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The Variant Effect Painkiller
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Book Synopsis The Variant Effect: PAINKILLER by : G. Wells Taylor
Download or read book The Variant Effect: PAINKILLER written by G. Wells Taylor and published by G. Wells Taylor. This book was released on 2010-11 with total page 78 pages. Available in PDF, EPUB and Kindle. Book excerpt: WHEN VARIANT SQUAD Captain Joe Borland works up the nerve to take care of some long-overdue business, he stumbles upon the terrifying shape of things to come. Dreams and reality collide in the shadow of the Variant Effect. Joe Borland returns in PAINKILLER, a gut-wrenching novella of grisly horror that takes place between the events in The Variant Effect books: SKIN EATERS and GREENMOURNING. It's been twenty years since Borland battled the Variant Effect, and twenty since he let his partner get skinned alive. Now both of them are being ordered back into action to meet the new threat.
Book Synopsis The Genetics of Pain by : Jeffrey Steven Mogil
Download or read book The Genetics of Pain written by Jeffrey Steven Mogil and published by Progress in Pain Research and. This book was released on 2004 with total page 376 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genetics more than any other biological approach can explain why some people experience more pain than others and receive less benefit from existing analgesics. Sixteen scholarly articles from international contributors describe the application of genetic techniques to the problem of pain and consider the knowledge that has so far resulted. Three themed sections review the techniques that are allowing the study of pain mechanisms at the genetic level; describe the progress being made in lab animals and humans in identifying the genes responsible for individual differences; and explore the practical and ethical issues that face pain researchers. The editor is associated with the Centre for Research on Pain, McGill U., Montreal. Annotation : 2004 Book News, Inc., Portland, OR (booknews.com).
Book Synopsis The Variant Effect: MADHOUSE 2 by : G. Wells Taylor
Download or read book The Variant Effect: MADHOUSE 2 written by G. Wells Taylor and published by G. Wells Taylor. This book was released on with total page 270 pages. Available in PDF, EPUB and Kindle. Book excerpt: JOE BORLAND and Captain Beachboy deliver Lazarus team scientists to Bezo Metro Headquarters and find things in upheaval, so the rest of 9-Squad is ordered in to provide security. The Variant Squad has been shaken and bloodied over the last twenty-four hours with a rising body count, and there hasn’t been time for wounds to heal or for the dead recruits to be replaced. But the Bezo Board of Directors has put Lazarus specialists in charge of efforts to halt the Variant Effect outbreak in Metro, and end the Ziploc that holds the city in quarantine. The veterans Borland and Hyde are suspicious of the change in command but cannot override their questionable orders or abandon their squad to a dubious mission. As they prepare to join the scientists underground and open research labs that have been sealed for decades, 9-Squad finds the enigmatic company man, Brass, is working the graveyard shift and overseeing a top secret project of his own. Brass is in survival mode and his “Plan B” has hit a few bumps, but that’s not the worst of it. There have been reports of unusual sounds and sightings that lend some truth to the old rumors that the HQ basement levels are haunted. The squad must investigate the eerie phenomena, but all the signs point to something far more tangible and terrifying than the dead. Borland, Hyde and the frazzled 9-Squad must decide who they can trust as lethal forces gather, and avenues of escape begin to close. The only way to save their skins and protect the public from annihilation may involve a terrifying descent into darkness. Explore the MADHOUSE with Gas Light, second stage in the final chapters of The Variant Effect Series.
Book Synopsis The Variant Effect: MADHOUSE 3 by : G. Wells Taylor
Download or read book The Variant Effect: MADHOUSE 3 written by G. Wells Taylor and published by G. Wells Taylor. This book was released on with total page 357 pages. Available in PDF, EPUB and Kindle. Book excerpt: THE VARIANT SQUAD barely had time to get back on its feet before the screaming started. Someone was getting skinned alive, and they knew it. But many of their comrades have just fallen to their deaths, and others are still missing, so Captain Beachboy knows that answering the cry for help would be suicide. Skin Eater packs are still hunting on the levels above and below them, and it’s only a matter of time before their ugly craving returns and they attack again. And that’s not the end of it. A murderous Kill Squad sent by an unknown enemy must have followed them underground. It has the Lazarus team’s innocent blood on its hands, and Beachboy suspects the unknown assassins are committed to spilling 9-Squad’s too. And the old myths about the basement are proving true. Something with an appetite for pain is haunting the bunker complex and feeds its hunger through the Biter packs. It has also poisoned the place with the Varion molecule that causes the lethal new form of the Variant Effect, forcing the squad to remain sealed in their bag-suits. And they’re running out of air. Variant Squad veteran Joe Borland knows that there are forces within the squad that might not want to win the battle underground, and would prefer leaving his bagged-comrades buried with the incriminating evidence they have found. So he’ll have to pick a side when his life’s on the line. In the meantime he and Beachboy take the squad survivors on a desperate search for a rumored escape tunnel while dark forces gather on all sides, and a secret clock winds down to doomsday and the final Variant Squad protocol of Ziploc, Gas and BURN! Explore the MADHOUSE to the END with BURN, third stage in the final chapters of The Variant Effect Series.
Book Synopsis Chronic Postsurgical Pain by : Gérard Mick
Download or read book Chronic Postsurgical Pain written by Gérard Mick and published by Springer Science & Business Media. This book was released on 2014-02-20 with total page 175 pages. Available in PDF, EPUB and Kindle. Book excerpt: Primum non nocere... The fact that a surgical procedure can leave any kind of pain casts a shadow over this tenet, which is seen as the basis of medical practice and anchor of its principle ethic... It is all the more surprising in that medicine has only paid attention to this paradoxical chronic pain situation for the past few years. Clarifying the knowledge acquired in this field has become all the more urgent for any care-giver today confronted by a legitimate request from patients: Why and how can a surgical procedure, which is supposed to bring relief, leave behind an unacceptable sequela? This is the approach which the contributors to this new subject of major clinical interest invite you to follow as you work your way through this book.
Author :National Academies of Sciences, Engineering, and Medicine Publisher :National Academies Press ISBN 13 :0309459575 Total Pages :483 pages Book Rating :4.3/5 (94 download)
Book Synopsis Pain Management and the Opioid Epidemic by : National Academies of Sciences, Engineering, and Medicine
Download or read book Pain Management and the Opioid Epidemic written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2017-09-28 with total page 483 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug overdose, driven largely by overdose related to the use of opioids, is now the leading cause of unintentional injury death in the United States. The ongoing opioid crisis lies at the intersection of two public health challenges: reducing the burden of suffering from pain and containing the rising toll of the harms that can arise from the use of opioid medications. Chronic pain and opioid use disorder both represent complex human conditions affecting millions of Americans and causing untold disability and loss of function. In the context of the growing opioid problem, the U.S. Food and Drug Administration (FDA) launched an Opioids Action Plan in early 2016. As part of this plan, the FDA asked the National Academies of Sciences, Engineering, and Medicine to convene a committee to update the state of the science on pain research, care, and education and to identify actions the FDA and others can take to respond to the opioid epidemic, with a particular focus on informing FDA's development of a formal method for incorporating individual and societal considerations into its risk-benefit framework for opioid approval and monitoring.
Book Synopsis Acute Pain Management by : Raymond S. Sinatra
Download or read book Acute Pain Management written by Raymond S. Sinatra and published by Cambridge University Press. This book was released on 2009-04-27 with total page 729 pages. Available in PDF, EPUB and Kindle. Book excerpt: This textbook provides an overview of pain management useful to specialists as well as non-specialists, surgeons, and nursing staff.
Author :Agency for Health Care Research and Quality (U.S.) Publisher :Government Printing Office ISBN 13 :1587634236 Total Pages :236 pages Book Rating :4.5/5 (876 download)
Book Synopsis Developing a Protocol for Observational Comparative Effectiveness Research: A User's Guide by : Agency for Health Care Research and Quality (U.S.)
Download or read book Developing a Protocol for Observational Comparative Effectiveness Research: A User's Guide written by Agency for Health Care Research and Quality (U.S.) and published by Government Printing Office. This book was released on 2013-02-21 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt: This User’s Guide is a resource for investigators and stakeholders who develop and review observational comparative effectiveness research protocols. It explains how to (1) identify key considerations and best practices for research design; (2) build a protocol based on these standards and best practices; and (3) judge the adequacy and completeness of a protocol. Eleven chapters cover all aspects of research design, including: developing study objectives, defining and refining study questions, addressing the heterogeneity of treatment effect, characterizing exposure, selecting a comparator, defining and measuring outcomes, and identifying optimal data sources. Checklists of guidance and key considerations for protocols are provided at the end of each chapter. The User’s Guide was created by researchers affiliated with AHRQ’s Effective Health Care Program, particularly those who participated in AHRQ’s DEcIDE (Developing Evidence to Inform Decisions About Effectiveness) program. Chapters were subject to multiple internal and external independent reviews. More more information, please consult the Agency website: www.effectivehealthcare.ahrq.gov)
Book Synopsis Pharmacology of Pain by : Pierre Beaulieu
Download or read book Pharmacology of Pain written by Pierre Beaulieu and published by Lippincott Williams & Wilkins. This book was released on 2015-06-01 with total page 978 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pharmacology of Pain provides a complete review of the pharmacology of pain, including mechanisms of drug actions, clinical aspects of drug usage, and new developments. This authoritative book describes the different systems involved in the perception, transmission, and modulation of pain and discusses the available options for pharmacological treatment of pain. Who should buy this book? Pharmacology of Pain is a particularly useful resource for: Basic researchers and clinicians, including physicians, dentists, pharmacists, nurses, and physical therapists Other professionals in the field of pain research and treatment Students and trainees
Book Synopsis The Variant Effect: GREENMOURNING by : G. Wells Taylor
Download or read book The Variant Effect: GREENMOURNING written by G. Wells Taylor and published by G. Wells Taylor. This book was released on 2010-06-14 with total page 396 pages. Available in PDF, EPUB and Kindle. Book excerpt: WHILE HYDE hunts for a Variant-enhanced serial killer, a fight with a skin-eating granny almost sends Borland back into retirement. Skin eaters, secrets, and murder close in as the squad scrambles to contain the Variant Effect. VARION was a popular medication that could cure anything from Anxiety and Depression to Schizophrenia and Zoophagia. Everybody took it back in the day, because there were no side effects ... AT FIRST. By the time they learned about the Variant Effect it was too late. It’s been twenty years since Borland battled the Variant Effect, and twenty since he let his partner get skinned alive. Now they have been ordered back into action to meet a terrifying new threat.
Book Synopsis Oxford Textbook of Palliative Medicine by : Nathan I. Cherny
Download or read book Oxford Textbook of Palliative Medicine written by Nathan I. Cherny and published by Oxford University Press, USA. This book was released on 2015 with total page 1281 pages. Available in PDF, EPUB and Kindle. Book excerpt: Emphasising the multi-disciplinary nature of palliative care the fourth edition of this text also looks at the individual professional roles that contribute to the best-quality palliative care.
Author :Hans-Christoph Diener Publisher :Springer Science & Business Media ISBN 13 :3642733271 Total Pages :174 pages Book Rating :4.6/5 (427 download)
Book Synopsis Drug-Induced Headache by : Hans-Christoph Diener
Download or read book Drug-Induced Headache written by Hans-Christoph Diener and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 174 pages. Available in PDF, EPUB and Kindle. Book excerpt: M. WILKINSON Patients with frequent or daily headaches pose a very difficult problem for the physician who has to treat them, particularly as many patients think that there should be a medicine or medicines which give them instant relief. In the search for the compound which would meet this very natural desire, many drugs have been manufactured and the temptation for the physician is either to increase the dose of a drug which seems to be, at any rate, partially effective, or to add one or more drugs to those which the patient is already taking. Although there have been some references to the dangers of overdosage of drugs for migraine in the past, it was not until relatively recently that it was recognized that drugs given for the relief of headache, if taken injudiciously, may themselves cause headache. The first drugs to be implicated in this way were ergotamine and phenazone. In the case of ergotamine tartrate, the dangers of ergotism were well known as this was a disorder which had been known and written about for many years. In the treatment of headache, fully blown ergotism is rare and in recent years has usually been due to self-medication in doses much greater than those prescribed although there are a few recorded cases where toxic amounts have been given.
Book Synopsis The Essence of Analgesia and Analgesics by : Raymond S. Sinatra
Download or read book The Essence of Analgesia and Analgesics written by Raymond S. Sinatra and published by Cambridge University Press. This book was released on 2010-10-14 with total page 551 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Essence of Analgesia and Analgesics is an invaluable practical resource for clinicians giving pain relief in any clinical setting, describing the pharmacologic principles and clinical use of all available pain medications. As well as detailed overviews of pain processing and analgesic theory, sections are dedicated to oral and panteral opioid analgesics, neuraxial opioids, NSAIDs, local anesthetics, anticonvulsant type analgesics, NMDA antagonists, alpha adrenergic analgesics, antidepressant analgesics, muscle relaxants, adjuvant medications, and new and emerging analgesics. The concise format of the chapters allows for quick and easy reading and assimilation of information. Enhanced by summary tables and figures, each chapter provides an overview of a particular drug, covering chemical structure, mode of activity, indications, contraindications, common doses and uses, advantages and disadvantages, and drug related adverse events. Key references are also provided. Edited by leading experts in pain management, this is essential reading for any clinician involved in pain management.
Book Synopsis Organic Cation Transporter 1 (OCT1): Not Vital for Life, but of Substantial Biomedical Relevance by : Jurgen Brockmoller
Download or read book Organic Cation Transporter 1 (OCT1): Not Vital for Life, but of Substantial Biomedical Relevance written by Jurgen Brockmoller and published by Frontiers Media SA. This book was released on 2022-01-12 with total page 145 pages. Available in PDF, EPUB and Kindle. Book excerpt: Around one third of all biologically relevant small molecules are organic cations. These include endogenous substances like catecholamines and other neurotransmitters, toxins and drugs designed to affect signaling processes. The organic cation transporter 1 (OCT1) is among the strongest expressed membrane transporters at the sinusoidal (blood-facing) side of liver cells and contributes substantially to the clearance of the blood from numerous organic cations. A most striking feature of OCT1 is its pronounced genetic diversity. Between 1 and 10% of all human populations have little to no OCT1 activity. With several of the OCT1 substrates up to 10% of Europeans are functionally OCT1 deficient. Apparently, the lack of OCT1 do not lead to apparent substantial pathological changes in these individuals. It thus appears that this transporter is not essential to human life, but does it means that OCT1 is irrelevant? In the last 25 years since the first cloning of this transporter, data on its pharmacological and physiological relevance is steadily accumulating. Numerous clinically relevant drugs (e.g. metformin, morphine, fenoterol, sumatriptan, tramadol and tropisetron) have been shown to be substrates of OCT1, and OCT1 deficiency has been shown to affect the pharmacokinetics, efficacy, or toxicity of these drugs. Also vitamin B1 has been shown to be a substrate of OCT1, and in genetically modified mice OCT1 substantially modulated hepatic lipid metabolism, total body fat and systemic glucose and lipid concentrations. Still, numerous important questions remain unsolved: For which drugs, toxins, or other endogenous or exogenous substances is OCT1 relevant? How can we predict the relevance of OCT1 from in vitro studies? What determines the substrate selectivity of OCT1 in comparison to other transporters or transport processes for organic cations? What regulates the expression of OCT1 in the liver and possibly in other tissues? What is the impact of OCT1 variation in different areas of medicine, including the therapies for cancer as well as for pulmonary, cardiovascular, or neurological diseases? How can evolutionary biology contribute to a better understanding of the roles of OCT1? And, importantly, what types of research are likely to significantly further the knowledge on OCT1 in the next decades?
Book Synopsis Hereditary Progressive Dystonia with Marked Diurnal Fluctuation by : Masaya Segawa
Download or read book Hereditary Progressive Dystonia with Marked Diurnal Fluctuation written by Masaya Segawa and published by Parthenon Publishing. This book was released on 1993-01-01 with total page 230 pages. Available in PDF, EPUB and Kindle. Book excerpt: This study examines the condition known as parkinsonism of early onset with diurnal fluctuation (PEDF). It aims to clarify the differences between PEDF and early-onset Parkinson disease, then to compare PEDF with HPD (hereditary progressive dystonia with marked diurnal fluctuation).
Book Synopsis The American Psychiatric Association Publishing Textbook of Psychopharmacology by : Alan F. Schatzberg
Download or read book The American Psychiatric Association Publishing Textbook of Psychopharmacology written by Alan F. Schatzberg and published by American Psychiatric Pub. This book was released on 2017-05-10 with total page 1850 pages. Available in PDF, EPUB and Kindle. Book excerpt: The American Psychiatric Association Publishing Textbook of Psychopharmacology is an indispensable and comprehensive resource for clinicians and trainees who prescribe psychotropic medications. Updated to reflect the new DSM-5 classification, this revised Fifth Edition maintains the user-friendly structure of its predecessors while offering in-depth coverage of the latest research in pharmacological principles, classes of drugs, and psychiatric disorders. Introductory chapters provide a theoretical grounding in clinical applications, with topics ranging from neurotransmitters to brain imaging in psychopharmacology. The bulk of the book is devoted to various classes of drugs, including antidepressants, anxiolytics, antipsychotics, mood stabilizers, and other agents, with each class divided into chapters on specific drugs -- either new or revised to include the latest findings and trends. Finally, the section on psychopharmacological treatment addresses evidence-based principles of clinical care for the full spectrum of mental disorders and conditions -- from depression to chronic pain -- as well as for specific populations and circumstances -- from children and adolescents to psychiatric emergencies -- offering information on topics such as medication selection, combination and maintenance dosing regimens, monitoring and management of side effects, and strategies for optimizing treatment response. The book's beneficial features are many: The section on principles of pharmacology has been revised and reorganized to incorporate recent discoveries from the fields of neurobiology, genetics, brain imaging, and epidemiology. History and discovery, structure--activity relationships, pharmacological profiles, pharmacokinetics and disposition, mechanisms of action, indications and efficacy, side effects and toxicology, and drug--drug interactions are addressed for each agent. This consistent structure places the desired information at the clinician's fingertips and facilitates study for trainees. Coverage of drugs approved since the last edition is thorough, encompassing new antidepressants (e.g., vortioxetine), new antipsychotics (e.g., cariprazine), and agents on the clinical horizon (e.g., ketamine). More than 180 tables and graphs present critically important data in an accessible way. A work of uncommon scientific rigor and clinical utility, The American Psychiatric Association Publishing Textbook of Psychopharmacology provides state-of-the-art information on both the principles and the practice of psychopharmacological treatment of psychiatric disorders.
Book Synopsis Opioids in Non-Cancer Pain by : Catherine F. Stannard
Download or read book Opioids in Non-Cancer Pain written by Catherine F. Stannard and published by Oxford University Press. This book was released on 2013-03-21 with total page 121 pages. Available in PDF, EPUB and Kindle. Book excerpt: This pocketbook summarizes the recent developments in this important and controversial aspect of pain management, looking at the benefits and adverse effects of opioids in non-cancer pain.
