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Author : Hsin-Lin Cheng
Publisher :
ISBN 13 :
Total Pages : 308 pages
Book Rating : 4.3/5 (91 download)
Download or read book The Role of the Insulin-like Growth Factor Family in the Nervous System written by Hsin-Lin Cheng and published by . This book was released on 1996 with total page 308 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Mohan K. Raizada
Publisher :
ISBN 13 :
Total Pages : 358 pages
Book Rating : 4.F/5 ( download)
Download or read book The Role of Insulin-like Growth Factors in the Nervous System written by Mohan K. Raizada and published by . This book was released on 1993 with total page 358 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume discusses various aspects of the insulin-like growth factors (IGFs), their binding proteins and receptors. The emphasis is on identification of these important growth factors in the nervous system and their potential role in nervous tissue physiology. The IFGs are compared to other growth factors that are important in the nervous system, including nerve growth factor.
Author : Derek LeRoith
Publisher : Springer
ISBN 13 : 9781461363019
Total Pages : 417 pages
Book Rating : 4.3/5 (63 download)
Download or read book Current Directions in Insulin-Like Growth Factor Research written by Derek LeRoith and published by Springer. This book was released on 2013-02-12 with total page 417 pages. Available in PDF, EPUB and Kindle. Book excerpt: The study of the insulin-like growth factor (IGF) family has become an exciting area of investigation. Initially, this family consisted of ligands (insulin, IGF-I and IGF-m and receptors (the insulin receptor, the type I or IGF-I receptor and the type II or IGF-IYM-6-P receptor). Subsequently, it was discovered that six specific binding proteips (lGFBPs 1-6) playa major role in the actions of this growth factor family. In addition, there are now more potential receptors when one considers the possible roles of the insulin-receptor related receptor (IRR) and hybrid receptor dimers composed of insulin and IGF-I receptor (half-receptors). Another important aspect of this area of research is the realization that the IGFs are not only essential for normal growth and development but, in addition play an important role in the normal specialized function(s) of all tissues of the body, including the nervous system, skeleton, reproductive system, kidney, and the immune system, to name but a few. The development of recombi!tant human IGF-I for clinical testing has been a major breakthrough for investigators. Potential uses include wound healing, reversal of catabolic states, diabetes, bone remodeling, recovery from acute renal failure and many others. will determine both its use and its potential hazards.
Author : Derek LeRoith
Publisher : Springer Science & Business Media
ISBN 13 : 146845949X
Total Pages : 528 pages
Book Rating : 4.4/5 (684 download)
Download or read book Molecular Biology and Physiology of Insulin and Insulin-Like Growth Factors written by Derek LeRoith and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 528 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume addresses a fundamental puzzle in biology and medicine, namely, how does tissue develop, repair and replace itself. The answer appears to lie in growth factors and their regulation. To thrive and survive we need growth factors and this book concentrates on two factors that are related to growth hormone. Growth hormone does not act directly on all tissues, but mediates many of its actions through the release of insulin-like growth factors from the liver. The growth factors were originally called somatomedins by McConaghey and Sledge (1), who discovered that they mediated growth-like effects of growth hormone. However, the factors were purified on the basis of their insulinomimetic actions on fat and muscle and it is their relationship to the insulin family of pep tides that now gives them their name (2,3) of insulin-like growth factors (IGFs). They mediate the actions of. growth hormone on the proteoglycan synthesis of cartilage and produce mitogenic effects in fibroblast cultures.
Author : George J. Siegel
Publisher : Lippincott Raven
ISBN 13 :
Total Pages : 1216 pages
Book Rating : 4.3/5 (91 download)
Download or read book Basic Neurochemistry written by George J. Siegel and published by Lippincott Raven. This book was released on 1999 with total page 1216 pages. Available in PDF, EPUB and Kindle. Book excerpt: Illustrations by Lorie M. Gavulic, MFA Sponsored by the American Society for Neurochemistry.
Author : Robert C. Bast, Jr.
Publisher : John Wiley & Sons
ISBN 13 : 111900084X
Total Pages : 2004 pages
Book Rating : 4.1/5 (19 download)
Download or read book Holland-Frei Cancer Medicine written by Robert C. Bast, Jr. and published by John Wiley & Sons. This book was released on 2017-03-10 with total page 2004 pages. Available in PDF, EPUB and Kindle. Book excerpt: Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates
Author : Cheryl Hawkes
Publisher :
ISBN 13 :
Total Pages : 572 pages
Book Rating : 4.:/5 (252 download)
Download or read book Distribution and Significance of the Insulin-like Growth Factor-II/Mannose-6 Phosphate Receptor in the Central Nervous System with Special Emphasis on the Cholinergic System written by Cheryl Hawkes and published by . This book was released on 2005 with total page 572 pages. Available in PDF, EPUB and Kindle. Book excerpt: "The insulin-like growth factor-II/mannose-6-phosphate (IGF-II/M6P) receptor is a multifunctional single transmembrane glycoprotein which mediates the trafficking of M6P-containing lysosomal enzymes from the trans-Golgi network to endosomes-lysosomes (EL). IGF-II/M6P receptors located at the cell surface also function in the internalization and subsequent degradation or activation of extracellular IGF-II and other M6P-bearing ligands. However, very little is currently known about the significance of the receptor in the function of the central nervous system. Results from this thesis project indicate that IGF-II/M6P receptors are widely, but selectively distributed throughout the adult rat brain and spinal cord, and that a subset of receptors is found to be expressed in cholinergic neurons/fibers. We have also found that the IGF-II/M6P receptor in the rat brain couples to a G protein and that its activation by Leu27IGF-II, an analog which binds preferentially to the IGF-II/M6P receptor, potentiates acetylcholine release from the adult rat hippocampal formation. Additionally, we have shown that Leu27IGF-II can cause a significant reduction in whole-cell currents and depolarization of dissociated basal forebrain cholinergic neurons. These effects are mediated by a pertussis toxin-sensitive, protein kinase Ca-dependent pathway. Furthermore, we have also demonstrated that selective in vivo degeneration of basal forebrain cholinergic neurons by 192 IgG-saporin, which is mediated in part by an increase in glycogen sythase kinase-3beta activity, results in an up-regulation of IGF-II/M6P receptor levels in surviving neurons of the basal forebrain and frontal cortex. This is accompanied by a parallel time-dependent increase in other EL proteins, including Rab5, LAMP2 and the lysosomal hydrolase cathepsin D. Given the critical role of the EL system in regulating cell viability, it is likely that the increase in the level of the IGF-II/M6P receptor and other components of the EL system in surviving neurons represents an adaptive mechanism to restore the metabolic and structural abnormalities which follow 192 IgG-saporin-induced toxicity. We also report that IGF-II/M6P receptors levels are decreased in the hippocampus of Alzheimer disease (AD) brains as a function of apolipoprotein epsilon4-allele number. Moreover, immunoreactive IGF-II/M6P receptors are found to colocalize with a subset of beta-amyloid-positive neuritic plaques and tau-positive neurofibrillary tangles in the frontal cortex and hippocampus of the AD brain. Taken together, these results suggest that IGF-II/M6P receptors which are widely expressed in the adult brain, can serve a multifunctional role, including the maintenance of cellular homeostasis, modulation of neurotransmitter release and possibly in the restoration of metabolic and structural abnormalities in neurons which survive toxicity/injury." --
Author : Deric L. Wheeler
Publisher : Springer
ISBN 13 : 3319118889
Total Pages : 888 pages
Book Rating : 4.3/5 (191 download)
Download or read book Receptor Tyrosine Kinases: Family and Subfamilies written by Deric L. Wheeler and published by Springer. This book was released on 2015-07-31 with total page 888 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book devotes a chapter to each RTK family and the multiple receptors within each family, thoroughly covering all of the RTKs. The chapters all follow the same structure, presenting this essential information in an accessible and user-friendly format. Each chapter covers one specific family of receptors and begins with a general introduction to that family and a comprehensive discussion of that receptor’s family in development and human disease. Following are in-depth analyses of each family’s receptors with discussions on the gene, protein, ligands, activation, and signaling pathways along with discussion of receptor processing and signal attenuation. Further, cross talk with other receptors systems, post-translational modification and specific unique characteristics to each RTK are discussed. Because it isolates and explains each family, this book is an essential companion volume to Receptor Tyrosine Kinases: Structure, Functions and Role in Human Disease, by the same authors, which talks about RTKs more generally and without the family-by-family detail.
Author : Brian Andrew Masters
Publisher :
ISBN 13 :
Total Pages : 658 pages
Book Rating : 4.:/5 (225 download)
Download or read book Insulin-like Growth Factors in Cell Differentiation and Development in the Nervous System written by Brian Andrew Masters and published by . This book was released on 1990 with total page 658 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :
Publisher : Academic Press
ISBN 13 : 0080922155
Total Pages : 766 pages
Book Rating : 4.0/5 (89 download)
Download or read book Insulin and IGFs written by and published by Academic Press. This book was released on 2009-03-10 with total page 766 pages. Available in PDF, EPUB and Kindle. Book excerpt: First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press. The Editorial Board now reflects expertise in the field of hormone action, vitamin action, X-ray crystal structure, physiology, and enzyme mechanisms. Under the capable and qualified editorial leadership of Dr. Gerald Litwack, Vitamins and Hormones continues to publish cutting-edge reviews of interest to endocrinologists, biochemists, nutritionists, pharmacologists, cell biologists, and molecular biologists. Others interested in the structure and function of biologically active molecules like hormones and vitamins will, as always, turn to this series for comprehensive reviews by leading contributors to this and related disciplines.This volume focuses on insulin and IGFs. - Longest running series published by Academic Press - Contributions by leading international authorities
Author : Deric L. Wheeler
Publisher : Springer
ISBN 13 : 1493920537
Total Pages : 452 pages
Book Rating : 4.4/5 (939 download)
Download or read book Receptor Tyrosine Kinases: Structure, Functions and Role in Human Disease written by Deric L. Wheeler and published by Springer. This book was released on 2014-11-26 with total page 452 pages. Available in PDF, EPUB and Kindle. Book excerpt: Receptor Tyrosine Kinase: Structure, Functions and Role in Human Disease, for the first time, systematically covers the shared structural and functional features of the RTK family. Receptor Tyrosine Kinases (RTKs) play critical roles in embryogenesis, normal physiology and several diseases. And over the last decade they have become the Number 1 targets of cancer drugs. To be able to conduct fundamental research or to attempt to develop pharmacological agents able to enhance or intercept them, it is essential first to understand the evolutionary origin of the 58 RTKs and their roles in invertebrates and in humans, as well as downstream signaling pathways. The assembly of chapters is written by experts and underscores commonalities between and among the RTKs. It is an ideal companion volume to The Receptor Tyrosine Kinase: Families and Subfamilies, which proceeds, family by family through all of the specific subfamilies of RTKs, along with their unique landmarks.
Author : Ramon Lim
Publisher : Springer Science & Business Media
ISBN 13 : 0387303480
Total Pages : 691 pages
Book Rating : 4.3/5 (873 download)
Download or read book Handbook of Neurochemistry and Molecular Neurobiology written by Ramon Lim and published by Springer Science & Business Media. This book was released on 2006-09-18 with total page 691 pages. Available in PDF, EPUB and Kindle. Book excerpt: "The Handbook is intended to be a service to the neuroscience community, to help in finding available and useful information, to point out gaps in our knowledge, and to encourage continued studies. It represents the valuable contributions of the many authors of the chapters and the guidance of the editors and most important, it represents support for research in this discipline. Based on the rapid advances in the years since the second edition."--Publisher's website.
Author : Derek LeRoith
Publisher : CRC Press
ISBN 13 : 9780849357121
Total Pages : 328 pages
Book Rating : 4.3/5 (571 download)
Download or read book Insulin-like Growth Factors written by Derek LeRoith and published by CRC Press. This book was released on 1991-05-28 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: During the past decade, the continued interest in insulin-related growth factors has been documented by a plethora of research programs and publications focused on these growth factors. Both molecular and cellular biological techniques have improved and enabled investigators to study the properties of the growth factors in depth. This volume covers the molecular (genetic) aspects of the growth factors, their binding proteins and receptors, as well as those factors affecting their gene transcription and translation. In addition, aspects of the cellular action of these growth factors through their receptors and how this impacts normal cellular function are discussed. The book will provide valuable information for researchers in physiology, biology, endocrinology, and metabolism.
Author : Vincenzo Carlo Russo
Publisher :
ISBN 13 :
Total Pages : 576 pages
Book Rating : 4.:/5 (222 download)
Download or read book The Role of the Insulin-like Growth Factor System in Brain Development and Neuronal Cells written by Vincenzo Carlo Russo and published by . This book was released on 2000 with total page 576 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Marilyn J. Cipolla
Publisher : Biota Publishing
ISBN 13 : 1615047239
Total Pages : 82 pages
Book Rating : 4.6/5 (15 download)
Download or read book The Cerebral Circulation written by Marilyn J. Cipolla and published by Biota Publishing. This book was released on 2016-07-28 with total page 82 pages. Available in PDF, EPUB and Kindle. Book excerpt: This e-book will review special features of the cerebral circulation and how they contribute to the physiology of the brain. It describes structural and functional properties of the cerebral circulation that are unique to the brain, an organ with high metabolic demands and the need for tight water and ion homeostasis. Autoregulation is pronounced in the brain, with myogenic, metabolic and neurogenic mechanisms contributing to maintain relatively constant blood flow during both increases and decreases in pressure. In addition, unlike peripheral organs where the majority of vascular resistance resides in small arteries and arterioles, large extracranial and intracranial arteries contribute significantly to vascular resistance in the brain. The prominent role of large arteries in cerebrovascular resistance helps maintain blood flow and protect downstream vessels during changes in perfusion pressure. The cerebral endothelium is also unique in that its barrier properties are in some way more like epithelium than endothelium in the periphery. The cerebral endothelium, known as the blood-brain barrier, has specialized tight junctions that do not allow ions to pass freely and has very low hydraulic conductivity and transcellular transport. This special configuration modifies Starling's forces in the brain microcirculation such that ions retained in the vascular lumen oppose water movement due to hydrostatic pressure. Tight water regulation is necessary in the brain because it has limited capacity for expansion within the skull. Increased intracranial pressure due to vasogenic edema can cause severe neurologic complications and death.
Author : Randi Jenssen Hagerman
Publisher : Oxford University Press, USA
ISBN 13 : 019993780X
Total Pages : 401 pages
Book Rating : 4.1/5 (999 download)
Download or read book Treatment of Neurodevelopmental Disorders written by Randi Jenssen Hagerman and published by Oxford University Press, USA. This book was released on 2014 with total page 401 pages. Available in PDF, EPUB and Kindle. Book excerpt: This cutting-edge book brings advances in genetics, neurobiology, and psychopharmacology to the clinic to enhance treatment for neurodevelopmental disorders. Significant progress has been made in identifying the neurobiological mechanisms of several disorders and targeted treatments are modifying the outcome of these disorders. However, the ability to utilize this knowledge has not been summarized in one place for the practicing clinician. This book will fill that gap by providing the theoretical underpinnings and the latest advances in targeted treatments. Several neurodevelopmental disorders are reviewed in detail including clinical features and behavioral phenotypes, standard treatments and new targeted treatments based on the latest advances in neurobiology and the animal model studies that have lead to new treatments. The disorders covered include psychiatric disorders: schizophrenia, depression, autism and ADHD; single gene disorders including Tuberous Sclerosis, Fragile X Syndrome and fragile X- associated disorders, Angelman Syndrome, PKU, and Muscular Dystrophies; and complex genetic disorders such as Down syndrome. This book also highlights the commonalities across disorders and new genetic and molecular concepts in an easy to read format. This is a very exciting time for new targeted treatments and this volume is a landmark treatise on this new age of treatment.
Author : Patrik Ernfors
Publisher :
ISBN 13 : 9789162802165
Total Pages : 56 pages
Book Rating : 4.8/5 (21 download)
Download or read book The Nerve Growth Factor Family of Neurotrophic Factors written by Patrik Ernfors and published by . This book was released on 1991 with total page 56 pages. Available in PDF, EPUB and Kindle. Book excerpt:
