Therapeutic Applications Of Interleukin 2

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Therapeutic Applications of Interleukin-2

Author : Michael Atkins
Publisher : CRC Press
ISBN 13 : 9780824788094
Total Pages : 520 pages
Book Rating : 4.7/5 (88 download)

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Book Synopsis Therapeutic Applications of Interleukin-2 by : Michael Atkins

Download or read book Therapeutic Applications of Interleukin-2 written by Michael Atkins and published by CRC Press. This book was released on 1993-03-08 with total page 520 pages. Available in PDF, EPUB and Kindle. Book excerpt: Covering everything from basic science to disease-specific clinical trials, current applications and future directions, this book discusses the novel biological response modifier interleukin-2. This immunoactive therapy is designed for use in the treatment of metastatic renal cancer and, possibly, melanoma and other malignancies. Examining the value and toxic manifestations of different treatment regimens, this text: describes the biochemistry of the IL-2 receptor, the activation of natural killer cells and the lymphokine-activated killer (LAK) cell phenomenon; explicates tumour-infiltrating lymphocytes and the effect of IL-2 on in vitro assays of immune function; emphasizes high-dose IL-2 therapy in renal cell carcinoma and malignant melanoma; reviews in detail IL-2 treatment of other solid tumours and haematologic malignancies; illustrates the use of lower dose regimens, regional administration and combinations of IL-2 with other therapies; elucidates toxicities associated with IL-2, their pathogenesis and clinical management; and highlights future developments, including gene therapy and the co-administration of cytokine antagonists to reduce toxicity.

The role of interleukin-2 in the treatment of cancer patients

Author : J. Wagstaff
Publisher : Springer Science & Business Media
ISBN 13 : 9401117535
Total Pages : 195 pages
Book Rating : 4.4/5 (11 download)

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Book Synopsis The role of interleukin-2 in the treatment of cancer patients by : J. Wagstaff

Download or read book The role of interleukin-2 in the treatment of cancer patients written by J. Wagstaff and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 195 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recombinant human interleukin-2 became available for clinical use in the mid 1980s. Recent years have seen an enormous amount of clinical research with this cytokine and interleukin-2 has now been registered for use in a number of European countries for the treatment of metastatic renal cell carcinoma. This book is designed to provide the clinical oncologist wishing to use interleukin-2 with a basic background concerning the biology of the agent, a discussion concerning practical aspects, of its clinical use including management of toxicity and an overview of the clinical results together with a description of how this internesting cytokine might be developed in the future.

The Biology and Clinical Applications of Interleukin-2

Author : Robert C. Rees
Publisher : IRL Press
ISBN 13 :
Total Pages : 208 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis The Biology and Clinical Applications of Interleukin-2 by : Robert C. Rees

Download or read book The Biology and Clinical Applications of Interleukin-2 written by Robert C. Rees and published by IRL Press. This book was released on 1990 with total page 208 pages. Available in PDF, EPUB and Kindle. Book excerpt: The molecular structure of interleukin-2 (IL-2) and that of its receptor subunits provide a basis for understanding lymphocyte activation by IL-2 and the generation of effector cells capable of mediating cytotoxicity towards tumors. This book provides an up-to-date account of IL-2, its effect on lymphocyte function, and clinical applications. Internationally know experts review the molecular aspects of cell signalling, giving insight on the in vivo pathways of activation likely to be important in determining clinical responses. They also examine the use of cytokines, particularly IL-2, in the treatment of cancer, and describe the results of recent clinical trials using IL-2, as well as of adoptive cell therapy. Providing a clear account of recent progress, the book also reviews the problems involved in attempting to improve the therapeutic benefit of IL-2, along with the importance of mechanisms which subverse IL-2 responses. This is the most up-to-date account of molecular research and clinical trials in this area, and will be of great benefit to students and researchers in immunology, pharmacology, biochemistry, and oncology who are interested in this vitally important topic.

Cytokine Knockouts

Author : Scott K. Durum
Publisher : Springer Science & Business Media
ISBN 13 : 1475727534
Total Pages : 498 pages
Book Rating : 4.4/5 (757 download)

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Book Synopsis Cytokine Knockouts by : Scott K. Durum

Download or read book Cytokine Knockouts written by Scott K. Durum and published by Springer Science & Business Media. This book was released on 2013-04-17 with total page 498 pages. Available in PDF, EPUB and Kindle. Book excerpt: My personal history in the field of cytokines had an initial period of several years during which my student and then colleague, Werner Muller, tried in vain to attract me to them. My interest always vanished when I was confronted with complex data pointing to func tional redundancy of cytokines in cell culture systems. When gene targeting in the mouse germline became possible, this frustration came to an end. We and others immediately embarked on analyzing the in vivo function of cytokines and the problem of functional redundancy with this powerful new approach. The early cytokine gene knockouts performed by colleagues in Wiirzburg (IL-2) and by ourselves (IL-4 and IL-l 0) seemed to give clear answers and at the same time led to surprises: Each of these cytokines apparently had its own special and irreplaceable function, and this function could be quite distinct from what had been anticipated from functional experiments in vitro. Al though the latter finding is of course a wonderful incentive for fur ther research, the former is pleasing in a general sense since it highlights the value of each of those one hundred thousand genes or so in our genome, cherished by evolution to become respectable mem bers of the community. Even in the present era of "genomics" there will be no way around the careful functional analysis of each gene by itself.

Immunotherapy

Author : Aung Naing
Publisher : Springer Nature
ISBN 13 : 3030793087
Total Pages : 445 pages
Book Rating : 4.0/5 (37 download)

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Book Synopsis Immunotherapy by : Aung Naing

Download or read book Immunotherapy written by Aung Naing and published by Springer Nature. This book was released on 2022-01-01 with total page 445 pages. Available in PDF, EPUB and Kindle. Book excerpt: The field of immuno-oncology continues to rapidly evolve as new insights to fight and treat cancer emerge. The fourth edition of Immunotherapy provides the most current overview of immuno-oncology in different cancer types and toxicities associated with immunotherapy. While immunotherapy has revolutionized the treatment landscape of several solid malignancies, several challenges still exist. Only a subset of patients derive clinical benefits; some do not respond at all, and others respond initially, only for their disease to progress later. Because these drugs can activate a broad range of immune cells, patients suffer from a unique set of side effects known as immune-related adverse events. As more immunotherapeutic agents are used in the clinic, it is important to provide updates about current and ongoing developments in the field to further research efforts and inform treatment decisions. The fourth edition will have a new focus on strategies to overcome the challenges associated with immunotherapy. Chapters will discuss topics such as biomarkers of response, resistance mechanisms, role of imaging in predicting immune-related adverse events, and management of immune-related adverse events. Written by leading experts conducting cutting-edge research, readers will gain up-to-date knowledge on the current state and future of immunotherapy.

Clinical Applications of Cytokines

Author : Joost J. Oppenheim
Publisher : Oxford University Press, USA
ISBN 13 : 9780195071290
Total Pages : 406 pages
Book Rating : 4.0/5 (712 download)

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Book Synopsis Clinical Applications of Cytokines by : Joost J. Oppenheim

Download or read book Clinical Applications of Cytokines written by Joost J. Oppenheim and published by Oxford University Press, USA. This book was released on 1993 with total page 406 pages. Available in PDF, EPUB and Kindle. Book excerpt: The driving force for research on cytokines has always been their clinical promise. Their biological properties suggested a key role in hematopoiesis, immunity, tumor genesis, hemostasis, vascularization, repair of connective tissues and integration of the immune system with the neuroendocrine system. Animal studies have shown that cytokines could be used as effective biotherapeutics with easily manageable and reversible toxicities. Clinical trials have confirmed these findings, culminating in the licensing of a number of the cytokines such as interferon alpha, interferon gamma, interleukin 2, erythropoietin, granulocyte colony stimulating factor, and granulocyte-macrophage colony stimulating factor. Many other cytokines are in clinical trials. This is the first comprehensive volume on the cytokines written primarily from a medical perspective. After presenting background information about the structure, production, assays and systemic effects of cytokines and their receptors, it is organized around diseases and organ systems. Infectious diseases, autoimmunity, immunodeficiency states, defective hematopoiesis, allergies, injury repair, cancer, vascular and skin diseases, and neurological disorders are all covered. This work reviews the role that cytokines play in the pathogenesis, diagnosis and therapy of each disease. The authors assess both the current state of the art and the potential for future applications.

Interleukin-2 and Killer Cells in Cancer

Author : Eva Lotzova
Publisher : CRC Press
ISBN 13 : 1351090690
Total Pages : 556 pages
Book Rating : 4.3/5 (51 download)

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Book Synopsis Interleukin-2 and Killer Cells in Cancer by : Eva Lotzova

Download or read book Interleukin-2 and Killer Cells in Cancer written by Eva Lotzova and published by CRC Press. This book was released on 2018-02-01 with total page 556 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the first-and only-publication available which provides the most recent information in this particular field of biomedicine. Interleukin-2 (IL-2) and IL-2 activated killer cells have been shown to have a potential in the treatment of a variety of human malignant diseases. This work comprehensively summarizes basic aspects of IL-2 as well as its clinical application, therefore making all these aspects easily accessible to the readers. Because of the clinical significance of this molecule in the treatment of cancer, the basic and clinical investigations in the IL-2 field are rapidly expanding, together with the interest of the scientific and medical community. This book is an excellent educational and teaching tool for scientists, clinicians, and students. Those who already have expertise in research in the IL-2 area will find this reference indispensible.

Therapeutic Use of Interleukin-2

Author : Paul M. Sondel
Publisher :
ISBN 13 :
Total Pages : 137 pages
Book Rating : 4.:/5 (269 download)

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Book Synopsis Therapeutic Use of Interleukin-2 by : Paul M. Sondel

Download or read book Therapeutic Use of Interleukin-2 written by Paul M. Sondel and published by . This book was released on 1991 with total page 137 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Innovative Medicine

Author : Kazuwa Nakao
Publisher : Springer
ISBN 13 : 4431556516
Total Pages : 330 pages
Book Rating : 4.4/5 (315 download)

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Book Synopsis Innovative Medicine by : Kazuwa Nakao

Download or read book Innovative Medicine written by Kazuwa Nakao and published by Springer. This book was released on 2015-10-13 with total page 330 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is devoted to innovative medicine, comprising the proceedings of the Uehara Memorial Foundation Symposium 2014. It remains extremely rare for the findings of basic research to be developed into clinical applications, and it takes a long time for the process to be achieved. The task of advancing the development of basic research into clinical reality lies with translational science, yet the field seems to struggle to find a way to move forward. To create innovative medical technology, many steps need to be taken: development and analysis of optimal animal models of human diseases, elucidation of genomic and epidemiological data, and establishment of “proof of concept”. There is also considerable demand for progress in drug research, new surgical procedures, and new clinical devices and equipment. While the original research target may be rare diseases, it is also important to apply those findings more broadly to common diseases. The book covers a wide range of topics and is organized into three complementary parts. The first part is basic research for innovative medicine, the second is translational research for innovative medicine, and the third is new technology for innovative medicine. This book helps to understand innovative medicine and to make progress in its realization.

Managing Interleukin-2 Therapy

Author : National Institutes of Health (U.S.). Clinical Center. Cancer Nursing Service. 2 East Nursing Staff
Publisher :
ISBN 13 :
Total Pages : 20 pages
Book Rating : 4.3/5 (121 download)

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Book Synopsis Managing Interleukin-2 Therapy by : National Institutes of Health (U.S.). Clinical Center. Cancer Nursing Service. 2 East Nursing Staff

Download or read book Managing Interleukin-2 Therapy written by National Institutes of Health (U.S.). Clinical Center. Cancer Nursing Service. 2 East Nursing Staff and published by . This book was released on 1989 with total page 20 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Cooperation of Liver Cells in Health and Disease

Author : Z. Kmiec
Publisher : Springer Science & Business Media
ISBN 13 : 3642565530
Total Pages : 154 pages
Book Rating : 4.6/5 (425 download)

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Book Synopsis Cooperation of Liver Cells in Health and Disease by : Z. Kmiec

Download or read book Cooperation of Liver Cells in Health and Disease written by Z. Kmiec and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 154 pages. Available in PDF, EPUB and Kindle. Book excerpt: It is only during the last decade that the functions of sinusoidal endothelial cells, Kupffer cells, hepatic stellate cells, pit cells and other intrahepatic lymphocytes have been better understood. The development of methods for isolation and co-culturing various types of liver cells has established that they communicate and cooperate via secretion of various intercellular mediators. This monograph summarizes multiple data that suggest the important role of cellular cross-talk for the functions of both normal and diseased liver. Special features of the book include concise presentation of the majority of detailed data in 19 tables. Original schemes allow for the clear illustration of complicated intercellular relationships. This is the first ever presentation of the newly emerging field of liver biology, which is important for hepatic function in health and disease and opens new avenues for therapeutic interventions.

Between Bench and Bedside

Author : Ilana Löwy
Publisher : Harvard University Press
ISBN 13 : 9780674068094
Total Pages : 396 pages
Book Rating : 4.0/5 (68 download)

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Book Synopsis Between Bench and Bedside by : Ilana Löwy

Download or read book Between Bench and Bedside written by Ilana Löwy and published by Harvard University Press. This book was released on 1996 with total page 396 pages. Available in PDF, EPUB and Kindle. Book excerpt: Between Bench and Bedside is a compelling account of the clinical trials of interleukin-2 at a major French cancer hospital. Löwy's book offers a remarkable insider's view of the culture of clinical experimentation in oncology.

Central Nervous System Metastases

Author : Manmeet Ahluwalia
Publisher : Springer Nature
ISBN 13 : 3030234177
Total Pages : 421 pages
Book Rating : 4.0/5 (32 download)

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Book Synopsis Central Nervous System Metastases by : Manmeet Ahluwalia

Download or read book Central Nervous System Metastases written by Manmeet Ahluwalia and published by Springer Nature. This book was released on 2019-11-05 with total page 421 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive overview of brain metastases, from the molecular biology aspects to therapeutic management and perspectives. Due to the increasing incidence of these tumors and the urgent need to effectively control brain metastatic diseases in these patients, new therapeutic strategies have emerged in recent years. The volume discusses all these innovative approaches combined with new surgical techniques (fluorescence, functional mapping, integrated navigation), novel radiation therapy techniques (stereotactic radiosurgery) and new systemic treatment approaches such as targeted- and immunotherapy. These combination strategies represent a new therapeutic model in brain metastatic patients in which each medical practitioner (neurosurgeon, neurologist, medical oncologist, radiation oncologist) plays a pivotal role in defining the optimal treatment in a multidisciplinary approach. Written by recognized experts in the field, this book is a valuable tool for neurosurgeons, neuro-oncologists, neuroradiologists, medical oncologists, radiation oncologists, cognitive therapists, basic scientists and students working in the area of brain tumors.

Interleukins in Cancer Biology

Author : Arseniy Yuzhalin
Publisher : Academic Press
ISBN 13 : 0128013338
Total Pages : 361 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Interleukins in Cancer Biology by : Arseniy Yuzhalin

Download or read book Interleukins in Cancer Biology written by Arseniy Yuzhalin and published by Academic Press. This book was released on 2014-06-27 with total page 361 pages. Available in PDF, EPUB and Kindle. Book excerpt: Interleukins in Cancer Biology responds to the growing need for credible and up-to-date information about the impact of interleukins on occurrence, development and progression of cancer. It provides reliable information about all known interleukins (38), describes recent discoveries in the field, and moreover, suggests further directions of research on the most promising aspects of this topic. The structure and presentation of the work is very understandable and clear with attention to detail maintained throughout. There are multiple illustrations throughout to help in comprehending and remembering the most important facts. . - Summarizes and discusses existing facts on the impact of all known interleukins in occurrence, development, and progression of cancer - Categorizes and clarifies all interleukins based on their role in cancer - Contains comprehensive and exhaustive information on each molecule

Biotechnology for Beginners

Author : Reinhard Renneberg
Publisher : Academic Press
ISBN 13 : 0323855709
Total Pages : 476 pages
Book Rating : 4.3/5 (238 download)

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Book Synopsis Biotechnology for Beginners by : Reinhard Renneberg

Download or read book Biotechnology for Beginners written by Reinhard Renneberg and published by Academic Press. This book was released on 2023-01-16 with total page 476 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biotechnology for Beginners, Third Edition presents the latest developments in the evolving field of biotechnology which has grown to such an extent over the past few years that increasing numbers of professional's work in areas that are directly impacted by the science. This book offers an exciting and colorful overview of biotechnology for professionals and students in a wide array of the life sciences, including genetics, immunology, biochemistry, agronomy and animal science. This book will also appeals to lay readers who do not have a scientific background but are interested in an entertaining and informative introduction to the key aspects of biotechnology. Authors Renneberg and Loroch discuss the opportunities and risks of individual technologies and provide historical data in easy-to-reference boxes, highlighting key topics. The book covers all major aspects of the field, from food biotechnology to enzymes, genetic engineering, viruses, antibodies, and vaccines, to environmental biotechnology, transgenic animals, analytical biotechnology, and the human genome. - Covers the whole of biotechnology - Presents an extremely accessible style, including lavish and humorous illustrations throughout - Includes new chapters on CRISPR cas-9, COVID-19, the biotechnology of cancer, and more

Moderate to Severe Psoriasis, Fourth Edition

Author : John Y. M. Koo
Publisher : CRC Press
ISBN 13 : 1482215160
Total Pages : 422 pages
Book Rating : 4.4/5 (822 download)

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Book Synopsis Moderate to Severe Psoriasis, Fourth Edition by : John Y. M. Koo

Download or read book Moderate to Severe Psoriasis, Fourth Edition written by John Y. M. Koo and published by CRC Press. This book was released on 2014-03-18 with total page 422 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by experts in the dermatology field, this new fourth edition of Moderate-to-Severe Psoriasis discusses the current use of biologics and other pharmacologic and phototherapy treatments for moderate-to-severe psoriasis. Illustrated with high quality color figures, this standalone text emphasizes safe and effective treatments for the psoriasis patient that are perfect for the dermatologist in daily practice. New to this edition are chapters on day treatment programs, new agents, erythrodermic and pustular psoriasis, special populations, and pharmacogenetics.

Nanoscience in Dermatology

Author : Michael R. Hamblin
Publisher : Academic Press
ISBN 13 : 0128029455
Total Pages : 404 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Nanoscience in Dermatology by : Michael R. Hamblin

Download or read book Nanoscience in Dermatology written by Michael R. Hamblin and published by Academic Press. This book was released on 2016-08-13 with total page 404 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nanoscience in Dermatology covers one of the two fastest growing areas within dermatological science, nanoscience and nanotechnology in dermatology. Recently, great progress has been made in the research and development of nanotechnologies and nanomaterials related to various applications in medicine and, in general, the life sciences. There is increasing enthusiasm for nanotechnology applications in dermatology (drug delivery, diagnostics, therapeutics, imaging, sensors, etc.) for understanding skin biology, improving early detection and treatment of skin diseases, and in the design and optimization of cosmetics. Light sensitive nanoparticles have recently been explored, opening a new era for the combined applications of light with nanotechnology, also called photonanodermatology. However, concerns have been raised regarding the adverse effects of intentional and unintentional nanoparticle exposure and their toxicity. Written by experts working in these exciting fields, this book extensively covers nanotechnology applications, together with the fundamentals and toxicity aspects. It not only addresses current applications of nanotechnology, but also discusses future trends of these ever-growing and rapidly changing fields, providing scientists and dermatologists with a clear understanding of the advantages and challenges of nanotechnology in skin medicine. - Provides knowledge of current and future applications of nanoscience and nanotechnology in dermatology - Outlines the fundamentals, methods, toxicity aspects, and other relevant aspects for nanotechnology based applications in dermatology - Coherently structured book written by experts working in the fields covered