Therapeutic Implications Of Circadian Rhythms

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Therapeutic Implications of Circadian Rhythms

Author : Guangrui Yang
Publisher : Frontiers Media SA
ISBN 13 : 2889196658
Total Pages : 98 pages
Book Rating : 4.8/5 (891 download)

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Book Synopsis Therapeutic Implications of Circadian Rhythms by : Guangrui Yang

Download or read book Therapeutic Implications of Circadian Rhythms written by Guangrui Yang and published by Frontiers Media SA. This book was released on 2015-10-12 with total page 98 pages. Available in PDF, EPUB and Kindle. Book excerpt: Circadian rhythms are biological processes displaying endogenous and entrainable oscillations of about 24 hours. They are driven by a group of genes called clock genes that have been widely observed in plants, animals and even in bacteria. In mammals, the core clock genes are rhythmically expressed in both the suprachiasmatic nucleus (SCN), the master clock residing in the hypothalamus, and almost all peripheral tissues where they control numerous target genes in a circadian manner, and thus affect many physiological and biochemical processes. Evidence suggests that disruption of the circadian rhythms (or desynchronization) is a significant risk factor for the development of metabolic diseases, cardiovascular diseases, cancer and sleep disorders. Evidence also suggests that the disruption suppresses immune function and increases vulnerability to infectious diseases. Restoring or strengthening the circadian rhythm may be therapeutic for these conditions. This becomes exceptionally important in modern societies because many people are suffering from frequent desynchronization due to shift working, exposure to artificial light, travel by transmeridian air flight, and involvement in social activities. Besides, the temporal variations in the incidence and severity of many diseases, such as the onset of cardiovascular events, chronic obstructive pulmonary disease (COPD), inflammatory diseases and mental disorders have also drawn increasing attention to the circadian clock. The circadian rhythms affect not only the health status, but also the drug efficiency. The effects (and side effects) of many drugs vary with biological timing. The tolerance of many medications displays circadian variation as well. The timing of medical treatment in coordination with the body clock may significantly increase the desired effects of drugs, and lower the dose and toxicity. In addition, circadian rhythms can also be modulated by some therapeutic drugs, for example, melatonin and modafinil, which are used to treat circadian rhythm sleep disorders. In this Research Topic, we assemble a series of critical review and research articles that focus on the therapeutic implications of circadian rhythms. Topics include, but are not limited to: • Circadian disruption caused diseases or disorders and related intervention • Temporal manifestation of diseases or disorders and therapeutic implications • The effects of circadian rhythms on drugs • The effects of drugs on circadian rhythms

The Circadian Code

Author : Satchin Panda, PhD
Publisher : Rodale Books
ISBN 13 : 0593135903
Total Pages : 290 pages
Book Rating : 4.5/5 (931 download)

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Book Synopsis The Circadian Code by : Satchin Panda, PhD

Download or read book The Circadian Code written by Satchin Panda, PhD and published by Rodale Books. This book was released on 2020-02-11 with total page 290 pages. Available in PDF, EPUB and Kindle. Book excerpt: When we eat may be as important as what we eat. Like most people, you probably wake up, get hungry for meals and doze off in bed around the same time every day. If you’ve ever experienced jet lag or pulled an all-nighter, you know that this schedule can easily be thrown off kilter. But for some people, that imbalance—difficulty sleeping at night, hunger at odd times, or sudden fatigue at noon—is a constant. If you're one of those people, Dr. Satchin Panda, one of the leading researchers on circadian rhythms, has a plan to reset your body clock. Beginning with an in-depth explanation of the circadian clock—why it’s important, how it works, and how to know it isn’t working—The Circadian Code outlines lifestyle changes to make to get back on track. It's a concrete plan to enhance weight loss, improve sleep, optimize exercise, and manage technology so that it doesn’t interfere with your body’s natural rhythm. Dr. Panda’s life changing methods show you how to prevent and reverse ailments like diabetes, cancer, and dementia, as well as microbiome conditions like acid reflux, heartburn, and irritable bowel disease.

Science of Circadian Rhythms, An Issue of Sleep Medicine Clinics, E-Book

Author : Phyllis C. Zee
Publisher : Elsevier Health Sciences
ISBN 13 : 0323402712
Total Pages : pages
Book Rating : 4.3/5 (234 download)

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Book Synopsis Science of Circadian Rhythms, An Issue of Sleep Medicine Clinics, E-Book by : Phyllis C. Zee

Download or read book Science of Circadian Rhythms, An Issue of Sleep Medicine Clinics, E-Book written by Phyllis C. Zee and published by Elsevier Health Sciences. This book was released on 2016-01-07 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Dr. Phyllis Zee has put together an expert panel of authors on the topic of the Science of Circadian Rhythms. Articles include: Neurobiology of Circadian Rhythm Regulation, Effect of Light and Melatonin and other Melatonin Receptor Agonists on Human Circadian Physiology, Consequences of Circadian Disruption on Cardiometabolic Health, Consequences Circadian Disruption on Neurologic and Psychiatric Health, Aging and Circadian Rhythms, Circadian and Homeostatic Regulation of Sleep and Performance, Circadian disruption in Psychiatric Disorders, and more!

Circadian Rhythms and Their Impact on Aging

Author : S. Michal Jazwinski
Publisher : Springer
ISBN 13 : 3319645439
Total Pages : 361 pages
Book Rating : 4.3/5 (196 download)

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Book Synopsis Circadian Rhythms and Their Impact on Aging by : S. Michal Jazwinski

Download or read book Circadian Rhythms and Their Impact on Aging written by S. Michal Jazwinski and published by Springer. This book was released on 2017-10-24 with total page 361 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biological rhythms time the ebb and flow of virtually every physiological process, and their mutual coordination guarantees the integrity of the organism over space and time. Aging leads to the disintegration of this coordination, as well as to changes in the amplitude and/or frequency of the underlying rhythms. The results of this are accelerated loss of health during aging, and in experimental model systems curtailed lifespan occurs. This book will examine the machinery that constitutes circadian systems and how they impact physiologic processes. It will also discuss how disturbances of circadian rhythms can lead to complex diseases associated with aging. Much of this treatment will focus on metabolism and genome stability. Importantly, the chapters in this book will encompass work in several different models, in addition to human. The book will conclude with a discussion of modeling approaches to biologic cycles and chronotherapy, for future research and translation.

Chronotherapeutics

Author : P. H. Redfern
Publisher : Pharmaceutical Press
ISBN 13 : 9780853694885
Total Pages : 456 pages
Book Rating : 4.6/5 (948 download)

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Book Synopsis Chronotherapeutics by : P. H. Redfern

Download or read book Chronotherapeutics written by P. H. Redfern and published by Pharmaceutical Press. This book was released on 2003 with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt: In nature, many physical processes are governed by the passage of time. The study of these processes - chronobiology - reveals rhythmic patterns which may be yearly, monthly, daily or more frequent. Novel drug delivery systems are currently being delivered that will release varying quantities of a drug at optimum times to coincide with these rhythmic patterns.Chronotherapeutics considers the pharmaceutical and therapeutic implications associated with biological clocks. The book presents a comprehensive discussion of specific diseases that are time dependent, and the drugs and new drug formulations that can be used as treatments.Written by leading international experts in the field, Chronotherapeutics provides up-to-date information on chronobiology for non-chronobiologists in pharmaceutical and medical sciences. Peter Redfern is Professor of Pharmacology at the University of Bath, UK.

Advances in the Psychobiology of Sleep and Circadian Rhythms

Author : Melinda L. Jackson
Publisher : Taylor & Francis
ISBN 13 : 1003830927
Total Pages : 236 pages
Book Rating : 4.0/5 (38 download)

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Book Synopsis Advances in the Psychobiology of Sleep and Circadian Rhythms by : Melinda L. Jackson

Download or read book Advances in the Psychobiology of Sleep and Circadian Rhythms written by Melinda L. Jackson and published by Taylor & Francis. This book was released on 2023-12-19 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in the Psychobiology of Sleep and Circadian Rhythms features international experts from the fields of psychobiology, sleep research and chronobiology to address and review cutting-edge scientific literature concerning recent advances in the psychobiology of sleep, sleep disorders, such as sleep apnoea and insomnia, and circadian rhythms, across the lifespan. In this illuminating volume, Melinda L. Jackson and Sean P.A. Drummond bring together leading international researchers to review cross-cutting issues in the field, including sleep and pain, sleep and dementia risk, and sleep issues in paediatric populations as well as the interaction between sleep and health conditions in different populations. The chapters offer coverage of the major explanatory models which underpin the empirical work as well as a discussion of the relevant theoretical and conceptual models on issues arising with specific psychiatric and medical disorders, including depression, dementia, posttraumatic stress disorder and pain. They also address new research in the area of chronobiology, and circadian impacts on health and diseases. The chapters also discuss important methodological and ethical issues arising in research and include sections addressing implications for public policy and practitioner interventions in the context of different social and cultural environments. This volume will be a crucial resource for professionals, practitioners and researchers engaged in the field as well as for postgraduate and upper-level undergraduate students undertaking research in areas related to psychobiology, neuropsychology, health psychology and other disciplines such as biology, physiology and psychopharmacology.

Human Circadian Physiology

Author : Charles A. Czeisler
Publisher :
ISBN 13 :
Total Pages : 692 pages
Book Rating : 4.:/5 (84 download)

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Book Synopsis Human Circadian Physiology by : Charles A. Czeisler

Download or read book Human Circadian Physiology written by Charles A. Czeisler and published by . This book was released on 1978 with total page 692 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Circadian Medicine

Author : Christopher S. Colwell
Publisher : John Wiley & Sons
ISBN 13 : 1118467787
Total Pages : 405 pages
Book Rating : 4.1/5 (184 download)

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Book Synopsis Circadian Medicine by : Christopher S. Colwell

Download or read book Circadian Medicine written by Christopher S. Colwell and published by John Wiley & Sons. This book was released on 2015-07-07 with total page 405 pages. Available in PDF, EPUB and Kindle. Book excerpt: Circadian rhythms, the biological oscillations based around our 24-hour clock, have a profound effect on human physiology and healthy cellular function. Circadian Rhythms: Health and Disease is a wide-ranging foundational text that provides students and researchers with valuable information on the molecular and genetic underpinnings of circadian rhythms and looks at the impacts of disruption in our biological clocks in health and disease. Circadian Rhythms opens with chapters that lay the fundamental groundwork on circadian rhythm biology. Section II looks at the impact of circadian rhythms on major organ systems. Section III then turns its focus to the central nervous system. The book then closes with a look at the role of biological rhythms in aging and neurodegeneration. Written in an accessible and informative style, Circadian Rhythms: Health and Disease,will be an invaluable resource and entry point into this fascinating interdisciplinary field that brings together aspects of neuroscience, cell and molecular biology, and physiology.

Circadian Rhythm Sleep-Wake Disorders

Author : R. Robert Auger
Publisher : Springer Nature
ISBN 13 : 3030438031
Total Pages : 251 pages
Book Rating : 4.0/5 (34 download)

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Book Synopsis Circadian Rhythm Sleep-Wake Disorders by : R. Robert Auger

Download or read book Circadian Rhythm Sleep-Wake Disorders written by R. Robert Auger and published by Springer Nature. This book was released on 2020-05-26 with total page 251 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book resolves to bridge the communication gap between research and clinical practice for circadian rhythm sleep-wake disorders. Beginning with a scientific background on biological timekeeping, opening chapters describe the crucial nature of maintaining delicate temporal organization of physiological and molecular events within the body. Following this are discussions on circadian physiology and methods of circadian assessments. Subsequent chapters then relay comprehensive information regarding the International Classification of Sleep Disorders-defined circadian rhythm sleep-wake disorders (CRSWDs), specifically discussing etiology and epidemiology, but focusing on evidence-based treatment data. Concluding discussions provide guidance for the application of light therapy and discuss future roles for optimized lighting environments. Nuanced and market-demanded, Circadian Rhythm Sleep-Wake Disorders: An Evidence-Based Guide for Clinicians and Investigators is an invaluable resource for Sleep Medicine clinicians, circadian researchers, and other interested parties.

Disorders of Circadian Rhythms

Author : Arturo Ortega
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (136 download)

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Book Synopsis Disorders of Circadian Rhythms by : Arturo Ortega

Download or read book Disorders of Circadian Rhythms written by Arturo Ortega and published by . This book was released on 2020 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.

Functional Somatic Symptoms in Children and Adolescents

Author : Kasia Kozlowska
Publisher : Springer Nature
ISBN 13 : 303046184X
Total Pages : 397 pages
Book Rating : 4.0/5 (34 download)

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Book Synopsis Functional Somatic Symptoms in Children and Adolescents by : Kasia Kozlowska

Download or read book Functional Somatic Symptoms in Children and Adolescents written by Kasia Kozlowska and published by Springer Nature. This book was released on 2020-09-30 with total page 397 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access book sets out the stress-system model for functional somatic symptoms in children and adolescents. The book begins by exploring the initial encounter between the paediatrician, child, and family, moves through the assessment process, including the formulation and the treatment contract, and then describes the various forms of treatment that are designed to settle the child’s dysregulated stress system. This approach both provides a new understanding of how such symptoms emerge – typically, through a history of recurrent or chronic stress, either physical or psychological – and points the way to effective assessment, management, and treatment that put the child (and family) back on the road to health and well-being.

Internal Time

Author : Till Roenneberg
Publisher : Harvard University Press
ISBN 13 : 0674069692
Total Pages : 313 pages
Book Rating : 4.6/5 (74 download)

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Book Synopsis Internal Time by : Till Roenneberg

Download or read book Internal Time written by Till Roenneberg and published by Harvard University Press. This book was released on 2012-04-30 with total page 313 pages. Available in PDF, EPUB and Kindle. Book excerpt: Winner of a British Medical Association Book Award A Brain Pickings Best Science Book of the Year Early birds and night owls are born, not made. Sleep patterns may be the most obvious manifestation of the highly individualized biological clocks we inherit, but these clocks also regulate bodily functions from digestion to hormone levels to cognition. Living at odds with our internal timepieces, Till Roenneberg shows, can make us chronically sleep deprived and more likely to smoke, gain weight, feel depressed, fall ill, and fail geometry. By understanding and respecting our internal time, we can live better. “Internal Time is a cautionary tale—actually a series of 24 tales, not coincidentally. Roenneberg ranges widely from the inner workings of biological rhythms to their social implications, illuminating each scientific tutorial with an anecdote inspired by clinical research...Written with grace and good humor, Internal Time is a serious work of science incorporating the latest research in chronobiology...[A] compelling volume.” —A. Roger Ekirch, Wall Street Journal “This is a fascinating introduction to an important topic, which will appeal to anyone who wishes to delve deep into the world of chronobiology, or simply wonders why they struggle to get a good night’s sleep.” —Richard Wiseman, New Scientist

The Rhythms Of Life

Author : Leon Kreitzman
Publisher : Profile Books
ISBN 13 : 1847653723
Total Pages : 469 pages
Book Rating : 4.8/5 (476 download)

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Book Synopsis The Rhythms Of Life by : Leon Kreitzman

Download or read book The Rhythms Of Life written by Leon Kreitzman and published by Profile Books. This book was released on 2011-09-30 with total page 469 pages. Available in PDF, EPUB and Kindle. Book excerpt: Popular science at its most exciting: the breaking new world of chronobiology - understanding the rhythm of life in humans and all plants and animals. The entire natural world is full of rhythms. The early bird catches the worm -and migrates to an internal calendar. Dormice hibernate away the winter. Plants open and close their flowers at the same hour each day. Bees search out nectar-rich flowers day after day. There are cicadas that can breed for only two weeks every 17 years. And in humans: why are people who work anti-social shifts more illness prone and die younger? What is jet-lag and can anything help? Why do teenagers refuse to get up in the morning, and are the rest of us really 'larks' or 'owls'? Why are most people born (and die) between 3am-5am? And should patients be given medicines (and operations) at set times of day, because the body reacts so differently in the morning, evening and at night? The answers lie in our biological clocks the mechanisms which give order to all living things. They impose a structure that enables us to change our behaviour in relation to the time of day, month or year. They are reset at sunrise and sunset each day to link astronomical time with an organism's internal time.

The Circadian Clock

Author : Urs Albrecht
Publisher : Springer Science & Business Media
ISBN 13 : 1441912622
Total Pages : 300 pages
Book Rating : 4.4/5 (419 download)

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Book Synopsis The Circadian Clock by : Urs Albrecht

Download or read book The Circadian Clock written by Urs Albrecht and published by Springer Science & Business Media. This book was released on 2010-01-23 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt: With the invitation to edit this volume, I wanted to take the opportunity to assemble reviews on different aspects of circadian clocks and rhythms. Although most c- tributions in this volume focus on mammalian circadian clocks, the historical int- duction and comparative clocks section illustrate the importance of various other organisms in deciphering the mechanisms and principles of circadian biology. Circadian rhythms have been studied for centuries, but only recently, a mole- lar understanding of this process has emerged. This has taken research on circadian clocks from mystic phenomenology to a mechanistic level; chains of molecular events can describe phenomena with remarkable accuracy. Nevertheless, current models of the functioning of circadian clocks are still rudimentary. This is not due to the faultiness of discovered mechanisms, but due to the lack of undiscovered processes involved in contributing to circadian rhythmicity. We know for example, that the general circadian mechanism is not regulated equally in all tissues of m- mals. Hence, a lot still needs to be discovered to get a full understanding of cir- dian rhythms at the systems level. In this respect, technology has advanced at high speed in the last years and provided us with data illustrating the sheer complexity of regulation of physiological processes in organisms. To handle this information, computer aided integration of the results is of utmost importance in order to d- cover novel concepts that ultimately need to be tested experimentally.

Seasonal Affective Disorder

Author : Timo Partonen
Publisher : Oxford University Press
ISBN 13 : 019954428X
Total Pages : 370 pages
Book Rating : 4.1/5 (995 download)

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Book Synopsis Seasonal Affective Disorder by : Timo Partonen

Download or read book Seasonal Affective Disorder written by Timo Partonen and published by Oxford University Press. This book was released on 2010 with total page 370 pages. Available in PDF, EPUB and Kindle. Book excerpt: Seasonal affective disorder (SAD), or winter depression, is a mood disorder related to the change in the seasons and lack of exposure to daylight. It affects 1 in 100 adults in western countries. SAD is a rare example of a psychiatric disorder with a clear, identifiable biological cause. The new edition of this award winning book brings together distinguished scientists and opinion leaders to discuss the current and anticipated developments in the study and care of Seasonal Affective Disorder. Highlighting the clinical diagnosis and management of Seasonal Affective Disorder (SAD), this book provides a valuable resource for all whom are involved in the health care for patients with SAD. This book deals with the range of therapeutic measures that are available for the treatment of SAD. In addition, this book elucidates potential areas of research that have emerged such as the study of the circadian pacemaker and the night-time sleep structure and their interaction that influences mood.

Circadian Rhythms and Metabolism

Author : Etienne Challet
Publisher : Frontiers Media SA
ISBN 13 : 2889452824
Total Pages : 190 pages
Book Rating : 4.8/5 (894 download)

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Book Synopsis Circadian Rhythms and Metabolism by : Etienne Challet

Download or read book Circadian Rhythms and Metabolism written by Etienne Challet and published by Frontiers Media SA. This book was released on 2017-09-18 with total page 190 pages. Available in PDF, EPUB and Kindle. Book excerpt: One of the major breakthroughs of the last decade in the understanding of energy homeostasis is the identification of a reciprocal control between circadian rhythmicity and cellular metabolism. Circadian rhythmicity is a fundamental endogenous process of almost every organism living on Earth. For instance, the alternation of hunger and satiety is not continuous over 24 h, but is instead structured in time along the light/dark cycle. In mammals, the temporal organization of metabolism, physiology and behavior around 24 h is controlled by a network of multiple cellular clocks, synchronized via neuronal and hormonal signals by a master clock located in the suprachiasmatic nuclei of the hypothalamus. This central circadian conductor in the brain is mainly reset by ambient light perceived by the retina, while secondary circadian clocks in other brain areas and peripheral organs can be reset by meal timing. Chronic disruption of circadian rhythms, as seen in human shift-workers (up to 20% of the active population), has been associated with the development of a number of adverse mental and metabolic conditions. Understanding of the functional links between circadian desynchronization and overall health in animal models and humans, however, is still scarce. Interactions between circadian clocks and metabolism can occur at different levels: the molecular clockwork, internal synchronization via neuro-hormonal signals, or external synchronization via photic or feeding cues. This Research Topic comprises a number of reviews as well as research and methods articles that feature recent advancements in the mechanisms linking circadian clocks with energy metabolism, and the pathophysiological implications of these interactions for metabolic health.

The Cancer Clock

Author : Sotiris Missailidis
Publisher : John Wiley & Sons
ISBN 13 : 0470061510
Total Pages : 321 pages
Book Rating : 4.4/5 (7 download)

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Book Synopsis The Cancer Clock by : Sotiris Missailidis

Download or read book The Cancer Clock written by Sotiris Missailidis and published by John Wiley & Sons. This book was released on 2007-10-15 with total page 321 pages. Available in PDF, EPUB and Kindle. Book excerpt: Edited by the winner of the 2008 Mike Price Fellowship The Cancer Clock is a comprehensive overview of cancer as a single topic and provides an all-encompassing account of the key aspects related to the disease from its causes and initial diagnosis through to treatment and care and the different support mechanisms available. Carefully divided into three key parts, the first part of the book focuses on the genesis of the disease through environmental, lifestyle and socioeconomic factors. The second part moves on to consider early disease, disease development, diagnosis, monitoring and imaging of the disease. The book then discusses standard treatments such as surgery, chemotherapy, radiotherapy and immunotherapy along with current developments in the field such as targeted therapeutics, antibody therapies and novel chemotherapy agents. The book closes with a discussion of patient care, pain control, nursing in cancer patients and rehabilitation processes and a final chapter that looks at the psychological and psychosocial aspects of the disease, from coping with the knowledge of having cancer to coping with the side effects of the treatments, family support and dedicated support groups. Written in a clear, accessible manner this book is an ideal starting point for students of pharmacy, pharmacology, the biomedical sciences and other related disciplines where an understanding of cancer as a whole is required. takes an interdisciplinary approach covering the chemistry, epidemiology, basic biology and genetics, radiology, medical physics, medicine, nursing, health and social welfare all associated with cancer diagnosis, treatment and care explains the various causes of cancer and suggests actions for the prevention of the disease includes chapters on current diagnostic tests, drug development and the techniques used in drug design both chemical and biological considers current experimental therapeutic and diagnostic approaches and their potential for future therapeutic development examines aspects of cancer care, physiotherapy, rehabilitation and the psychological aspects of the disease includes self assessment questions/answers, summary sections and review questions and information boxes to enhance student understanding