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Transport And Deposition Of Submicron Aerosol Particles For Unsteady State Flows In Pores With Application To The Lung
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Book Synopsis Transport and Deposition of Submicron Aerosol Particles for Unsteady-state Flows in Pores with Application to the Lung by : Sumanta K. Pal
Download or read book Transport and Deposition of Submicron Aerosol Particles for Unsteady-state Flows in Pores with Application to the Lung written by Sumanta K. Pal and published by . This book was released on 1996 with total page 182 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Inhaled Particles by : Chiu-sen Wang
Download or read book Inhaled Particles written by Chiu-sen Wang and published by Elsevier. This book was released on 2005-01-20 with total page 214 pages. Available in PDF, EPUB and Kindle. Book excerpt: Inhaled Particles integrates all that is known about inhaled particles in a unified treatment. It aims to provide a scientific framework essential to a reasonable understanding of inhaled particles. The emphasis is placed on demonstrating the key roles of lung morphology on airflow and particle transport as well as identifying physical and biological factors that influence deposition. Special attention is paid to maintaining consistency of treatment and a balance between theoretical modeling and experimental measurements. The book covers all important aspects of inhaled particles including inhalability, aerosol dispersion, particle deposition, and clearance. It reviews concisely the basic background of lung morphology, respiratory physiology, aerodynamics, and aerosol science pertinent to the subject. Essential aspects of health effects and applications are also included. An easy-to-read, self contained introduction to the field An excellent source of updated research information Useful for students and professionals in aerosol science, environmental health science, occupational hygiene, health physics and biomedical engineering
Book Synopsis Masters Theses in the Pure and Applied Sciences Accepted by Colleges and Universities of the United States and Canada by :
Download or read book Masters Theses in the Pure and Applied Sciences Accepted by Colleges and Universities of the United States and Canada written by and published by . This book was released on 1996 with total page 442 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Pulmonary Deposition and Retention of Inhaled Aerosols by : Theodore F. Hatch
Download or read book Pulmonary Deposition and Retention of Inhaled Aerosols written by Theodore F. Hatch and published by Elsevier. This book was released on 2013-09-12 with total page 209 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pulmonary Deposition and Retention of Inhaled Aerosols is concerned with the respiratory deposition and retention of inhaled aerosols, starting with initial intake and concluding with events that precede pathological tissue response, drawing equally upon both the physical and biological aspects of the subject. The book opens with an introductory chapter on the relationship between the dose of an inhaled aerosol and the kind and degree of response, and classification of particulate substances. This is followed by separate chapters on pulmonary deposition and retention of inhaled aerosols; the factors that influence disease risks associated with atmospheric exposure to aerosols; and measurement of aerosol composition and concentration. It is hoped that the book will help the specialists from both sides as well as technical and administrative personnel to acquire a common understanding of the important intermediate factors that operate between the outside dusty atmosphere and the internal tissue damage and disease—factors that may operate to make one exposure dangerous to life and another altogether innocuous.
Book Synopsis Aerosol Inhalation: Recent Research Frontiers by : J.C. Marijnissen
Download or read book Aerosol Inhalation: Recent Research Frontiers written by J.C. Marijnissen and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 399 pages. Available in PDF, EPUB and Kindle. Book excerpt: A group of highly esteemed aerosol scientists - physicists, chemists, biologists and toxicologists - met in Warsaw in September, 1995, in order to discuss the latest developments in the field of aerosol health subjects, including inhalation, lung transport and deposition. The relationship of these subjects with the environment was also addressed. This book contains the proceedings of the Workshop and also documents the ensuing panel discussions. Subject Index included.
Book Synopsis Respiratory Flows in the Pulmonary Acinus by : Josué Sznitman
Download or read book Respiratory Flows in the Pulmonary Acinus written by Josué Sznitman and published by Sudwestdeutscher Verlag Fur Hochschulschriften AG. This book was released on 2009 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt: The pulmonary acinus, known as the gas exchange region of the lung, encompasses the complex of millions of sub-millimeter alveoli and may represent a potential host for pulmonary complications and diseases. These health disorders may require the inhalation of therapeutic drugs typically administered in the form of aerosolized particles. Both a precise understanding of the mechanisms leading to particle deposition as well as the need to target aerosols to specific pulmonary sites, remain ongoing challenges and depend directly on the fluid dynamics in the lung, and specifically on the microflows present in the acinar region. These considerations call not only for a deepening of our understanding of the fluid mechanics pertinent to the acinar region of the lung, but also, for the potential development of novel strategies towards improved and enhanced particle deposition inside the lung. The present thesis, which lies at the interface between engineering and medicine, is concerned with the role of convective respiratory flows in the acinar region of the lung, in conjunction with the transport and deposition of inhaled particles.
Book Synopsis Drug Delivery to the Lung by : Hans Bisgaard
Download or read book Drug Delivery to the Lung written by Hans Bisgaard and published by CRC Press. This book was released on 2001-10-02 with total page 536 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on the aerosol treatment of lung diseases, recent improvements in the understanding of proper dosage, and major innovations in device technology applied to clinical practice. Examines the behavior of inspired spherical particles in the respiratory tract!Featuring over 1300 references, drawings, tables, and photographs.
Book Synopsis Particle-Lung Interactions by : Peter Gehr
Download or read book Particle-Lung Interactions written by Peter Gehr and published by CRC Press. This book was released on 2000-02-18 with total page 718 pages. Available in PDF, EPUB and Kindle. Book excerpt: This wide-ranging, comprehensive reference presents the latest developments in aerosol science and interactions between particles and the respiratory tract-utilizing an inter-disciplinary approach that integrates advances in physics, chemistry, and engineering with the epidemiological and biomedical sciences, and focusing on the dynamics of particl
Book Synopsis Optimization of Aerosol Drug Delivery by : Leon Gradon
Download or read book Optimization of Aerosol Drug Delivery written by Leon Gradon and published by Springer Science & Business Media. This book was released on 2003-11-30 with total page 330 pages. Available in PDF, EPUB and Kindle. Book excerpt: Aerosol therapy has significantly improved the treatment of a variety of respiratory diseases. Besides the treatment of respiratory diseases there is currently also a great interest to use the lungs as a portal to introduce drugs for systemic therapy. The success of therapy with the application of aerosolized medicaments depends on the possibility to deliver the proper amount of drug to the appropriate sites in the respiratory system, thus limiting the side effects to a minimum. Aerosolized delivery of drugs to the lung is optimized if, for a given chemical composition of a medicine, the target of deposition and the required mass of drug to be deposited are precisely defined. The next step is the specification of the number of respirable particles or droplets, to be generated by appropriate devices. Another very important factor for successful aerosol therapy is the condition of the patient coupled with his or her inhalation technique.
Book Synopsis Airflow and Micro-Particle Transport and Deposition in Realistic Lung Airways Including the Alveolar Region by :
Download or read book Airflow and Micro-Particle Transport and Deposition in Realistic Lung Airways Including the Alveolar Region written by and published by . This book was released on 2004 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: People may inhale 100 millions of particles each day, including toxic particulate matter as well as drug aerosols. Some of those deposited in the respiratory system can be either harmful or therapeutic to humans depending upon the particle material, deposition site, and local concentration. These transport and deposition phenomena as well as the resulting biomedical processes are greatly determined by the airflow field, particle properties, breathing pattern, and geometric airway characteristics. Realistic models of tracheobronchial and nasal⁄oral- tracheobronchial airways were built. Airflow and particle transport and deposition in these airway models were investigated in detail by mainly using the validated, in-house FORTRAN code CFPD (computational fluid-particle dynamics), which is a cell-centered, finite volume multi-block code. Both laminar and transitional-turbulent-laminar flows were considered for different transient and steady inhalation flow rates and inlet velocity profiles. The resulting effects of transients, upstream conditions and geometric characteristics, i.e., spatial angle and/or cartilaginous rings, are fully discussed. A new code based on the lattice-Boltzmann method (LBM) has been developed and validated to investigate airflow patterns and pressure changes in representative alveolar structures of the human respiratory zone. The new idea of targeted drug aerosol delivery technology was numerically tested for a more realistic human airway configuration and thereby addressing the problem of inter-subject variability. Specifically, controlled air-particle streams were studied using the oral and asymmetric tracheobronchial airway models. The results were compared with data obtained for a symmetric Weibel Type A tracheobronchial airway model.
Book Synopsis Aerosol Particles in Lungs by : Gennady Fedorovitch
Download or read book Aerosol Particles in Lungs written by Gennady Fedorovitch and published by . This book was released on 2020 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: A theoretical model of the movement of aerosols in the lungs is proposed. The model is based upon the transport equations taking into account the aerosol inertial deposition processes. Particles move along curvilinear trajectories in self-twisted vortex air flows. Deposition occurs over several cycles of inhalation and exhalation. This mechanism works for particles with a diameter greater than 1,Äì2 microns. All particles with a diameter of 4 microns and more are captured in the respiratory tract before the terminal bronchioles. Only particles with a size of less than 2 microns can penetrate into the respiratory parts of the lungs, but the cleaning coefficient for them is close to unity. The lung cleaning model describes the limiting capabilities of the mucociliar-É system. The importance of taking into account the temporal characteristics of the mucociliary escalation of dust deposited in the lungs has been demonstrated. The existence of a mode of accumulation of particles in the lungs, due to a lack of cleaning time during periodic dust exposure, has been established.
Book Synopsis Deposition of Small Particles in Oscillatory Flows by : Mark Herring
Download or read book Deposition of Small Particles in Oscillatory Flows written by Mark Herring and published by . This book was released on 1996 with total page 86 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Deposition of Aerosol Particles from Low-speed Flows Through Granular Beds by : Larry Alan Mann
Download or read book Deposition of Aerosol Particles from Low-speed Flows Through Granular Beds written by Larry Alan Mann and published by . This book was released on 1983 with total page 434 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Transport and Deposition of Aerosol Particles in a Tube by : Nitash P. Balsara
Download or read book The Transport and Deposition of Aerosol Particles in a Tube written by Nitash P. Balsara and published by . This book was released on 1984 with total page 266 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :United States. Environmental Protection Agency. Office of Research and Development Publisher : ISBN 13 : Total Pages :846 pages Book Rating :4.F/5 ( download)
Book Synopsis Proceedings [of A] Symposium on Fine Particles, Minneapolis, Minnesota, May 1975 by : United States. Environmental Protection Agency. Office of Research and Development
Download or read book Proceedings [of A] Symposium on Fine Particles, Minneapolis, Minnesota, May 1975 written by United States. Environmental Protection Agency. Office of Research and Development and published by . This book was released on 1975 with total page 846 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Numerical Analysis of Respiratory Aerosol Deposition by : Samir C. Vinchurkar
Download or read book Numerical Analysis of Respiratory Aerosol Deposition written by Samir C. Vinchurkar and published by . This book was released on 2008 with total page 470 pages. Available in PDF, EPUB and Kindle. Book excerpt: The dynamics of particle laden flows are integral to the analysis of toxic particle deposition and medical respiratory aerosol delivery. Computational fluid-particle dynamics (CFPD) can play a critical role in developing a better understanding of particle laden flows, especially in a number of under-explored areas. The applications considered in this study include both the numerical aspects and the physical phenomena of respiratory aerosol transport. Objective I: Considering the effects of mesh type and grid convergence, four commonly implemented mesh styles were applied to a double bifurcation respiratory geometry and tested for flow patterns and aerosol deposition. Results indicated that the mesh style employed had a significant effect on the transport and deposition of aerosols with hexahedral meshes being most accurate. Objective II: In order to evaluate the effects of bronchoconstriction under exhalation conditions, normal and constricted pediatric airway models were considered. Results include (i) a significant increase in deposition for constricted airways, and (ii) a novel correlation for deposition during exhalation based on the Dean and Stokes numbers. Objective IIIa: Considering evaluation of an aerosol size sampler, an eight-stage Andersen cascade impactor (ACI) was numerically analyzed. The numerical simulations indicated high non-uniformity and recirculation in the flow field. Numerical predictions of retention fraction matched well with existing experiments (0.5 - 11% error). Objective IIIb: As an extension to this study, numerical predictions of electrostatic charge effects on aerosol transport and deposition in the ACI were presented. Charges consistent with standard pharmaceutical pressurized metered dose inhalers and dry powder inhalers were considered. The numerical predictions indicated that charged aerosols deposit as if they were 5 - 85% larger due to electrostatic effects. Applications of the studies considered include (i) quantitative guidance in selecting numerical mesh styles and development of standard grid convergence criteria, (ii) the development of more accurate whole-lung deposition models that better evaluate exhalation conditions, (iii) improvements in the design of pharmaceutical assessment and delivery devices, and (vi) correction values to account for electrostatic charge on pharmaceutical aerosols.
Book Synopsis Inhaled Particles and Vapours by : C. N. Davies
Download or read book Inhaled Particles and Vapours written by C. N. Davies and published by Elsevier. This book was released on 2013-09-17 with total page 701 pages. Available in PDF, EPUB and Kindle. Book excerpt: Inhaled Particles and Vapors covers the proceedings of an International Symposium by the same title on September 28 – October 1, 1965, organized by the British Occupational Hygiene Society. This book is organized into seven sections encompassing 48 chapters. Section I reviews the anatomy and physiology of human lung. Section II describes the pulmonary response to dust in terms of airway changes and reactions to silica. Sections III and IV deal with lung clearance in animals, the retention, penetration, and elimination of inhaled dusts, and lung deposition and clearance in human. Section V emphasizes the sources of dust inhaled by the human lungs, while Section VI discusses the relationship between pneumonoconiosis and dust exposure. Section VII presents the results of the investigations of dust exposure. This book will prove useful to pulmonologists, toxicologists, and workers in the field of occupational health.
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