Thermo And Ph Sensitive Hydrophilic Block Copolymers

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Thermo- and PH-sensitive Hydrophilic Block Copolymers

Author : Thomas G. O'Lenick
Publisher :
ISBN 13 :
Total Pages : 233 pages
Book Rating : 4.:/5 (743 download)

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Book Synopsis Thermo- and PH-sensitive Hydrophilic Block Copolymers by : Thomas G. O'Lenick

Download or read book Thermo- and PH-sensitive Hydrophilic Block Copolymers written by Thomas G. O'Lenick and published by . This book was released on 2011 with total page 233 pages. Available in PDF, EPUB and Kindle. Book excerpt: This dissertation presents the synthesis of a series of thermo- and pH-sensitive hydrophilic block copolymers and the study of their solution behavior in water. By incorporating a small amount of weak acid or base groups into the thermosensitive block(s) of a hydrophilic block copolymer, the LCST of the thermosensitive block(s) can be modified by changing the solution pH. Accordingly, the critical micellization temperature (CMT) and the sol-gel transition temperature (T[subscript sol-gel]) of the block copolymer in water can be tuned. Chapter 1 describes the synthesis of thermo- and pH-sensitive poly(methoxydi(ethylene glycol) methacrylate-co-methacrylic acid)-b-PEO-b-poly(methoxydi(ethylene glycol) methacrylate-co-methacrylic acid) and the study of sol-gel transitions of its aqueous solutions at various pH values. The CMT of the 0.2 wt% solution and the T[subscript sol-gel] of the 12.0 wt% solution of this copolymer can be varied over a large temperature range. By judiciously controlling temperature and pH, multiple sol-gel-sol transitions were realized. Chapter 2 presents a systematic study of pH effect on rheological properties of micellar gels formed from 10.0 wt% aqueous solutions of thermo- and pH-sensitive poly(ethoxydi(ethylene glycol) acrylate-co-acrylic acid)-b-PEO-b-poly(ethoxydi(ethylene glycol) acrylate-co-acrylic acid). With the increase of pH, the sol-gel transition became broader. The plateau moduli (G[subscript N]) evaluated from frequency sweeps at T/T[subscript sol-gel] of 1.025, 1.032, and 1.039 decreased with the increase of pH from 3.00 to 5.40 with the largest drop observed at pH = ~ 4.7. The decrease in G[subscript N] reflects the reduction of the number of bridging chains. The ionization of carboxylic acid introduced charges onto the thermosensitive blocks and made the polymer more hydrophilic, facilitating the formation of loops and dangling chains. Chapter 3 presents the synthesis of PEO-b-poly(methoxydi(ethylene glycol) methacrylate-co-2-(N-methyl-N-(4-pyridyl)amino)ethyl methacrylate) with the thermosensitive block containing a catalytic 4-N, N-dialkylaminopyridine and the study of the effect of thermo-induced micellization on its activity in the hydrolysis of p-nitrophenyl acetate. The CMTs of this copolymer at pH of 7.06 and 7.56 were 40 and 37 °C, respectively. Below CMT, the logarithm of initial hydrolysis rate changed linearly with 1/T. Above CMT, the reaction rate leveled off, which is presumably because it was controlled by mass transport to the core of micelles above CMT.

Synthesis and Solution Behavior of Doubly Responsive Hydrophilic Block Copolymers

Author : Xueguang Jiang
Publisher :
ISBN 13 :
Total Pages : 282 pages
Book Rating : 4.:/5 (664 download)

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Book Synopsis Synthesis and Solution Behavior of Doubly Responsive Hydrophilic Block Copolymers by : Xueguang Jiang

Download or read book Synthesis and Solution Behavior of Doubly Responsive Hydrophilic Block Copolymers written by Xueguang Jiang and published by . This book was released on 2010 with total page 282 pages. Available in PDF, EPUB and Kindle. Book excerpt: This dissertation presents the synthesis of stimuli-sensitive hydrophilic polymers, particularly doubly responsive hydrophilic block copolymers, by controlled radical polymerizations and the study of their solution behavior in water. By incorporating a small amount of stimuli-responsive groups into the thermosensitive block of a hydrophilic block copolymer, the lower critical solution temperature (LCST) of the thermosensitive block can be tuned by a stimulus and multiple micellization/dissociation transitions can be achieved by combining two external triggers. Chapter 1 describes the synthesis and thermosensitive properties of two new watersoluble polystyrenics with a short oligo(ethyl glycol) pendant from each repeat unit and the study of hydrophobic end group effects on cloud points of thermosensitive polystyrenics. Well-defined polymers were prepared from monomer-based initiators via nitroxide-mediated polymerization and the alkoxyamine end groups were removed by tri(n-butyl)tin hydride, yielding thermoresponsive polystyrenics with essentially no end groups. The results showed that hydrophobic end groups could significantly change the cloud points and the molecular weight dependences of cloud points of polystyrenics. Chapter 2 presents the synthesis of thermo- and light-sensitive hydrophilic block copolymers, poly(ethylene oxide)-b-poly(ethoxytri(ethylene glycol) acrylate-co-o-nitrobenzyl acrylate), and their responsive behavior in dilute aqueous solutions. Dynamic light scattering and fluorescence spectroscopy studies showed that these copolymers were molecularly dissolved in water at lower temperatures and self-assembled into micelles at temperatures above the LCST of the thermosensitive block. Upon UV irradiation, the o-nitrobenzyl group was cleaved and the LCST of the thermosensitive block was increased, causing the dissociation of micelles into unimers. The resultant copolymers underwent thermo-induced reversible micellization at higher temperatures. Chapter 3 describes multiple micellization/dissociation transitions of thermo- and pH-sensitive hydrophilic block copolymers, poly(ethylene oxide)-b-poly(methoxydi(ethylene glycol) methacrylate-co-methacrylic acid), in response to temperature and pH changes. The LCST of the thermosensitive block can be reversibly tuned and precisely controlled by solution pH. Chapter 4 presents the study on multiple sol-gel-sol transitions of a 20.0 wt % aqueous solution of poly(ethylene oxide)-b-poly(ethoxytri(ethylene glycol) acrylate-co-o-nitrobenzyl acrylate) induced by temperature changes and UV irradiation. The solution underwent thermo-induced sol-gel-sol transitions. Upon UV irradiation to dissociate micelles, the gel was transformed into a free-flowing liquid, which upon heating underwent sol-gel-sol transitions again.

New Hydrogel Forming Thermo-responsive Block Copolymers of Increasing Structural Complexity

Author : Anna Miasnikova
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (849 download)

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Book Synopsis New Hydrogel Forming Thermo-responsive Block Copolymers of Increasing Structural Complexity by : Anna Miasnikova

Download or read book New Hydrogel Forming Thermo-responsive Block Copolymers of Increasing Structural Complexity written by Anna Miasnikova and published by . This book was released on 2012 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This work describes the synthesis and characterization of stimuli-responsive polymers made by reversible addition-fragmentation chain transfer (RAFT) polymerization and the investigation of their self-assembly into "smart" hydrogels. In particular the hydrogels were designed to swell at low temperature and could be reversibly switched to a collapsed hydrophobic state by rising the temperature. Starting from two constituents, a short permanently hydrophobic polystyrene (PS) block and a thermo-responsive poly(methoxy diethylene glycol acrylate) (PMDEGA) block, various gelation behaviors and switching temperatures were achieved. New RAFT agents bearing tert-butyl benzoate or benzoic acid groups, were developed for the synthesis of diblock, symmetrical triblock and 3-arm star block copolymers. Thus, specific end groups were attached to the polymers that facilitate efficient macromolecular characterization, e.g by routine 1H-NMR spectroscopy. Further, the carboxyl end-groups allowed functionalizing the various polymers by a fluorophore. Because reports on PMDEGA have been extremely rare, at first, the thermo-responsive behavior of the polymer was investigated and the influence of factors such as molar mass, nature of the end-groups, and architecture, was studied. The use of special RAFT agents enabled the design of polymer with specific hydrophobic and hydrophilic end-groups. Cloud points (CP) of the polymers proved to be sensitive to all molecular variables studied, namely molar mass, nature and number of the end-groups, up to relatively high molar masses. Thus, by changing molecular parameters, CPs of the PMDEGA could be easily adjusted within the physiological interesting range of 20 to 40°C. A second responsivity, namely to light, was added to the PMDEGA system via random copolymerization of MDEGA with a specifically designed photo-switchable azobenzene acrylate. The composition of the copolymers was varied in order to determine the optimal conditions for an isothermal cloud point variation triggered by light. Though reversible light-induced solubility changes were achieved, the differences between the cloud points before and after the irradiation were small. Remarkably, the response to light differed from common observations for azobenzene-based systems, as CPs decreased after UV-irradiation, i.e with increasing content of cis-azobenzene units. The viscosifying and gelling abilities of the various block copolymers made from PS and PMDEGA blocks were studied by rheology. Important differences were observed between diblock copolymers, containing one hydrophobic PS block only, the telechelic symmetrical triblock copolymers made of two associating PS termini, and the star block copolymers having three associating end blocks. Regardless of their hydrophilic block length, diblock copolymers PS11 PMDEGAn were freely flowing even at concentrations as high as 40 wt. %. In contrast, all studied symmetrical triblock copolymers PS8-PMDEGAn-PS8 formed gels at low temperatures and at concentrations as low as 3.5 wt. % at best. When heated, these gels underwent a gel-sol transition at intermediate temperatures, well below the cloud point where phase separation occurs. The gel-sol transition shifted to markedly higher transition temperatures with increasing length of the hydrophilic inner block. This effect increased also with the number of arms, and with the length of the hydrophobic end blocks. The mechanical properties of the gels were significantly altered at the cloud point and liquid-like dispersions were formed. These could be reversibly transformed into hydrogels by cooling. This thesis demonstrates that high molar mass PMDEGA is an easily accessible, presumably also biocompatible and at ambient temperature well water-soluble, non-ionic thermo-responsive polymer. PMDEGA can be easily molecularly engineered via the RAFT method, implementing defined end-groups, and producing different, also complex, architectures, such as amphiphilic triblock and star block copolymers, having an analogous structure to associative telechelics. With appropriate design, such amphiphilic copolymers give way to efficient, "smart" viscosifiers and gelators displaying tunable gelling and mechanical properties.

Polymers in Nanomedicine

Author : Shigeru Kunugi
Publisher : Springer Science & Business Media
ISBN 13 : 3642278558
Total Pages : 290 pages
Book Rating : 4.6/5 (422 download)

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Book Synopsis Polymers in Nanomedicine by : Shigeru Kunugi

Download or read book Polymers in Nanomedicine written by Shigeru Kunugi and published by Springer Science & Business Media. This book was released on 2012-02-02 with total page 290 pages. Available in PDF, EPUB and Kindle. Book excerpt: Functional Polymer Conjugates for Medicinal Nucleic Acid Delivery, by Ernst Wagner Biodegradable Nanoparticles as Vaccine Adjuvants and Delivery Systems: Regulation of Immune Responses by Nanoparticle-Based Vaccine, by Takami Akagi, Masanori Baba and Mitsuru Akashi Biodegradable Polymeric Assemblies for Biomedical Materials, by Yuichi Ohya, Akihiro Takahashi and Koji Nagahama PEGylation Technology in Nanomedicine, by Yutaka Ikeda and Yukio Nagasaki Cytocompatible Hydrogel Composed of Phospholipid Polymers for Regulation of Cell Functions, by Kazuhiko Ishihara, Yan Xu and Tomohiro Konno Design of Biointerfaces for Regenerative Medicine, by Yusuke Arima, Koichi Kato, Yuji Teramura and Hiroo Iwata Advances in Tissue Engineering Approaches to Treatment of Intervertebral Disc Degeneration: Cells and Polymeric Scaffolds for Nucleus Pulposus Regeneration, by Jeremy J. Mercuri and Dan T. Simionescu Functionalized Biocompatible Nanoparticles for Site-Specific Imaging and Therapeutics, by Ranu K. Dutta, Prashant K. Sharma, Hisatoshi Kobayashi and Avinash C. Pandey

Novel PH-responsive Hybrid Peptide Block Copolymers for Intracellular Delivery Applications

Author : Angela Mu Hsien Leung
Publisher :
ISBN 13 :
Total Pages : 95 pages
Book Rating : 4.:/5 (926 download)

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Book Synopsis Novel PH-responsive Hybrid Peptide Block Copolymers for Intracellular Delivery Applications by : Angela Mu Hsien Leung

Download or read book Novel PH-responsive Hybrid Peptide Block Copolymers for Intracellular Delivery Applications written by Angela Mu Hsien Leung and published by . This book was released on 2010 with total page 95 pages. Available in PDF, EPUB and Kindle. Book excerpt: The creation of novel polymeric materials remains a vital field, particularly for potential applications in drug and gene delivery. The synthesis of these materials is important, as well as a clear understanding of the physical properties. Lastly, tests for potential applications are vital in order to improve and optimize the polymeric system. The polyglutamate-b-poly(N,N-diethylaminoethyl methacrylate) (PLG-b-PDEAEMA) block copolymer was successfully synthesized. The resulting polymer had a defined molecular weight with approximately 18 L-glutamate and 38 DEAEMA units and a low polydispersity index. The physical properties of the PLG-b-PDEAEMA block copolymer were investigated. As a result of the pH-sensitive groups of the polymer, the solution characteristics changed depending on the charge density of the individual blocks. At low pH, the PDEAEMA block is soluble and positively charged while the PLG block is insoluble. At high pH, the PLG block is negatively charged and hydrophilic, while the PDEAEMA block is hydrophobic. At mid-range pH values, the polymer chain is partially charge with both positive and negative moieties. The critical micelle concentration, size of the self-assembled structures, surface charge and morphology were found to change with pH. In order to investigate the potential applications of the PLG-b-PDEAEMA polymer, the interactions between the polymer and plasmid DNA were investigated. The delivery of the polymer/DNA polyplexes to a cell culture was investigated, however, no cell transfection was observed. Another aspect of the project was to understand the physical properties of poly(L-glutamate) dendritic polymers. Well-defined poly(L-glutamate) arborescent polymers from linear to G3 were characterized for their acid-base characteristics and aggregation behaviour at high solution pH. The Gibbs free energy required to abstract a proton was studied using potentiometric titration and it was found that both the pKa and the free energy increased at higher generations due to greater electrostatic forces. As a result of the hydrophilic glutamate groups and the hydrophobic hexyl group, the dendritic polymers aggregated to form self-assembled structures. The structures possessed similar hydrodynamic radii, ranging from 90 to 110 nm. The radius of gyration, in comparison, deceased from 90 to 30 nm with increasing polymer generations, indicating more core-dense aggregates at higher generations.

Amphiphilic Polymer Co-networks

Author : Costas S Patrickios
Publisher : Royal Society of Chemistry
ISBN 13 : 1839161345
Total Pages : 347 pages
Book Rating : 4.8/5 (391 download)

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Book Synopsis Amphiphilic Polymer Co-networks by : Costas S Patrickios

Download or read book Amphiphilic Polymer Co-networks written by Costas S Patrickios and published by Royal Society of Chemistry. This book was released on 2020-04-23 with total page 347 pages. Available in PDF, EPUB and Kindle. Book excerpt: Amphiphilic polymer co-networks (APCNs) are a type of polymeric hydrogel, their hydrophobic polymer segments and hydrophilic components produce less aqueous swelling, giving better mechanical properties than conventional hydrogels. This new class of polymers is attracting increasing attention, resulting in further basic research on the system, as well as new applications. This book focuses on new developments in the field of APCNs, and is organised in four sections: synthesis, properties, applications and modelling. Co-network architectures included in the book chapters are mainly those deriving from hydrophobic macro-cross-linkers, representing the classical approach; however, more modern designs are also presented. Properties of interest discussed include aqueous swelling, thermophysical and mechanical properties, self-assembly, electrical actuation, and protein adsorption. Applications described in the book chapters include the use of co-networks as soft contact lenses, scaffolds for drug delivery and tissue engineering, matrices for heterogeneous biocatalysis, and membranes of controllable permeability. Finally, an important theory chapter on the modelling of the self-assembly of APCNs is also included. The book is suitable for graduate students and researchers interested in hydrogels, polymer networks, polymer chemistry, block copolymers, self-assembly and nanomaterials, as well as their applications in contact lenses, drug delivery, tissue engineering, membranes and biocatalysis.

Tuning Sol-gel Phase Diagrams of Doubly Thermosensitive Hydrophilic Diblock Copolymers in Water

Author : Naixiong Jin
Publisher :
ISBN 13 :
Total Pages : 244 pages
Book Rating : 4.:/5 (12 download)

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Book Synopsis Tuning Sol-gel Phase Diagrams of Doubly Thermosensitive Hydrophilic Diblock Copolymers in Water by : Naixiong Jin

Download or read book Tuning Sol-gel Phase Diagrams of Doubly Thermosensitive Hydrophilic Diblock Copolymers in Water written by Naixiong Jin and published by . This book was released on 2013 with total page 244 pages. Available in PDF, EPUB and Kindle. Book excerpt: This dissertation presents the synthesis of stimuli-responsive hydrophilic diblock copolymers and the study of their behavior in water under various conditions. The polymers were made by "living"/controlled radical polymerization. Chapter 1 presents a background of this dissertation. Chapters 2-4 describe a family of doubly thermosensitive diblock copolymers with a small amount of carboxylic acid groups incorporated into either one or both blocks. The lower critical solution temperature (LCST) of the weak acid-containing block increases with increasing pH due to the ionization of carboxylic acid. Chapter 5 presents the preparation of pH-sensitive diblock copolymer micelle-embedded agarose hydrogels. Chapter 2 describes the synthesis and solution behavior of poly(methoxytri(ethylene glycol) acrylate-co-acrylic acid)-b-poly(ethoxydi(ethylene glycol) acrylate) (P(TEGMA-co-AA)-b-PDEGEA)). PTEGMA and PDEGEA are thermosensitive polymers with LCSTs of 58 and 9 °C [degree Celsius], respectively, in water. A 20 wt% aqueous solution of P(TEGMA-co-AA)-b-PDEGEA with pH of 3.11 underwent transitions from a free-flowing liquid, to a free-standing gel, to a hot liquid, and to a cloudy mixture upon heating. The Ts̳o̳l̳-̳g̳̳̳̳e̳̳l̳̳̳̳ [sol-to-gel transition temperature] and Tg̳̳̳̳e̳̳l̳̳̳̳-̳so̳l̳ [gel-to-sol transition temperature] are closely related to the LCSTs of the two blocks. Upon raising pH, the Tg̳̳̳̳e̳̳l̳̳̳̳-̳so̳l̳ increased, while the Ts̳o̳l̳-g̳̳̳̳e̳̳l̳̳̳̳ remained the same. Accordingly, only the upper boundary of the ̳so̳l̳-g̳̳̳̳e̳̳l̳̳̳̳ phase diagram shifted upward. Chapter 3 presents the tuning of Ts̳o̳l̳-g̳̳̳̳e̳̳l̳̳̳̳ of moderately concentrated aqueous solutions of doubly thermosensitive diblock copolymers by incorporating a small amount of AA groups into the lower LCST block and changing the solution pH. The AA content had a significant effect on the pH dependence of Ts̳o̳l̳-g̳̳̳̳e̳̳l̳̳̳̳-. Chapter 4 shows that by incorporating a small amount of carboxylic acid groups into both blocks of a doubly thermosensitive diblock copolymer, the C-shaped sol-gel phase diagram can be readily and reversibly shifted by changing the solution pH. Chapter 5 presents the fabrication of pH-sensitive diblock copolymer micelle-embedded agarose hydrogels. The gel properties were not significantly affected by the incorporation of the micelles even when the polymer concentration reached 5 mg/g. The pH-induced release of the payload from the core of micelles in a hybrid gel was studied. Chapter 6 presents conclusions and future work.

Aqueous Micellar Gels of Multiresponsive Hydrophilic ABA Linear Triblock Copolymers

Author : Jeremiah Wallace Woodcock
Publisher :
ISBN 13 :
Total Pages : 233 pages
Book Rating : 4.:/5 (793 download)

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Book Synopsis Aqueous Micellar Gels of Multiresponsive Hydrophilic ABA Linear Triblock Copolymers by : Jeremiah Wallace Woodcock

Download or read book Aqueous Micellar Gels of Multiresponsive Hydrophilic ABA Linear Triblock Copolymers written by Jeremiah Wallace Woodcock and published by . This book was released on 2011 with total page 233 pages. Available in PDF, EPUB and Kindle. Book excerpt: This dissertation presents the synthesis of a series of well-defined multiresponsive hydrophilic ABA linear triblock copolymers and the study of their aqueous micellar gels. By incorporating a small amount of stimuli-responsive groups into thermosensitive outer blocks of ABA triblock copolymers, the lower critical solution temperatures (LCST) of thermosensitive blocks can be modified by external stimuli. Consequently, the sol-gel transition temperatures (Ts̳o̳l̳-g̳e̳l̳) of their aqueous solutions can be altered. Chapter 1 describes the synthesis and solution behavior of a series of thermo- and light-sensitive triblock copolymers, poly(ethoxytri(ethylene glycol) acrylate-co-o-nitrobenzyl acrylate)-b-poly(ethylene oxide)-b-poly(ethoxytri(ethylene glycol) acrylate-co-o-nitrobenzyl acrylate), with different contents of light-responsive o-nitrobenzyl groups. Aqueous solutions of these block copolymers with a 10.0 wt% concentration exhibited thermo-induced sol-gel transitions. Upon UV irradiation, the hydrophobic o-nitrobenzyl groups were cleaved, resulting in an increase in the LCST and consequently gel-to-sol transitions. The UV-irradiated solutions again underwent temperature-induced sol-gel transitions but at higher temperatures. The change of Ts̳o̳̳l̳-g̳e̳l̳ was, in general, larger for the copolymer with a higher o-nitrobenzyl content after UV irradiation. Chapter 2 presents the synthesis of thermo- and enzyme-responsive ABA triblock copolymers, poly(ethoxydi(ethylene glycol) acrylate-co-4-((dihydroxyphosphoryl)oxy)butyl acrylate)-b-poly(ethylene oxide)-b-poly(ethoxydi(ethylene glycol) acrylate-co-4-((dihydroxyphosphoryl)oxy)butyl acrylate), and the enzyme-induced formation of thermoreversible micellar gels from their moderately concentrated aqueous solutions at 37 °C. The dephosphorylation by acid phosphatase decreased the LCST of thermosensitive outer blocks from above to below 37 °C. The enzyme-induced gelation of 7.9 wt % aqueous polymer solutions at pH 4.4 was monitored by rheological measurements. The Ts̳o̳̳l̳-g̳e̳l̳ decreased and the gel strength increased with the increase of reaction time. The gels formed were thermoreversible. Chapter 3 presents the synthesis of two thermo- and pH-sensitive tertiary amine-containing ABA triblock copolymers and the sol-gel transitions of their aqueous solutions with a 10 wt% concentration at different pH values. Chapter 4 describes the use of reversible addition-fragmentation chain transfer (RAFT) polymerization for the synthesis of well-defined thermosensitive polymethacrylates and polyacrylates. Eight chain transfer agents were synthesized. The RAFT polymerizations of alkoxyoligo(ethylene glycol) (meth)acrylates using these chain transfer agents were well controlled, producing well-defined polymers. A summary of this dissertation research and future work are presented in Chapter 5.

Reversible Deactivation Radical Polymerization

Author : Nikhil K. Singha
Publisher : Walter de Gruyter GmbH & Co KG
ISBN 13 : 3110643693
Total Pages : 302 pages
Book Rating : 4.1/5 (16 download)

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Book Synopsis Reversible Deactivation Radical Polymerization by : Nikhil K. Singha

Download or read book Reversible Deactivation Radical Polymerization written by Nikhil K. Singha and published by Walter de Gruyter GmbH & Co KG. This book was released on 2020-01-20 with total page 302 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes strategies and mechanism of reversible deactivation radical polymerization (RDRP) to synthesize functional polymers. Several approaches such as atom transfer radical polymerization and the combination of click chemistry and RDRP are summarized. Contributors from interdisciplinary fields highlight applications in nanotechnology, self-healing materials, oil and water resistant coatings and controlled drug delivery systems.

Block Co-polymeric Nanocarriers: Design, Concept, and Therapeutic Applications

Author : Neeraj Mishra
Publisher : Springer Nature
ISBN 13 : 9819969174
Total Pages : 440 pages
Book Rating : 4.8/5 (199 download)

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Book Synopsis Block Co-polymeric Nanocarriers: Design, Concept, and Therapeutic Applications by : Neeraj Mishra

Download or read book Block Co-polymeric Nanocarriers: Design, Concept, and Therapeutic Applications written by Neeraj Mishra and published by Springer Nature. This book was released on 2023-11-29 with total page 440 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on current advancements in the field of block copolymers and covers design, concept, and various therapeutic applications in the drug delivery. It also reviews the use of block copolymers in drug delivery applications from the development of sustained release products to smart polymeric delivery systems such as stimuli-responsive polymeric systems, for example, thermosensitive, redox-sensitive, photo-sensitive, and enzyme-sensitive. The book further discusses the nano assemblies from amphiphilic block copolymers as nanomedicine platforms for diagnosis and therapy due to their relatively small size, high drug loading capacity, controlled drug release, in vivo stability, and prolonged blood circulation. The chapters also review the various patents and ongoing clinical trials on the applications, covering several important new concepts and findings in the field of block copolymers. The book is aimed at researchers, academicians, and industrial scientists involved in the development of drug-delivery systems based on polymers.

Functional Polymers

Author : Raja Shunmugam
Publisher : CRC Press
ISBN 13 : 1315342316
Total Pages : 327 pages
Book Rating : 4.3/5 (153 download)

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Book Synopsis Functional Polymers by : Raja Shunmugam

Download or read book Functional Polymers written by Raja Shunmugam and published by CRC Press. This book was released on 2017-05-08 with total page 327 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new book covers the synthetic as well application aspects of functional polymers. It highlights modern trends in the field and showcases the recent characterization techniques that are being employed in the field of polymer science. The chapters are written by top-notch scientists who are internationally recognized in the field. The chapters will highlight the modern trend in the field.

Design and Precise Synthesis of Thermoresponsive Polyacrylamides

Author : Keita Fuchise
Publisher : Springer
ISBN 13 : 4431550461
Total Pages : 94 pages
Book Rating : 4.4/5 (315 download)

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Book Synopsis Design and Precise Synthesis of Thermoresponsive Polyacrylamides by : Keita Fuchise

Download or read book Design and Precise Synthesis of Thermoresponsive Polyacrylamides written by Keita Fuchise and published by Springer. This book was released on 2014-05-22 with total page 94 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this thesis, the author describes versatile and easy-to-use methods to control the properties of thermoresponsive polyacrylamides by developing novel synthetic methods for end-functionalized poly(N-isopropylacrylamide) (PNIPAM) and block copolymers of poly(N,N-diethylacrylamide) (PDEAA). The synthesis of various urea end-functionalized PNIPAMs was achieved by the atom transfer radical polymerization (ATRP) and the click reaction. The phase transition temperature of PNIPAM in water was controlled depending on the strength of the hydrogen bonding of the urea groups introduced at the chain end of the polymer. Novel living polymerization methods for N,N-dimethylacrylamide and N,N-diethylacrylamide were developed by group transfer polymerization (GTP) using a strong Brønsted acid as a precatalyst and an amino silyl enolate as an initiator. This process enabled the precise synthesis of PDEAA and its block copolymers—namely, thermoresponsive amphiphilic block copolymers and double-hydrophilic block copolymers.

Smart Polymers and their Applications

Author : Maria Rosa Aguilar
Publisher : Elsevier
ISBN 13 : 0857097024
Total Pages : 587 pages
Book Rating : 4.8/5 (57 download)

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Book Synopsis Smart Polymers and their Applications by : Maria Rosa Aguilar

Download or read book Smart Polymers and their Applications written by Maria Rosa Aguilar and published by Elsevier. This book was released on 2014-02-19 with total page 587 pages. Available in PDF, EPUB and Kindle. Book excerpt: Smart polymers are polymers that respond to different stimuli or changes in the environment. Smart Polymers and their Applications reviews the types, synthesis, properties, and applications of smart polymers. Chapters in part one focus on types of polymers, including temperature-, pH-, photo-, and enzyme-responsive polymers. Shape memory polymers, smart polymer hydrogels, and self-healing polymer systems are also explored. Part two highlights applications of smart polymers, including smart instructive polymer substrates for tissue engineering; smart polymer nanocarriers for drug delivery; the use of smart polymers in medical devices for minimally invasive surgery, diagnosis, and other applications; and smart polymers for bioseparation and other biotechnology applications. Further chapters discuss the use of smart polymers for textile and packaging applications, and for optical data storage. Smart Polymers and their Applications is a technical resource for chemists, chemical engineers, mechanical engineers, and other professionals in the polymer industry; manufacturers in such sectors as medical, automotive, and aerospace engineering; and academic researchers in polymer science. Reviews the different types of smart polymer, discussing their properties, structure, design, and characterization Reviews applications of smart polymers in such areas as biomedical engineering, textiles, and food packaging

Temperature-Responsive Polymers

Author : Vitaliy V. Khutoryanskiy
Publisher : John Wiley & Sons
ISBN 13 : 111915779X
Total Pages : 410 pages
Book Rating : 4.1/5 (191 download)

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Book Synopsis Temperature-Responsive Polymers by : Vitaliy V. Khutoryanskiy

Download or read book Temperature-Responsive Polymers written by Vitaliy V. Khutoryanskiy and published by John Wiley & Sons. This book was released on 2018-05-31 with total page 410 pages. Available in PDF, EPUB and Kindle. Book excerpt: An authoritative resource that offers an understanding of the chemistry, properties and applications of temperature-responsive polymers With contributions from a distinguished panel of experts, Temperature-Responsive Polymers puts the focus on hydrophilic polymers capable of changing their physicochemical properties in response to changes in environmental temperature. The contributors review the chemistry of these systems, and discuss a variety of synthetic approaches for preparation of temperature-responsive polymers, physicochemical methods of their characterisation and potential applications in biomedical areas. The text reviews a wide-variety of topics including: The characterisation of temperature-responsive polymers; Infrared and Raman spectroscopy; Applications of temperature-responsive polymers grafted onto solid core nanoparticles; and much more. The contributors also explore how temperature-responsive polymers can be used in the biomedical field for applications such as tissue engineering. This important resource: Offers an important synthesis of the current research on temperature-responsive polymers Covers the chemistry, the synthetic approaches for presentation and the physiochemical method of temperature-responsive polymers Includes a review of the fundamental characteristics of temperature-responsive polymers Explores many of the potential applications in biomedical science, including drug delivery and gene therapy Written for polymer scientists in both academia and industry as well as postgraduate students working in the area of stimuli-responsive materials, this vital text offers an exploration of the chemistry, properties and current applications of temperature-responsive polymers.

Polymers for Biomedical Applications

Author : Anil Mahapatro
Publisher : American Chemical Society
ISBN 13 :
Total Pages : 442 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Polymers for Biomedical Applications by : Anil Mahapatro

Download or read book Polymers for Biomedical Applications written by Anil Mahapatro and published by American Chemical Society. This book was released on 2008-04-17 with total page 442 pages. Available in PDF, EPUB and Kindle. Book excerpt: Research on applications of polymers for biomedical applications has increased dramatically to find improved medical plastics for this rapidly evolving field. This book brings together various aspects of recent research and developments within academia and industry related to polymers for biomedical applications.

CRC Handbook of Phase Equilibria and Thermodynamic Data of Aqueous Polymer Solutions

Author : Christian Wohlfarth
Publisher : CRC Press
ISBN 13 : 146655438X
Total Pages : 777 pages
Book Rating : 4.4/5 (665 download)

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Book Synopsis CRC Handbook of Phase Equilibria and Thermodynamic Data of Aqueous Polymer Solutions by : Christian Wohlfarth

Download or read book CRC Handbook of Phase Equilibria and Thermodynamic Data of Aqueous Polymer Solutions written by Christian Wohlfarth and published by CRC Press. This book was released on 2012-08-10 with total page 777 pages. Available in PDF, EPUB and Kindle. Book excerpt: A large amount of experimental data has been published since the debut of the original CRC Handbook of Thermodynamic Data of Aqueous Polymer Solutions. Incorporating new and updated material, the CRC Handbook of Phase Equilibria and Thermodynamic Data of Aqueous Polymer Solutions provides a comprehensive collection of thermodynamic data of polymer solutions. It helps readers quickly retrieve necessary information from the literature, and assists researchers in planning new measurements where data are missing. A valuable resource for the modern chemistry field, the Handbook clearly details how measurements were conducted and methodically explains the nomenclature. It presents data essential for the production and use of polymers as well as for understanding the physical behavior and intermolecular interactions in polymer solutions.

Biodegradable Thermogels

Author : Xian Jun Loh
Publisher : Royal Society of Chemistry
ISBN 13 : 1782629408
Total Pages : 198 pages
Book Rating : 4.7/5 (826 download)

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Book Synopsis Biodegradable Thermogels by : Xian Jun Loh

Download or read book Biodegradable Thermogels written by Xian Jun Loh and published by Royal Society of Chemistry. This book was released on 2018-09-27 with total page 198 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biodegradable thermogels are a promising class of stimuli-responsive polymers. This book summarizes recent developments in thermogel research with a focus on synthesis and self-assembly mechanisms, gel biodegradability, and applications for drug delivery, cell encapsulation and tissue engineering. A closing chapter on commercialisation shows the challenges faced bringing this new material to market. Edited by leading authorities on the subject, this book offers a comprehensive overview for academics and professionals across polymer science, materials science and biomedical and chemical engineering.