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Transcriptional Regulation Of The Gm Csf Gene In T Lymphocytes
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Book Synopsis Transcriptional Regulation of the GM-CSF Gene in T Lymphocytes by : Cameron Stuart Osborne
Download or read book Transcriptional Regulation of the GM-CSF Gene in T Lymphocytes written by Cameron Stuart Osborne and published by . This book was released on 1996 with total page 218 pages. Available in PDF, EPUB and Kindle. Book excerpt: Describes the investigation as to whether the mouse granulocyte-macrophage colony-stimulating factor and interleukin-3 genes are regulated in a similar manner as those of the human, focussing on regulation through an enhancer.
Book Synopsis Regulation of Gene Expression in T Lymphocytes by the Transcription Factor Runx3 by : Ivana Djuretic
Download or read book Regulation of Gene Expression in T Lymphocytes by the Transcription Factor Runx3 written by Ivana Djuretic and published by . This book was released on 2009 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: T lymphocytes have served as a model system for studying gene regulation and cell fate decisions in many laboratories over the last two decades. In particular, the differentiation of antigen-inexperienced (naïve) T helper cells upon encounter of antigen has received the most attention, as this process can be very efficiently and accurately recapitulated in vitro. T helper (T H) differentiation results in the acquisition of specialized effector functions (i.e. secretion of cytokines) that enable T helper cells to direct appropriate and effective immune responses against a great diversity of pathogens. Thus, dramatic changes in transcriptional profiles occur during this process resulting in selective activation and silencing of the transcriptional potential of cytokine genes (e.g. activation of interferon-gamma [IFN-[gamma]] and silencing of interleukin-4 [IL-4] during T helper-1 differentiation). In an effort to study the mechanism of silencing of one essential T helper cytokine, IL-4, we discovered a role for the Runx family of transcription factors in T H differentiation.
Book Synopsis Transcriptional Regulation of the Human T Cell Receptor [beta] Gene by :
Download or read book Transcriptional Regulation of the Human T Cell Receptor [beta] Gene written by and published by . This book was released on 1991 with total page 542 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Mononuclear Phagocytes by : R. van Furth
Download or read book Mononuclear Phagocytes written by R. van Furth and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 1949 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Mechanisms of Regulation of Human T Cell Activation and GM-CSF Production by : Stefan Emming
Download or read book Mechanisms of Regulation of Human T Cell Activation and GM-CSF Production written by Stefan Emming and published by . This book was released on 2019 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Transcriptional Regulation of the Human IL-2 Gene by : Milena Iacobelli Martinez
Download or read book Transcriptional Regulation of the Human IL-2 Gene written by Milena Iacobelli Martinez and published by . This book was released on 2000 with total page 206 pages. Available in PDF, EPUB and Kindle. Book excerpt: Interleukin 2 (IL-2) is produced by optimally stimulated T cells and is the major growth factor for T cells. Quiescent T cells do not synthesize IL-2, but upon stimulation, IL-2 is quickly expressed due to the coordinate binding of transcription factors within a 300 base pair promoter. Activation of the transcription factors involved in IL-2 transcription is highly dependent on proper stimulation through the T cell receptor (TCR) as well as a co-stimulatory molecule such as the CD28 receptor. TCR-induced signals are necessary to induce the binding of most, but not all, factors to the IL-2 promoter. CD28 stimulation synergizes with the TCR to activate many of these factors, but is also responsible for the induced binding of a novel complex to a region of the IL-2 promoter known as the CD28 responsive element (CD28RE). Determination of the proteins which function at this site was investigated. Functional studies led to the discovery that the CD28RE forms a composite element with a proximal AP-1 site. Together, the CD28RE/AP-1 sequences bind a complex that contains c-Rel, c-Fos, c-Jun, and the novel protein p21 SNFT in Jurkat T cells. Further analysis of p21SNFT indicates that it inhibits IL-2 promoter activity due to its ability to repress AP-1-associated enhancers required for transcription. Functional and binding studies using nuclear extracts and purified proteins suggest that p21 SNFT competes with Fos proteins for Jun binding, thereby effectively decreasing the numbers of transcriptionally active AP-1 heterodimers that form. While much is known about transactivation requirements for IL-2 expression, less is known about the inhibitory processes that shut down or prevent IL-2 transcription. Therefore, the identity of a novel protein that represses IL-2 promoter activity may help in our understanding of the mechanisms involved in the silencing of the IL-2 gene in situations such as in sub-optimally stimulated T cells, anergic T cells, or during T cell differentiation.
Book Synopsis A Laboratory Guide to the Mammalian Embryo by : David K. Gardner
Download or read book A Laboratory Guide to the Mammalian Embryo written by David K. Gardner and published by Oxford University Press. This book was released on 2004-01-08 with total page 434 pages. Available in PDF, EPUB and Kindle. Book excerpt: Never before has there been such a comprehensive book of protocols. This compendium offers a full range of research techniques-from cell culture, to biochemical, to microscopic and genetic. More focused books, like Cold Spring Harbor's Manipulating the Mouse Embryo, are similar though more narrow in scope. This book will appeal to a broad range of researchers, from basic experimental scientists to clinical and animal scientists.
Book Synopsis Colony-Stimulating Factors by : John M. Garland
Download or read book Colony-Stimulating Factors written by John M. Garland and published by CRC Press. This book was released on 2020-08-26 with total page 588 pages. Available in PDF, EPUB and Kindle. Book excerpt: Concentrating on proven data and adopting a structure-function approach, this text provides grounding for an intricate understanding of the molecular biology, physiological mechanisms, and routine clinical use in disease settings of colony-stimulating factors (CSFs). This edition includes eight additional chapters, with updates of recently-discovered and established CSFs, each indexed individually.
Book Synopsis Experimental Hematology Today—1988 by : Siegmund J. Baum
Download or read book Experimental Hematology Today—1988 written by Siegmund J. Baum and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 185 pages. Available in PDF, EPUB and Kindle. Book excerpt: Experimental Hematology Today - 1988 presents the latest results of research reflecting the diverse interests of basic and clinical hematologists. The major areas explored are hematopoietic regulation by cytokines; hematopoietic cellular growth regulation, with emphasis on the interaction of stromal with hematopoietic stem and progenitor cells; granulopoietic regulators; gene transfers into hematopoietic progenitor cells; leukemogenesis; and bone marrow transplantation. All chapters report on research or clinical findings of the past year.
Book Synopsis Cytokines and Cytokine Receptors by : Constantin A. Bona
Download or read book Cytokines and Cytokine Receptors written by Constantin A. Bona and published by CRC Press. This book was released on 2003-09-02 with total page 864 pages. Available in PDF, EPUB and Kindle. Book excerpt: The field of cytokine research is expanding at a rapid pace Contributions from the major leading groups in the world on the structure and biological properties of cytokine and cytokine receptors, as well as integrated reviews on cytokines in various physiological and pathological conditions were presented in three issues of International Reviews of Immunology This collection of articles provided a unique source of information However, important discoveries are emerging very rapidly and some of the reviews written in 1997 are already outdated In this book, the editors assemble reviews that have been updated by their authors to include all the recent publications and unpublished data from the authors' laboratories This volume should serve as an excellent reference source for all those concerned by the multiple faces of cytokines in basic research and in the clinic
Book Synopsis Transcriptional Gene Regulation in Health and Disease by :
Download or read book Transcriptional Gene Regulation in Health and Disease written by and published by Academic Press. This book was released on 2018-01-02 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt: Transcriptional Gene Regulation in Health and Disease, Volume 335, the latest release in the International Review of Cell and Molecular Biology reviews and details current advances in cell and molecular biology. The IRCMB series has a worldwide readership, maintaining a high standard by publishing invited articles on important and timely topics that are authored by prominent cell and molecular biologists. The articles published in IRCMB have a high impact and an average cited half-life of nine years. This great resource ranks high amongst scientific journals dealing with cell biology. Publishes only invited review articles on selected topics Authored by established and active cell and molecular biologists drawn from international sources Offers a wide range of perspectives on specific subjects
Book Synopsis Molecular Biology of the Lung by : Robert Stockley
Download or read book Molecular Biology of the Lung written by Robert Stockley and published by Birkhäuser. This book was released on 2013-12-01 with total page 209 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Immune Biology of Allogeneic Hematopoietic Stem Cell Transplantation by : Gerard Socie
Download or read book Immune Biology of Allogeneic Hematopoietic Stem Cell Transplantation written by Gerard Socie and published by Academic Press. This book was released on 2018-11-22 with total page 450 pages. Available in PDF, EPUB and Kindle. Book excerpt: Immune Biology of Allogeneic Hematopoietic Stem Cell Transplantation: Models in Discovery and Translation, Second Edition once again provides clinical and scientific researchers with a deep understanding of the current research in this field and the implications for translational practice. By providing an overview of the immune biology of HSCT, an explanation of immune rejection, and detail on antigens and their role in HSCT success, this book embraces biologists and clinicians who need a broad view of the deeply complex processes involved. It then moves on to discuss the immunobiology mechanisms that influence graft-versus-host disease (GVHD), graft-versus-leukemia effect, and transplantation success. Using illustrative figures, highlighting key issues, describing recent successes, and discussing unanswered questions, this book sums up the current state of HSCT to enhance the prospects for the future. The second edition is fully revised and includes new chapters on microbiome, metabolism, kinase targets, micro-RNA and mRNA regulatory mechanisms, signaling pathways in GVHD, innate lymphoid system development, recovery and function in GVHD, genetically engineered T-cell therapies, immune system engagers for GVHD and graft-versus-tumor, and hematopoietic cell transplant for tolerance induction in solid organ grafts. - Brings together perspectives from leading laboratories and clinical research groups to highlight advances from bench to the bedside - Guides readers through the caveats that must be considered when drawing conclusions from studies with animal models before correlating to clinical allogeneic hematopoietic stem cell transplantation (HSCT) scenarios - Categorizes the published advances in various aspects of immune biology of allogeneic HSCT to illustrate opportunities for clinical applications
Author :Robert A. Stockley Publisher :Springer Science & Business Media ISBN 13 :9783764359683 Total Pages :220 pages Book Rating :4.3/5 (596 download)
Book Synopsis Molecular Biology of the Lung by : Robert A. Stockley
Download or read book Molecular Biology of the Lung written by Robert A. Stockley and published by Springer Science & Business Media. This book was released on 1998 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt: The purpose of this two-volume work is to provide an update on the use of this powerful technology. As such, the books provide an insight in to the techniques for the non-specialist. Scientists embarking upon st udies in chronic lung disease will find a review of the current status of research. At the same time, the books are useful to clinicians, bo th specialist and academic, and to scientists already involved in the basic aspects of the pathogenesis of lung disease. Both volumes deal w ith basic mechanisms of cell biology, receptors and cellactivation and provide an insight as to how the technology influences our concepts o f pathogenesis and viceversa.
Book Synopsis The Cytokines of the Immune System by : Zlatko Dembic
Download or read book The Cytokines of the Immune System written by Zlatko Dembic and published by Academic Press. This book was released on 2015-05-23 with total page 323 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Cytokines of the Immune System catalogs cytokines and links them to physiology and pathology, providing a welcome and hugely timely tool for scientists in all related fields. In cataloguing cytokines, it lists their potential for therapeutic use, links them to disease treatments needing further research and development, and shows their utility for learning about the immune system. This book offers a new approach in the study of cytokines by combining detailed guidebook-style cytokine description, disease linking, and presentation of immunologic roles. - Supplies new ideas for basic and clinical research - Provides cytokine descriptions in a guidebook-style, cataloging the origins, structures, functions, receptors, disease-linkage, and therapeutic potentials - Offers a textbook-style view on the immune system with the immunologic role of each cytokine
Book Synopsis Post-Transcriptional Regulation of Immune Responses by : Manuel Daniel Díaz-Muñoz
Download or read book Post-Transcriptional Regulation of Immune Responses written by Manuel Daniel Díaz-Muñoz and published by Frontiers Media SA. This book was released on 2022-11-17 with total page 169 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Immunopharmacology by : Manzoor M. Khan
Download or read book Immunopharmacology written by Manzoor M. Khan and published by Springer Science & Business Media. This book was released on 2008-12-19 with total page 275 pages. Available in PDF, EPUB and Kindle. Book excerpt: During the past decades, with the introduction of the recombinant DNA, hybridoma and transgenic technologies there has been an exponential evolution in understanding the pathogenesis, diagnosis and treatment of a large number of human diseases. The technologies are evident with the development of cytokines and monoclonal antibodies as therapeutic agents and the techniques used in gene therapy. Immunopharmacology is that area of biomedical sciences where immunology, pharmacology and pathology overlap. It concerns the pharmacological approach to the immune response in physiological as well as pathological events. This goals and objectives of this textbook are to emphasize the developments in immunology and pharmacology as they relate to the modulation of immune response. The information includes the pharmacology of cytokines, monoclonal antibodies, mechanism of action of immune-suppressive agents and their relevance in tissue transplantation, therapeutic strategies for the treatment of AIDS and the techniques employed in gene therapy. The book is intended for health care professional students and graduate students in pharmacology and immunology.
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