Trials For Cerebellar Ataxias

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Trials for Cerebellar Ataxias

Author : Bing-wen Soong
Publisher : Springer Nature
ISBN 13 : 3031243455
Total Pages : 716 pages
Book Rating : 4.0/5 (312 download)

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Book Synopsis Trials for Cerebellar Ataxias by : Bing-wen Soong

Download or read book Trials for Cerebellar Ataxias written by Bing-wen Soong and published by Springer Nature. This book was released on 2023-05-29 with total page 716 pages. Available in PDF, EPUB and Kindle. Book excerpt: Despite the critical importance of the cerebellum in brain function, the scientific community still lacks effective treatments for most cerebellar ataxias. This book provides a link between the pathogenesis and therapies of cerebellar ataxias while also providing a comprehensive assessment of the preclinical and clinical trials dedicated to cerebellar ataxias over the past 20 years of progress. This is the first book fully dedicated to the trials and therapies of these disorders. It is a truly authoritative and comprehensive reference, and comes at a time of major advances in genetic tools and neuroimaging assessments. The coverage begins by laying a foundation of the basic science of the cerebellum and ataxias, proceeds to discuss biomarkers and the tools of trials, offers guidelines on conducting trials, and then explores the full range of therapeutics and their trials, including gene therapy and cell transplantation. The authors are top experts on cerebellar research and the contributing authors have all made seminal contributions in the field.

Cerebellar Disorders

Author : Mario Ubaldo Manto
Publisher : Cambridge University Press
ISBN 13 : 1139487264
Total Pages : 313 pages
Book Rating : 4.1/5 (394 download)

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Book Synopsis Cerebellar Disorders by : Mario Ubaldo Manto

Download or read book Cerebellar Disorders written by Mario Ubaldo Manto and published by Cambridge University Press. This book was released on 2010-03-25 with total page 313 pages. Available in PDF, EPUB and Kindle. Book excerpt: During the last three decades, many laboratories worldwide have dedicated their research activities to understanding the roles of the cerebellum in motor control, cognitive processes and the biology of mental processes, behavioral symptoms and emotion. These advances have been associated with discoveries of new clinical disorders, in particular in the field of genetic ataxias, and the growing number of diseases presents a source of difficulty for clinicians during daily practice. This practical guide summarizes and evaluates current knowledge in the field of cerebellar disorders. Encompassing details of both common and uncommon cerebellar ataxias, including vascular, immune, neoplastic, infectious, traumatic, toxic and inherited disorders, this book will assist clinicians in the diagnosis and management of the full spectrum of cerebellar ataxias encountered in daily practice. Essential reading for clinicians, including general practitioners, neurologists, pediatricians, radiologists, psychiatrists and neuropsychologists, this will also prove a valuable tool for students, trainees and researchers.

Genetics of Movement Disorders

Author : Stefan M. Pulst
Publisher : Elsevier
ISBN 13 : 0080532411
Total Pages : 585 pages
Book Rating : 4.0/5 (85 download)

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Book Synopsis Genetics of Movement Disorders by : Stefan M. Pulst

Download or read book Genetics of Movement Disorders written by Stefan M. Pulst and published by Elsevier. This book was released on 2002-10-25 with total page 585 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hereditary or genetic diseases featuring involuntary movements constitute a major aspect of the practice of neurology, functional neurosurgery, genetics, and many areas of basic and applied neuroscience research. Describing the current knowledge on these disorders, Genetics of Movement Disorders brings together information essential for clinicians, geneticists, and neuroscientists in one source. Utilizing a convenient and accessible format, the book is designed to allow easy identification of relevant information, with the overall organization of topics following established phenotypic classifications of movement disorders such as Parkinsonian syndromes, chorea, ataxia, and major categories of diseases grouped by gene locus. This book broadly appeals to neurologists, neuroscientists, geneticists, as well as cell and molecular biologists and hematologists. - Consistently formatted to present a clinical description of the disorder, followed by an in-depth analysis of the mutation and function of the mutated gene including cellular and animal models - Emphasizes the use of DNA tests for each respective disorder - Provides up-to-date, easily accessible information for clinicians, geneticists, and neuroscientists

Neurogenetics

Author : Stefan-M. Pulst
Publisher : Contemporary Neurology
ISBN 13 : 9780195129755
Total Pages : 496 pages
Book Rating : 4.1/5 (297 download)

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Book Synopsis Neurogenetics by : Stefan-M. Pulst

Download or read book Neurogenetics written by Stefan-M. Pulst and published by Contemporary Neurology. This book was released on 2000 with total page 496 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neurogenetics is intended for any physician or scientist who manages patients with inherited diseases of the nervous system. It presents the clinical phenotypes of the most commonly inherited neurologic diseases, and their molecular pathogenesis, followed by a description of the appropriate tests to be used in diagnosis. Two introductory chapters familiarize the nongeneticist with medical genetic terminology and molecular genetic techniques useful in the analysis of genetic disease and genetic testing. Subsequent chapters examine major neurologic disorders caused by single defects, as well as disease phenotypes such as Alzheimer disease or amyotrophic lateral sclerosis which may be caused by defects in single genes, but may also be seen as sporadic diseases. The genetic components of other common neurologic disorders, such as epilepsy, multiple sclerosis, migraine, and stroke are all covered in detail. The final chapter discusses genetic counseling of symptomatic and pre-symptomatic individuals. Throughout, chapters discuss genotype/phenotype correlations and, where appropriate, animal models for inherited human neurologic diseases. Several chapters are devoted to recently discovered diseases caused by unstable DNA repeats. Special emphasis is placed on conveying how DNA testing can be applied to the daily practice of geneticists and neurologists.

Polyglutamine Disorders

Author : Clévio Nóbrega
Publisher : Springer
ISBN 13 : 3319717790
Total Pages : 467 pages
Book Rating : 4.3/5 (197 download)

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Book Synopsis Polyglutamine Disorders by : Clévio Nóbrega

Download or read book Polyglutamine Disorders written by Clévio Nóbrega and published by Springer. This book was released on 2018-02-09 with total page 467 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a cutting-edge review of polyglutamine disorders. It primarily focuses on two main aspects: (1) the mechanisms underlying the pathologies’ development and progression, and (2) the therapeutic strategies that are currently being explored to stop or delay disease progression. Polyglutamine (polyQ) disorders are a group of inherited neurodegenerative diseases with a fatal outcome that are caused by an abnormal expansion of a coding trinucleotide repeat (CAG), which is then translated in an abnormal protein with an elongated glutamine tract (Q). To date, nine polyQ disorders have been identified and described: dentatorubral-pallidoluysian atrophy (DRPLA); Huntington’s disease (HD); spinal–bulbar muscular atrophy (SBMA); and six spinocerebellar ataxias (SCA 1, 2, 3, 6, 7, and 17). The genetic basis of polyQ disorders is well established and described, and despite important advances that have opened up the possibility of generating genetic models of the disease, the mechanisms that cause neuronal degeneration are still largely unknown and there is currently no treatment available for these disorders. Further, it is believed that the different polyQ may share some mechanisms and pathways contributing to neurodegeneration and disease progression.

Neurological Physical Therapy

Author : Toshiaki Suzuki
Publisher : BoD – Books on Demand
ISBN 13 : 9535131133
Total Pages : 236 pages
Book Rating : 4.5/5 (351 download)

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Book Synopsis Neurological Physical Therapy by : Toshiaki Suzuki

Download or read book Neurological Physical Therapy written by Toshiaki Suzuki and published by BoD – Books on Demand. This book was released on 2017-05-10 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt: Physical therapy services may be provided alongside or in conjunction with other medical services. They are performed by physical therapists (known as physiotherapists in many countries) with the help of other medical professionals. This book consists of 12 chapters written by several professionals from different parts of the world. The book covers different subjects, such as the effects of physical therapy, motor imagery, neuroscience-based rehabilitation for neurological patients, and applications of robotics for stroke and cerebral palsy. We hope that this book will open up new directions for physical therapists in the field of neurological physical therapy.

Cerebellar Disorders in Children

Author : Eugen Boltshauser
Publisher : Mac Keith Press
ISBN 13 : 9781907655012
Total Pages : 0 pages
Book Rating : 4.6/5 (55 download)

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Book Synopsis Cerebellar Disorders in Children by : Eugen Boltshauser

Download or read book Cerebellar Disorders in Children written by Eugen Boltshauser and published by Mac Keith Press. This book was released on 2012-03-05 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Clinics in Developmental Medicine No. 191-192 This clinically orientated text by an international group of experts is the first definitive reference book on disorders of the cerebellum in children. It presents a wealth of practical clinical experience backed up by a strong scientific basis for the information and guidance given. The first part sets out the theoretical underpinnings of cerebellar disorders. This is followed by sections on clinical conditions grouped according to common characteristics such as aetiology and symptomatology. The descriptions of the clinical conditions each systematically cover, as appropriate, epidemiology, prevalence, diagnostic criteria, clinical features (including course and prognosis), pathophysiology, genetics, investigations, differential diagnosis, and management and treatment. This book will be an invaluable resource for all those caring for children affected by cerebellar disorders, including malformations, genetic and metabolic disorders, acquired cerebellar damage, vascular disorders and acute ataxias. This comprehensive reference text on cerebellar disorders in children includes chapters on cerebellar development, prenatal cerebellar imaging, imaging of the posterior fossa, with coverage of a broad range of malformations, genetic and metabolic disorders involving the cerebellum, prenatal cerebellar disruptions (as related to prematurity), vascular disorders, tumors and paraneoplastic syndromes, as well as acute ataxia and trauma to the posterior fossa. Numerous checklists are provided to assist in the differential diagnosis of clinical signs and neuroimaging findings. Readership: Paediatric neurologists, paediatricians, neurologists, developmental paediatricians, neuroimaging specialists, geneticists, neonatologists

The Paroxysmal Disorders

Author : Bettina Schmitz
Publisher : Cambridge University Press
ISBN 13 : 1139487566
Total Pages : pages
Book Rating : 4.1/5 (394 download)

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Book Synopsis The Paroxysmal Disorders by : Bettina Schmitz

Download or read book The Paroxysmal Disorders written by Bettina Schmitz and published by Cambridge University Press. This book was released on 2010-09-09 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The paroxysmal disorders present neurologists and other medical professionals with diagnostic problems across a range of disorders, including multiple sclerosis, migraine and epilepsy. This new English language edition of a compendium of the paroxysmal disorders, originally published in German as Paroxysmale Störugen in der Neurologie, is an informative and practical resource for clinicians, which provides invaluable help with differential diagnosis and management. Fully updated throughout, this new edition comprehensively covers the entire spectrum of the paroxysmal disorders, including sudden falls, headache, vertigo attacks, memory loss, visual disturbances, seizures and anxiety. Each chapter is practice oriented, covering definitions, etiology, epidemiology, diagnosis, examination techniques and therapy. Detailed guidelines for gathering case-histories, essential for accurate diagnosis, are also provided. Important reading for clinicians, professionals and academic researchers working in neurology, psychiatry, epilepsy, internal medicine and ENT.

Circadian and Visual Neuroscience

Author :
Publisher : Elsevier
ISBN 13 : 0323859445
Total Pages : 380 pages
Book Rating : 4.3/5 (238 download)

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Book Synopsis Circadian and Visual Neuroscience by :

Download or read book Circadian and Visual Neuroscience written by and published by Elsevier. This book was released on 2022-08-05 with total page 380 pages. Available in PDF, EPUB and Kindle. Book excerpt: Circadian and Visual Neuroscience, Volume 273 in the Methods in Enzymology series, highlights new advances in the field with this new volume presenting interesting chapters on topics including Optical set-ups, Psychophysics of Luminance and Color Vision, Psychophysics of non-visual photoreception PRC/IRC/DRC/Spectral Sensitivity, Circadian and visual photometry, Modelling (retina), Modelling (circadian), Techniques for examining vision at the cellular level, Advanced techniques for characterizing the world hyperspectrally, Circadian physiology in mice: Melanopsin, Circadian physiology in mice: Color and cones, Translational aspects of animal studies, Retinal clocks, Primate non-visual physiology, Light and mood in animal models, and much more. - Provides the authority and expertise of leading contributors from an international board of authors - Presents the latest release in Progress in Brain Research series - Updated release includes the latest information on Circadian and Visual Neuroscience

The Cerebellum and Cognition

Author :
Publisher : Academic Press
ISBN 13 : 0080857752
Total Pages : 709 pages
Book Rating : 4.0/5 (88 download)

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Book Synopsis The Cerebellum and Cognition by :

Download or read book The Cerebellum and Cognition written by and published by Academic Press. This book was released on 1997-10-02 with total page 709 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Cerebellum and Cognition pulls together a preeminent group of authors. The cerebellum has been previously considered as a highly complex structure involved only with motor control. The cerebellum is essential to nonmotor functions, and recent research has revealed new medically important roles of the cerebellum and cognitive processes. - Selected for inclusion in Doody's Core Titles 2013, an essential collection development tool for health sciences libraries - Comprehensive coverage of cerebellum in motor control and cognition - New developments regarding the cerebellum and motor systems - Therapeutic implications of cerebellar contributions to cognition - Preeminent group of contributors

Vertebrobasilar Ischemia and Hemorrhage

Author : Louis R. Caplan
Publisher : Cambridge University Press
ISBN 13 : 0521763061
Total Pages : 609 pages
Book Rating : 4.5/5 (217 download)

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Book Synopsis Vertebrobasilar Ischemia and Hemorrhage by : Louis R. Caplan

Download or read book Vertebrobasilar Ischemia and Hemorrhage written by Louis R. Caplan and published by Cambridge University Press. This book was released on 2015-04-02 with total page 609 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive review of vascular disease in the vertebrobasilar circulation by one of the world's leading authorities, fully updated throughout.

Paroxysmal Movement Disorders

Author : Kapil D. Sethi
Publisher : Springer Nature
ISBN 13 : 3030537218
Total Pages : 145 pages
Book Rating : 4.0/5 (35 download)

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Book Synopsis Paroxysmal Movement Disorders by : Kapil D. Sethi

Download or read book Paroxysmal Movement Disorders written by Kapil D. Sethi and published by Springer Nature. This book was released on 2020-11-18 with total page 145 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book addresses the challenges in the differential diagnosis and management of paroxysmal movement disorders. It provides the latest information on the genetics and pathophysiology, neurophysiology and neuroimaging of the core group of disorders in the field, namely the paroxysmal dyskinesias (PxD). Focused and concise, this guide features chapters that discuss other conditions that may be paroxysmal such as, episodic ataxia, startle syndromes and other more complicated groups of paroxysmal movement disorders such as ATP1A3 spectrum disorders. A chapter on secondary (acquired) paroxysmal dyskinesia highlights medical and other disorders that may result in paroxysmal dyskinesia. The book features a particularly nuanced chapter that discusses recent discoveries in the genetic aspects of PxD, relaying that paroxysmal dyskinesias are not channelpathies, but in fact are synaptophies and transportopathies. Additionally, expertly written chapters are supplemented by high quality images, tables, and videos. Paroxysmal Movement Disorders: A Practical Guide is primarily written to educate the reader on how to make a syndromic diagnosis of paroxysmal movement disorders and how to build the diagnostic work-up accordingly, as well as how to manage patients with paroxysmal movement disorders.

Oxford Textbook of Vertigo and Imbalance

Author : Adolfo Bronstein
Publisher : OUP Oxford
ISBN 13 : 0191642061
Total Pages : 375 pages
Book Rating : 4.1/5 (916 download)

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Book Synopsis Oxford Textbook of Vertigo and Imbalance by : Adolfo Bronstein

Download or read book Oxford Textbook of Vertigo and Imbalance written by Adolfo Bronstein and published by OUP Oxford. This book was released on 2013-02-21 with total page 375 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vertigo, dizziness, and imbalance rank amongst the most common presenting symptoms in neurology, ENT, geriatric medicine, and general practice. These symptoms can originate from many different organs and systems, such as the inner ear, general medical conditions, neurological and psychological disorders. The Oxford Textbook of Vertigo and Imbalance provides an up-to-date summary of the scientific basis, clinical diagnosis, and management of disorders leading to dizziness and poor balance. This textbook is conceptually divided into three sections, detailing the scientific basis, general clinical issues, and specific diseases diagnosed in clinical practice that are responsible for complaints of dizziness and imbalance. Individual chapters address benign paroxysmal positional vertigo, vestibular migraine, vestibular neuritis, stroke, and Ménière's disease. Additional chapters follow a syndrome-based approach and cover multiple conditions, including cerebellar disorders, bilateral vestibular failure and gait, and psychological disorders. The print edition is complemented by an online version, which allows access to the full content of the textbook, contains links from the references to primary research journal articles, allows full text searches, and provides access to figures and tables that can be downloaded to PowerPoint. It serves a useful clinical reference for neurologists, otorhinolaryngologists, audio-vestibular physicians, and senior trainees in those specialties.

Movement Disorders

Author : Mark S. LeDoux
Publisher : Elsevier
ISBN 13 : 0080470564
Total Pages : 821 pages
Book Rating : 4.0/5 (84 download)

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Book Synopsis Movement Disorders by : Mark S. LeDoux

Download or read book Movement Disorders written by Mark S. LeDoux and published by Elsevier. This book was released on 2005-01-25 with total page 821 pages. Available in PDF, EPUB and Kindle. Book excerpt: The use of animal models is a key aspect of scientific research in numerous fields of medicine. This book vigorously examines the important contributions and application of animal models to the understanding of human movement disorders and will serve as an essential resource for basic neuroscientists engaged in movement disorders research. Academic clinicians, translational researchers and basic scientists are brought together to connect experimental findings made in different animal models to the clinical features, pathophysiology and treatment of human movement disorders. A vital feature of this book is an accompanying DVD with video clips of human movement disorders and their corresponding animal models. The book is divided into sections on Parkinson disease, Huntington disease, dystonia, tremor, paroxysmal movement disorders, ataxia, myoclonus, restless legs syndrome, drug-induced movement disorders, multiple system atrophy, progressive supranuclear palsy/corticobasal degeneration and spasticity. This book serves as an essential resource for both clinicians interested in the science being generated with animal models and basic scientists studying the pathogenesis of particular movement disorders.* Provides a single comprehensive resource on animal models of movement disorders that academic clinicians, translational researchers, and basic neuroscientists can refer to* Includes contributions by expert movement disorder clinicians and top-level researchers in the field* Features a DVD containing over 170 video clips of human movement disorders and the corresponding animal models

Cerebellum as a CNS Hub

Author : Hidehiro Mizusawa
Publisher : Springer Nature
ISBN 13 : 3030758176
Total Pages : 543 pages
Book Rating : 4.0/5 (37 download)

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Book Synopsis Cerebellum as a CNS Hub by : Hidehiro Mizusawa

Download or read book Cerebellum as a CNS Hub written by Hidehiro Mizusawa and published by Springer Nature. This book was released on 2021-11-10 with total page 543 pages. Available in PDF, EPUB and Kindle. Book excerpt: Based on the 75th Fujihara Seminar held in December 2018 in Tokyo, Japan, this volume explores the latest research on the cerebellum. Contributors seek to examine the cerebellum's role as a unique hub for brain activity and discover new information about its purpose. The discussion is broad, ranging from evolutionary topics to therapeutic strategy and addresses both physiology and pathology. Subjects covered include anatomy, information processing, complex spikes, plasticity, modeling, and spinocerebellar ataxias. The volume is intended to set the stage for the future of cerebellar research and guide both basic and clinical researchers.

Cerebellar Degenerations: Clinical Neurobiology

Author : Andreas Plaitakis
Publisher : Springer Science & Business Media
ISBN 13 : 9780792314905
Total Pages : 534 pages
Book Rating : 4.3/5 (149 download)

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Book Synopsis Cerebellar Degenerations: Clinical Neurobiology by : Andreas Plaitakis

Download or read book Cerebellar Degenerations: Clinical Neurobiology written by Andreas Plaitakis and published by Springer Science & Business Media. This book was released on 1992-05-31 with total page 534 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book encompasses basic and clinical reports on the cerebellum and its primary atrophic disorders, the cerebellar degenerations. Rapid progress has been made in undestanding the organization and function of the cerebellum at the neuronal, synaptic, and molecular level. Of particular importance has been the identification of the chemical transmitters utilized by the cer ebellar cellular systems. More than any other brain region, the cerebellum utilizes amino acids as its main excitatory and inhibitory neurotransmitters. Excitatory amino acid transmitters, in addition to serving neuronal com munication, may also mediate trophic and toxic effects, and as such, they may playa role in neurodegenerative processes. The cerebellar degenerations were among the first human disorders with primary system atrophy to be studied clinically and pathologically. This field of clinical cerebellar sciences, no longer confined to the previously known descriptive level, is now advancing rapidly, propelled by rapid advances in neuroimaging, immunology, and molecular biology. The advent of CT, MRI, and PET has in recent years permitted the study of central nervous system alterations in living patients, thus contributing substantially to the accuracy of the diagnosis and the classification of these disorders. The nosology of cerebellar degenerations, which has been the subject of much debate for over a century, is presently a dynamic field, with new entities being recognized and old "classic ataxias" being redefined in the light of new genetic evidence.

Medication-Induced Movement Disorders

Author : Joseph H. Friedman
Publisher : Cambridge University Press
ISBN 13 : 9781316636817
Total Pages : 210 pages
Book Rating : 4.6/5 (368 download)

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Book Synopsis Medication-Induced Movement Disorders by : Joseph H. Friedman

Download or read book Medication-Induced Movement Disorders written by Joseph H. Friedman and published by Cambridge University Press. This book was released on 2020-05-07 with total page 210 pages. Available in PDF, EPUB and Kindle. Book excerpt: Medications that may produce movement disorders are widely used. The resulting disorders are often highly disconcerting for the patient and their relatives, especially when the connection between medication and disorder is not recognized. However, ascribing an adverse drug effect to medication exposure is often difficult, especially when the side effect is rare. Covering various drugs - including the major classes of medications working primarily on the brain, specifically antipsychotics and antidepressants - this all-encompassing review of medication-induced movement disorders aids early recognition and improved treatment. The problem of what to do when the offending medication cannot be reduced is also reviewed. It discusses the best options for evaluation and treatment, including medical imaging and deep brain stimulation, and guides the clinician in managing the disorder, making this a vital reference for medical specialists and consultants in neurology and neuropharmacology and any clinician seeing patients on medications crossing the blood brain barrier.