Tuberculosis Research And Development

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A global strategy for tuberculosis research and innovation

Author :
Publisher : World Health Organization
ISBN 13 : 9240010017
Total Pages : 44 pages
Book Rating : 4.2/5 (4 download)

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Book Synopsis A global strategy for tuberculosis research and innovation by :

Download or read book A global strategy for tuberculosis research and innovation written by and published by World Health Organization. This book was released on 2020-08-21 with total page 44 pages. Available in PDF, EPUB and Kindle. Book excerpt: Tuberculosis (TB) is the leading cause of death from a single infectious agent, and one of the leading causes of death from antimicrobial resistance. To reach the milestones of the End TB Strategy, rapid progress must be made towards universal access to existing TB tools and services in the context of universal health coverage and socioeconomic development. At the same time, new technologies must be developed and introduced to make meaningful progress. The Global Strategy for Tuberculosis Research and Innovation will support the efforts of governments and other stakeholders to accelerate TB research and innovation, and improve equitable access to the benefits of research. This document is aimed primarily at Member States, particularly ministries of health, science and technology, finance and education.

Disease Control Priorities, Third Edition (Volume 6)

Author : King K. Holmes
Publisher : World Bank Publications
ISBN 13 : 1464805253
Total Pages : 1027 pages
Book Rating : 4.4/5 (648 download)

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Book Synopsis Disease Control Priorities, Third Edition (Volume 6) by : King K. Holmes

Download or read book Disease Control Priorities, Third Edition (Volume 6) written by King K. Holmes and published by World Bank Publications. This book was released on 2017-11-06 with total page 1027 pages. Available in PDF, EPUB and Kindle. Book excerpt: Infectious diseases are the leading cause of death globally, particularly among children and young adults. The spread of new pathogens and the threat of antimicrobial resistance pose particular challenges in combating these diseases. Major Infectious Diseases identifies feasible, cost-effective packages of interventions and strategies across delivery platforms to prevent and treat HIV/AIDS, other sexually transmitted infections, tuberculosis, malaria, adult febrile illness, viral hepatitis, and neglected tropical diseases. The volume emphasizes the need to effectively address emerging antimicrobial resistance, strengthen health systems, and increase access to care. The attainable goals are to reduce incidence, develop innovative approaches, and optimize existing tools in resource-constrained settings.

Evidence and research gaps identified during development of policy guidelines for tuberculosis

Author :
Publisher : World Health Organization
ISBN 13 : 9240040471
Total Pages : 36 pages
Book Rating : 4.2/5 (4 download)

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Book Synopsis Evidence and research gaps identified during development of policy guidelines for tuberculosis by :

Download or read book Evidence and research gaps identified during development of policy guidelines for tuberculosis written by and published by World Health Organization. This book was released on 2021-12-13 with total page 36 pages. Available in PDF, EPUB and Kindle. Book excerpt: Achieving the goals and targets of the WHO End TB Strategy requires innovative tools and strategies as well as rapid progress towards universal access. This document summarizes evidence gaps articulated in various WHO tuberculosis TB policy guidance to help steer innovation towards sustainable, desirable, acceptable, and feasible public health interventions required to end TB. It aims to serve as a reference for research policy-makers, funders, civil society and other relevant actors on the urgent TB research priorities for policy guidance.

The New Profile of Drug-Resistant Tuberculosis in Russia

Author : Russian Academy of Medical Sciences
Publisher : National Academies Press
ISBN 13 : 0309162971
Total Pages : 158 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis The New Profile of Drug-Resistant Tuberculosis in Russia by : Russian Academy of Medical Sciences

Download or read book The New Profile of Drug-Resistant Tuberculosis in Russia written by Russian Academy of Medical Sciences and published by National Academies Press. This book was released on 2011-08-07 with total page 158 pages. Available in PDF, EPUB and Kindle. Book excerpt: An estimated 2 billion people, one third of the global population, are infected with Mycobacterium tuberculosis, the bacterium that causes tuberculosis. Spread through the air, this infectious disease killed 1.7 million in 2009, and is the leading killer of people with HIV. Tuberculosis (TB) is also a disease of poverty-the vast majority of tuberculosis deaths occur in the developing world. Exacerbating the devastation caused by TB is the growing threat of drug-resistant forms of the disease in many parts of the world. Drug-resistant tuberculosis presents a number of significant challenges in terms of controlling its spread, diagnosing patients quickly and accurately, and using drugs to treat patients effectively. In Russia in recent decades, the rise of these strains of TB, resistant to standard antibiotic treatment, has been exacerbated by the occurrence of social, political, and economic upheavals. The Institute of Medicine (IOM) Forum on Drug Discovery, Development, and Translation, in conjunction with the Russian Academy of Medical Sciences held a workshop to discuss ways to fight the growing threat of drug-resistant TB. The New Profile of Drug-Resistant Tuberculosis in Russia: A Global and Local Perspective: Summary of a Joint Workshop presents information from experts on the nature of this threat and how it can be addressed by exploring various treatment and diagnostic options.

Tuberculosis Research and Development

Author : Cindra Feuer
Publisher :
ISBN 13 : 9780979107313
Total Pages : 70 pages
Book Rating : 4.1/5 (73 download)

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Book Synopsis Tuberculosis Research and Development by : Cindra Feuer

Download or read book Tuberculosis Research and Development written by Cindra Feuer and published by . This book was released on 2007-01-01 with total page 70 pages. Available in PDF, EPUB and Kindle. Book excerpt: "This report is the product of an effort by the Treatment Action Group (TAG) to ascertain the major funders of tuberculosis (TB) research and development (R&D) in 2005, what kinds of research activity they funded, and how much research activity is already taking place. This assessment will help policymakers, funders, researchers, and advocates understand the current state of research on TB, and it provides a baseline for understanding how much TB research funding will need to increase in order to bring TB under control over the next decade. " - p. 6

Evidence and research gaps identified during development of policy guidelines for tuberculosis

Author : World Health Organization
Publisher : World Health Organization
ISBN 13 : 9240087591
Total Pages : 40 pages
Book Rating : 4.2/5 (4 download)

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Book Synopsis Evidence and research gaps identified during development of policy guidelines for tuberculosis by : World Health Organization

Download or read book Evidence and research gaps identified during development of policy guidelines for tuberculosis written by World Health Organization and published by World Health Organization. This book was released on 2024-01-22 with total page 40 pages. Available in PDF, EPUB and Kindle. Book excerpt: Achieving the goals and targets of the WHO End TB Strategy requires innovative tools and strategies as well as rapid progress towards universal access. This document serves as an update to a previously released report with an identical title: It summarizes evidence gaps articulated in various WHO TB policy guidance to help steer innovation towards sustainable, desirable, acceptable, and feasible public health interventions required to end TB. It aims to serve as a reference for research policy-makers, funders, civil society and other relevant actors on the urgent TB research priorities for policy guidance.

Facing the Reality of Drug-Resistant Tuberculosis in India

Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 0309219663
Total Pages : 186 pages
Book Rating : 4.3/5 (92 download)

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Book Synopsis Facing the Reality of Drug-Resistant Tuberculosis in India by : Institute of Medicine

Download or read book Facing the Reality of Drug-Resistant Tuberculosis in India written by Institute of Medicine and published by National Academies Press. This book was released on 2012-08-20 with total page 186 pages. Available in PDF, EPUB and Kindle. Book excerpt: An estimated 8.8 million people fell ill with tuberculosis (TB) in 2010 and 1.4 million died from the disease. Although antibiotics to treat TB were developed in the 1950s and are effective against a majority of TB cases, resistance to these antibiotics has emerged over the years, resulting in the growing spread of multidrug-resistant (MDR) TB. Due to challenges in timely and accurate diagnosis of drug-resistant TB, length and tolerability of treatment regimens, and expense of second-line anti-TB drugs, effectively controlling the disease requires complex public health interventions. The IOM Forum on Drug Discovery, Development, and Translation held three international workshops to gather information from local experts around the world on the threat of drug resistant TB and how the challenges it presents can be met. Workshops were held in South Africa and Russia in 2010. The third workshop was held April 18-19, 2011, in New Delhi, India, in collaboration with the Indian National Science Academy and the Indian Council of Medical Research. The aim of the workshop was to highlight key challenges to controlling the spread of drug-resistant strains of TB in India and to discuss strategies for advancing and integrating local and international efforts to prevent and treat drug-resistant TB. This document summarizes the workshop.

Facing the Reality of Drug-Resistant Tuberculosis in India

Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 0309219698
Total Pages : 186 pages
Book Rating : 4.3/5 (92 download)

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Book Synopsis Facing the Reality of Drug-Resistant Tuberculosis in India by : Institute of Medicine

Download or read book Facing the Reality of Drug-Resistant Tuberculosis in India written by Institute of Medicine and published by National Academies Press. This book was released on 2012-07-20 with total page 186 pages. Available in PDF, EPUB and Kindle. Book excerpt: An estimated 8.8 million people fell ill with tuberculosis (TB) in 2010 and 1.4 million died from the disease. Although antibiotics to treat TB were developed in the 1950s and are effective against a majority of TB cases, resistance to these antibiotics has emerged over the years, resulting in the growing spread of multidrug-resistant (MDR) TB. Due to challenges in timely and accurate diagnosis of drug-resistant TB, length and tolerability of treatment regimens, and expense of second-line anti-TB drugs, effectively controlling the disease requires complex public health interventions. The IOM Forum on Drug Discovery, Development, and Translation held three international workshops to gather information from local experts around the world on the threat of drug resistant TB and how the challenges it presents can be met. Workshops were held in South Africa and Russia in 2010. The third workshop was held April 18-19, 2011, in New Delhi, India, in collaboration with the Indian National Science Academy and the Indian Council of Medical Research. The aim of the workshop was to highlight key challenges to controlling the spread of drug-resistant strains of TB in India and to discuss strategies for advancing and integrating local and international efforts to prevent and treat drug-resistant TB. This document summarizes the workshop.

Tuberculosis Research and Development

Author : Cindra Feuer
Publisher :
ISBN 13 : 9780979107306
Total Pages : pages
Book Rating : 4.1/5 (73 download)

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Book Synopsis Tuberculosis Research and Development by : Cindra Feuer

Download or read book Tuberculosis Research and Development written by Cindra Feuer and published by . This book was released on 2006-10 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: "This report is the product of an effort by the Treatment Action Group (TAG) to ascertain the major funders of tuberculosis (TB) research and development (R & D) in 2005, what kinds of research activity they funded, and how much research activity is already taking place. This assessment will help policymakers, funders, researchers, and advocates understand the current state of research on TB, and it provides a baseline for understanding how much TB research funding will need to increase in order to bring TB under control over the next decade."--Page 6.

Developing and Strengthening the Global Supply Chain for Second-Line Drugs for Multidrug-Resistant Tuberculosis

Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 0309265959
Total Pages : 171 pages
Book Rating : 4.3/5 (92 download)

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Book Synopsis Developing and Strengthening the Global Supply Chain for Second-Line Drugs for Multidrug-Resistant Tuberculosis by : Institute of Medicine

Download or read book Developing and Strengthening the Global Supply Chain for Second-Line Drugs for Multidrug-Resistant Tuberculosis written by Institute of Medicine and published by National Academies Press. This book was released on 2013-03-06 with total page 171 pages. Available in PDF, EPUB and Kindle. Book excerpt: To effectively treat patients diagnosed with drug-resistant (DR) tuberculosis (TB) and protect the population from further transmission of this infectious disease, an uninterrupted supply of quality-assured (QA), second-line anti-TB drugs (SLDs) is necessary. Patients diagnosed with multidrug-resistant tuberculosis (MDR TB)-a disease caused by strains of Mycobacterium tuberculosis (M.tb.) resistant to two primary TB drugs (isoniazid and rifampicin)-face lengthy treatment regimens of 2 years or more with daily, directly observed treatment (DOT) with SLDs that are less potent, more toxic, and more expensive than those used to treat drug-susceptible TB. From 2000 to 2009, only 0.2-0.5 percent of the estimated 5 million MDR TB cases globally were treated with drugs of known quality and in programs capable of delivering appropriate care (Keshavjee, 2012). The vast majority of MDR TB patients either died from lack of treatment or contributed to the spread of MDR TB in their communities. A strengthened global supply chain for SLDs could save lives by consistently delivering high quality medicines to more of the people who need them. This public workshop explored innovative solutions to the problem of how to get the right SLDs for MDR TB to people who critically need them. More specifically, the workshop examined current problems and potential opportunities for coordinated international efforts to ensure that a reliable and affordable supply of high-quality SLDs is available. Developing and Strengthening the Global Supply Chain for Second-Line Drugs for Multidrug-Resistant Tuberculosis: Workshop Summary covers the objectives of the workshop, which were to review: -To what extent and in what ways current mechanisms are or are not effectively accomplishing what is needed, including consideration of bottlenecks. -The advantages and disadvantages of centralization in the management of the global drug supply chain, and potential decentralized approaches to improve operations of the supply chain. -What can be learned from case studies and examples from other diseases (e.g., the Affordable Medicines Facility-malaria (AMFm) and the U.S. President's Emergency Plan for AIDS Relief [PEPFAR]) - The current allocation of responsibilities and roles of the private (including industry and nonprofit public health organizations) and public sectors, and examination of opportunities for enhancing and optimizing collaboration -Identification of potential innovative solutions to the problem

Situational assessment checklist to guide implementation of the global strategy for tuberculosis research and innovation

Author :
Publisher : World Health Organization
ISBN 13 : 9240020888
Total Pages : 21 pages
Book Rating : 4.2/5 (4 download)

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Book Synopsis Situational assessment checklist to guide implementation of the global strategy for tuberculosis research and innovation by :

Download or read book Situational assessment checklist to guide implementation of the global strategy for tuberculosis research and innovation written by and published by World Health Organization. This book was released on 2021-03-23 with total page 21 pages. Available in PDF, EPUB and Kindle. Book excerpt: Research along its full spectrum is critical for developing new tools and strategies for better tuberculosis (TB) prevention, diagnosis, treatment and care and to provide scientific evidence for programmes, practitioners and policy-makers working to alleviate morbidity and mortality from TB. Under the leadership of WHO, a global strategy for TB research and innovation was developed and adopted by Member States in 2020 to advance research and innovation, by translating political commitments made in the Moscow Declaration to End TB (2017) and the political declaration at the United Nations high-level meeting on TB (2018) into concrete actions. The present document is a checklist that allows for a robust analysis of the current situation at country level, to build an evidence base for prioritizing the implementations of the recommendations made in the global strategy through changes in policies, programmes and interventions. It is designed as a reference for ministries of health and other entities responsible for overseeing the implementation of the global strategy.

The Global Crisis of Drug-Resistant Tuberculosis and Leadership of China and the BRICS

Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 0309285992
Total Pages : 219 pages
Book Rating : 4.3/5 (92 download)

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Book Synopsis The Global Crisis of Drug-Resistant Tuberculosis and Leadership of China and the BRICS by : Institute of Medicine

Download or read book The Global Crisis of Drug-Resistant Tuberculosis and Leadership of China and the BRICS written by Institute of Medicine and published by National Academies Press. This book was released on 2014-02-28 with total page 219 pages. Available in PDF, EPUB and Kindle. Book excerpt: Multidrug-resistant tuberculosis (TB) is caused by bacteria resistant to isoniazid and rifampicin, the two most effective first-line anti-TB drugs, originally developed and introduced in the 1950 and 1960s. Since 2008, the Forum on Drug Discovery, Development, and Translation of the Institute of Medicine has hosted or co-hosted six domestic and international workshops addressing the global crisis of drug-resistant TB, with special attention to the BRICS countries - Brazil, Russia, India, China, and South Africa. The Global Crisis of Drug-Resistant Tuberculosis and Leadership of China and the BRICS is the summary of a workshop convened to address the current status of drug-resistant TB globally and in China. This report considers lessons learned from high burden countries; highlights global challenges to controlling the spread of drug-resistant strains; and discusses innovative strategies to advance and harmonize local and international efforts to prevent and treat drug-resistant TB. Additionally, the report examines the problem of MDR TB and emergent TB strains that are potentially untreatable with drugs available and considers the critical leadership role of the BRICS countries in addressing the threats and opportunities in drug-resistant TB.

Handbook of Global Tuberculosis Control

Author : Yichen Lu
Publisher : Springer
ISBN 13 : 1493966677
Total Pages : 557 pages
Book Rating : 4.4/5 (939 download)

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Book Synopsis Handbook of Global Tuberculosis Control by : Yichen Lu

Download or read book Handbook of Global Tuberculosis Control written by Yichen Lu and published by Springer. This book was released on 2017-06-09 with total page 557 pages. Available in PDF, EPUB and Kindle. Book excerpt: This ambitious reference surveys worldwide efforts at controlling the spread of tuberculosis, with special emphasis on the developing world. Case studies from China, Pakistan, Nigeria, Indonesia, and other frontline countries demonstrate a wealth of information on clinical, cultural, socioeconomic, and other relevant factors. This compilation provides a valuable resource for creating successful intervention and prevention strategies. State-of-the-science snapshots pinpoint where short- and long-term initiatives stand today, from early detection and vaccination programs to new genetic technologies and drug therapies. This diverse group of perspectives and approaches offers innovative paths toward control and realistic odds for containing the threat, especially in the face of current co-epidemics and new drug-resistant strains. Among the topics in the Handbook: Diagnosis of tuberculosis: current pipeline, unmet needs, and new developments Concurrence of tuberculosis and other major diseases The tuberculosis outbreak response, investigation, and control The promise of new TB vaccines DNA fingerprinting of Mycobacterium tuberculosis: a rich source of fundamental and daily applicable knowledge Global tuberculosis surveillance The Handbook of Global Tuberculosis Control is urgent reading for leadership and staff of non-governmental organizations, government agencies, academic institutions, research centers, hospitals, and potentially businesses with interests in tuberculosis control. Additionally, the book's focus on TB in developing countries will attract a wider audience of practitioners, particularly those working in the broader fields of global public health, epidemiology, international development, and the socioeconomics of infectious diseases.

Fourth WHO consultation on the translation of tuberculosis research into global policy guidelines

Author : World Health Organization
Publisher : World Health Organization
ISBN 13 : 924009203X
Total Pages : 16 pages
Book Rating : 4.2/5 (4 download)

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Book Synopsis Fourth WHO consultation on the translation of tuberculosis research into global policy guidelines by : World Health Organization

Download or read book Fourth WHO consultation on the translation of tuberculosis research into global policy guidelines written by World Health Organization and published by World Health Organization. This book was released on 2024-04-17 with total page 16 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Global Tuberculosis Programme of the World Health Organization has the mandate to develop and disseminate evidence-based policy for tuberculosis prevention, diagnosis, treatment, and care. Regular review of evidence, and assessment of country needs for policy across the cascade of care is part of its core function. In this regard, GTB organized a fourth consultation assembling scientists, public health experts, partners, civil society, and countries to exchange views on emerging areas of need for evidence and for global TB policy guidance to achieve the goals and targets of the WHO End TB Strategy. The present report summarizes the outcome of this meeting.

Development of New Antituberculosis Drugs

Author : W. W. Yew
Publisher : Nova Publishers
ISBN 13 : 9781594548574
Total Pages : 328 pages
Book Rating : 4.5/5 (485 download)

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Book Synopsis Development of New Antituberculosis Drugs by : W. W. Yew

Download or read book Development of New Antituberculosis Drugs written by W. W. Yew and published by Nova Publishers. This book was released on 2006 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the global war to control tuberculosis (TB), there are several critical battles which must be waged and won if we are to make significant progress. Broadly speaking, these battlefields may be regarded as diagnosis, treatment and prevention. Within the arena of treatment are various critical elements. Current drug regimens require 6 months to achieve predictable cures; it is essential that shorter regimens be developed to lessen non-adherence and to improve affordability. To facilitate directly-observed therapy, intermittent (less than daily) regimens have been employed. To ensure favourable outcomes, including patients with AIDS, thrice-weekly regimens are the current standard; reducing the frequency of dosing to twice- or once-weekly may offer significant advantages. Drug resistance to the current major medications, the rifamycins and isoniazid, threatens to make tuberculosis untreatable for rising numbers of patients in many regions of the world. Finding new, effective agents is essential to ensure cures for these cases and to halt transmission of multidrug-resistant tuberculosis to others. Additional issues include reducing the side effects and toxicity of anti-tuberculosis regimens and developing regimens that can be given simultaneously with anti-retroviral therapy without deleterious drug-drug interactions or unacceptable toxicity. Finally, attention must be directed to the potential utility of treating latent infection to prevent the evolution of active disease. The current vaccine Bacille Calmette-Guerin (BCG), while protecting infants and children against potentially lethal forms of TB, has done little to control the incidence of communicable adult pulmonary disease. Research is underway to develop improved vaccines, but due to the prolonged period to determine the efficacy of a TB vaccine (a minimum of 10 to 20 years) -- alternative strategies must be pursued. Furthermore, the utility of a traditional vaccine would be sorely limited by the fact that roughly two billion persons today harbour latent tuberculosis infection. This huge reservoir of future disease would not be eligible for a traditional pre-infection vaccine. "Preventive therapy" with isoniazid has been shown to reduce the subsequent risk of tuberculosis by about 70% in large, randomised placebo-controlled clinical trials. However, this strategy is limited by the requirement for extended duration of treatment (6 to 9 months), the risks of drug-induced hepatitis and rising rates of resistance to isoniazid in many regions of the world where the TB epidemic is most intense. Alternative means for the treatment of latent tuberculosis infection should be given high priority. The authors have assembled an outstanding panel of contributors to address these issues. The topics herein have great relevance both in the industrialised nations where contemporary medications and strategies appear to have exacted their maximum benefits and for the developing nations where this ancient scourge remains rampant. This book will provide an impetus for authorities and organisations devoted to the development of new drugs to address the aforementioned growing problems of TB world-wide.

WHO consultation on the translation of tuberculosis research into global policy guidelines

Author :
Publisher : World Health Organization
ISBN 13 : 9240024395
Total Pages : 24 pages
Book Rating : 4.2/5 (4 download)

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Book Synopsis WHO consultation on the translation of tuberculosis research into global policy guidelines by :

Download or read book WHO consultation on the translation of tuberculosis research into global policy guidelines written by and published by World Health Organization. This book was released on 2021-04-30 with total page 24 pages. Available in PDF, EPUB and Kindle. Book excerpt: Regular review of evidence, and assessment of country needs for policy across the cascade of care is part of the core function of the Global Tuberculosis Programme of the World Health Organization (WHO/GTB). In this regard, GTB organized a consultation (2-4 March 2021) assembling scientists, public health experts, partners, civil society and countries to exchange views on emerging needs of Member States for policy guidance; to discuss critical evidence gaps related to emerging global TB policy development needs; and, to identify topical strategies best positioned to enhance the implementation and evaluation of global TB policy guidance. The present report summarizes the discussions from this meeting.

Second WHO consultation on the translation of tuberculosis research into global policy guidelines

Author : World Health Organization
Publisher : World Health Organization
ISBN 13 : 9240050906
Total Pages : 18 pages
Book Rating : 4.2/5 (4 download)

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Book Synopsis Second WHO consultation on the translation of tuberculosis research into global policy guidelines by : World Health Organization

Download or read book Second WHO consultation on the translation of tuberculosis research into global policy guidelines written by World Health Organization and published by World Health Organization. This book was released on 2022-05-30 with total page 18 pages. Available in PDF, EPUB and Kindle. Book excerpt: