Read Books Online and Download eBooks, EPub, PDF, Mobi, Kindle, Text Full Free.
The Study Of Human Cerebral Metabolism Using 31 Phosphorus Magnetic Resonance Spectroscopy
Download The Study Of Human Cerebral Metabolism Using 31 Phosphorus Magnetic Resonance Spectroscopy full books in PDF, epub, and Kindle. Read online The Study Of Human Cerebral Metabolism Using 31 Phosphorus Magnetic Resonance Spectroscopy ebook anywhere anytime directly on your device. Fast Download speed and no annoying ads. We cannot guarantee that every ebooks is available!
Book Synopsis The Study of Human Cerebral Metabolism Using 31-phosphorus Magnetic Resonance Spectroscopy by : Nicholas S. R. Brooke
Download or read book The Study of Human Cerebral Metabolism Using 31-phosphorus Magnetic Resonance Spectroscopy written by Nicholas S. R. Brooke and published by . This book was released on 1997 with total page 342 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Study of the In-vivo Human Brain Metabolism Using 1H Magnetic Resonance Spectroscopy by : Reem Thomas
Download or read book Study of the In-vivo Human Brain Metabolism Using 1H Magnetic Resonance Spectroscopy written by Reem Thomas and published by . This book was released on 1993 with total page 84 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Relationship of Brain Phosphate Metabolism and Cognition Using 31 Phosphorus Magnetic Resonance Spectroscopy at 7-Tesla in Alzheimer's Disease by : Namrata Das
Download or read book Relationship of Brain Phosphate Metabolism and Cognition Using 31 Phosphorus Magnetic Resonance Spectroscopy at 7-Tesla in Alzheimer's Disease written by Namrata Das and published by . This book was released on 2020 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Mitochondrial dysfunction, a neurometabolic marker, is considered an early marker in Alzheimer's disease (AD) that has speculated to precede toxic levels of amyloid and tau. Abnormal mitochondria function can negatively impact brain energy metabolism (BEM), oxidative and metabolic stress, leading to cell senescence and death. In-vitro cell line culture and postmortem AD studies suggest BEM abnormality, however have limited capability to capture the human brain's full complexity. Examining BEM in the in-vivo brain would confirm whether such abnormality is present and if so, to what extent, and how early it occurs in relation to the transitory stages of AD i.e., amnestic mild cognitive impairment (aMCI). The dissertation had three main goals. My first goal was to develop a methodology to measure BEM using advanced imaging technology such as 31-phosphorus magnetic resonance spectroscopy (31P MRS) at ultra-high-field (UHF) magnetic strength 7-T in human brain invivo. In the first phase, using partial volume-coil 31P MRS at 7-T over a brain region, i.e., parieto-occipital area, showed a well-separated high-resolution spectral display of thirteen metabolites signals, including energy phosphates and membrane phospholipid metabolites, in a single population of interest, i.e., aMCI. In my expanded research, I showed similar BEM data acquisition from the whole-brain volume-coil using same imaging technique. This work focused on three main energy phosphate metabolites-adenosine triphosphate (ATP), inorganic phosphate (Pi), and phosphocreatine (PCr). The measurements of these three metabolites were utilized to formulate three (3) BEM markers and two (2) regulatory co-factors [magnesium (Mg2+) and pH], including energy reserve index (PCr/t-ATP), energy consumption index (Pi/t-ATP), and metabolic state indicator (Pi/PCr). The next goal was to investigate if BEM markers and co-factors were significantly different across the three groups - cognitively normal (CN) (n=15), aMCI (n=15), and mild AD (n=11) in the four bilateral brain regions. The results showed that BEM markers was reduced in aMCI with further decrease in AD when compared to CN except metabolic state indicator. Interestingly, all the significant differences in BEM markers and regulatory co-factors were observed in the temporal region bilaterally, a vulnerable region where the AD pathology starts. The final goal was to study if the sensitive BEM markers and co-factors in the temporal lobe were associated with cognitive performance of memory, executive function (EF), attention, visuospatial skills, and language, respectively, across the groups. The findings showed a significant association of higher Mg2+ with improved memory, and EF in CN. On the other hand, in aMCI and mild AD, higher Mg2+ was related to lower performance in the same cognitive domains. Results suggest that in healthy brains, the Mg2+ supports the BEM mechanism, neuronal function and cognition. Whereas in aMCI and AD, the Mg2+ co-factor fails to support these systems. Overall, this work laid a foundation to investigate mitochondrial function using BEM in healthy and compromised brain in-vivo using novel and advanced imaging technology at UHF 7-T. Future work may explore ways to use this methodology using 31P MRS imaging technology to objectively measure the effectiveness of novel neurotherapeutics on mitochondrial function and dysfunction.
Book Synopsis In Vivo NMR Spectroscopy by : Robin A. de Graaf
Download or read book In Vivo NMR Spectroscopy written by Robin A. de Graaf and published by John Wiley & Sons. This book was released on 2019-03-11 with total page 584 pages. Available in PDF, EPUB and Kindle. Book excerpt: Presents basic concepts, experimental methodology and data acquisition, and processing standards of in vivo NMR spectroscopy This book covers, in detail, the technical and biophysical aspects of in vivo NMR techniques and includes novel developments in the field such as hyperpolarized NMR, dynamic 13C NMR, automated shimming, and parallel acquisitions. Most of the techniques are described from an educational point of view, yet it still retains the practical aspects appreciated by experimental NMR spectroscopists. In addition, each chapter concludes with a number of exercises designed to review, and often extend, the presented NMR principles and techniques. The third edition of In Vivo NMR Spectroscopy: Principles and Techniques has been updated to include experimental detail on the developing area of hyperpolarization; a description of the semi-LASER sequence, which is now a method of choice; updated chemical shift data, including the addition of 31P data; a troubleshooting section on common problems related to shimming, water suppression, and quantification; recent developments in data acquisition and processing standards; and MatLab scripts on the accompanying website for helping readers calculate radiofrequency pulses. Provide an educational explanation and overview of in vivo NMR, while maintaining the practical aspects appreciated by experimental NMR spectroscopists Features more experimental methodology than the previous edition End-of-chapter exercises that help drive home the principles and techniques and offer a more in-depth exploration of quantitative MR equations Designed to be used in conjunction with a teaching course on the subject In Vivo NMR Spectroscopy: Principles and Techniques, 3rd Edition is aimed at all those involved in fundamental and/or diagnostic in vivo NMR, ranging from people working in dedicated in vivo NMR institutes, to radiologists in hospitals, researchers in high-resolution NMR and MRI, and in areas such as neurology, physiology, chemistry, and medical biology.
Book Synopsis Magnesium in the Central Nervous System by : Robert Vink
Download or read book Magnesium in the Central Nervous System written by Robert Vink and published by University of Adelaide Press. This book was released on 2011 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: The brain is the most complex organ in our body. Indeed, it is perhaps the most complex structure we have ever encountered in nature. Both structurally and functionally, there are many peculiarities that differentiate the brain from all other organs. The brain is our connection to the world around us and by governing nervous system and higher function, any disturbance induces severe neurological and psychiatric disorders that can have a devastating effect on quality of life. Our understanding of the physiology and biochemistry of the brain has improved dramatically in the last two decades. In particular, the critical role of cations, including magnesium, has become evident, even if incompletely understood at a mechanistic level. The exact role and regulation of magnesium, in particular, remains elusive, largely because intracellular levels are so difficult to routinely quantify. Nonetheless, the importance of magnesium to normal central nervous system activity is self-evident given the complicated homeostatic mechanisms that maintain the concentration of this cation within strict limits essential for normal physiology and metabolism. There is also considerable accumulating evidence to suggest alterations to some brain functions in both normal and pathological conditions may be linked to alterations in local magnesium concentration. This book, containing chapters written by some of the foremost experts in the field of magnesium research, brings together the latest in experimental and clinical magnesium research as it relates to the central nervous system. It offers a complete and updated view of magnesiums involvement in central nervous system function and in so doing, brings together two main pillars of contemporary neuroscience research, namely providing an explanation for the molecular mechanisms involved in brain function, and emphasizing the connections between the molecular changes and behavior. It is the untiring efforts of those magnesium researchers who have dedicated their lives to unraveling the mysteries of magnesiums role in biological systems that has inspired the collation of this volume of work.
Book Synopsis Neuroimaging in Developmental Clinical Neuroscience by : Judith M. Rumsey
Download or read book Neuroimaging in Developmental Clinical Neuroscience written by Judith M. Rumsey and published by Cambridge University Press. This book was released on 2009-02-19 with total page 473 pages. Available in PDF, EPUB and Kindle. Book excerpt: Modern neuroimaging offers tremendous opportunities for gaining insights into normative development and a wide array of developmental neuropsychiatric disorders. Focusing on ontogeny, this text covers basic processes involved in both healthy and atypical maturation, and also addresses the range of neuroimaging techniques most widely used for studying children. This book will enable you to understand normative structural and functional brain maturation and the mechanisms underlying basic developmental processes; become familiar with current knowledge and hypotheses concerning the neural bases of developmental neuropsychiatric disorders; and learn about neuroimaging techniques, including their unique strengths and limitations. Coverage includes normal developmental processes, atypical processing in developmental neuropsychiatric disorders, ethical issues, neuroimaging techniques and their integration with psychopharmacologic and molecular genetic research approaches, and future directions. This comprehensive volume is an essential resource for neurologists, neuropsychologists, psychiatrists, pediatricians, and radiologists concerned with normal development and developmental neuropsychiatric disorders.
Book Synopsis Methodologies for Metabolomics by : Norbert W. Lutz
Download or read book Methodologies for Metabolomics written by Norbert W. Lutz and published by Cambridge University Press. This book was released on 2013-01-21 with total page 641 pages. Available in PDF, EPUB and Kindle. Book excerpt: Metabolomics, the global characterisation of the small molecule complement involved in metabolism, has evolved into a powerful suite of approaches for understanding the global physiological and pathological processes occurring in biological organisms. The diversity of metabolites, the wide range of metabolic pathways and their divergent biological contexts require a range of methodological strategies and techniques. Methodologies for Metabolomics provides a comprehensive description of the newest methodological approaches in metabolomic research. The most important technologies used to identify and quantify metabolites, including nuclear magnetic resonance and mass spectrometry, are highlighted. The integration of these techniques with classical biological methods is also addressed. Furthermore, the book presents statistical and chemometric methods for evaluation of the resultant data. The broad spectrum of topics includes a vast variety of organisms, samples and diseases, ranging from in vivo metabolomics in humans and animals to in vitro analysis of tissue samples, cultured cells and biofluids.
Download or read book Neuroimaging, Part I written by and published by Newnes. This book was released on 2016-07-12 with total page 724 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neuroimaging, Part One, a text from The Handbook of Clinical Neurology illustrates how neuroimaging is rapidly expanding its reach and applications in clinical neurology. It is an ideal resource for anyone interested in the study of the nervous system, and is useful to both beginners in various related fields and to specialists who want to update or refresh their knowledge base on neuroimaging. This first volume specifically covers a description of imaging techniques used in the adult brain, aiming to bring a comprehensive view of the field of neuroimaging to a varying audience. It brings broad coverage of the topic using many color images to illustrate key points. Contributions from leading global experts are collated, providing the broadest view of neuroimaging as it currently stands. For a number of neurological disorders, imaging is not only critical for diagnosis, but also for monitoring the effect of therapies, and the entire field is moving from curing diseases to preventing them. Most of the information contained in this volume reflects the newness of this approach, pointing to this new horizon in the study of neurological disorders. Provides a relevant description of the technologies used in neuroimaging, including computed tomography (CT), magnetic resonance imaging (MRI), positron emission tomography (PET), and several others Ideal resource for anyone studying the nervous system, from beginners to specialists interested in recent advances in neuroimaging of the adult brain Discusses the application of imaging techniques to the study of brain and spinal cord disease and its use in various syndromes Contains vibrant, colorful images to illustrate key points
Book Synopsis The Neuropsychology of Mental Illness by : Stephen J. Wood
Download or read book The Neuropsychology of Mental Illness written by Stephen J. Wood and published by Cambridge University Press. This book was released on 2009-10 with total page 465 pages. Available in PDF, EPUB and Kindle. Book excerpt: Describes neuropsychological approaches to the investigation, description, measurement and management of a wide range of mental illnesses.
Book Synopsis Handbook of Neuro-Oncology Neuroimaging by : Herbert B. Newton
Download or read book Handbook of Neuro-Oncology Neuroimaging written by Herbert B. Newton and published by Academic Press. This book was released on 2022-08-21 with total page 1022 pages. Available in PDF, EPUB and Kindle. Book excerpt: With treatment approaches and the field of neuro-oncology neuroimaging changing rapidly, this third edition of the Handbook of Neuro-Oncology Neuroimaging is very relevant to those in the field, providing a single-source, comprehensive, reference handbook of the most up-to-date clinical and technical information regarding the application of neuroimaging techniques to brain tumor and neuro-oncology patients. This new volume will have updates on all of the material from the second edition, and in addition features several new important chapters covering diverse topics such as imaging for the use of Laser Interstitial Thermal Therapy, advanced imaging techniques in radiation therapy, therapeutic treatment fields, response assessment in clinical trials, surgical planning of neoplastic disease of the spine, and more. Sections first overview neuro-oncological disorders before delving into the physics and basic science of neuroimaging and great focus on CT and MRI. The book then focuses on advances in the neuroimaging of brain tumors and neuroimaging of specific tumor types. There is also discussion of neuroimaging of other neuro-oncological syndromes. This book will serve as a resource of background information to neuroimaging researchers and basic scientists with an interest in brain tumors and neuro-oncology. Summarizes translational research on brain imaging for brain tumors Discusses limitations of neuroimaging for diagnosis and treatment Presents advanced imaging technologies, including CT, MRI, and PET Contains new coverage on Laser Interstitial Thermal Therapy, radiation therapy, clinical trials, and more
Book Synopsis Clinical Magnetic Resonance Spectroscopy by : E.B. Cady
Download or read book Clinical Magnetic Resonance Spectroscopy written by E.B. Cady and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 286 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nobody can know everything. For the successful application of techniques based on nuclear magnetic resonance to clinical problems, it is a vital necessity that individuals with widely different skills should learn a little of each others' trades by co-operation and communication. Ernest Cady has long proved himself a master of these arts to his colleagues at University College London, and by writing this excellent book he extends his experience to a wide circle of readers. Although the nuclear magnetic resonance (NMR) phenomenon had been predicted theoretically (and to some degree demonstrated experimentally) appreciably earlier, it required the advances in electronics that took place during World War II to turn NMR into a practical technique, as demonstrated independently in 1946 by Bloch and Purcell. Since then, NMR has been used extensively and increasingly by chemists and physicists. In the 1970s the first applications of NMR to animal organs yielded important advances in our knowledge of the biochemical and physiological processes as they occur in genuinely intact tissues. They showed incidentally that some conventional techniques introduce significant artifacts.
Book Synopsis Clinical MR Neuroimaging by : Jonathan H. Gillard
Download or read book Clinical MR Neuroimaging written by Jonathan H. Gillard and published by Cambridge University Press. This book was released on 2010 with total page 917 pages. Available in PDF, EPUB and Kindle. Book excerpt: Covers each physiological MR methodology and their applications to all major neurological diseases.
Book Synopsis Neuroimaging in Schizophrenia by : Marek Kubicki
Download or read book Neuroimaging in Schizophrenia written by Marek Kubicki and published by Springer Nature. This book was released on 2020-02-18 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive book explains the importance of imaging techniques in exploring and understanding the role of brain abnormalities in schizophrenia. The findings obtained using individual imaging modalities and their biological interpretation are reviewed in detail, and updates are provided on methodology, testable hypotheses, limitations, and new directions for research. The coverage also includes important recent applications of neuroimaging to schizophrenia, for example in relation to non-pharmacological interventions, brain development, genetics, and prediction of treatment response and outcome. Written by world renowned experts in the field, the book will be invaluable to all who wish to learn about the newest and most important developments in neuroimaging research in schizophrenia, how these developments relate to the last 30 years of research, and how they can be leveraged to bring us closer to a cure for this devastating disorder. Neuroimaging in Schizophrenia will assist clinicians in navigating what is an extremely complex field and will be a source of insight and stimulation for researchers.
Book Synopsis EEG and Evoked Potentials in Psychiatry and Behavioral Neurology by : John R. Hughes
Download or read book EEG and Evoked Potentials in Psychiatry and Behavioral Neurology written by John R. Hughes and published by Butterworth-Heinemann. This book was released on 1983 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt: EEG and Evoked Potentials in Psychiatry and Behavioral Neurology discusses the two techniques of examining brain function: electroencephalography (EEG) and evoked potentials. The book also addresses conditions that fall under the umbrella term """"behavioral sciences"""" and are associated with psychiatry and neurology. The book begins by discussing current definitions of organic brain syndrome in order to delineate more clearly the processes whose EEG correlates are to be described. It then outlines the various EEG correlates of impaired central nervous system (CNS) dysfunction for a variety ...
Book Synopsis MRI from Picture to Proton by : Donald W. McRobbie
Download or read book MRI from Picture to Proton written by Donald W. McRobbie and published by Cambridge University Press. This book was released on 2017-04-13 with total page 405 pages. Available in PDF, EPUB and Kindle. Book excerpt: MR is a powerful modality. At its most advanced, it can be used not just to image anatomy and pathology, but to investigate organ function, to probe in vivo chemistry, and even to visualise the brain thinking. However, clinicians, technologists and scientists struggle with the study of the subject. The result is sometimes an obscurity of understanding, or a dilution of scientific truth, resulting in misconceptions. This is why MRI from Picture to Proton has achieved its reputation for practical clarity. MR is introduced as a tool, with coverage starting from the images, equipment and scanning protocols and traced back towards the underlying physics theory. With new content on quantitative MRI, MR safety, multi-band excitation, Dixon imaging, MR elastography and advanced pulse sequences, and with additional supportive materials available on the book's website, this new edition is completely revised and updated to reflect the best use of modern MR technology.
Book Synopsis Encephalopathy and Nitrogen Metabolism in Liver Failure by : E. Anthony Jones
Download or read book Encephalopathy and Nitrogen Metabolism in Liver Failure written by E. Anthony Jones and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 454 pages. Available in PDF, EPUB and Kindle. Book excerpt: Encephalopathy and Nitrogen Metabolism in Liver Failure contains research reports and state-of-the-art reviews that were presented at the 11th International Symposium on Hepatic Encephalopathy and Nitrogen Metabolism in relation to liver disease, that was held in Amsterdam, The Netherlands from 30 May to 1 June, 2002. Themes covered include the metabolism of ammonia and amino acids in relation to liver disease, the assessment of hepatic encephalopathy (HE), minimal HE, animal models of HE, neuropsychiatric dysfunction in patients with chronic liver disease, the pathogenesis of HE, the astrocyte in liver disease, acute liver failure and cerebral edema, treatment of HE and artificial liver support systems. This volume provides an indispensable source of important new research findings and ideas for clinicians and biomedical scientists working in the field of HE and nitrogen metabolism in relation to liver disease.
Book Synopsis Nuclear Magnetic Resonance Spectroscopy in the Study of Neoplastic Tissue by : Raffaella Tosi
Download or read book Nuclear Magnetic Resonance Spectroscopy in the Study of Neoplastic Tissue written by Raffaella Tosi and published by Nova Publishers. This book was released on 2005 with total page 462 pages. Available in PDF, EPUB and Kindle. Book excerpt:
