The Third Histamine Receptor

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The Third Histamine Receptor

Author : Divya Vohora
Publisher : CRC Press
ISBN 13 : 1420053922
Total Pages : 408 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis The Third Histamine Receptor by : Divya Vohora

Download or read book The Third Histamine Receptor written by Divya Vohora and published by CRC Press. This book was released on 2008-11-14 with total page 408 pages. Available in PDF, EPUB and Kindle. Book excerpt: Reveals an Emerging Avenue of Potential Treatments for a Host of Challenging Diseases and Disorders The H3 receptor is known to play a major role in a range of CNS disorders, including those affecting cognitive functions such as ADHD and Alzheimer’s disease, as well as sleep disorders, obesity, epilepsy, schizophrenia, depression, and neurodegeneration. In light of dramatic advances in research at the molecular level, supported by impressive clinical studies, optimism remains high that an H3 receptor-related drug could hit the market soon. The Third Histamine Receptor: Selective Ligands as Potential Therapeutic Agents in CNS Disorders provides a thorough grounding in advances made over the last two decades. It brings together an elite group of 30 pioneering researchers. In writing about their own work, these scientists report on the cutting-edge investigations that are now being conducted across a variety of disciplines. This text is designed to aid researchers and inform those involved in the treatment and clinical aspects of a number of histamine-related diseases. Presents Several Disease-Specific Chapters Certainly, the most comprehensive and cutting-edge volume in the field, this text includes material drawn from groundbreaking research techniques and patent literature. Put together with great thought and passion, it is written to serve as a primary resource for anyone involved with or interested in the identification and localization of H3 receptors and the ligands being developed as therapeutic agents to treat a wide range of diseases including some that were once considered intractable.

Histamine Receptors

Author : Patrizio Blandina
Publisher : Springer
ISBN 13 : 3319403087
Total Pages : 378 pages
Book Rating : 4.3/5 (194 download)

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Book Synopsis Histamine Receptors by : Patrizio Blandina

Download or read book Histamine Receptors written by Patrizio Blandina and published by Springer. This book was released on 2016-11-07 with total page 378 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive and detailed overview of the current state of preclinical research on histamine and histamine receptors. Part of the book focuses on novel approaches to the study of histamine receptors such as polymorphism, genetic linkage, and computational analysis, and on the use of new histaminergic ligands in diseases such as asthma and dermatitis. Several chapters will be devoted to the role of histamine in the control of homeostatic and behavioral responses such as the sleep-wake cycle, regulation of the blood brain barrier, food intake, alertness, itch, and memory formation and consolidation.

Histamine in the brain

Author : Jian-Sheng Lin
Publisher : Frontiers Media SA
ISBN 13 : 2889194345
Total Pages : 100 pages
Book Rating : 4.8/5 (891 download)

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Book Synopsis Histamine in the brain by : Jian-Sheng Lin

Download or read book Histamine in the brain written by Jian-Sheng Lin and published by Frontiers Media SA. This book was released on 2015-03-18 with total page 100 pages. Available in PDF, EPUB and Kindle. Book excerpt: Brain aminergic pathways are organized in parallel and interacting systems, which support a range of functions, from homoeostatic regulations to cognitive, and motivational processes. Despite overlapping functional influences, dopamine, serotonin, noradrenaline and histamine systems provide different contributions to these processes. The histaminergic system, long ignored as a major regulator of the sleep-wake cycle, has now been fully acknowledged also as a major coordinator of attention, learning and memory, decision making. Although histaminergic neurons project widely to the whole brain, they are functionally heterogeneous, a feature which may provide the substrate for differential regulation, in a region-specific manner, of other neurotransmitter systems. Neurochemical preclinical studies have clearly shown that histamine interacts and modulates the release of neurotransmitters that are recognized as major modulators of cognitive processing and motivated behaviours. As a consequence, the histamine system has been proposed as a therapeutic target to treat sleep-wake disorders and cognitive dysfunctions that accompany neurodegenerative and neuroinflammatory pathologies. Last decades have witnessed an unexpected explosion of interest in brain histamine system, as new receptors have been discovered and selective ligands synthesised. Nevertheless, the complete picture of the histamine systems fine-tuning and its orchestration with other pathways remains rather elusive. This Research Topic is intended to offer an inter-disciplinary forum that will improve our current understanding of the role of brain histamine and provide the fundamentals necessary to drive innovation in clinical practice and to improve the management and treatment of neurological disorders.

Pharmacology of Histamine Receptors

Author : C. R. Ganellin
Publisher : Elsevier
ISBN 13 : 1483193411
Total Pages : 540 pages
Book Rating : 4.4/5 (831 download)

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Book Synopsis Pharmacology of Histamine Receptors by : C. R. Ganellin

Download or read book Pharmacology of Histamine Receptors written by C. R. Ganellin and published by Elsevier. This book was released on 2013-10-22 with total page 540 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pharmacology of Histamine Receptors presents a summary of the pharmacology of histamine receptors. It discusses the research and developments made in the use of histamine. It addresses the biological actions of the drug in various pathological instances. Some of the topics covered in the book are the classification of histamine receptors; mepyramine and related histamine antagonists; activity relationships of drugs acting at histamine receptors; chemical structure of histamine; effects of methyl substituents in histamine; enzymes involved in histamine metabolism; and histamine in body fluids. The cellular sources of histamine in tissues and blood are fully covered. The relationship of the mast cell to basophil is discussed in detail. The text describes in depth the urinary excretion of histamine and metabolites. The pathological conditions in man are presented completely. A chapter is devoted to the fundamental properties of adenylate cyclase and its measurement. The book can provide useful information to pharmacists, doctors, chemists, students, and researchers.

Histamine Receptors as Drug Targets

Author : Ekaterini Tiligada
Publisher : Humana
ISBN 13 : 9781493968411
Total Pages : 0 pages
Book Rating : 4.9/5 (684 download)

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Book Synopsis Histamine Receptors as Drug Targets by : Ekaterini Tiligada

Download or read book Histamine Receptors as Drug Targets written by Ekaterini Tiligada and published by Humana. This book was released on 2017-03-09 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book illustrates the current state-of-the-art in histamine research, with a focus on the appropriate methodologies to investigate the pharmacological properties and the therapeutic exploitation of HRs and their ligands. In addition, the range of techniques described provides an introduction to complementary cross-methodological disciplines beyond these fields. This multi-disciplinary approach is required to define the ‘decision gates’ that determine the development of more effective and safer therapeutic options for many forms of highly prevalent and debilitating diseases, such as asthma, dementias, dermatitis, and arthritis. Written for the Methods in Pharmacology and Toxicology series, chapters concentrate on practical, hands-on protocols from experts in the techniques. Authoritative and thorough, Histamine Receptors as Drug Targets seeks to aid pharmacologists, biochemists, drug discovery researchers, molecular biologists, chemists, toxicologists, lab scientists, medical doctors, principle investigators, research scientists, lab directors and technicians, as well as graduate students around the world in pursuing the study of this vital scientific area.

Histamine H4 receptor

Author : Holger Stark
Publisher : Walter de Gruyter
ISBN 13 : 8376560565
Total Pages : 368 pages
Book Rating : 4.3/5 (765 download)

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Book Synopsis Histamine H4 receptor by : Holger Stark

Download or read book Histamine H4 receptor written by Holger Stark and published by Walter de Gruyter. This book was released on 2013-11-20 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: H4 R is the newest member of the histamine receptor family, which was discovered about twelve years ago. It is considered a very promising drug target. The effort to improve the pharmacokinetic properties of the currently available H4 R ligands is reflected in a steadily growing number of scientific publications and patent applications. Preclinical data strongly confirms the need for novel potent H4 R ligands to explore their therapeutic value in allergy, inflammation, autoimmune disorders, and possibly, cancer. Readers will be provided with extensive knowledge on histamine metabolism, as well as cellular histamine transport, storage and release, effects of histamine and histamine receptor ligands, with particular attention to the H4 R, on inflammatory cells including mast cells, basophils, eosinophils, neutrophils, macrophages, dendritic cells, and T cells. The present knowledge on the regulatory role of histamine and the therapeutic exploitation of histamine receptor ligands in atopic diseases, with emphasis on human and animal models of asthma, allergic dermatitis and pruritus are discussed.

Pharmacoepigenetics

Author :
Publisher : Academic Press
ISBN 13 : 0128139404
Total Pages : 983 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Pharmacoepigenetics by :

Download or read book Pharmacoepigenetics written by and published by Academic Press. This book was released on 2019-06-04 with total page 983 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pharmacoepigenetics, Volume Eleven provides a comprehensive volume on the role of epigenetics and epigenomics in drug discovery and development, providing a detailed, but accessible, view of the field, from basic principles, to applications in disease therapeutics. Leading international researchers from across academia, clinical settings and the pharmaceutical industry discuss the influence of epigenetics and epigenomics in human pathology, epigenetic biomarkers for disease prediction, diagnosis, and treatment, current epigenetic drugs, and the application of epigenetic procedures in drug development. Throughout the book, chapter authors offer a balanced and objective discussion of the future of pharmacoepigenetics and its crucial contribution to the growth of precision and personalized medicine. Fully examines the influence of epigenetics and epigenomics in human pathology, epigenetic biomarkers for disease prediction, diagnosis, treatment, current epigenetic drugs and the application of epigenetic procedures in drug development Features chapter contributions from leading international researchers in academia, clinical settings and the pharmaceutical industry Instructs researchers, students and clinicians on how to better interpret and employ pharmacoepigenetics in drug development, efficiency and safety Provides a balanced and objective discussion of the future of pharmacoepigenetics and its crucial role in precision medicine

Biomedical Aspects of Histamine

Author : Nancy Khardori
Publisher : Springer Science & Business Media
ISBN 13 : 9048193494
Total Pages : 451 pages
Book Rating : 4.0/5 (481 download)

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Book Synopsis Biomedical Aspects of Histamine by : Nancy Khardori

Download or read book Biomedical Aspects of Histamine written by Nancy Khardori and published by Springer Science & Business Media. This book was released on 2010-09-30 with total page 451 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since its identification by Sir Henry H. Dale a century ago, histamine has become one of the most important multifunctional biogenic amines in the field of biomedicine. The pharmacological effects of histamine are mediated through four types of membrane histamine receptors; H1R, H2R, H3R and H4R, which are all heptahelical G-protein-coupled receptors. It has been known to play the broadest spectrum of activities in various physiological and pathological conditions including cell proliferation, differentiation, hematopoiesis, embryonic development, regeneration, wound healing, aminergic neurotransmission and numerous brain functions, secretion of pituitary hormones, regulation of gastrointestinal and circulatory functions, cardiovascular system, as well as inflammatory reactions, modulation of the immune response, endocrine function and homeostasis, and other important areas. This book is a compendium of the current state of established and investigational literature on Histamine, its receptors and their Agonists and antagonists. It provides a comprehensive overview of histamine biology in the field of biochemistry, cell biology, molecular biology, immunology, allergy, neurobiology, pharmacology, microbiology and reproductive biology. The first section on Histamine biology and physiology leads into subsequent sections on enzymology, pharmacology, regulation of the immune system and cell proliferation and role in allergic and other diseases including acid peptic diseases, inflammatory diseases, autoimmune and cancer diseases, nervous system, reproductive functions and hematopoiesis. The compilation of chapters in the book presents the most recent advances in histamine research and bridges the basic and clinical aspects of histamine biology.

Successful Drug Discovery, Volume 3

Author : János Fischer
Publisher : John Wiley & Sons
ISBN 13 : 3527343032
Total Pages : 472 pages
Book Rating : 4.5/5 (273 download)

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Book Synopsis Successful Drug Discovery, Volume 3 by : János Fischer

Download or read book Successful Drug Discovery, Volume 3 written by János Fischer and published by John Wiley & Sons. This book was released on 2018-06-05 with total page 472 pages. Available in PDF, EPUB and Kindle. Book excerpt: With its focus on drugs so recently introduced that they have yet to be found in any other textbooks or general references, the information and insight found here makes this a genuinely unique handbook and reference. Following the successful approach of the previous volumes in the series, inventors and primary developers of successful drugs from both industry and academia tell the story of the drug's discovery and describe the sometimes twisted route from the first drug candidate molecule to the final marketed drug. The 11 case studies selected describe recent drugs ranging across many therapeutic fields and provide a representative cross-section of present-day drug developments. Backed by plenty of data and chemical information, the insight and experience of today's top drug creators makes this one of the most useful training manuals that a junior medicinal chemist may hope to find. The International Union of Pure and Applied Chemistry has endorsed and sponsored this project because of its high educational merit.

Hepatotoxicity

Author : Hyman J. Zimmerman
Publisher : Lippincott Williams & Wilkins
ISBN 13 : 9780781719520
Total Pages : 848 pages
Book Rating : 4.7/5 (195 download)

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Book Synopsis Hepatotoxicity by : Hyman J. Zimmerman

Download or read book Hepatotoxicity written by Hyman J. Zimmerman and published by Lippincott Williams & Wilkins. This book was released on 1999 with total page 848 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by the foremost authority in the field, this volume is a comprehensive review of the multifaceted phenomenon of hepatotoxicity. Dr. Zimmerman examines the interface between chemicals and the liver; the latest research in experimental hepatotoxicology; the hepatotoxic risks of household, industrial, and environmental chemicals; and the adverse effects of drugs on the liver. This thoroughly revised, updated Second Edition features a greatly expanded section on the wide variety of drugs that can cause liver injury. For quick reference, an appendix lists these medications and their associated hepatic injuries. Also included are in-depth discussions of drug metabolism and factors affecting susceptibility to liver injury.

Brain Protection Strategies and Nanomedicine

Author :
Publisher : Elsevier
ISBN 13 : 0323989284
Total Pages : 418 pages
Book Rating : 4.3/5 (239 download)

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Book Synopsis Brain Protection Strategies and Nanomedicine by :

Download or read book Brain Protection Strategies and Nanomedicine written by and published by Elsevier. This book was released on 2021-10-22 with total page 418 pages. Available in PDF, EPUB and Kindle. Book excerpt: Brain Protection Strategies and Nanomedicine, Volume 266 in the Progress in Brain Research serial highlights new advances in the field, with this new volume presenting interesting chapters on a variety of topics, including Histamine H3 and H4 receptors modulate Parkinson’s disease induced brain pathology: Neuroprotective effects of nanowired BF-2649 and clobenpropit with anti-histamine-antibody therapy, Ultra Early Molecular Biologic Diagnosis Of Malignant And Neurodegenerative Diseases By The Immunospecific Profiles Of The Proteins Markers Of The Surface Of The Mobilized Autologous Hematopoietic Stem Cells, Neuroprotective effects of Insulin like growth factor-1 on Engineered metal Nanoparticles Ag, Cu and Al induced blood-brain barrier breakdown, and more. Other chapters cover how Methamphetamine exacerbates pathophysiology of traumatic brain injury at high altitude: Neuroprotective effects of nanodelivery of a potent antioxidant compound H-290/51, Effectiveness of bortezomib and temozolomide for eradication of recurrent human glioblastoma cells, resistant to radiation, and more. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in Progress in Brain Research serials Includes the latest information on brain protection strategies and nanomedicine

History of Allergy

Author : K.-C. Bergmann
Publisher : Karger Medical and Scientific Publishers
ISBN 13 : 3318021954
Total Pages : 445 pages
Book Rating : 4.3/5 (18 download)

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Book Synopsis History of Allergy by : K.-C. Bergmann

Download or read book History of Allergy written by K.-C. Bergmann and published by Karger Medical and Scientific Publishers. This book was released on 2014-05-27 with total page 445 pages. Available in PDF, EPUB and Kindle. Book excerpt: The prevalence of allergic diseases has increased dramatically over recent decades, both in terms of the number of sufferers and the number of allergies. This is a trend that has frequently been referred to as 'the epidemic of the 21st century'. As described in ancient texts, allergies have been known for over 2,000 years, but the term 'allergy' was only coined at the beginning of the 20th century when doctors began to understand their pathophysiological basis. This book presents a detailed and varied historical overview of the field of allergology. Beginning with insights on allergy from antiquity to the 20th century and the development of the associated terminology, it compiles historical reflections on the understanding of the most common allergic diseases. Important milestones in the discovery of mechanisms of allergy are described, followed by historical accounts of the detection of allergens such as pollen, dust mites, peanuts and latex, and of environmental influences such as pollution and the relationship between farmers and their environment. Several chapters illustrate the progress made in allergy management to date. Particular highlights of this book are the personal reflections of and interviews with a number of pioneers of allergy, including F. Austen, J. Bienenstock, K. Blaser, A. de Weck, A.W. Frankland, K. Ishizaka, and many more. Concluding with portrayals of allergy societies and collections, as well as being supplemented by two films, this book represents a veritable treasure trove of fascinating and richly illustrated information. Not only researchers, physicians and medical historians, but also students and even non-scientists will find History of Allergy a scientific adventure well worth reading.

Histamine and Histamine Receptors in Health and Disease

Author : Yuichi Hattori
Publisher : Springer
ISBN 13 : 3319581945
Total Pages : 353 pages
Book Rating : 4.3/5 (195 download)

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Book Synopsis Histamine and Histamine Receptors in Health and Disease by : Yuichi Hattori

Download or read book Histamine and Histamine Receptors in Health and Disease written by Yuichi Hattori and published by Springer. This book was released on 2017-05-22 with total page 353 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive overview on current histamine and histamine receptor research in context of human health and disease and reflect the multidisciplinary nature of the field. While the editors realize that it is almost impossible to cover the field completely within the constraints of a single HEP volume, nonetheless, all important aspects will be covered in one way or the other. An overarching introductory chapter will link the individual chapters and provide an overview on the field. This chapter will also link the book to the previous HEP volume on histamine receptors and the recent HEP volume on the pharmacology of itch. Great attention will be paid to complementation of existing literature while avoiding undue duplication. The book will cover new methods for analysis of histamine and histamine metabolites, development of methods for histamine receptor analysis, signal transduction, histamine release, regulation of immune cells by histamine, histamine metabolism and associated diseases, regulation of major organ systems by histamine and development of new drugs and experimental tools for the study of histamine receptors.

Encyclopedia of Respiratory Medicine

Author : Geoffrey J. Laurent
Publisher : Academic Press
ISBN 13 :
Total Pages : 680 pages
Book Rating : 4.:/5 ( download)

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Book Synopsis Encyclopedia of Respiratory Medicine by : Geoffrey J. Laurent

Download or read book Encyclopedia of Respiratory Medicine written by Geoffrey J. Laurent and published by Academic Press. This book was released on 2006 with total page 680 pages. Available in PDF, EPUB and Kindle. Book excerpt: An impressive four-volume work that provides an authoritative and comprehensive coverage of the complete field of respiratory medicine. It provides a vital interface between the pure and clinical science environments covering all aspects of respiratory medicine from the relevant molecular biology to the treatment of diseases that affect the respiratory system. It includes comprehensive coverage of lung cells, the structural components of the lung and key molecules that regulate lung function as well as all the major respiratory diseases. Students, researchers and professionals alike will find this an authoritative source of information on all aspects of respiratory medicine. Also available online via ScienceDirect (2006) - featuring extensive browsing, searching, and internal cross-referencing between articles in the work, plus dynamic linking to journal articles and abstract databases, making navigation flexible and easy. For more information, pricing options and availability visit www.info.sciencedirect.com. Includes diagrams of uniformly high quality and references to enable readers to access the wider literature Highly structured through the use of chapter templates Key four-color illustrations that will be invaluable teaching tools

Histamine and Histamine Antagonists

Author : Börje Uvnäs
Publisher : Springer
ISBN 13 : 9783642758423
Total Pages : 763 pages
Book Rating : 4.7/5 (584 download)

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Book Synopsis Histamine and Histamine Antagonists by : Börje Uvnäs

Download or read book Histamine and Histamine Antagonists written by Börje Uvnäs and published by Springer. This book was released on 2011-12-03 with total page 763 pages. Available in PDF, EPUB and Kindle. Book excerpt: Together with the two previous volumes of the Handbook of Experimental Pharmacology on histamine and antihistamines the present publication yields a picture of a still rapidly developing field of research. New techniques and new experimental approaches have brought us new knowledge and deeper insight into the biomedical significance of histamine, even if many questions remain to be answered about the functional and medical implications of this old biogenic amine. The present volume covers the progress in histamine research during the past two decades. A significant chapter concerns techniques for histamine determination. As the result of a consensus meeting in Munich in December 1988, a panel of eminent specialists arrived at common recommendations as to the usefulness of the available histamine assays for the most common experimental biomedical conditions. The heterogeneity of mast cells, with great differences in their reactivity to various stimuli, has become apparent, not only among species but also among the tissues of a species. New informa tion is presented about the mechanism of exocytosis. The old questions about the role of histamine in the mechanism of gastric secretion and in cardio vascular and respiratory functions have been studied with new techniques, and the role of HI and H2 receptors discussed. New observations have been made on the occurrence and possible functions of histaminergic neurons and histamine receptors in CNS where a new type of receptor, the H , seems to 3 be widely represented.

Itch

Author : E. Carstens
Publisher : CRC Press
ISBN 13 : 1466505435
Total Pages : 482 pages
Book Rating : 4.4/5 (665 download)

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Book Synopsis Itch by : E. Carstens

Download or read book Itch written by E. Carstens and published by CRC Press. This book was released on 2014-02-25 with total page 482 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in itch research have elucidated differences between itch and pain but have also blurred the distinction between them. There is a long debate about how somatic sensations including touch, pain, itch, and temperature sensitivity are encoded by the nervous system. Research suggests that each sensory modality is processed along a fixed, direct-line communication system from the skin to the brain. Itch: Mechanisms and Treatment presents a timely update on all aspects of itch research and the clinical treatment of itch that accompanies many dermatological conditions including psoriasis, neuropathic itch, cutaneous t-cells lymphomas, and systemic diseases such as kidney and liver disease and cancer. Composed of contributions from distinguished researchers around the world, the book explores topics such as: Neuropathic itch Peripheral neuronal mechanism of itch The role of PAR-2 in neuroimmune communication and itch Mrgprs as itch receptors The role of interleukin-31 and oncostatin M in itch and neuroimmune communication Spinal coding of itch and pain Spinal microcircuits and the regulation of itch Examining new findings on cellular and molecular mechanisms, the book is a compendium of the most current research on itch, its prevalence in society, and the problems associated with treatment.

Blood-Spinal Cord and Brain Barriers in Health and Disease

Author : Hari Shanker Sharma
Publisher : Academic Press
ISBN 13 :
Total Pages : 632 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Blood-Spinal Cord and Brain Barriers in Health and Disease by : Hari Shanker Sharma

Download or read book Blood-Spinal Cord and Brain Barriers in Health and Disease written by Hari Shanker Sharma and published by Academic Press. This book was released on 2004 with total page 632 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent research into the anatomy and pathophysiology of the blood-brain and blood-spinal cord barriers suggests that a breakdown in these barriers can result in several diseases affecting the central nervous system (CNS). This book presents new findings in the area of blood-brain barrier research that suggest barriers play important roles in health and disease conditions. It also discusses the development of new drugs that can modulate the barrier function in the CNS and may provide new approaches to treating neurological diseases such as Alzheimer's disease and other motor neuron diseases, as well as spinal cord trauma. Key Features * Presents the recent progress made in the research on the blood-brain and spinal cord barrier * Contains numerous illustrations of light and electron micrographs * Includes Foreword written by two eminent researchers in the field, Milton Brightman and Jorge Cervos-Navarro