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Author : Peter Vaupel
Publisher : Lubrecht & Cramer, Limited
ISBN 13 :
Total Pages : 348 pages
Book Rating : 4.3/5 (91 download)
Download or read book Tumor Oxygenation written by Peter Vaupel and published by Lubrecht & Cramer, Limited. This book was released on 1995 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Giovanni Melillo
Publisher : Springer Science & Business Media
ISBN 13 : 1461491673
Total Pages : 362 pages
Book Rating : 4.4/5 (614 download)
Download or read book Hypoxia and Cancer written by Giovanni Melillo and published by Springer Science & Business Media. This book was released on 2013-11-09 with total page 362 pages. Available in PDF, EPUB and Kindle. Book excerpt: The imbalance between rapidly proliferating tumor cells and inadequate and inefficient tumor vasculature leads to a decrease in oxygen levels (hypoxia and/or anoxia) in tumor tissues. Intra-tumor hypoxia profoundly affects the biological behavior of cancer cells, which become resistant to conventional therapies and acquire a more invasive and metastatic phenotype. Hypoxia is a hallmark of the malignant phenotype and a key feature of the tumor microenvironment. Hypoxia Inducible Factor 1 (HIF-1) is a master regulator of the transcriptional response to oxygen deprivation. HIF triggers the expression of genes whose products induce angiogenesis, decrease oxygen consumption, switch metabolism to glycolysis, maintain a stem cell phenotype and select for more invasive and metastatic cells. Therapeutic approaches targeting HIF, directly or downstream mediators of its transcriptional activity, are being developed. Intra-tumor hypoxia is a topic has been gaining scientific interest over the last few years for its wide involvement in many physiological and pathological processes. This volume will cover the latest research and translational aspects associated with intra-tumor hypoxia, along with opportunities for drug development offered by this unique feature of the tumor microenvironment. The ongoing efforts to translate our understanding of the biology underlying intra-tumor hypoxia in viable therapeutic options face many challenges, but this book will provide an opportunity for an in-depth analysis of the fundamental mechanisms implicated in the adaption to low oxygen levels and will scrutinize the potential for opportunities that are being pursued in both research and the drug development industry.
Author : Christopher J. Gulledge
Publisher :
ISBN 13 :
Total Pages : 76 pages
Book Rating : 4.:/5 (362 download)
Download or read book Importance of Supply and Demand in Tumor Oxygenation written by Christopher J. Gulledge and published by . This book was released on 1996 with total page 76 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : David F. Wilson
Publisher : Springer Science & Business Media
ISBN 13 : 1461502055
Total Pages : 395 pages
Book Rating : 4.4/5 (615 download)
Download or read book Oxygen Transport To Tissue XXIII written by David F. Wilson and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 395 pages. Available in PDF, EPUB and Kindle. Book excerpt: The ISOTT 2001 local organizing committee was pleased to welcome over 140 delegates from around the world to the 29th annual general meeting of the International Society for Oxygen Transport to Tissue. The meeting was held in historic Philadelphia, USA, on the campus of the University of Pennsylvania from August 11 to 15, 2001. In the tradition of ISOTT, the conference was a total immersion experience. Attendees were encouraged to eat together and spend their evenings relaxing together in a style that maximized exchange of ideas and interactions of younger scientists with their more senior colleagues. Delegates participated in a total of 122 presentations including poster displays, selected oral presentations, seminars by invited speakers and a round table discussion. In choosing invited speakers and oral presenters, special emphasis was placed on methods for oxygen measurement in living tissue and application of these technologies to understanding physiological and biochemical basis for pathology related to tissue oxygenation. All of the manuscripts contained in this volume underwent both an editorial and scientific review, and only those meeting both criteria have been published. However, while all efforts have been made to eliminate editorial errors, some have undoubtedly been overlooked, for which the editors apologize.
Author : Paul Okunieff
Publisher : Springer Science & Business Media
ISBN 13 : 0387262067
Total Pages : 390 pages
Book Rating : 4.3/5 (872 download)
Download or read book Oxygen Transport to Tissue XXVI written by Paul Okunieff and published by Springer Science & Business Media. This book was released on 2006-06-18 with total page 390 pages. Available in PDF, EPUB and Kindle. Book excerpt: The International Society of Oxygen Transport to Tissue (ISOTT) was founded in 1973 to provide a forum for bioengineers, basic scientists, physiologists, and physicians to discuss new data, original theories, new interpretations of old data, and new technologies for the measurement of oxygen. At each annual meeting all posters are presented orally along with plenary lectures, and all presentations are given in a general session attended by everyone. Each meeting has had a specific focus, ranging from neonatology to physical chemistry to cancer biology. The Society has helped to build many careers, through opportunities to meet leaders in the field, and through awards made to young physicians and scientists. The Society also, through cross fertilization of ideas and scientific comradery, has inspired many breakthroughs in clinical medicine that now benefit mankind. I find myself president of the society after having been a winner of the Melvin Knisely Award for young scientists, in 1991. The 2003 meeting emphasized the role of oxygen and oxygen measurement in tumor growth, metastasis, physiology, and treatment resistance. Additionally, however, completely novel approaches to measurement of tissue oxygen were presented (notably work by Dr. Takahashi) and molecular methods for estimating tissue oxygen were evaluated. Papers discussing other aspects of oxygen measurement and pathophysiology were presented including in vivo ESR spectroscopy (notably including Dr. Swartz and colleagues), exercise physiology, organ transplant outcome (discussed by Dr. Cicco, our 2004 president), circulatory physiology, and cerebral oxygenation (notably including Dr. Chance).
Author : Yulin Song
Publisher :
ISBN 13 :
Total Pages : 486 pages
Book Rating : 4.:/5 (484 download)
Download or read book Tumor Oxygenation and Physiology in Response to Therapeutic Interventions Investigated by 19F MRI and NIR Spectroscopy written by Yulin Song and published by . This book was released on 2001 with total page 486 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Jeffrey Dunn
Publisher : Springer Science & Business Media
ISBN 13 : 1461500753
Total Pages : 728 pages
Book Rating : 4.4/5 (615 download)
Download or read book Oxygen Transport to Tissue XXIV written by Jeffrey Dunn and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 728 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume contains refereed manuscripts prepared from presentations made at the 2ih annual meeting of the International Society on Oxygen Transport to Tissue (ISOTT). The meeting was held in Hanover, NH, USA, at Dartmouth Medical School, the 3rd oldest medical school in the USA. ISOTT attempts to produce high quality pUblications on cutting edge topics relating to oxygen in living systerns. The goal is to allow contributors to contribute original data, as with a main-stream journal article, but also to voice individual opinions and ideas in a more relaxed scientific forum. The meeting brought together an international group of scientists who share a common interest in the measurement and role of oxygen in living systems. The organizers of ISOTT99 made a special effort to bring together people from industry, medicine, and basic sciences in order to improve the links in the chain of discovery through to application. As a result, this volume contains publications on a range of subjects. There are contributions from companies on modifiers of oxygen carrying capacity (allosteric modifiers of hemoglobin and infusible oxygen carriers or blood substitutes); technical reports on oxygen measurement devices including advances in near-infrared spectroscopy and imaging, oxygen electrodes, magnetic resonance spectroscopy and imaging, and fluorescence based measurements. There are medically related sections on modifying and measuring tumor oxygenation in order to improve therapy, assessment and interpretation of oxygenation in the central nervous system, and general issues relating oxygen to pathological conditions.
Author :
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (946 download)
Download or read book Non-Invasive Monitoring of Breast Tumor Oxygenation: A Key to Tumor Therapy Planning and Tumor Prognosis written by and published by . This book was released on 2001 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This report presents the specific aims and accomplishments of our breast cancer research project during the second year of funding sponsored by the U.S. Department of the Army. It covers our activities from September 1, 2001 to October 31, 2002. Introduction The overall goal of this research project is to develop and evaluate a new approach to monitoring of oxygenated hemoglobin concentration (HbO2) of breast tumors under respiratory interventions using near infrared (NIR) spectroscopy and imaging techniques. Furthermore, we wish to compare and validate the optical method with concurrent measurements of tumor oxygen tension with the use of 19F EPI relaxation of hexafluorobenzene (HFB). Once we have rigorously established the integrated approach to tumor physiology, we will explore the influence of three interventions expected to modify tumor physiology. A better understanding of the interplay of these parameters in the natural history of a tumor could lead to enhanced therapeutic approaches and provide a novel diagnostic/prognostic tool for breast cancer research and clinical practice.
Author : Anne Le
Publisher : Springer
ISBN 13 : 331977736X
Total Pages : 186 pages
Book Rating : 4.3/5 (197 download)
Download or read book The Heterogeneity of Cancer Metabolism written by Anne Le and published by Springer. This book was released on 2018-06-26 with total page 186 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genetic alterations in cancer, in addition to being the fundamental drivers of tumorigenesis, can give rise to a variety of metabolic adaptations that allow cancer cells to survive and proliferate in diverse tumor microenvironments. This metabolic flexibility is different from normal cellular metabolic processes and leads to heterogeneity in cancer metabolism within the same cancer type or even within the same tumor. In this book, we delve into the complexity and diversity of cancer metabolism, and highlight how understanding the heterogeneity of cancer metabolism is fundamental to the development of effective metabolism-based therapeutic strategies. Deciphering how cancer cells utilize various nutrient resources will enable clinicians and researchers to pair specific chemotherapeutic agents with patients who are most likely to respond with positive outcomes, allowing for more cost-effective and personalized cancer therapeutic strategies.
Author : Oliver Thews
Publisher : Springer
ISBN 13 : 3319912879
Total Pages : 452 pages
Book Rating : 4.3/5 (199 download)
Download or read book Oxygen Transport to Tissue XL written by Oliver Thews and published by Springer. This book was released on 2018-09-03 with total page 452 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book contains the refereed contributions from the 45th Annual Meeting of the International Society on Oxygen Transport to Tissue (ISOTT) 2017. This volume covers cross-disciplinary work on a broad range of topics related to the dynamics of oxygen transport: microcirculation and vascular medicine; O2 deficiency and its impact on molecular processes in cells and tissues; cellular metabolism and mitochondrial function; multimodal functional imaging; mathematical modeling; the clinical relevance of oxygen supply as well as therapeutic interventions (e.g. in oncology or critical care medicine). The annual meetings of ISOTT bring together scientists from diverse fields (medicine, physiology, mathematics, biology, chemistry, physics, engineering, etc.) in a unique international forum. The book includes sections on brain oxygenation and function, NIRS oxygenation measurements, tumor oxygenation, cell metabolism, tissue oxygenation and treatment, methodical aspects of O2 measurements and physicochemical aspects of oxygen diffusion. Chapters 3, 24, 49 and 51 of this book are open access under a CC BY 4.0 license.
Author : Hania A. Al-Hallaq
Publisher :
ISBN 13 :
Total Pages : 300 pages
Book Rating : 4.:/5 (453 download)
Download or read book Measurement of Changes in Tumor Oxygenation by High Spectral and Spatial Resolution MRI written by Hania A. Al-Hallaq and published by . This book was released on 2000 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Howard J. Halpern
Publisher : Springer
ISBN 13 : 3319552317
Total Pages : 427 pages
Book Rating : 4.3/5 (195 download)
Download or read book Oxygen Transport to Tissue XXXIX written by Howard J. Halpern and published by Springer. This book was released on 2017-07-06 with total page 427 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume presents all aspects of delivery of oxygen to tissues and tumors in peer reviewed short articles. Both overview and the most recent, advanced techniques for oxygen measurement are presented. Articles and peer reviewers include those from leaders in their field. Topics such as molecular signaling in the organismal and tumor response to low levels of local oxygenation, hypoxia inducible factor (HIF) , cancer metabolism, individual human and animal response to oxygen changes monitored by optical/near infrared spectroscopy/ tomography to novel electron resonance spectroscopy and spectroscopic imaging, instrumentation, progress in blood substitute research, retinal physiology, cellular hypoxia, mitochondrial function; brain oxygenation and function; oxygen transport in sports, hypoxia in diseases and clinical care. Chapters 10 and 19 of this book are open access under a CC BY 4.0 license.
Author : Pan-Dong Ryu
Publisher : Springer Nature
ISBN 13 : 3030344614
Total Pages : 431 pages
Book Rating : 4.0/5 (33 download)
Download or read book Oxygen Transport to Tissue XLI written by Pan-Dong Ryu and published by Springer Nature. This book was released on 2019-12-31 with total page 431 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents cutting-edge papers and perspectives on the transport of oxygen to tissues by scientists in a multitude of disciplines such as biochemistry, engineering, mathematics, medicine, physics, physiology, veterinary and complementary medicine. The book is composed of the following 6 parts: Brain Oxygenation and Function, Tumor Oxygenation and Metabolism, Muscle Oxygenation and Sports Medicine, Cell Metabolism and Tissue Oxygenation, Methodology of O2 Measurements, and Special Topics. The articles in this book have been presented at the 46th annual meeting of the International Society on Oxygen Transport to Tissue (ISOTT 2018) held in Seoul, Republic of Korea, from July 1 to July 5, 2018. Academics, clinical and industry researchers, engineers, as well as graduate students who are interested in oxygen transport to tissue will find this book a great reference and a useful learning resource.
Author : United States. Public Health Service. Office of the Surgeon General
Publisher :
ISBN 13 :
Total Pages : 728 pages
Book Rating : 4.:/5 (318 download)
Download or read book How Tobacco Smoke Causes Disease written by United States. Public Health Service. Office of the Surgeon General and published by . This book was released on 2010 with total page 728 pages. Available in PDF, EPUB and Kindle. Book excerpt: This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.
Author : Donald Andrew Belcher
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (114 download)
Download or read book Oxygenation of Solid Tumor Tissue Facilitated by Polymerized Human Hemoglobins written by Donald Andrew Belcher and published by . This book was released on 2019 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Cai Grau
Publisher :
ISBN 13 :
Total Pages : 27 pages
Book Rating : 4.:/5 (246 download)
Download or read book Radiobiological Studies on the Importance of Tumor Oxygenation for Anti-neoplastic Therapy written by Cai Grau and published by . This book was released on 1994 with total page 27 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Edwin M. Nemoto
Publisher : Springer Nature
ISBN 13 : 3030482383
Total Pages : 389 pages
Book Rating : 4.0/5 (34 download)
Download or read book Oxygen Transport to Tissue XLII written by Edwin M. Nemoto and published by Springer Nature. This book was released on 2021-05-08 with total page 389 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents cutting-edge papers and perspectives on the transport of oxygen to tissues by scientists in a multitude of disciplines such as biochemistry, engineering, mathematics, medicine, physics, physiology, veterinary and complementary medicine. The book is composed of the following 6 parts: Brain Oxygenation and Function, Tumor Oxygenation and Metabolism, Muscle Oxygenation and Sports Medicine, Cell Metabolism and Tissue Oxygenation, Methodology of O2 Measurements, and Special Topics. The articles in this book have been presented at the 42nd annual meeting of the International Society on Oxygen Transport to Tissue (ISOTT 2019) held in Albuquerque, New Mexico, USA, from July 28 to July 31, 2019. Academics, clinical and industry researchers, engineers, as well as graduate students who are interested in oxygen transport to tissue will find this book a great reference and a useful learning resource.
