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Author : Konstanze Simbriger
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (119 download)
Download or read book Translational Control of MRNAs in the Brain in Health and Disease written by Konstanze Simbriger and published by . This book was released on 2019 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Tatiana Nevarko
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (87 download)
Download or read book Translational Control of Neuronal MRNAs written by Tatiana Nevarko and published by . This book was released on 2013 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: "The processes of learning and memory require accurate translational control of neuronal mRNAs. This control can be carried out through the regulation of the general translation machinery and upstream factors, as well as through the recognition and selective translation of specific mRNAs. In this work we explore two molecular mechanisms of translational control in neurons. First, we investigate the roles of RNA helicases eIF4A1 and DHX29 in controlling the translation of synaptically-localized mRNAs. We demonstrate the preferential translation of mRNAs with extensively structured 5'UTR, underlining the importance of this region in translational control. We also pinpoint the post-synaptic localization of DHX29 and propose a technique for monitoring the rate of 5'UTR-dependent translation in vivo with the use of a photoconvertible fluorescent reporter protein. Second, we study the role of cap-dependent translation in autism spectrum disorders (ASD) by examining translationally controlled mRNAs. We show that knockout of eIF4E binding protein 2 (4E-BP2, eIF4E repressor downstream of mTOR) or overexpression of eIF4E in mice lead to increased translation of neuroligin mRNAs, which can explain the autistic-like behaviours in these mice. Moreover, we design short hairpin RNAs packaged in lentiviral particles to modulate the expression of neuroligins in vivo. We use this technology to validate the mechanism of dysregulated neuroligin mRNA translation as the causal factor for the autism-like behaviour in the 4E-BP2 knockout mice. Finally, we propose a mechanism for the exaggerated translation of neuroligin mRNAs through their 5'UTRs. In conclusion, in this work we provide evidence that translational control of specific brain mRNAs is crucial for synaptic function and behaviour." --
Author : Bruce Alberts
Publisher :
ISBN 13 : 9780815332183
Total Pages : 0 pages
Book Rating : 4.3/5 (321 download)
Download or read book Molecular Biology of The Cell written by Bruce Alberts and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :
Publisher : Academic Press
ISBN 13 : 008091196X
Total Pages : 437 pages
Book Rating : 4.0/5 (89 download)
Download or read book Translational Control in Health and Disease written by and published by Academic Press. This book was released on 2009-10-26 with total page 437 pages. Available in PDF, EPUB and Kindle. Book excerpt: Progress in Molecular Biology and Translational Science provides a forum for discussion of new discoveries, approaches, and ideas in molecular biology and translational science. It contains contributions from leaders in their fields and abundant references. This volume focuses on translational control in health and disease. Contributions from leading scholars and industry experts Reference guide for researchers involved in molecular biology and related fields
Author : Wayne S. Sossin
Publisher : Oxford University Press
ISBN 13 : 0190686324
Total Pages : 512 pages
Book Rating : 4.1/5 (96 download)
Download or read book The Oxford Handbook of Neuronal Protein Synthesis written by Wayne S. Sossin and published by Oxford University Press. This book was released on 2021-04-15 with total page 512 pages. Available in PDF, EPUB and Kindle. Book excerpt: Translational control in the nervous system is important. Many physiological processes in the nervous system depend on accurate control of the proteome that is mediated through protein synthetic mechanisms and thus, the nervous system is very sensitive to dysregulation of translational control. The Oxford Handbook of Neuronal Protein Synthesis reviews the mechanisms of translational control used by the nervous system, as well as how important nervous system functions, such as plasticity and homeostasis, depend on accurate translational control. The handbook extensively covers how dysregulation of protein synthesis can manifest itself in many distinct pathological processes including neurodevelopmental, neuropsychiatric, and neurodegenerative diseases. The handbook is comprehensive in its coverage of translational control mechanisms with particular focus on how these general control mechanisms are specifically utilized in the context of the cell biological constraints of the nervous system from both a mechanistic and systems perspective.
Author : Per Andersen
Publisher : Oxford University Press
ISBN 13 : 9780195100273
Total Pages : 892 pages
Book Rating : 4.1/5 (2 download)
Download or read book The Hippocampus Book written by Per Andersen and published by Oxford University Press. This book was released on 2007 with total page 892 pages. Available in PDF, EPUB and Kindle. Book excerpt: The hippocampus is one of a group of remarkable structures embedded within the brain's medial temporal lobe. Long known to be important for memory, it has been a prime focus of neuroscience research for many years. The Hippocampus Book promises to facilitate developments in the field in a major way by bringing together, for the first time, contributions by leading international scientists knowledgeable about hippocampal anatomy, physiology, and function. This authoritative volume offers the most comprehensive, up-to-date account of what the hippocampus does, how it does it, and what happens when things go wrong. At the same time, it illustrates how research focusing on this single brain structure has revealed principles of wider generality for the whole brain in relation to anatomical connectivity, synaptic plasticity, cognition and behavior, and computational algorithms. Well-organized in its presentation of both theory and experimental data, this peerless work vividly illustrates the astonishing progress that has been made in unraveling the workings of the brain. The Hippocampus Book is destined to take a central place on every neuroscientist's bookshelf.
Author : Hermona Soreq
Publisher : Frontiers E-books
ISBN 13 : 2889193098
Total Pages : 214 pages
Book Rating : 4.8/5 (891 download)
Download or read book Novel roles of non-coding brain RNAs in health and disease written by Hermona Soreq and published by Frontiers E-books. This book was released on 2014-10-23 with total page 214 pages. Available in PDF, EPUB and Kindle. Book excerpt: Non-coding RNAs (ncRNAs), and in particular microRNAs are rapidly becoming the focus of research interest in numerous basic and translational fields, including brain research; and their importance for many aspects in brain functioning merits special discussion. The wide-scope, multi-targeted and highly efficient manner of ncRNA regulatory activities draws attention to this topic by many, but the available research and analysis tools and experimental protocols are still at their infancy, and calls for special discussion given their importance for many aspects in brain functioning. This eBook is correspondingly focused on the search for, identification and exploration of those non-coding RNAs whose activities modulate the multi-leveled functions of the eukaryotic brain. The different articles strive to cover novel approaches for identifying and establishing ncRNA-target relationships, provide state of the art reports of the affected neurotransmission pathways, describe inherited and acquired changes in ncRNA functioning and cover the use of ncRNA mimics and blockade tools for interference with their functions in health and disease of the brain. Non-coding RNAs are here to stay, and this exciting eBook provides a glimpse into their impact on our brain’s functioning at the physiology, cell biology, behavior and immune levels.
Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 0309224187
Total Pages : 354 pages
Book Rating : 4.3/5 (92 download)
Download or read book Evolution of Translational Omics written by Institute of Medicine and published by National Academies Press. This book was released on 2012-09-13 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: Technologies collectively called omics enable simultaneous measurement of an enormous number of biomolecules; for example, genomics investigates thousands of DNA sequences, and proteomics examines large numbers of proteins. Scientists are using these technologies to develop innovative tests to detect disease and to predict a patient's likelihood of responding to specific drugs. Following a recent case involving premature use of omics-based tests in cancer clinical trials at Duke University, the NCI requested that the IOM establish a committee to recommend ways to strengthen omics-based test development and evaluation. This report identifies best practices to enhance development, evaluation, and translation of omics-based tests while simultaneously reinforcing steps to ensure that these tests are appropriately assessed for scientific validity before they are used to guide patient treatment in clinical trials.
Author : Lucy W. Barrett
Publisher : Springer Science & Business Media
ISBN 13 : 3034806795
Total Pages : 63 pages
Book Rating : 4.0/5 (348 download)
Download or read book Untranslated Gene Regions and Other Non-coding Elements written by Lucy W. Barrett and published by Springer Science & Business Media. This book was released on 2013-06-26 with total page 63 pages. Available in PDF, EPUB and Kindle. Book excerpt: There is now compelling evidence that the complexity of higher organisms correlates with the relative amount of non-coding RNA rather than the number of protein-coding genes. Previously dismissed as “junk DNA”, it is the non-coding regions of the genome that are responsible for regulation, facilitating complex temporal and spatial gene expression through the combinatorial effect of numerous mechanisms and interactions working together to fine-tune gene expression. The major regions involved in regulation of a particular gene are the 5’ and 3’ untranslated regions and introns. In addition, pervasive transcription of complex genomes produces a variety of non-coding transcripts that interact with these regions and contribute to regulation. This book discusses recent insights into the regulatory roles of the untranslated gene regions and non-coding RNAs in the control of complex gene expression, as well as the implications of this in terms of organism complexity and evolution.
Author : John W. B. Hershey
Publisher :
ISBN 13 : 9780879694586
Total Pages : 0 pages
Book Rating : 4.6/5 (945 download)
Download or read book Translational Control written by John W. B. Hershey and published by . This book was released on 1996 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive account of recent research in translational control and the molecular mechanisms involved, focusing on the numerous control mechanisms observed in eukaryotes. Subjects include basic mechanisms; the role of phosphorylation; regulation by trans-acting proteins; effects of viral infection; and mRNA stability. Other topics include translational control mediated by upstream AUG codons; a comparative view of initiation site selection mechanisms; and genetics of mitochondrial translation. For researchers with interests in gene expression, RNA biology, and protein synthesis. Annotation copyright by Book News, Inc., Portland, OR
Author : Margaret S. Ho
Publisher : Frontiers Media SA
ISBN 13 : 2889458504
Total Pages : 385 pages
Book Rating : 4.8/5 (894 download)
Download or read book Glia in Health and Disease written by Margaret S. Ho and published by Frontiers Media SA. This book was released on 2019-08-16 with total page 385 pages. Available in PDF, EPUB and Kindle. Book excerpt: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Author : Krishnarao Appasani
Publisher : Cambridge University Press
ISBN 13 : 0521865980
Total Pages : 0 pages
Book Rating : 4.5/5 (218 download)
Download or read book MicroRNAs written by Krishnarao Appasani and published by Cambridge University Press. This book was released on 2008 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: A wide-ranging reference on microRNA technology, integrating basic science with applications in biotechnology and pharmaceutical industry.
Author : Wayne S. Sossin
Publisher : Oxford University Press
ISBN 13 : 0190686308
Total Pages : 676 pages
Book Rating : 4.1/5 (96 download)
Download or read book The Oxford Handbook of Neuronal Protein Synthesis written by Wayne S. Sossin and published by Oxford University Press. This book was released on 2021 with total page 676 pages. Available in PDF, EPUB and Kindle. Book excerpt: This handbook is currently in development, with individual articles publishing online in advance of print publication. At this time, we cannot add information about unpublished articles in this handbook, however the table of contents will continue to grow as additional articles pass through the review process and are added to the site. Please note that the online publication date for this handbook is the date that the first article in the title was published online.
Author :
Publisher :
ISBN 13 :
Total Pages : 826 pages
Book Rating : 4.:/5 (3 download)
Download or read book Research Awards Index written by and published by . This book was released on 1987 with total page 826 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :
Publisher :
ISBN 13 :
Total Pages : 1064 pages
Book Rating : 4.:/5 (319 download)
Download or read book Biomedical Index to PHS-supported Research: pt. A. Subject access A-H written by and published by . This book was released on 1992 with total page 1064 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :
Publisher :
ISBN 13 :
Total Pages : 1860 pages
Book Rating : 4.:/5 (319 download)
Download or read book Cumulated Index Medicus written by and published by . This book was released on 1997 with total page 1860 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Daniel L. Kiss
Publisher : Frontiers Media SA
ISBN 13 : 2889765903
Total Pages : 135 pages
Book Rating : 4.8/5 (897 download)
Download or read book mRNA Translational Control as a Mechanism of Post-transcriptional Gene Regulation written by Daniel L. Kiss and published by Frontiers Media SA. This book was released on 2022-07-25 with total page 135 pages. Available in PDF, EPUB and Kindle. Book excerpt:
