Topics In Chemical Carcinogenesis

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Chemical Carcinogenesis

Author : Trevor M. Penning
Publisher : Springer Science & Business Media
ISBN 13 : 1617379956
Total Pages : 447 pages
Book Rating : 4.6/5 (173 download)

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Book Synopsis Chemical Carcinogenesis by : Trevor M. Penning

Download or read book Chemical Carcinogenesis written by Trevor M. Penning and published by Springer Science & Business Media. This book was released on 2011-03-03 with total page 447 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume will provide a contemporary account of advances in chemical carcinogenesis. It will promote the view that it is chemical alteration of the DNA that is a route cause of many cancers. The multi-stage model of chemical carcinogenesis, exposure to major classes of human carcinogens and their mode-of-action will be a focal point. The balance between metabolic activation to form biological reactive intermediates and their detoxification, ensuing DNA-lesions and their repair will be profiled. It will describe the chemical changes that occur in DNA that result from endogenous insults including epigenetic changes that lead to gene silencing. It will describe major mechanisms of mutagenesis, affects on tumor suppressor genes and proto-oncogenes, and how cell-cycle check points can be by-passed by the "stealth-like" properties of chemical carcinogens. Environmental agents that can promote tumor formation will be discussed. The monograph will have wide appeal as a knowledge base for graduate students, post-doctoral fellows and faculty interested in this aspect of cancer causation and research.

Recent Topics in Chemical Carcinogenesis

Author : Tomizō Yoshida
Publisher :
ISBN 13 :
Total Pages : 492 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Recent Topics in Chemical Carcinogenesis by : Tomizō Yoshida

Download or read book Recent Topics in Chemical Carcinogenesis written by Tomizō Yoshida and published by . This book was released on 1975 with total page 492 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Recent Topics in Chemical Carcinogenesis

Author : Shigeyoshi Odashima
Publisher :
ISBN 13 :
Total Pages : 456 pages
Book Rating : 4.:/5 (476 download)

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Book Synopsis Recent Topics in Chemical Carcinogenesis by : Shigeyoshi Odashima

Download or read book Recent Topics in Chemical Carcinogenesis written by Shigeyoshi Odashima and published by . This book was released on 1975 with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Toxicological Carcinogenesis

Author : David B. Clayson
Publisher : CRC Press
ISBN 13 : 9781420032727
Total Pages : 212 pages
Book Rating : 4.0/5 (327 download)

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Book Synopsis Toxicological Carcinogenesis by : David B. Clayson

Download or read book Toxicological Carcinogenesis written by David B. Clayson and published by CRC Press. This book was released on 2000-09-28 with total page 212 pages. Available in PDF, EPUB and Kindle. Book excerpt: How do we know if a chemical is carcinogenic? How accurate and relevant to humans are the current assays? With the increasing influx of chemicals in our food and environment, these questions become more critical everyday. Written by an expert with more than fifty years experience in this field, Toxicological Carcinogenesis gives you a balanced and authoritative treatment of the issues. The book provides a summary of the present knowledge of chemicals that induce cancer. The author avoids the overuse of technical jargon and explains scientific concepts clearly and succinctly. He has included an appendix containing bibliographic references, making the text easier to read and keeping the information available as a reference. He covers: How carcinogens are detected in humans using epidemiology, bioassays, and alternative approaches Agents leading to human cancer such as exposure due to occupation, cigarette smoking, and diet and nutrition Carcinogenesis mechanisms The use of legislation to control exposures to noxious agents. Toxicological Carcinogenesis fills a gap in the current literature by providing just enough background information to give a complete general overview of the subject. It explores the emerging debates that related to the potential chemical causes of cancer. In addition to the comprehensive coverage the book provides, it explains the potential problems caused by possible misinformation about chemical carcinogenesis.

Carcinogens, Dna Damage And Cancer Risk: Mechanisms Of Chemical Carcinogenesis

Author : Miriam Christine Poirier
Publisher : World Scientific
ISBN 13 : 981323721X
Total Pages : 391 pages
Book Rating : 4.8/5 (132 download)

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Book Synopsis Carcinogens, Dna Damage And Cancer Risk: Mechanisms Of Chemical Carcinogenesis by : Miriam Christine Poirier

Download or read book Carcinogens, Dna Damage And Cancer Risk: Mechanisms Of Chemical Carcinogenesis written by Miriam Christine Poirier and published by World Scientific. This book was released on 2018-09-28 with total page 391 pages. Available in PDF, EPUB and Kindle. Book excerpt: As chemical exposures and cancer rates increase worldwide, there is a need for students, researchers, public health professionals, and physicians to understand the mechanisms connecting exposure with human cancer risk. This new book is an essential reference, as well as introduction to the field of chemical carcinogenesis, with particular focus on DNA damage as a critical link between exposure and disease, and emphasis on biomarkers associated with cancer risk in humans. In addition to DNA damage, related topics covered include metabolism of selected chemical carcinogens, exposure-induced epigenetic changes, cancer-associated mutations and reduction of DNA damage and cancer risk by chemoprevention. The book is designed to be a comprehensive guide to basic principles, a teaching tool for academics, and a map for the development of protective mechanisms to reduce human cancer risk.

Topics in Chemical Carcinogenesis

Author : Takamatsu no Miya Hi Gan Kenkyū Kikin. International Symposium
Publisher :
ISBN 13 :
Total Pages : 564 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Topics in Chemical Carcinogenesis by : Takamatsu no Miya Hi Gan Kenkyū Kikin. International Symposium

Download or read book Topics in Chemical Carcinogenesis written by Takamatsu no Miya Hi Gan Kenkyū Kikin. International Symposium and published by . This book was released on 1972 with total page 564 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Mechanisms of Carcinogenesis

Author : Elizabeth K. Weisburger
Publisher : Springer Science & Business Media
ISBN 13 : 9400925263
Total Pages : 210 pages
Book Rating : 4.4/5 (9 download)

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Book Synopsis Mechanisms of Carcinogenesis by : Elizabeth K. Weisburger

Download or read book Mechanisms of Carcinogenesis written by Elizabeth K. Weisburger and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 210 pages. Available in PDF, EPUB and Kindle. Book excerpt: but also the possibility of intervention in specific stages. In Human behavior, including stress and other factors, plays an important role in neoplasia, although too little is known addition, variables which affect cancer development as well on the reasons for such development. Carcinogens, which as some endogenous factors can be better delineated help initiate the neoplastic process, may be either synthetic through such investigations. The topics of this volume encompass premalignant non or naturally-occurring. Cancer causation may be ascribed to invasive lesions, species-specific aspects of carcinogenicity, certain chemicals, physical agents, radioactive materials, viruses, parasites, the genetic make-up of the organism, and radiation, viruses, a quantum theory of carinogenesis, onco bacteria. Humans, eumetazoan animals and vascular plants genes, and selected environmental carcinogens. are susceptible to the first six groups of cancer causes, whe reas the last group, bacteria, seems to affect only vascular plants. Neoplastic development may begin with impairment ofJmdy defenses by a toxic material (carcinogen) which acts as an initiator, followed by promotion and progression to an overt neoplastic state. Investigation of these processes Series Editor Volume Editor allows not only a better insight into the mechanism of action Hans E. Kaiser Elizabeth K. Weisburger vii ACKNOWLEDGEMENT Inspiration and encouragement for this wide ranging project on cancer distribution and dissemination from a comparative biological and clinical point of view, was given by my late friend E. H. Krokowski.

Recent Topics in Chemical Carcinogenesis

Author : Shigeyoshi Odashima
Publisher :
ISBN 13 :
Total Pages : 456 pages
Book Rating : 4.:/5 (763 download)

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Book Synopsis Recent Topics in Chemical Carcinogenesis by : Shigeyoshi Odashima

Carcinogens and Anticarcinogens in the Human Diet

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309053919
Total Pages : 434 pages
Book Rating : 4.3/5 (9 download)

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Book Synopsis Carcinogens and Anticarcinogens in the Human Diet by : National Research Council

Download or read book Carcinogens and Anticarcinogens in the Human Diet written by National Research Council and published by National Academies Press. This book was released on 1996-03-12 with total page 434 pages. Available in PDF, EPUB and Kindle. Book excerpt: Despite increasing knowledge of human nutrition, the dietary contribution to cancer remains a troubling question. Carcinogens and Anticarcinogens assembles the best available information on the magnitude of potential cancer riskâ€"and potential anticarcinogenic effectâ€"from naturally occurring chemicals compared with risk from synthetic chemical constituents. The committee draws important conclusions about diet and cancer, including the carcinogenic role of excess calories and fat, the anticarcinogenic benefit of fiber and other substances, and the impact of food additive regulation. The book offers recommendations for epidemiological and diet research. Carcinogens and Anticarcinogens provides a readable overview of issues and addresses critical questions: Does diet contribute to an appreciable proportion of human cancer? Are there significant interactions between carcinogens and anticarcinogens in the diet? The volume discusses the mechanisms of carcinogenic and anticarcinogenic properties and considers whether techniques used to evaluate the carcinogenic potential of synthetics can be used with naturally occurring chemicals. The committee provides criteria for prioritizing the vast number of substances that need to be tested. Carcinogens and Anticarcinogens clarifies the issues and sets the direction for further investigations into diet and cancer. This volume will be of interest to anyone involved in food and health issues: policymakers, regulators, researchers, nutrition professionals, and health advocates.

Chemical Carcinogens & Dna

Author : Philip L. Grover
Publisher : CRC Press
ISBN 13 : 0429536291
Total Pages : 344 pages
Book Rating : 4.4/5 (295 download)

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Book Synopsis Chemical Carcinogens & Dna by : Philip L. Grover

Download or read book Chemical Carcinogens & Dna written by Philip L. Grover and published by CRC Press. This book was released on 2019-06-04 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt: First published in 1979, Chemical Carcinogenesis and DNA is an essential guide to the relationship between mutagens, carcinogens and our own genetic makeup. Covering a range of associated topics, this volume provides information that would prove most beneficial for practitioners of medicine and students alike.

Chemical Carcinogenesis and Mutagenesis II

Author : Colin S. Cooper
Publisher : Springer Science & Business Media
ISBN 13 : 3642747787
Total Pages : 482 pages
Book Rating : 4.6/5 (427 download)

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Book Synopsis Chemical Carcinogenesis and Mutagenesis II by : Colin S. Cooper

Download or read book Chemical Carcinogenesis and Mutagenesis II written by Colin S. Cooper and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 482 pages. Available in PDF, EPUB and Kindle. Book excerpt: I have been privileged to witness and participate in the great growth of knowledge on chemical carcinogenesis and mutagenesis since 1939 when I entered graduate school in biochemistry at the University of Wisconsin Madison. I immediately started to work with the carcinogenic aminoazo dyes un der the direction of Professor CARL BAUMANN. In 1942 I joined a fellow graduate student, ELIZABETH CA VERT, in marriage and we soon commenced a joyous part nership in research on chemical carcinogenesis at the McArdle Laboratory for Cancer Research in the University of Wisconsin Medical School in Madison. This collaboration lasted 45 years. I am very grateful that this volume is dedi cated to the memory of Elizabeth. The important and varied topics that are reviewed here attest to the continued growth of the fields of chemical car cinogenesis and mutagenesis, including their recent and fruitful union with viral oncology. I feel very optimistic about the application of knowledge in these fields to the eventual solution of numerous problems, including the detection and estimation of the risks to humans of environmental chemical carcinogens and re lated factors.

Topics in Chemical Carcinogenesis

Author : Waro Nakahara
Publisher :
ISBN 13 :
Total Pages : 530 pages
Book Rating : 4.:/5 (97 download)

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Book Synopsis Topics in Chemical Carcinogenesis by : Waro Nakahara

Download or read book Topics in Chemical Carcinogenesis written by Waro Nakahara and published by . This book was released on 1974 with total page 530 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Encyclopedia of Cancer

Author :
Publisher : Academic Press
ISBN 13 : 0128124857
Total Pages : 1841 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Encyclopedia of Cancer by :

Download or read book Encyclopedia of Cancer written by and published by Academic Press. This book was released on 2018-10-12 with total page 1841 pages. Available in PDF, EPUB and Kindle. Book excerpt: Encyclopedia of Cancer, Third Edition provides a comprehensive, up-to-date overview of the multiple facets of the disease, including research, treatment and societal impact. This new edition comprises 180 contributions from renown experts who present the latest in Mechanisms, Hallmarks of Cancer, Causes of Cancer, Prevention and Control, Diagnosis and Therapy, Pathology and the Genetics of specific Cancers. Readers will find a comprehensive overview of the main areas of oncology, including etiology, mechanisms, prevention, and treatments, from basic science to clinical applications and public health, all set alongside the latest advances and hot topics that have emerged since the previous edition. Topics of interest in the field, including genomics and epigenomics, our understanding of the causes of cancer and the approaches to preventing it (e.g., HPV vaccination, role of obesity and nutrition, molecular markers of environmental exposures), new screening techniques (e.g., low-dose CT for lung cancer) and improvements in the treatment of many cancers (e.g., breast cancer, lung adenocarcinoma) are comprehensively and authoritatively presented. Comprises 180 contributions from renowned experts who present the latest in mechanisms, hallmarks of cancer, causes, prevention and control, diagnosis and therapy, pathology and genetics Presents a comprehensive overview of the main areas of oncology, including etiology, mechanisms, prevention, and treatments, from basic science to clinical applications and public health

Biochemistry of Chemical Carcinogenesis

Author : R. Colin Garner
Publisher : Springer Science & Business Media
ISBN 13 : 146130539X
Total Pages : 262 pages
Book Rating : 4.4/5 (613 download)

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Book Synopsis Biochemistry of Chemical Carcinogenesis by : R. Colin Garner

Download or read book Biochemistry of Chemical Carcinogenesis written by R. Colin Garner and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 262 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Holland-Frei Cancer Medicine

Author : Robert C. Bast, Jr.
Publisher : John Wiley & Sons
ISBN 13 : 111900084X
Total Pages : 2004 pages
Book Rating : 4.1/5 (19 download)

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Book Synopsis Holland-Frei Cancer Medicine by : Robert C. Bast, Jr.

Download or read book Holland-Frei Cancer Medicine written by Robert C. Bast, Jr. and published by John Wiley & Sons. This book was released on 2017-03-10 with total page 2004 pages. Available in PDF, EPUB and Kindle. Book excerpt: Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates

How Tobacco Smoke Causes Disease

Author : United States. Public Health Service. Office of the Surgeon General
Publisher :
ISBN 13 :
Total Pages : 728 pages
Book Rating : 4.:/5 (318 download)

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Book Synopsis How Tobacco Smoke Causes Disease by : United States. Public Health Service. Office of the Surgeon General

Download or read book How Tobacco Smoke Causes Disease written by United States. Public Health Service. Office of the Surgeon General and published by . This book was released on 2010 with total page 728 pages. Available in PDF, EPUB and Kindle. Book excerpt: This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.

Issues in Risk Assessment

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309047862
Total Pages : 375 pages
Book Rating : 4.3/5 (9 download)

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Book Synopsis Issues in Risk Assessment by : National Research Council

Download or read book Issues in Risk Assessment written by National Research Council and published by National Academies Press. This book was released on 1993-02-01 with total page 375 pages. Available in PDF, EPUB and Kindle. Book excerpt: The scientific basis, inference assumptions, regulatory uses, and research needs in risk assessment are considered in this two-part volume. The first part, Use of Maximum Tolerated Dose in Animal Bioassays for Carcinogenicity, focuses on whether the maximum tolerated dose should continue to be used in carcinogenesis bioassays. The committee considers several options for modifying current bioassay procedures. The second part, Two-Stage Models of Carcinogenesis, stems from efforts to identify improved means of cancer risk assessment that have resulted in the development of a mathematical dose-response model based on a paradigm for the biologic phenomena thought to be associated with carcinogenesis.