : MDPI
ISBN 13 : 3036505466
Total Pages : 292 pages
Book Rating : 4.0/5 (365 download)

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Book Synopsis Ubiquitination in Health and Diseases by : Tomoaki Ishigami

Download or read book Ubiquitination in Health and Diseases written by Tomoaki Ishigami and published by MDPI. This book was released on 2021-05-18 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ubiquitination is a biological process mediated by ubiquitin itself, the E1 ubiquitin-activating enzyme, E2 ubiquitin-conjugating enzyme, E3 ubiquitin ligase, and deubiquitinating enzyme, respectively. Currently, these multiple biological steps are revealed to participate in various life phenomena, such as cell proliferation, regulation of cell surface proteins expression, and mitochondrial function, which are profoundly related to human health and diseases. Although clinical applications targeting ubiquitination are still limited compared to those directed toward kinase systems such as tyrosine kinases, multiple enzymatic consequences should be future therapeutic implications. This Special Issue of IJMS entitled “Ubiquitination in Health and Disease” successfully published15 distinguished manuscripts, with a total of 66 international authors and. This book provides the latest and most useful information for researchers and scientists in this field.

The Ubiquitin System in Health and Disease

Author : Stefan Jentsch
Publisher : Springer Science & Business Media
ISBN 13 : 3540851070
Total Pages : 203 pages
Book Rating : 4.5/5 (48 download)

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Book Synopsis The Ubiquitin System in Health and Disease by : Stefan Jentsch

Download or read book The Ubiquitin System in Health and Disease written by Stefan Jentsch and published by Springer Science & Business Media. This book was released on 2008-11-14 with total page 203 pages. Available in PDF, EPUB and Kindle. Book excerpt: The ubiquitin system plays an essential role in numerous cellular processes by controlling protein stability and function. An understanding of the mechanisms governing these processes is likely to allow the identification of novel targets for pharmacological intervention. This work covers the developments in this field.

Ubiquitination Governing DNA Repair

Author : Effrossyni Boutou
Publisher : BoD – Books on Demand
ISBN 13 : 1789235847
Total Pages : 221 pages
Book Rating : 4.7/5 (892 download)

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Book Synopsis Ubiquitination Governing DNA Repair by : Effrossyni Boutou

Download or read book Ubiquitination Governing DNA Repair written by Effrossyni Boutou and published by BoD – Books on Demand. This book was released on 2018-08-01 with total page 221 pages. Available in PDF, EPUB and Kindle. Book excerpt: DNA damage response (DDR) and lesion repair are vital processes ensuring genome integrity through various pathways depending mainly on the nature of DNA injury and cell cycle stage. DDR is finely regulated at many levels in co-ordination with other ongoing processes as is genome replication and cell cycle progression. Posttranslational modifications (PTMs), affecting both protein-protein and protein-DNA interactions, play a crucial role in finely tuning all processes involved in the restoration of genome lesions. Regarding damaged chromatin, PTMs serve in many cases as recruitment platforms for DNA repair mechanisms by facilitating binding sites or regulating interactions between involved proteins. Ubiquitination, the addition of ubiquitin moieties on a target protein, apart from controlling protein availability through degradation, is also involved, together with partner small ubiquitin-like modifier (SUMO), in controlling many pathways involved in DDR by modifying the structure-function relationship and thus interacting with partner molecules. The aim of this book is to cover a broad spectrum of current topics in ubiquitination and to a lesser extent SUMOylation involvement in regulation of DDR and repair in health and disease. This book is intended for pre- and postgraduate students and young scientists in this field. Members of both academic and research institutions, actively involved in the field, have described their current understanding of major mechanisms involved, highlighted key events, described ongoing applications in both developmental diseases and cancer and provided hints for future potential applications.

Ubiquitination in Health and Diseases

Author : Tomoaki Ishigami
Publisher :
ISBN 13 : 9783036505473
Total Pages : 292 pages
Book Rating : 4.5/5 (54 download)

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Book Synopsis Ubiquitination in Health and Diseases by : Tomoaki Ishigami

Download or read book Ubiquitination in Health and Diseases written by Tomoaki Ishigami and published by . This book was released on 2021 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ubiquitination is a biological process mediated by ubiquitin itself, the E1 ubiquitin-activating enzyme, E2 ubiquitin-conjugating enzyme, E3 ubiquitin ligase, and deubiquitinating enzyme, respectively. Currently, these multiple biological steps are revealed to participate in various life phenomena, such as cell proliferation, regulation of cell surface proteins expression, and mitochondrial function, which are profoundly related to human health and diseases. Although clinical applications targeting ubiquitination are still limited compared to those directed toward kinase systems such as tyrosine kinases, multiple enzymatic consequences should be future therapeutic implications. This Special Issue of IJMS entitled “Ubiquitination in Health and Disease” successfully published15 distinguished manuscripts, with a total of 66 international authors and. This book provides the latest and most useful information for researchers and scientists in this field.

Ubiquitin Proteasome System

Author : Matthew Summers
Publisher : BoD – Books on Demand
ISBN 13 : 1838804900
Total Pages : 228 pages
Book Rating : 4.8/5 (388 download)

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Book Synopsis Ubiquitin Proteasome System by : Matthew Summers

Download or read book Ubiquitin Proteasome System written by Matthew Summers and published by BoD – Books on Demand. This book was released on 2019-06-19 with total page 228 pages. Available in PDF, EPUB and Kindle. Book excerpt: The human ubiquitin proteasome system (UPS) is comprised of nearly 1000 proteins. Although originally identified as a mechanism of protein destruction, the UPS has numerous additional functions and mediates central signaling events in myriad processes involved in both cellular and organismal health and homeostasis. Numerous pathways within the UPS are implicated in disease, ranging from cancer to neurodegenerative diseases such as Parkinson's. The goal of this book is to deliver a collection of synopses of current areas of UPS research that highlights the importance of understanding the biology of the UPS to identify disease-relevant pathways, and the need to elucidate the molecular machinations within the UPS to develop methods for therapeutic modulation of these pathways.

Ubiquitin Proteasome System - Current Insights into Mechanism Cellular Regulation and Disease

Author : Matthew Summers
Publisher :
ISBN 13 : 9781838804916
Total Pages : 226 pages
Book Rating : 4.8/5 (49 download)

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Book Synopsis Ubiquitin Proteasome System - Current Insights into Mechanism Cellular Regulation and Disease by : Matthew Summers

Download or read book Ubiquitin Proteasome System - Current Insights into Mechanism Cellular Regulation and Disease written by Matthew Summers and published by . This book was released on 2019 with total page 226 pages. Available in PDF, EPUB and Kindle. Book excerpt: The human ubiquitin proteasome system (UPS) is comprised of nearly 1000 proteins. Although originally identified as a mechanism of protein destruction, the UPS has numerous additional functions and mediates central signaling events in myriad processes involved in both cellular and organismal health and homeostasis. Numerous pathways within the UPS are implicated in disease, ranging from cancer to neurodegenerative diseases such as Parkinson's. The goal of this book is to deliver a collection of synopses of current areas of UPS research that highlights the importance of understanding the biology of the UPS to identify disease-relevant pathways, and the need to elucidate the molecular machinations within the UPS to develop methods for therapeutic modulation of these pathways.

The Ubiquitin-proteasome Proteolytic System

Author : Aaron J. Ciechanover
Publisher : World Scientific
ISBN 13 : 9812381007
Total Pages : 242 pages
Book Rating : 4.8/5 (123 download)

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Book Synopsis The Ubiquitin-proteasome Proteolytic System by : Aaron J. Ciechanover

Download or read book The Ubiquitin-proteasome Proteolytic System written by Aaron J. Ciechanover and published by World Scientific. This book was released on 2002 with total page 242 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ubiquitin-proteasome-dependent proteolysis is central to an incredible multitude of processes in all eukaryotes, including the cell cycle, cell growth and differentiation, embryogenesis, apoptosis, signal transduction, DNA repair, regulation of transcription and DNA replication, transmembrane transport, endocytosis, stress responses, antigen presentation and other aspects of the immune response, the functions of the nervous system including circadian rhythms, axon guidance and acquisition of memory.This book tells the story of the ubiquitin system as we currently know it: from the regulation of basic cellular processes to quality control and the pathogenetic mechanisms of disease, from X-ray crystallography of the 26S proteasome to the interaction between substrates and their ligases, to the development of mechanism-based drugs, and to target-specific aberrant processes.

Ubiquitination Governing DNA Repair - Implications in Health and Disease

Author : Horst-Werner Stürzbecher
Publisher :
ISBN 13 : 9781789235852
Total Pages : 220 pages
Book Rating : 4.2/5 (358 download)

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Book Synopsis Ubiquitination Governing DNA Repair - Implications in Health and Disease by : Horst-Werner Stürzbecher

Download or read book Ubiquitination Governing DNA Repair - Implications in Health and Disease written by Horst-Werner Stürzbecher and published by . This book was released on 2018 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt: DNA damage response (DDR) and lesion repair are vital processes ensuring genome integrity through various pathways depending mainly on the nature of DNA injury and cell cycle stage. DDR is finely regulated at many levels in co-ordination with other ongoing processes as is genome replication and cell cycle progression. Posttranslational modifications (PTMs), affecting both protein-protein and protein-DNA interactions, play a crucial role in finely tuning all processes involved in the restoration of genome lesions. Regarding damaged chromatin, PTMs serve in many cases as recruitment platforms for DNA repair mechanisms by facilitating binding sites or regulating interactions between involved proteins. Ubiquitination, the addition of ubiquitin moieties on a target protein, apart from controlling protein availability through degradation, is also involved, together with partner small ubiquitin-like modifier (SUMO), in controlling many pathways involved in DDR by modifying the structure-function relationship and thus interacting with partner molecules. The aim of this book is to cover a broad spectrum of current topics in ubiquitination and to a lesser extent SUMOylation involvement in regulation of DDR and repair in health and disease. This book is intended for pre- and postgraduate students and young scientists in this field. Members of both academic and research institutions, actively involved in the field, have described their current understanding of major mechanisms involved, highlighted key events, described ongoing applications in both developmental diseases and cancer and provided hints for future potential applications.

The Ubiquitin System in Health and Disease (2009).

Author :
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (785 download)

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Book Synopsis The Ubiquitin System in Health and Disease (2009). by :

Download or read book The Ubiquitin System in Health and Disease (2009). written by and published by . This book was released on with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

The Ubiquitin System

Author : Milton J. Schlesinger
Publisher : Cold Spring Harbor Laboratory Press
ISBN 13 :
Total Pages : 218 pages
Book Rating : 4.:/5 (319 download)

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Book Synopsis The Ubiquitin System by : Milton J. Schlesinger

Download or read book The Ubiquitin System written by Milton J. Schlesinger and published by Cold Spring Harbor Laboratory Press. This book was released on 1988 with total page 218 pages. Available in PDF, EPUB and Kindle. Book excerpt:

The Ubiquitin Proteasome System

Author : Thibault Mayor
Publisher : Humana
ISBN 13 : 9781493993710
Total Pages : 413 pages
Book Rating : 4.9/5 (937 download)

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Book Synopsis The Ubiquitin Proteasome System by : Thibault Mayor

Download or read book The Ubiquitin Proteasome System written by Thibault Mayor and published by Humana. This book was released on 2019-10-06 with total page 413 pages. Available in PDF, EPUB and Kindle. Book excerpt: “This volume explores numerous techniques used to study the ubiquitin proteasome system. The chapters in this book are organized into five parts and cover topics such as determining the mechanisms of action for E2s, E3s, and DUB enzymes; the latest advances to study the formation of poly-ubiquitin chains as well as their linkage types; the binding partners of proteins in the UPS; methods for structure determination by x-ray crystallography, cryo electron microscopy and SAXS; screening assays to select for degrons or modulators of E3s and DUBs; proteomics approaches in the ubiquitin field and methods to study 26S proteasome function. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Thorough and authoritative, The Ubiquitin Proteasome System: Methods and Protocols is a valuable resource for both experienced and novice scientists who are interested in expanding their knowledge in this field.

SUMOylation and Ubiquitination

Author : Van G. Wilson
Publisher :
ISBN 13 : 9781912530120
Total Pages : 512 pages
Book Rating : 4.5/5 (31 download)

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Book Synopsis SUMOylation and Ubiquitination by : Van G. Wilson

Download or read book SUMOylation and Ubiquitination written by Van G. Wilson and published by . This book was released on 2019-09 with total page 512 pages. Available in PDF, EPUB and Kindle. Book excerpt: Most proteins undergo post-translational modifications altering physical and chemical properties, folding, conformation distribution, stability, activity and function. Ubiquitin and SUMOs are related small proteins that are members of the large ubiquitin superfamily of post-translational modifiers. Written by highly respected leaders in their fields under the expert guidance of the editor, this volume covers the principles of ubiquitination and SUMOylation, presents detailed reviews of current and emerging concepts and highlights new advances in all areas of SUMOylation and ubiquitination. Topics of note include: the ubiquitin superfamily, the ubiquitin toolbox, onco viral exploitation of the SUMO system, small molecule modulators of desumoylation, mass spectrometry, global proteomic profiling of SUMO and ubiquitin, biotin-based approaches, genetic screening, SUMOylation networks in humans, targets for ubiquitin ligases, regulation of p53, protein homeostasis, miRNAs, DNA replication, DNA damage response, telomere biology, intracellular trafficking, regulation of angiogenesis, brain ischemia, autophagy, assembly and activity, antiviral defense, HIV infection, amyloid and amyloid-like proteins, plant immunity. This comprehensive and up-to-date book is the definitive reference volume on all aspects of SUMOylation and ubiquitination and is an essential acquisition for anyone involved in this area of biology.

NF-κB-Related Genetic Diseases

Author : Gilles Courtois
Publisher : Springer
ISBN 13 : 3319258508
Total Pages : 78 pages
Book Rating : 4.3/5 (192 download)

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Book Synopsis NF-κB-Related Genetic Diseases by : Gilles Courtois

Download or read book NF-κB-Related Genetic Diseases written by Gilles Courtois and published by Springer. This book was released on 2015-12-29 with total page 78 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents the diverse clinical, cellular and molecular manifestations of NF-KB-related genetic diseases. It shows that studying patient-related pathologies affecting the components of the NF-KB signaling pathway offers the opportunity to understand the various functions of NF-KB in humans, complementing studies performed with mouse models. In addition, people treating those patients acquire a deeper understanding of the molecular basis of the pathophysiological processes.

Ubiquitin Proteasome System

Author : Aldrin V. Gomes
Publisher : Nova Medicine & Health
ISBN 13 : 9781536135183
Total Pages : 0 pages
Book Rating : 4.1/5 (351 download)

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Book Synopsis Ubiquitin Proteasome System by : Aldrin V. Gomes

Download or read book Ubiquitin Proteasome System written by Aldrin V. Gomes and published by Nova Medicine & Health. This book was released on 2018 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the last decade, major advancements in our understanding of the ubiquitin-proteasome system (UPS) have occurred. This book focuses on recent trends in the UPS. The UPS is possibly the most complex of all intracellular pathways as close to 7% of all genes in the human genome make up part of the UPS. This complex system serves as an essential role in intracellular protein degradation, and because of its critical function, improper functioning of the UPS is associated with nearly all know diseases, including cancer, cardiovascular disease, and neurological diseases. The proteolytic component of the UPS is the proteasome, a multicatalytic complex found in the nucleus and cytoplasm. Another form of the proteasome, the immunoproteasome, is less abundant than the constitutive proteasome, but is important in immune response and degradation of oxidized proteins, and recent research suggests that it may be important in longevity. The articles in this book discuss recent findings which indicate that mutations in proteins involved with the UPS are associated with genetic diseases such as familial dilated cardiomyopathy, Nakajo syndrome, and spinal muscular atrophy (X-linked). Some chapters also discuss recent results which suggest that the UPS is heavily regulated by post-translational modifications such as phosphorylation, acetylation, and methylation. The UPS is also heavily regulated by ubiquitination itself. This book contains a research article using PubMed bibliometric data to present current research trends in the UPS. Articles are written so that no one tissue is emphasized to allow readers from any discipline to benefit from this information.

Neuropathology of Neurodegenerative Diseases Book and Online

Author : Gabor G. Kovacs
Publisher : Cambridge University Press
ISBN 13 : 1107442427
Total Pages : 319 pages
Book Rating : 4.1/5 (74 download)

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Book Synopsis Neuropathology of Neurodegenerative Diseases Book and Online by : Gabor G. Kovacs

Download or read book Neuropathology of Neurodegenerative Diseases Book and Online written by Gabor G. Kovacs and published by Cambridge University Press. This book was released on 2015 with total page 319 pages. Available in PDF, EPUB and Kindle. Book excerpt: This heavily illustrated, must-have practical guide aids medical specialists and trainees in the diagnosis of neurodegenerative diseases. Includes diagnostic algorithms.

Ubiquitin-proteasome Proteolytic System, The: From Classical Biochemistry To Human Diseases

Author : Aaron J Ciechanover
Publisher : World Scientific
ISBN 13 : 9814487880
Total Pages : 242 pages
Book Rating : 4.8/5 (144 download)

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Book Synopsis Ubiquitin-proteasome Proteolytic System, The: From Classical Biochemistry To Human Diseases by : Aaron J Ciechanover

Download or read book Ubiquitin-proteasome Proteolytic System, The: From Classical Biochemistry To Human Diseases written by Aaron J Ciechanover and published by World Scientific. This book was released on 2002-11-12 with total page 242 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ubiquitin-proteasome-dependent proteolysis is central to an incredible multitude of processes in all eukaryotes, including the cell cycle, cell growth and differentiation, embryogenesis, apoptosis, signal transduction, DNA repair, regulation of transcription and DNA replication, transmembrane transport, endocytosis, stress responses, antigen presentation and other aspects of the immune response, the functions of the nervous system including circadian rhythms, axon guidance and acquisition of memory.This book tells the story of the ubiquitin system as we currently know it: from the regulation of basic cellular processes to quality control and the pathogenetic mechanisms of disease, from X-ray crystallography of the 26S proteasome to the interaction between substrates and their ligases, to the development of mechanism-based drugs, and to target-specific aberrant processes.

Proteolytic Signaling in Health and Disease

Author : Andre Zelanis
Publisher : Academic Press
ISBN 13 : 0323856977
Total Pages : 308 pages
Book Rating : 4.3/5 (238 download)

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Book Synopsis Proteolytic Signaling in Health and Disease by : Andre Zelanis

Download or read book Proteolytic Signaling in Health and Disease written by Andre Zelanis and published by Academic Press. This book was released on 2021-10-13 with total page 308 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years, powered by evolving technologies and experimental design, studies have better illuminated the regulating role of proteolytic enzymes across human development and pathologies. Proteolytic Signaling in Health and Disease provides an in-depth discussion of fundamental physiological and developmental processes regulated by proteases, from protein turnover and autophagy to antigen processing and presentation and major histocompatibility complex (MHC) molecules. Moving on from basic biology, international chapter authors examine a range of pathological conditions associated with proteolysis, including inflammation, wound healing, and cancer. Later chapters discuss the newly discovered network of connected events among proteases (and their inhibitors), the so-called ‘protease web’, and how best to study it. This book also empowers new research with up-to-date analytical methods and step-by-step protocols for studying proteolytic signaling events. Examines biological events triggered by proteolytic enzyme activity across human development and pathologies Discusses the role of proteolytic signaling in inflammation, wound healing, and cancer, among other disease types Features methods and protocols supporting further study of proteolytic signaling events Includes chapter contributions from international leaders in the field