Tumor Targeting Taxane Based Anti Cancer Agents

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Tumor-Targeting Taxane-Based Anti-Cancer Agents

Author : Melvin Parasram
Publisher : LAP Lambert Academic Publishing
ISBN 13 : 9783846508046
Total Pages : 148 pages
Book Rating : 4.5/5 (8 download)

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Book Synopsis Tumor-Targeting Taxane-Based Anti-Cancer Agents by : Melvin Parasram

Download or read book Tumor-Targeting Taxane-Based Anti-Cancer Agents written by Melvin Parasram and published by LAP Lambert Academic Publishing. This book was released on 2011-09 with total page 148 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer is the leading cause of death of patients below the age of 85. Traditional chemotherapeutics, such as Taxol (r) and Taxotere (r) have had a significant impact in the field of chemotherapy because of their unique mechanism of action of inducing apoptosis by stabilizing microtubules during mitotic cell division. However, studies have indicated that these drugs are not active in multi-drug resistant (MDR) cancer cells. MDR arises from the overexpression of ATP-binding cassette proteins which enable the cancer cell to remove cytotoxic agents from the cell via ATP dependent efflux pumps, resulting in the loss of efficacy of the drug. In addition to the problem of MDR, traditional chemotherapeutics have little or no specificity, which leads to systemic toxicity, causing severe and harmful side effects. Therefore, it is important to develop next generation taxoids with increased potency and activity in MDR expressing cancers, as well as to incorporate these cytotoxic agents to tumor-targeting delivery systems to ensure selective cytotoxicity and reduce systemic toxicity. In general, these delivery systems include a tumor-targeting module and a cytotoxic ag

Design, Synthesis and Biological Evaluation of Novel Tumor-targeting Taxane-based Anticancer Agents

Author : Jin Chen
Publisher :
ISBN 13 : 9781109967388
Total Pages : 373 pages
Book Rating : 4.9/5 (673 download)

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Book Synopsis Design, Synthesis and Biological Evaluation of Novel Tumor-targeting Taxane-based Anticancer Agents by : Jin Chen

Download or read book Design, Synthesis and Biological Evaluation of Novel Tumor-targeting Taxane-based Anticancer Agents written by Jin Chen and published by . This book was released on 2006 with total page 373 pages. Available in PDF, EPUB and Kindle. Book excerpt: A novel series of the second-generation taxoid conjugates with o-3 polyunsaturated fatty acids (PUFA) such as docosahexanoic acid (DHA), linolenic acid (LNA) and linoleic acid (LA) has been successfully developed. The new conjugates, tested in vivo, exhibited strong activity against both resistant and sensitive colon and ovarian cancer xenografts. Two of the new conjugates (DHA-SB-T-1214 and DHA-SB-T-1213) caused the total regression of resistant and sensitive type cancers, respectively, with reduced side toxicity.

Design, Synthesis and Biological Evaluation of Tumor-targeting Taxane-based Anticancer Agents and MDR Modulators

Author : Xinyuan Wu
Publisher :
ISBN 13 :
Total Pages : 754 pages
Book Rating : 4.:/5 (57 download)

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Book Synopsis Design, Synthesis and Biological Evaluation of Tumor-targeting Taxane-based Anticancer Agents and MDR Modulators by : Xinyuan Wu

Download or read book Design, Synthesis and Biological Evaluation of Tumor-targeting Taxane-based Anticancer Agents and MDR Modulators written by Xinyuan Wu and published by . This book was released on 2003 with total page 754 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Design, Synthesis and Biological Evaluation of Novel Taxane-based Anticancer Agents and Their Applications to Tumor-targeting Drug Delivery Systems

Download Design, Synthesis and Biological Evaluation of Novel Taxane-based Anticancer Agents and Their Applications to Tumor-targeting Drug Delivery Systems PDF Online Free

Author : Xianrui Zhao
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (729 download)

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Book Synopsis Design, Synthesis and Biological Evaluation of Novel Taxane-based Anticancer Agents and Their Applications to Tumor-targeting Drug Delivery Systems by : Xianrui Zhao

Download or read book Design, Synthesis and Biological Evaluation of Novel Taxane-based Anticancer Agents and Their Applications to Tumor-targeting Drug Delivery Systems written by Xianrui Zhao and published by . This book was released on 2009 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Design, Synthesis and Biological Evaluation of Novel Taxane-based Anticancer Agents and Their Tumor Targeting Delivery

Author : Larisa Kuznetsova
Publisher :
ISBN 13 :
Total Pages : 584 pages
Book Rating : 4.:/5 (669 download)

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Book Synopsis Design, Synthesis and Biological Evaluation of Novel Taxane-based Anticancer Agents and Their Tumor Targeting Delivery by : Larisa Kuznetsova

Download or read book Design, Synthesis and Biological Evaluation of Novel Taxane-based Anticancer Agents and Their Tumor Targeting Delivery written by Larisa Kuznetsova and published by . This book was released on 2005 with total page 584 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Drugs Affecting Growth of Tumours

Author : Herbert M. Pinedo
Publisher : Springer Science & Business Media
ISBN 13 : 3764374071
Total Pages : 241 pages
Book Rating : 4.7/5 (643 download)

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Book Synopsis Drugs Affecting Growth of Tumours by : Herbert M. Pinedo

Download or read book Drugs Affecting Growth of Tumours written by Herbert M. Pinedo and published by Springer Science & Business Media. This book was released on 2007-06-12 with total page 241 pages. Available in PDF, EPUB and Kindle. Book excerpt: This topical volume provides an overview of clinically relevant data on anticancer agents. It is not only intended medical doctors working with cancer patients, and for medical researchers and students. The different classes of anticancer drugs are described by international authorities on the various topics. Apart from new targets for anticancer agents, attention is also focused on improving efficacy and tolerability of existing compounds.

Topics in Anti-Cancer Research

Author : Atta-ur-Rahman
Publisher : Bentham Science Publishers
ISBN 13 : 1681086271
Total Pages : 246 pages
Book Rating : 4.6/5 (81 download)

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Book Synopsis Topics in Anti-Cancer Research by : Atta-ur-Rahman

Download or read book Topics in Anti-Cancer Research written by Atta-ur-Rahman and published by Bentham Science Publishers. This book was released on 2018-11-30 with total page 246 pages. Available in PDF, EPUB and Kindle. Book excerpt: Topics in Anti-Cancer Research covers important advances on both experimental (preclinical) and clinical cancer research in drug development. The book series offers readers an insight into current and future therapeutic approaches for the prevention of different types of cancers, synthesizing new anti-cancer agents, new patented compounds, targets and agents for cancer therapy as well as recent molecular and gene therapy research. The comprehensive range of themes covered in each volume will be beneficial to clinicians, immunologists, and R&D experts looking for new anti-cancer targets and patents for the treatment of neoplasms, as well as varied approaches for cancer therapy. The topics covered in the seventh volume of this series include: - The role of inflammation in chemotherapy-induced neuromuscular effects - Advances in nutrigenomics and relevant anti-cancer patents - Stimuli-responsive nanocarriers for on-demand anti-cancer drug release - Harnessing biochemical mechanisms that control autophagy for treating esophageal cancer.

Natural Products and Cancer Drug Discovery

Author : Frank E. Koehn
Publisher : Springer Science & Business Media
ISBN 13 : 1461446546
Total Pages : 248 pages
Book Rating : 4.4/5 (614 download)

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Book Synopsis Natural Products and Cancer Drug Discovery by : Frank E. Koehn

Download or read book Natural Products and Cancer Drug Discovery written by Frank E. Koehn and published by Springer Science & Business Media. This book was released on 2012-11-09 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume will cover the natural products as they relate to cancer chemotherapy. The topics will include history and current status , recent launches, new clinical candidates and approved drugs directly derived from natural products, current and future cancer target opportunities for natural products, leveraging natural products as tools for new target generation , new approaches to cancer drug discovery through natural products based lead generation, and enabling technologies which leverage the unique attributes of natural products.

New Approaches to Natural Anticancer Drugs

Author : Soodabeh Saeidnia
Publisher : Springer
ISBN 13 : 3319140272
Total Pages : 117 pages
Book Rating : 4.3/5 (191 download)

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Book Synopsis New Approaches to Natural Anticancer Drugs by : Soodabeh Saeidnia

Download or read book New Approaches to Natural Anticancer Drugs written by Soodabeh Saeidnia and published by Springer. This book was released on 2015-02-05 with total page 117 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides an up-to-date review of recently identified natural anti-tumor compounds from various natural origins including plants, fungi, endophytic fungi and marine organisms. It also includes discussion of new areas such as biotechnology and nanoparticles. Chapters explain the challenges and developments in anti-cancer drug discovery approaches, traditional remedies for prevention and treatment of cancer, marine-derived anti-cancer compounds, and antibiotics used as anti-cancer agents, as well as different classes of terpenoids and carbohydrates, which have been the subject of discussion in this field as efficient anti-cancer candidates. This book will be a concise guide for researchers in the field of pharmaceutical sciences, students and residents in pharmacy and medicine as well as those researching phytochemistry and natural products.

Paclitaxel

Author : Mallappa Kumara Swamy
Publisher : Academic Press
ISBN 13 : 0323909523
Total Pages : 356 pages
Book Rating : 4.3/5 (239 download)

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Book Synopsis Paclitaxel by : Mallappa Kumara Swamy

Download or read book Paclitaxel written by Mallappa Kumara Swamy and published by Academic Press. This book was released on 2021-10-08 with total page 356 pages. Available in PDF, EPUB and Kindle. Book excerpt: Paclitaxel: Sources, Chemistry, Anticancer Actions, and Current Biotechnology provides a comprehensive survey of Paclitaxel and its derivatives chemistry, biosynthesis and anticancer activities. In addition, biotechnological methods, including cell cultures, the use of bioreactors and metabolic engineering strategies to improve Paclitaxel production are also discussed. The book discusses topics such as mechanisms of action against cancer, novel forms of Paclitaxel for an effective cancer treatment, strategies for enhancing its bioavailability, and the application of nanocarriers for its delivery and chemotherapy of cancer. This is a valuable resource for cancer researchers, biotechnologists and members of biomedical field who are interested in the promising anticancer qualities of this antineoplastic drug and how to enhance them for better treatments. - Presents detailed information about Paclitaxel research, from its discovery to clinical uses and biotechnological routes of commercial production - Focuses on Paclitaxel development as an effective chemotherapeutic drug, along with its application in different types of cancers - Encompasses descriptive illustrations and workflows to help the reader fully understand the content and easily apply it to their research

Natural Products in Medicinal Chemistry

Author : Stephen Hanessian
Publisher : John Wiley & Sons
ISBN 13 : 3527676554
Total Pages : 652 pages
Book Rating : 4.5/5 (276 download)

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Book Synopsis Natural Products in Medicinal Chemistry by : Stephen Hanessian

Download or read book Natural Products in Medicinal Chemistry written by Stephen Hanessian and published by John Wiley & Sons. This book was released on 2013-12-18 with total page 652 pages. Available in PDF, EPUB and Kindle. Book excerpt: The inspiration provided by biologically active natural products to conceive of hybrids, congeners, analogs and unnatural variants is discussed by experts in the field in 16 highly informative chapters. Using well-documented studies over the past decade, this timely monograph demonstrates the current importance and future potential of natural products as starting points for the development of new drugs with improved properties over their progenitors. The examples are chosen so as to represent a wide range of natural products with therapeutic relevance among others, as anticancer agents, antimicrobials, antifungals, antisense nucleosides, antidiabetics, and analgesics. From the content: * Part I: Natural Products as Sources of Potential Drugs and Systematic Compound Collections * Part II: From Marketed Drugs to Designed Analogs and Clinical Candidates * Part III: Natural Products as an Incentive for Enabling Technologies * Part IV: Natural Products as Pharmacological Tools * Part V: Nature: The Provider, the Enticer, and the Healer

Tumor Targeting in Cancer Therapy

Author : Michel Pagé
Publisher : Humana Press
ISBN 13 : 9781617372513
Total Pages : 0 pages
Book Rating : 4.3/5 (725 download)

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Book Synopsis Tumor Targeting in Cancer Therapy by : Michel Pagé

Download or read book Tumor Targeting in Cancer Therapy written by Michel Pagé and published by Humana Press. This book was released on 2010-11-19 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: In Tumor Targeting in Cancer Therapy, Dr. Michel Pagé and a panel of authoritative experts from the drug industry, clinics, and academia introduce the principles and techniques of tumor targeting and critically survey their applications from laboratory to bedside. By concisely synthesizing the many technical details, the authors illuminate this innovative technique, ranging from the fundamentals of drug targeting and in vivo and in vitro experimentation, to such emerging therapeutic uses as radioimmunotherapy, radioimmunodetection, therapy with cytotoxic antibodies, immunotoxins, enzyme prodrug immunotherapy, and immunotherapeutics with fusion proteins. There are also reviews of targeting tumors with radioimmunoconjugates, photodynamic therapy, and magnetic drugs, as well as discussions of the internalization of antibodies, bioconjugation and biodistribution, the use of cytotoxic drugs, and the pros and cons of targeting by antibody or ligand.

Comparative Oncology

Author : Alecsandru Ioan Baba
Publisher :
ISBN 13 : 9789732714577
Total Pages : 787 pages
Book Rating : 4.7/5 (145 download)

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Book Synopsis Comparative Oncology by : Alecsandru Ioan Baba

Download or read book Comparative Oncology written by Alecsandru Ioan Baba and published by . This book was released on 2007 with total page 787 pages. Available in PDF, EPUB and Kindle. Book excerpt:

The Story of Taxol

Author : Jordan Goodman
Publisher : Cambridge University Press
ISBN 13 : 9780521561235
Total Pages : 302 pages
Book Rating : 4.5/5 (612 download)

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Book Synopsis The Story of Taxol by : Jordan Goodman

Download or read book The Story of Taxol written by Jordan Goodman and published by Cambridge University Press. This book was released on 2001-03-05 with total page 302 pages. Available in PDF, EPUB and Kindle. Book excerpt: Taxol is arguably the most celebrated, talked-about and controversial natural product in recent years. It is celebrated because of its efficacy as an anti-cancer drug and because its discovery has provided powerful support for policies concerned with biodiversity; talked about because in the late 1980s and early 1990s the American public was bombarded with news reports and special programmes about the molecule and its host, the Pacific yew; and controversial because during the early 1990s the drug and the tree became embroiled in a number of very sensitive political issues with wide implications for the conduct of public policy. The Story of Taxol tells this story.

Anticancer Therapeutics

Author : Adam Todd
Publisher : John Wiley & Sons
ISBN 13 : 111862212X
Total Pages : 446 pages
Book Rating : 4.1/5 (186 download)

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Book Synopsis Anticancer Therapeutics by : Adam Todd

Download or read book Anticancer Therapeutics written by Adam Todd and published by John Wiley & Sons. This book was released on 2018-02-20 with total page 446 pages. Available in PDF, EPUB and Kindle. Book excerpt: An integrated presentation of the basic science and clinical applications of anticancer agents Aimed at both undergraduate and postgraduate readers, this unique text provides readers with a fully-integrated presentation of all aspects of the science of anticancer drugs, including their chemistry, pharmacology, and clinical applications. After heart disease, cancer is the number one killer worldwide, and the tumor microenvironment is forever changing, creating an ever-greater demand for safer, more effective anticancer agents. In response to that demand, the $100 billion cancer drug market continues to grow, with our increased understanding of cancer leading to new drugs being used clinically almost every year. Anticancer Therapeutics is divided into three sections. Section 1 is an introduction to cancer and therapeutics, and covers the etiology and cellular and molecular basis of cancer. In Section 2, the authors focus on the anticancer agents — their discovery, synthesis, mode of action, mechanisms of resistance, and adverse reactions. Section 3 focuses on specific cancers, explaining how and why the various agents discussed in Section 2 are used, both individually and in combination, to treat different cancers. Integrates aspects of basic science, including chemistry and pharmacology and clinical medicine in relation to cancer therapeutics Written by an author team comprising specialists in medicinal chemistry, pharmacology, and oncology Features full-color images throughout illustrating how drugs bind to cellular targets and exert their pharmacological effect Divided into three sections, covering the etiology and cellular and molecular basis of cancer, anticancer agents, and drug applications for different cancers. Providing the reader with an integrated understanding of all aspects of the science of anticancer agents, this is an ideal textbook for undergraduates studying medicine, nursing, medicinal chemistry, pharmacy, pharmacology and other allied heath / life sciences. It is also a valuable bench reference for pharmacists, medics, and pharmaceutical researchers working in both academia and industry.

Anticancer Agents

Author : Qiao-Hong Chen
Publisher : MDPI
ISBN 13 : 3036501401
Total Pages : 606 pages
Book Rating : 4.0/5 (365 download)

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Book Synopsis Anticancer Agents by : Qiao-Hong Chen

Download or read book Anticancer Agents written by Qiao-Hong Chen and published by MDPI. This book was released on 2021-03-02 with total page 606 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a printed edition of the Special Issue entitled “Anticancer Agents: Design, Synthesis and Evaluation” that was published in Molecules. Two review articles and thirty research papers are included in the Special Issue. Three second-generation androgen receptor antagonists that have been approved by the U.S. FDA for the treatment of prostate cancer have been reviewed. Identification of mimics of protein partners as protein-protein interaction inhibitors via virtual screening has been summarized and discussed. Anticancer agents targeting various protein targets, including IGF-1R, Src, protein kinase, aromatase, HDAC, PARP, Toll-Like receptor, c-Met, PI3Kdelta, topoisomerase II, p53, and indoleamine 2,3-dioxygenase, have been explored. The analogs of three well-known tubulin-interacting natural products, paclitaxel, zampanolide, and colchicine, have been designed, synthesized, and evaluated. Several anticancer agents representing diverse chemical scaffolds were assessed in different kinds of cancer cell models. The capability of some anticancer agents to overcome the resistance to currently available drugs was also studied. In addition to looking into the in vitro ability of the anticancer agents to inhibit cancer cell proliferation, apoptosis, and cell cycle, in vivo antitumor efficacy in animal models and DFT were also investigated in some papers.

Synthesis of Best-Seller Drugs

Author : Ruben Vardanyan
Publisher : Academic Press
ISBN 13 : 0124115241
Total Pages : 870 pages
Book Rating : 4.1/5 (241 download)

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Book Synopsis Synthesis of Best-Seller Drugs by : Ruben Vardanyan

Download or read book Synthesis of Best-Seller Drugs written by Ruben Vardanyan and published by Academic Press. This book was released on 2016-01-07 with total page 870 pages. Available in PDF, EPUB and Kindle. Book excerpt: Synthesis of Best-Seller Drugs is a key reference guide for all those involved with the design, development, and use of the best-selling drugs. Designed for ease of use, this book provides detailed information on the most popular drugs, using a practical layout arranged according to drug type. Each chapter reviews the main drugs in each of nearly 40 key therapeutic areas, also examining their classification, novel structural features, models of action, and synthesis. Of high interest to all those who work in the captivating areas of biologically active compounds and medicinal drug synthesis, in particular medicinal chemists, biochemists, and pharmacologists, the book aims to support current research efforts, while also encouraging future developments in this important field. - Describes methods of synthesis, bioactivity and related drugs in key therapeutic areas - Reviews the main drugs in each of nearly 40 key therapeutic areas, also examining their classification, novel structural features, models of action, and more - Presents a practical layout designed for use as a quick reference tool by those working in drug design, development and implementation