Translational And Clinical Research In Autism Spectrum Disorders

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Neuronal and Synaptic Dysfunction in Autism Spectrum Disorder and Intellectual Disability

Author : Carlo Sala
Publisher : Academic Press
ISBN 13 : 0128005335
Total Pages : 396 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Neuronal and Synaptic Dysfunction in Autism Spectrum Disorder and Intellectual Disability by : Carlo Sala

Download or read book Neuronal and Synaptic Dysfunction in Autism Spectrum Disorder and Intellectual Disability written by Carlo Sala and published by Academic Press. This book was released on 2016-04-30 with total page 396 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neuronal and Synaptic Dysfunction in Autism Spectrum Disorder and Intellectual Disability provides the latest information on Autism spectrum disorders (ASDs), the lifelong neurodevelopmental disorders that present in early childhood and affect how individuals communicate and relate to others and their surroundings. In addition, three quarters of ASD patients also manifest severe intellectual disability. Though certain genes have been implicated, ASDs remain largely a mystery, and research looking into causes and cellular deficits are crucial for better understanding of neurodevelopmental disorders. Despite the prevalence and insidious nature of this disorder, this book remains to be an extensive resource of information and background on the state of current research in the field. The book serves as a reference for this purpose, and discusses the crucial role synaptic activity plays in proper brain function. In addition, the volume discusses the neurodevelopmental synaptopathies and serves as a resource for scientists and clinicians in all biomedical science specialties. This research has been crucial for recent studies that have provided a rationale for the development of pharmacological agents able to counteract functional synaptic anomalies and potentially ameliorate some ASD symptoms. - Introduces the genetic and non-genetic causes of autism and associated intellectual disabilities - Describes the genes implicated in autistic spectrum disorders and their function - Considers major individual genetic causes of autism, Rett syndrome, Fragile X syndrome, and other autism spectrum disorders, as well as their classification as synaptopathies - Presents a thorough discussion of the clinical aspects of multiple neurodevelopmental disorders and the experimental models that exist to study their pathophysiology in vitro and in vivo, including animal models and patient-derived stem cell culture

Translational Neuroimaging

Author : Robert A. McArthur
Publisher : Academic Press
ISBN 13 : 0123869455
Total Pages : 464 pages
Book Rating : 4.1/5 (238 download)

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Book Synopsis Translational Neuroimaging by : Robert A. McArthur

Download or read book Translational Neuroimaging written by Robert A. McArthur and published by Academic Press. This book was released on 2012-10-26 with total page 464 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers methodical issues in human and animal neuroimaging translational research as well as detailed applied examples of the use of neuroimaging in neuropsychiatric disorders and the development of drugs for their treatment. Offering an accompanying website with illustrations and text available for further knowledge and presentations, Translational Neuroimaging: Tools for CNS Drug Discovery, Development and Treatment appeals to non-clinical and clinical neuroscientists working in and studying neuropsychiatric disorders and their treatment as well as providing the novice researcher or researcher outside of his/her expertise the opportunity to understand the background of translational research and the use of imaging in this field. Provides a background to translational research and the use of brain imaging in neuropsychiatric disorders.

Autism Spectrum Disorders

Author : David Amaral
Publisher : Oxford University Press
ISBN 13 : 0199707472
Total Pages : 1445 pages
Book Rating : 4.1/5 (997 download)

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Book Synopsis Autism Spectrum Disorders by : David Amaral

Download or read book Autism Spectrum Disorders written by David Amaral and published by Oxford University Press. This book was released on 2011-05-01 with total page 1445 pages. Available in PDF, EPUB and Kindle. Book excerpt: Autism is an emerging area of basic and clinical research, and has only recently been recognized as a major topic in biomedical research. Approximately 1 in 150 children are diagnosed as autistic, so it is also an intense growth area in behavioral and educational treatments. Financial resources have begun to be raised for more comprehensive research and an increasing number of scientists are becoming involved in autism research. In many respects, autism has become a model for conducting translational research on a psychiatric disorder. This text provides a comprehensive summary of all current knowledge related to the behavioral, experiential, and biomedical features of the autism spectrum disorders including major behavioral and cognitive syndromology, common co-morbid conditions, neuropathology, neuroimmunology, and other neurological correlates such as seizures, allergy and immunology, gastroenterology, infectious disease, and epidemiology. Edited by three leading researchers, this volume contains over 80 chapters and nine shorter commentaries by thought leaders in the field, making the book a virtual "who's who" of autism research. This carefully developed book is a comprehensive and authoritative reference for what we know in this area as well as a guidepost for the next several years in all areas of autism research.

Translational Approaches to Autism Spectrum Disorder

Author : Maria de los Angeles Robinson-Agramonte
Publisher : Springer
ISBN 13 : 3319163213
Total Pages : 222 pages
Book Rating : 4.3/5 (191 download)

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Book Synopsis Translational Approaches to Autism Spectrum Disorder by : Maria de los Angeles Robinson-Agramonte

Download or read book Translational Approaches to Autism Spectrum Disorder written by Maria de los Angeles Robinson-Agramonte and published by Springer. This book was released on 2015-06-10 with total page 222 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book addresses and synthesizes recent basic, translational, and clinical research with the goal of understanding the mechanisms behind autism spectrum disorder (ASD) and how they lead to altered brain function and behavior. Bringing clarity to these mechanisms will lead to more effective therapies for the various heterogeneous pathologies that comprise ASD. Currently there are few, if any, proven therapies for the majority of the disorders. Among the topic addressed are neural plasticity, neuroimmunology, neuroinflammation, neuroimaging, and appropriate animal and genetic models.

Translational and Clinical Research in Autism Spectrum Disorders

Author : Paul Spencer
Publisher : American Medical Publishers
ISBN 13 : 9781639279029
Total Pages : 0 pages
Book Rating : 4.2/5 (79 download)

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Book Synopsis Translational and Clinical Research in Autism Spectrum Disorders by : Paul Spencer

Download or read book Translational and Clinical Research in Autism Spectrum Disorders written by Paul Spencer and published by American Medical Publishers. This book was released on 2023-09-26 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Autism spectrum disorder (ASD) is a neurodevelopmental disorder that affects how a person perceives and interacts with others, leading to problems in social interaction and communication. Limited and repetitive patterns of conduct are also part of the disorder. While autism is a lifelong disease, the extent to which these challenges limit a person's capacity to function varies from person to person. The term 'spectrum disorders' signifies the wide variety of symptoms and severity associated with autism. Genetic factors are primarily the reason for the disorder's occurrence. ASD appears early in childhood and is related to social, scholastic, and occupational challenges. Autism signs appear as early as the first year of life. Some of the complications linked with the disease include difficulties in school and successful learning, work issues, inability to live independently, social isolation, and family stress. This book is a collection of translational and clinical researches on autism. The readers would gain knowledge that would broaden their perspective about autism spectrum disorders.

The Neuropsychology of Autism

Author : Deborah Fein
Publisher : Oxford University Press
ISBN 13 : 0195378318
Total Pages : 559 pages
Book Rating : 4.1/5 (953 download)

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Book Synopsis The Neuropsychology of Autism by : Deborah Fein

Download or read book The Neuropsychology of Autism written by Deborah Fein and published by Oxford University Press. This book was released on 2011-06-09 with total page 559 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Neuropsychology of Autism provides an up-to-date summary on the neuropsychology of autism spectrum disorders (ASD), written by leaders in the field. It summarizes current knowledge about neurochemistry, neuroanatomy, genetics, and clinical presentations and provides helpful discussions on key functions such as language, memory, attention, executive functions, social cognition, motor and sensory functioning.

Anhedonia: Preclinical, Translational, and Clinical Integration

Author : Diego A. Pizzagalli
Publisher : Springer Nature
ISBN 13 : 3031096835
Total Pages : 526 pages
Book Rating : 4.0/5 (31 download)

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Book Synopsis Anhedonia: Preclinical, Translational, and Clinical Integration by : Diego A. Pizzagalli

Download or read book Anhedonia: Preclinical, Translational, and Clinical Integration written by Diego A. Pizzagalli and published by Springer Nature. This book was released on 2022-08-08 with total page 526 pages. Available in PDF, EPUB and Kindle. Book excerpt: Anhedonia is a key symptom (and often risk factor) for various neuropsychiatric disorders, including depression, schizophrenia, substance use disorders, post-traumatic stress disorders, and Parkinson's Disease, among others. Across disorders, anhedonia has been associated with worse disease course, including poor response to pharmacological, psychological and neurostimulation treatments as well as completed suicide. Mounting evidence emerging from preclinical and translational sciences has clarified that "anhedonia" can be parsed into partially independent subcomponents, including incentive motivation, consummatory pleasure, reward learning, and effort-based decision making, pointing to distinct neurobiological substrates that could underlie anhedonic phenotypes. Taking an integrative approach that emphasizes cross-species integration and dimensional conceptualization of mental illnesses (e.g., Research Domain Criteria (RDoC)), this book represents the most comprehensive evaluation, synthesis and integration of theories and empirical findings focused on anhedonia. Organized across five parts, the handbook starts with chapters on the history, etiology, and assessments of anhedonia (Part I), followed by a section on the role of anhedonia in psychiatric and neurological disorders (Part II). Using the RDoC Matrix as a guide, Part III presents chapters synthetizing preclinical and clinical findings on different reward processing subdomains (e.g., reward responsiveness, reward valuation, reward learning). Part IV is focused on selected special topics, including historical and current perspectives on the transdiagnostic nature and importance of social anhedonia, the role of inflammation in the pathophysiology of anhedonia, the use of computational modeling to “dissect” anhedonia and improve its understanding, and links between anhedonia and suicide. Finally, Part V includes chapters on pharmacological, psychological and neurostimulation treatments for anhedonia.

A Time for Metabolism and Hormones

Author : Paolo Sassone-Corsi
Publisher : Springer
ISBN 13 : 3319270699
Total Pages : 141 pages
Book Rating : 4.3/5 (192 download)

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Book Synopsis A Time for Metabolism and Hormones by : Paolo Sassone-Corsi

Download or read book A Time for Metabolism and Hormones written by Paolo Sassone-Corsi and published by Springer. This book was released on 2016-04-04 with total page 141 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent years have seen spectacular advances in the field of circadian biology. These have attracted the interest of researchers in many fields, including endocrinology, neurosciences, cancer, and behavior. By integrating a circadian view within the fields of endocrinology and metabolism, researchers will be able to reveal many, yet-unsuspected aspects of how organisms cope with changes in the environment and subsequent control of homeostasis. This field is opening new avenues in our understanding of metabolism and endocrinology. A panel of the most distinguished investigators in the field gathered together to discuss the present state and the future of the field. The editors trust that this volume will be of use to those colleagues who will be picking up the challenge to unravel how the circadian clock can be targeted for the future development of specific pharmacological strategies toward a number of pathologies.

Textbook of Autism Spectrum Disorders, Second Edition

Author : Eric Hollander, M.D.
Publisher : American Psychiatric Pub
ISBN 13 : 1615373047
Total Pages : 744 pages
Book Rating : 4.6/5 (153 download)

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Book Synopsis Textbook of Autism Spectrum Disorders, Second Edition by : Eric Hollander, M.D.

Download or read book Textbook of Autism Spectrum Disorders, Second Edition written by Eric Hollander, M.D. and published by American Psychiatric Pub. This book was released on 2022-03-15 with total page 744 pages. Available in PDF, EPUB and Kindle. Book excerpt: More than 40 years after the official recognition of infantile autism in DSM-III, advances continue to be made in our understanding of the possible causes, assessment and evaluation, and treatment of autism spectrum disorder (ASD). With contributions by dozens of experts in the field, this second edition of the Textbook of Autism Spectrum Disorders has been updated to reflect the latest research in ASD. Unrivaled in its thoroughness, this volume discusses issues of assessment and evaluation; examines the etiology of ASD and its recognized associations with other medical conditions; analyzes standard and experimental treatments; and delves into social policy issues pertinent to individuals with ASD and those who treat them. With summary points in each chapter and copious lists of recommended readings, this is an indispensable resource for psychiatrists, psychologists, neurologists, social workers, speech therapists, educators, and all others in the continuum of care.

Autism Spectrum Disorders

Author : David Amaral
Publisher : OUP USA
ISBN 13 : 0195371828
Total Pages : 1445 pages
Book Rating : 4.1/5 (953 download)

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Book Synopsis Autism Spectrum Disorders by : David Amaral

Download or read book Autism Spectrum Disorders written by David Amaral and published by OUP USA. This book was released on 2011-06-17 with total page 1445 pages. Available in PDF, EPUB and Kindle. Book excerpt: Information about the symptoms, treatment, and research on Autism spectrum disorders including Autism and Asperger syndrome.

Translational Neuropsychopharmacology

Author : Trevor W. Robbins
Publisher : Springer
ISBN 13 : 3319339133
Total Pages : 503 pages
Book Rating : 4.3/5 (193 download)

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Book Synopsis Translational Neuropsychopharmacology by : Trevor W. Robbins

Download or read book Translational Neuropsychopharmacology written by Trevor W. Robbins and published by Springer. This book was released on 2016-09-22 with total page 503 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers wide areas of animal and human psychopharmacology with clinical utility in the treatment of psychiatric and neurological (e.g Alzheimer's disease) disorders. The main theme is to develop a new paradigm for drug discovery that questions the claim that animal models or assays fail adequately to predict Phase 3 clinical trials. A new paradigm is advocated that stresses the importance of intermediate staging points between these extremes that depend on suitable translation of findings from animal studies to Phase 1 or Phase 2 studies utilising experimental medicine.

Handbook of Life Course Health Development

Author : Neal Halfon
Publisher : Springer
ISBN 13 : 3319471430
Total Pages : 667 pages
Book Rating : 4.3/5 (194 download)

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Book Synopsis Handbook of Life Course Health Development by : Neal Halfon

Download or read book Handbook of Life Course Health Development written by Neal Halfon and published by Springer. This book was released on 2017-11-20 with total page 667 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is open access under a CC BY 4.0 license. This handbook synthesizes and analyzes the growing knowledge base on life course health development (LCHD) from the prenatal period through emerging adulthood, with implications for clinical practice and public health. It presents LCHD as an innovative field with a sound theoretical framework for understanding wellness and disease from a lifespan perspective, replacing previous medical, biopsychosocial, and early genomic models of health. Interdisciplinary chapters discuss major health concerns (diabetes, obesity), important less-studied conditions (hearing, kidney health), and large-scale issues (nutrition, adversity) from a lifespan viewpoint. In addition, chapters address methodological approaches and challenges by analyzing existing measures, studies, and surveys. The book concludes with the editors’ research agenda that proposes priorities for future LCHD research and its application to health care practice and health policy. Topics featured in the Handbook include: The prenatal period and its effect on child obesity and metabolic outcomes. Pregnancy complications and their effect on women’s cardiovascular health. A multi-level approach for obesity prevention in children. Application of the LCHD framework to autism spectrum disorder. Socioeconomic disadvantage and its influence on health development across the lifespan. The importance of nutrition to optimal health development across the lifespan. The Handbook of Life Course Health Development is a must-have resource for researchers, clinicians/professionals, and graduate students in developmental psychology/science; maternal and child health; social work; health economics; educational policy and politics; and medical law as well as many interrelated subdisciplines in psychology, medicine, public health, mental health, education, social welfare, economics, sociology, and law.

Transcranial Direct Current Stimulation in Neuropsychiatric Disorders

Author : André R. Brunoni
Publisher : Springer Nature
ISBN 13 : 3030761363
Total Pages : 779 pages
Book Rating : 4.0/5 (37 download)

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Book Synopsis Transcranial Direct Current Stimulation in Neuropsychiatric Disorders by : André R. Brunoni

Download or read book Transcranial Direct Current Stimulation in Neuropsychiatric Disorders written by André R. Brunoni and published by Springer Nature. This book was released on 2021-09-20 with total page 779 pages. Available in PDF, EPUB and Kindle. Book excerpt: The 2nd edition of this book incorporates the tremendous clinical advances that have occurred in the field of transcranial direct current stimulation (tDCS) over the past 5 years. Since the 1st edition was published, the clinical use of tDCS has moved from its infancy, and is now in a thrilling new phase with numerous possibilities as well as challenges. tDCS is a technique that excels in terms of safety and tolerability, and within a few years, novel technological developments will allow its use at home. At the same time, large, phase III trials have been exploring the clinical efficacy of tDCS, the results of which have been published in leading journals such as the New England Journal of Medicine and JAMA Psychiatry. This 2nd edition summarizes the state of the art of the field. Written by leading experts in the field, the book is divided into 5 parts: Introduction and Mechanisms of Action; Research Methods; tDCS in the life cycle; Applications of tDCS in neuropsychiatric disorders (further divided into Psychiatry and Neurology); and The clinical use of tDCS. It also includes several new chapters, covering topics such as precision stimulation of tDCS; combination of tDCS with different neuroimaging modalities; and use of tDCS in new clinical conditions. Moreover, all chapters have been rewritten and updated. This book will be of significant interest to psychiatrists, neurologists and neuroscientists new to the field as well as those with a background in tDCS who want to increase their understanding of particular psychiatric conditions.

United States Congressional Serial Set, Serial No. 14921, House Reports Nos. 636-666

Author :
Publisher : Government Printing Office
ISBN 13 :
Total Pages : 1376 pages
Book Rating : 4./5 ( download)

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Book Synopsis United States Congressional Serial Set, Serial No. 14921, House Reports Nos. 636-666 by :

Download or read book United States Congressional Serial Set, Serial No. 14921, House Reports Nos. 636-666 written by and published by Government Printing Office. This book was released on with total page 1376 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Algorithms in Advanced Artificial Intelligence

Author : R. N. V. Jagan Mohan
Publisher : CRC Press
ISBN 13 : 104014537X
Total Pages : 547 pages
Book Rating : 4.0/5 (41 download)

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Book Synopsis Algorithms in Advanced Artificial Intelligence by : R. N. V. Jagan Mohan

Download or read book Algorithms in Advanced Artificial Intelligence written by R. N. V. Jagan Mohan and published by CRC Press. This book was released on 2024-07-08 with total page 547 pages. Available in PDF, EPUB and Kindle. Book excerpt: The most common form of severe dementia, Alzheimer’s disease (AD), is a cumulative neurological disorder because of the degradation and death of nerve cells in the brain tissue, intelligence steadily declines and most of its activities are compromised in AD. Before diving into the level of AD diagnosis, it is essential to highlight the fundamental differences between conventional machine learning (ML) and deep learning (DL). This work covers a number of photo-preprocessing approaches that aid in learning because image processing is essential for the diagnosis of AD. The most crucial kind of neural network for computer vision used in medical image processing is called a Convolutional Neural Network (CNN). The proposed study will consider facial characteristics, including expressions and eye movements using the diffusion model, as part of CNN’s meticulous approach to Alzheimer’s diagnosis. Convolutional neural networks were used in an effort to sense Alzheimer’s disease in its early stages using a big collection of pictures of facial expressions.

Etiology and treatment for children and adolescents with autism spectrum disorder

Author : Feiyong Jia
Publisher : Frontiers Media SA
ISBN 13 : 2832531180
Total Pages : 185 pages
Book Rating : 4.8/5 (325 download)

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Book Synopsis Etiology and treatment for children and adolescents with autism spectrum disorder by : Feiyong Jia

Download or read book Etiology and treatment for children and adolescents with autism spectrum disorder written by Feiyong Jia and published by Frontiers Media SA. This book was released on 2023-08-02 with total page 185 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Autism Spectrum Disorder

Author : Christopher McDougle
Publisher : Oxford University Press
ISBN 13 : 0199349738
Total Pages : 521 pages
Book Rating : 4.1/5 (993 download)

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Book Synopsis Autism Spectrum Disorder by : Christopher McDougle

Download or read book Autism Spectrum Disorder written by Christopher McDougle and published by Oxford University Press. This book was released on 2016-01-22 with total page 521 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Primer on Autism Spectrum Disorder provides a quick yet comprehensive overview of clinically-relevant topics related to autism spectrum disorder (ASD) for the medical or mental health student, trainee, or recent graduate who seeks efficient learning. Chapters are designed to give an overview of a topic area in real time while on a rotation; while studying for professional board examinations in primary care, pediatrics, neurology or psychiatry; or even during preparation for a presentation or discussion scheduled to occur the next day. The sections include Background and Diagnostic Assessment, Etiology, Treatment, and Other Care Delivery Services and Perspectives, with each chapter written by an internationally recognized expert in the field. The chapters on diagnosis and treatment are written from a practical "how to" perspective. Those on etiology are written with the clinician in mind. These clinically-focused chapters include one or more vignettes that present simulated patient cases designed to highlight teaching points related to each chapter's content area. The book ends with a chapter written by family members of individuals with ASD and another written by an adult with ASD that illustrate the human impact these disorders have on day-to-day lives, hopes, and dreams. At the end of each chapter, "Key Points" for summarizing the intended take home messages of each author/authors are listed.