Translational Research And Discovery In Gastroenterology

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Translational Research and Discovery in Gastroenterology

Author : Deborah L. Gumucio
Publisher : John Wiley & Sons
ISBN 13 : 1118492870
Total Pages : 378 pages
Book Rating : 4.1/5 (184 download)

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Book Synopsis Translational Research and Discovery in Gastroenterology by : Deborah L. Gumucio

Download or read book Translational Research and Discovery in Gastroenterology written by Deborah L. Gumucio and published by John Wiley & Sons. This book was released on 2014-08-11 with total page 378 pages. Available in PDF, EPUB and Kindle. Book excerpt: Translational Gastroenterology: Organogenesis to Disease bridges the gap between basic and clinical research by providing information on GI (gastrointestinal) organ development discovered through scientific inquiry, alongside clinical observations of acquired and congenital abnormalities. Paired chapters, written from basic science and clinical viewpoints, review the major biological pathways and molecules at work in organ ontogeny and disease. In addition to a comprehensive survey of GI organ development and pathologies, the book also highlights model organisms and new areas of research, with chapters devoted to recent advances in the field of GI stem cell biology, and the potential for tissue engineering of GI organs. The topics covered provide a unique window onto current activity in the field of gastroenterology, fostering enhanced knowledge for developmental biologists as well as for clinical practitioners. Notable features include the following: • Basic science chapters review the molecular and cellular pathways of GI organ development alongside clinical chapters examining organ-based diseases, closing the gap between the bench and the clinic. • Derivative organs – esophagus, stomach, pylorus, small intestine, colon, liver, and pancreas –as well as tissues such as serosa and enteric nervous system that are common to multiple GI organs. • Chapters detailing the use of model organisms – Drosophila, sea urchin, zebrafish, C. elegans, Xenopus – for basic discovery studies are included. • Chapters on GI stem cells and the potential for tissue engineering of the GI organs provide a view to the future of research and therapy in these organs.

Translational Research and Discovery in Gastroenterology

Author : Deborah L. Gumucio
Publisher : John Wiley & Sons
ISBN 13 : 1118492854
Total Pages : 378 pages
Book Rating : 4.1/5 (184 download)

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Book Synopsis Translational Research and Discovery in Gastroenterology by : Deborah L. Gumucio

Download or read book Translational Research and Discovery in Gastroenterology written by Deborah L. Gumucio and published by John Wiley & Sons. This book was released on 2014-05-23 with total page 378 pages. Available in PDF, EPUB and Kindle. Book excerpt: Translational Gastroenterology: Organogenesis to Disease bridges the gap between basic and clinical research by providing information on GI (gastrointestinal) organ development discovered through scientific inquiry, alongside clinical observations of acquired and congenital abnormalities. Paired chapters, written from basic science and clinical viewpoints, review the major biological pathways and molecules at work in organ ontogeny and disease. In addition to a comprehensive survey of GI organ development and pathologies, the book also highlights model organisms and new areas of research, with chapters devoted to recent advances in the field of GI stem cell biology, and the potential for tissue engineering of GI organs. The topics covered provide a unique window onto current activity in the field of gastroenterology, fostering enhanced knowledge for developmental biologists as well as for clinical practitioners. Notable features include the following: • Basic science chapters review the molecular and cellular pathways of GI organ development alongside clinical chapters examining organ-based diseases, closing the gap between the bench and the clinic. • Derivative organs – esophagus, stomach, pylorus, small intestine, colon, liver, and pancreas –as well as tissues such as serosa and enteric nervous system that are common to multiple GI organs. • Chapters detailing the use of model organisms – Drosophila, sea urchin, zebrafish, C. elegans, Xenopus – for basic discovery studies are included. • Chapters on GI stem cells and the potential for tissue engineering of the GI organs provide a view to the future of research and therapy in these organs.

Development, Differentiation, and Disease of the Luminal Gastrointestinal Tract

Author :
Publisher : Academic Press
ISBN 13 : 9780123812803
Total Pages : 292 pages
Book Rating : 4.8/5 (128 download)

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Book Synopsis Development, Differentiation, and Disease of the Luminal Gastrointestinal Tract by :

Download or read book Development, Differentiation, and Disease of the Luminal Gastrointestinal Tract written by and published by Academic Press. This book was released on 2010-12-16 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt: Understanding how digestive organs develop, their physiology and structure is important for determining new therapies to combat diseases of the digestive organs. Development, Differentiation, and Disease of the Luminal Gastrointestinal Tract reviews the latest research and developments in this field. Discusses new discoveries, approaches, and ideas Contributions from leading scholars and industry experts Includes reference guide for researchers involved in molecular biology and related fields

Peptide Drug Discovery and Development

Author : Miguel Castanho
Publisher : John Wiley & Sons
ISBN 13 : 3527636749
Total Pages : 547 pages
Book Rating : 4.5/5 (276 download)

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Book Synopsis Peptide Drug Discovery and Development by : Miguel Castanho

Download or read book Peptide Drug Discovery and Development written by Miguel Castanho and published by John Wiley & Sons. This book was released on 2011-10-24 with total page 547 pages. Available in PDF, EPUB and Kindle. Book excerpt: Filling a real knowledge gap, this handbook and ready reference is both modern and forward-looking in its emphasis on the "bench to bedside" translational approach to drug development. Clearly structured into three major parts, the book stakes out the boundaries of peptide drug development in the preclinical as well as clinical stages. The first part provides a general background and focuses on the characteristic strengths and weaknesses of peptide drugs. The second section contains five cases studies of peptides from diverse therapeutic fields, and the lessons to be learned from them, while the final part looks at new targets and opportunities, discussing several drug targets and diseases for which peptide drugs are currently being developed.

Translational Systems Medicine and Oral Disease

Author : Stephen Sonis
Publisher : Academic Press
ISBN 13 : 0128137630
Total Pages : 458 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Translational Systems Medicine and Oral Disease by : Stephen Sonis

Download or read book Translational Systems Medicine and Oral Disease written by Stephen Sonis and published by Academic Press. This book was released on 2019-09-14 with total page 458 pages. Available in PDF, EPUB and Kindle. Book excerpt: Translational Systems Medicine and Oral Disease bridges the gap between discovery science and clinical oral medicine, providing opportunities for both the scientific and clinical communities to understand how to apply recent findings in cell biology, genomic profiling, and systems medicine to favorably impact the diagnosis, treatment and management of oral diseases. Fully illustrated chapters from leading international contributors explore clinical applications of genomics, proteomics, metabolomics, microbiomics and epigenetics, as well as analytic methods and functional omics in oral medicine. Disease specific chapters detail systems approaches to periodontal disease, salivary gland diseases, oral cancer, bone disease, and autoimmune disease, among others. In addition, the book emphasizes biological synergisms across disciplines and their translational impact for clinicians, researchers and students in the fields of dentistry, dermatology, gastroenterology, otolaryngology, oncology and primary care. Presents the work of leading international researchers and clinicians who speak on the clinical applications of genomics, proteomics, metabolomics, microbiomics, and epigenetics, as well as analytic methods and functional omics in oral medicine Provides full-color, richly illustrated chapters that examine systems approaches to periodontal disease, salivary gland diseases, oral cancer, bone disease and autoimmune diseases Includes clinical case studies that illustrate examples of oral disease diagnostics and management, highlighting points of key importance for the reader Emphasizes biological synergisms across disciplines and their translational impact for clinicians, researchers, and students in the fields of dentistry, dermatology, gastroenterology, otolaryngology, oncology, and primary care

Oxford Textbook of Global Public Health

Author : Roger Detels
Publisher : Oxford University Press
ISBN 13 : 019881013X
Total Pages : 1717 pages
Book Rating : 4.1/5 (988 download)

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Book Synopsis Oxford Textbook of Global Public Health by : Roger Detels

Download or read book Oxford Textbook of Global Public Health written by Roger Detels and published by Oxford University Press. This book was released on 2017 with total page 1717 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sixth edition of the hugely successful, internationally recognised textbook on global public health and epidemiology, with 3 volumes comprehensively covering the scope, methods, and practice of the discipline

Encyclopedia of Gastroenterology

Author :
Publisher : Academic Press
ISBN 13 : 012818728X
Total Pages : 3420 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Encyclopedia of Gastroenterology by :

Download or read book Encyclopedia of Gastroenterology written by and published by Academic Press. This book was released on 2019-11-06 with total page 3420 pages. Available in PDF, EPUB and Kindle. Book excerpt: Encyclopedia of Gastroenterology, Second Edition provides a comprehensive and concise reference on all aspects of gastroenterology and hepatology, including the organs in the gastrointestinal system, their functions in health and disease, and strategies or procedures to resolve or prevent problems and disease. This concise, up-to-date information includes comprehensive sections on the impact of nutrition, gastrointestinal microbiota, lifestyle, commonly used drugs, and surgical procedures on health and disease. Since the first edition, attention to the roles of nutrition and gastrointestinal microorganisms (microbiota, formerly Microbiota) in health and disease has skyrocketed. In addition, an entirely new section on obesity and diabetes is included. Presents comprehensive coverage of every topic within gastroenterology Offers researchers a one-stop, fully-referenced resource to explore questions Includes teaching tools, multimedia and interactive elements Provides readers with multi-layered content and a media-rich learning resource for both instructors and students Covers hot new topics in GI health and disease, including new sections on stem cells, intestinal bacteria, obesity and intestinal microbiota

Handbook of Biomarkers and Precision Medicine

Author : Claudio Carini
Publisher : CRC Press
ISBN 13 : 0429574622
Total Pages : 1025 pages
Book Rating : 4.4/5 (295 download)

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Book Synopsis Handbook of Biomarkers and Precision Medicine by : Claudio Carini

Download or read book Handbook of Biomarkers and Precision Medicine written by Claudio Carini and published by CRC Press. This book was released on 2019-04-16 with total page 1025 pages. Available in PDF, EPUB and Kindle. Book excerpt: "The field of Biomarkers and Precision Medicine in drug development is rapidly evolving and this book presents a snapshot of exciting new approaches. By presenting a wide range of biomarker applications, discussed by knowledgeable and experienced scientists, readers will develop an appreciation of the scope and breadth of biomarker knowledge and find examples that will help them in their own work." -Maria Freire, Foundation for the National Institutes of Health Handbook of Biomarkers and Precision Medicine provides comprehensive insights into biomarker discovery and development which has driven the new era of Precision Medicine. A wide variety of renowned experts from government, academia, teaching hospitals, biotechnology and pharmaceutical companies share best practices, examples and exciting new developments. The handbook aims to provide in-depth knowledge to research scientists, students and decision makers engaged in Biomarker and Precision Medicine-centric drug development. Features: Detailed insights into biomarker discovery, validation and diagnostic development with implementation strategies Lessons-learned from successful Precision Medicine case studies A variety of exciting and emerging biomarker technologies The next frontiers and future challenges of biomarkers in Precision Medicine Claudio Carini, Mark Fidock and Alain van Gool are internationally recognized as scientific leaders in Biomarkers and Precision Medicine. They have worked for decades in academia and pharmaceutical industry in EU, USA and Asia. Currently, Dr. Carini is Honorary Faculty at Kings’s College School of Medicine, London, UK. Dr. Fidock is Vice President of Precision Medicine Laboratories at AstraZeneca, Cambridge, UK. Prof.dr. van Gool is Head Translational Metabolic Laboratory at Radboud university medical school, Nijmegen, NL.

Textbook of Pediatric Gastroenterology, Hepatology and Nutrition

Author : Stefano Guandalini
Publisher : Springer
ISBN 13 : 3319171690
Total Pages : 889 pages
Book Rating : 4.3/5 (191 download)

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Book Synopsis Textbook of Pediatric Gastroenterology, Hepatology and Nutrition by : Stefano Guandalini

Download or read book Textbook of Pediatric Gastroenterology, Hepatology and Nutrition written by Stefano Guandalini and published by Springer. This book was released on 2015-09-30 with total page 889 pages. Available in PDF, EPUB and Kindle. Book excerpt: This textbook provides a comprehensive and state-of-the-art overview of the major issues specific to the field of pediatric gastroenterology, hepatology, and nutrition. The first part of the book, Gastroenterology and Nutrition, presents in a systematic way the overall scope of issues encountered by children (newborn to teenagers) suffering from disorders of the gastrointestinal tract, pancreas and/or presenting nutritional issues. These chapters are structured in logical sections to facilitate consultation and include major topics ranging from congenital disorders to gastrointestinal problems of the newborn, infectious diseases of the gastrointestinal tract, and approach to nutritional problems in the various pediatric ages. The second part of the book, Hepatology, is articulated in a series of chapters which present a comprehensive review of congenital and acquired disorders of the biliary tract and liver. This section also includes a critical analysis of available diagnostic and therapeutic procedures and future perspectives. Written by experts in the field, Textbook of Pediatric Gastroenterology, Hepatology and Nutrition: A Comprehensive Guide to Practice constitutes a much needed, innovative resource combining updated, reliable and comprehensive information with agile consultation for a streamlined approach to the care of children with such disorders.

The CTSA Program at NIH

Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 0309284740
Total Pages : 179 pages
Book Rating : 4.3/5 (92 download)

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Book Synopsis The CTSA Program at NIH by : Institute of Medicine

Download or read book The CTSA Program at NIH written by Institute of Medicine and published by National Academies Press. This book was released on 2013-10-09 with total page 179 pages. Available in PDF, EPUB and Kindle. Book excerpt: In 2006 the National Institutes of Health (NIH) established the Clinical and Translational Science Awards (CTSA) Program, recognizing the need for a new impetus to encourage clinical and translational research. At the time it was very difficult to translate basic and clinical research into clinical and community practice; making it difficult for individual patients and communities to receive its benefits. Since its creation the CTSA Program has expanded, with 61 sites spread across the nation's academic health centers and other institutions, hoping to provide catalysts and test beds for policies and practices that can benefit clinical and translation research organizations throughout the country. The NIH contracted with the Institute of Medicine (IOM) in 2012 to conduct a study to assess and provide recommendations on appropriateness of the CTSA Program's mission and strategic goals and whether changes were needed. The study was also address the implementation of the program by the National Center for Advancing Translational Sciences (NCATS) while exploring the CTSA's contributions in the acceleration of the development of new therapeutics. A 13-member committee was established to head this task; the committee had collective expertise in community outreach and engagement, public health and health policy, bioethics, education and training, pharmaceutical research and development, program evaluation, clinical and biomedical research, and child health research. The CTSA Program at NIH: Opportunities for Advancing Clinical and Translational Research is the result of investigations into previous program evaluations and assessments, open-session meetings and conference class, and the review of scientific literature. Overall, the committee believes that the CTSA Program is significant to the advancement of clinical and translational research through its contributions. The Program would benefit from a variety of revisions, however, to make it more efficient and effective.

Advanced Imaging and Bio Techniques for Convergence Science

Author : Jun Ki Kim
Publisher : Springer Nature
ISBN 13 : 981336064X
Total Pages : 560 pages
Book Rating : 4.8/5 (133 download)

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Book Synopsis Advanced Imaging and Bio Techniques for Convergence Science by : Jun Ki Kim

Download or read book Advanced Imaging and Bio Techniques for Convergence Science written by Jun Ki Kim and published by Springer Nature. This book was released on 2021-04-08 with total page 560 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a wide-ranging guide to advanced imaging techniques and related methods with important applications in translational research or convergence science as progress is made toward a new era in integrative healthcare. Conventional and advanced microscopic imaging techniques, including both non-fluorescent (i.e., label-free) and fluorescent methods, have to date provided researchers with specific and quantitative information about molecules, cells, and tissues. Now, however, the different imaging techniques can be correlated with each other and multimodal methods developed to simultaneously obtain diverse and complementary information. In addition, the latest advanced imaging techniques can be integrated with non-imaging techniques such as mass spectroscopic methods, genome editing, organic/inorganic probe synthesis, nanomedicine, and drug discovery. The book will be of high value for researchers in the biological and biomedical sciences or convergence science who need to use these multidisciplinary and integrated techniques or are involved in developing new analytical methods focused on convergence science.

Gastrointestinal Diseases and Their Associated Infections

Author : Guy D. Eslick
Publisher : Elsevier Health Sciences
ISBN 13 : 032354844X
Total Pages : 285 pages
Book Rating : 4.3/5 (235 download)

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Book Synopsis Gastrointestinal Diseases and Their Associated Infections by : Guy D. Eslick

Download or read book Gastrointestinal Diseases and Their Associated Infections written by Guy D. Eslick and published by Elsevier Health Sciences. This book was released on 2019-01-17 with total page 285 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many bacteria, viruses, protozoa, and fungi play key roles in the development of gastrointestinal diseases, and this practical reference brings you up to speed with this increasingly important area. Covering a broad range of GI diseases and cancers, this resource provides an expert overview of the field, ideal for all gastroenterologists and infectious disease physicians. Covers infections associated with gastroesophageal reflux disease and Barrett’s esophagus, gallbladder disease, acute pancreatitis, small intestinal bacterial overgrowth, irritable bowel syndrome, inflammatory bowel disease, appendicitis, Whipple Disease, Crohn’s Disease, and more. Discusses esophageal cancer, gastric cancer, cholangiocarcinoma, hepatocellular carcinoma, and colorectal cancer. Includes chapters on gut microbiome, fecal transplants, and the molecular pathgenesis of gastrointestinal infections. Consolidates today’s available information on this timely topic into a single convenient resource.

Translational Biotechnology

Author : Yasha Hasija
Publisher : Academic Press
ISBN 13 : 0128219726
Total Pages : 452 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis Translational Biotechnology by : Yasha Hasija

Download or read book Translational Biotechnology written by Yasha Hasija and published by Academic Press. This book was released on 2021-02-04 with total page 452 pages. Available in PDF, EPUB and Kindle. Book excerpt: Translational Biotechnology: A Journey from Laboratory to Clinics presents an integrative and multidisciplinary approach to biotechnology to help readers bridge the gaps between fundamental and functional research. The book provides state-of-the-art and integrative views of translational biotechnology by covering topics from basic concepts to novel methodologies. Topics discussed include biotechnology-based therapeutics, pathway and target discovery, biological therapeutic modalities, translational bioinformatics, and system and synthetic biology. Additional sections cover drug discovery, precision medicine and the socioeconomic impact of translational biotechnology. This book is valuable for bioinformaticians, biotechnologists, and members of the biomedical field who are interested in learning more about this promising field. Explains biotechnology in a different light by using an application-oriented approach Discusses practical approaches in the development of precision medicine tools, systems and dynamical medicine approaches Promotes research in the field of biotechnology that is translational in nature, cost-effective and readily available to the community

Drug Discovery Toxicology

Author : Yvonne Will
Publisher : John Wiley & Sons
ISBN 13 : 1119053390
Total Pages : 899 pages
Book Rating : 4.1/5 (19 download)

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Book Synopsis Drug Discovery Toxicology by : Yvonne Will

Download or read book Drug Discovery Toxicology written by Yvonne Will and published by John Wiley & Sons. This book was released on 2016-03-22 with total page 899 pages. Available in PDF, EPUB and Kindle. Book excerpt: As a guide for pharmaceutical professionals to the issues and practices of drug discovery toxicology, this book integrates and reviews the strategy and application of tools and methods at each step of the drug discovery process. • Guides researchers as to what drug safety experiments are both practical and useful • Covers a variety of key topics – safety lead optimization, in vitro-in vivo translation, organ toxicology, ADME, animal models, biomarkers, and –omics tools • Describes what experiments are possible and useful and offers a view into the future, indicating key areas to watch for new predictive methods • Features contributions from firsthand industry experience, giving readers insight into the strategy and execution of predictive toxicology practices

Translational Research in Cancer

Author : Sivapatham Sundaresan
Publisher : BoD – Books on Demand
ISBN 13 : 1838805346
Total Pages : 212 pages
Book Rating : 4.8/5 (388 download)

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Book Synopsis Translational Research in Cancer by : Sivapatham Sundaresan

Download or read book Translational Research in Cancer written by Sivapatham Sundaresan and published by BoD – Books on Demand. This book was released on 2021-02-03 with total page 212 pages. Available in PDF, EPUB and Kindle. Book excerpt: Translational research in oncology benefits from an abundance of knowledge resulting from genome-scale studies concerning the molecular pathways involved in tumorigenesis. Translational oncology represents a bridge between basic research and clinical practice in cancer medicine. The vast majority of cancer cases are due to environmental risk factors. Many of these environmental factors are controllable lifestyle choices. Experimental cancer treatments are studied in clinical trials to compare the proposed treatment to the best existing treatment through translational research. The key features of the book include: 1) New screening for the development of radioprotectors: radioprotection and anti-cancer effect of β-Glucan (Enterococcus faecalis) 2) Translational perspective on hepatocellular carcinoma 3) Brachytherapy for endometrial cancer 4) Discovery of small molecule inhibitors for histone methyltransferases in cancer

Animal Models in Cancer Drug Discovery

Author : Asfar Azmi
Publisher : Academic Press
ISBN 13 : 0128147059
Total Pages : 470 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Animal Models in Cancer Drug Discovery by : Asfar Azmi

Download or read book Animal Models in Cancer Drug Discovery written by Asfar Azmi and published by Academic Press. This book was released on 2019-04-16 with total page 470 pages. Available in PDF, EPUB and Kindle. Book excerpt: Animal Models in Cancer Drug Discovery brings forward the most cutting-edge developments in tumor model systems for translational cancer research. The reader can find under this one volume virtually all types of existing and emerging tumor models in use by the research community. This book provides a deeper insight on how these newer models could de-risk modern drug discovery. Areas covered include up to date information on latest organoid derived models and newer genetic models. Additionally, the book discusses humanized animal tumor models for cancer immunotherapy and how they leverage personalized therapies. The chapter on larger animal, canine models and their use in and their use in pre-investigational new drug (pre-IND) development makes the volume unique. Unlike before, the incorporation of several simplified protocols, breeding methodologies, handling and assessment procedures to study drug intervention makes this book a must read. Animal Models in Cancer Drug Discovery is a valuable resource for basic and translational cancer researchers, drug discovery researchers, contract research organizations, and knowledge seekers at all levels in the biomedical field. Encompasses discussions on innovative animal models, xenograft, genetic models, primary models, organoid systems, humanized and other models in modern biology paradigms that are enhancing research in the field of drug discover Covers the use of these models in personalized medicine, immunotherapy, toxicology, pre-IND assessments and related drug development arenas Presents protocols, procedures, and a comprehensive glossary to help new readers understand technical terms and specialized nomenclature

Adult Short Bowel Syndrome

Author : Mandy L. Corrigan
Publisher : Academic Press
ISBN 13 : 0128143312
Total Pages : 252 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Adult Short Bowel Syndrome by : Mandy L. Corrigan

Download or read book Adult Short Bowel Syndrome written by Mandy L. Corrigan and published by Academic Press. This book was released on 2018-10-09 with total page 252 pages. Available in PDF, EPUB and Kindle. Book excerpt: Adult Short Bowel Syndrome: Nutritional, Medical, and Surgical Management serves as a practical guide to the medical, surgical and nutritional care of complex patients with Short Bowel Syndrome (SBS), providing information on SBS with the most up-to-date, evidence-based data available. Additionally, the book presents global perspectives and highlights emerging areas of research that are influencing the care of patients with SBS. Intended for nutritionists, dieticians, physicians (specifically, general practitioners, gastroenterologists, and surgeons), nurse practitioners, pharmacists, students and researchers, this book serves as a quick reference on the medical, surgical and nutritional care of complex patients with short bowel syndrome. Presents emerging areas of research related to Short Bowel Syndrome (gut microbiome, pre/probiotics), as well as current applications in clinical practice Compiles an overview, classification and complications of the Short Bowel Syndrome disease state Contains effective dietary concepts (including rationale and use of oral rehydration solutions) for managing malabsorption caused by Short Bowel Syndrome Includes medical and pharmaceutical management techniques to compliment nutrition interventions Discusses surgical options for consideration in patients with Short Bowel Syndrome Highlights international perspectives on treatment and care