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The Role Of Phosphoinositide 3 Kinase Gamma In The Host Immune Response Against Cutaneous Leishmaniasis Caused By Leishmania Mexicana
Download The Role Of Phosphoinositide 3 Kinase Gamma In The Host Immune Response Against Cutaneous Leishmaniasis Caused By Leishmania Mexicana full books in PDF, epub, and Kindle. Read online The Role Of Phosphoinositide 3 Kinase Gamma In The Host Immune Response Against Cutaneous Leishmaniasis Caused By Leishmania Mexicana ebook anywhere anytime directly on your device. Fast Download speed and no annoying ads. We cannot guarantee that every ebooks is available!
Book Synopsis Drug Resistance in Leishmania Parasites by : Alicia Ponte-Sucre
Download or read book Drug Resistance in Leishmania Parasites written by Alicia Ponte-Sucre and published by Springer Science & Business Media. This book was released on 2012-09-04 with total page 458 pages. Available in PDF, EPUB and Kindle. Book excerpt: One of the main problems concerning therapeutic tools for the treatment of parasitic diseases, including leishmaniasis, is that some field parasites are naturally resistant to the classical drugs; additionally, current therapies may select parasites prone to be resistant to the applied drugs. These features are (at least partially) responsible for the disappointing persistence of the disease and resultant deaths worldwide. This book provides a comprehensive view of the pathology of the disease itself, and of parasitic drug resistance, its molecular basis, consequences and possible treatments. Scientists both from academic fields and from the industry involved in biomedical research and drug design, will find in this book a valuable and fundamental guide that conveys the knowledge needed to understand and to improve the success in combating this disease worldwide.
Book Synopsis Research and innovation by : Universidade do Minho
Download or read book Research and innovation written by Universidade do Minho and published by UMinho Editora. This book was released on 2020-07-14 with total page 254 pages. Available in PDF, EPUB and Kindle. Book excerpt: The University of Minho (UMinho) defined some years ago a comprehensive and integrative research policy in order to actively contribute to pushing the frontiers of human knowledge, to the reinforcement of the national scientific system, and to the consolidation of its institutional position both in national and international arenas. Thus, the commitment to become a research university is stated in the different strategic documents approved by the University along the last decade. UMinho defined a clear strategy in order to be an open and permanent space for the creation of knowledge and the furtherance of nationally and internationally relevant innovation across the different areas of knowledge. Being a comprehensive University, UMinho aims at fostering high quality research in all the scientific domains in which our Research Units inscribe their activity: Sciences, Health and Life Sciences, Engineering and Technology, Social Sciences and Arts and Humanities. From the very beginning, UMinho has adopted the principles of open access and open science. We aim at carrying out our scientific activity in a transparent and collaborative way, actively promoting the sharing and communication of research processes, data and outputs. We are convinced that we do better science when we make it both more sensitive to the needs of society and also more effective in what concerns the allocated resources. As we see it, accountability is a pre-requisite for reinforcing citizen awareness of the contributions of science to a better world. These are the reasons why UMinho played a pioneering role in allowing open access to its publications and why it is currently expanding its sharing of research data. At UMinho, research is carried out in close connection with education. The University is increasingly involving students of the different learning cycles in research activities. Conversely, both PhD students and post-doctoral researchers play a role in teaching activities. Acting in this way, not only do we guarantee better quality education but we also establish the basis for a sustainable development of the scientific system and the fostering of scientific culture. We conceive research as a global enterprise, seeking for the answers to the main challenges of our times. In this sense, research is essentially international and requires the continuous reinforcement of international collaborations and participation in international initiatives, namely in the context of the European Research Area. At the same time, we are always promoting the multiplier effects of the scientific research we undertake for the socio-economic and cultural development of the country and of our region. The University’s high-quality scientific performance is clear when we consider: (i) the results of the international evaluation of our Research Units carried out by the National Science Foundation (FCT); (ii) the position that UMinho has been achieving in important international rankings; (iii) the number and diversity of University projects approved under the 7th Framework Program and the H2020; and (iv) the large collaboration projects with companies and other organisations that are under development. The high standards of the activity of our Research Units is made clear in this publication. When we consider the characteristics of their human resources, their publications, the projects funded by national and international agencies, the national and international recognition of their researchers, the networks with which they are engaged, and the scientific events they promote it becomes clear how well positioned in the national and international context our Research Units are. This publication gives a general overview of research in UMinho along the year of 2018. It is the first of a series providing detailed information about the research work of the University. Research at UMinho is governed by a permanent concern with providing feedback to the scientific community and to our fellow citizens as most of our funding is from public sources. Together with the adoption of external evaluation procedures, providing feedback is one of the best ways to establish the relevance of science undertaken for the public good, and for guaranteeing the scientific independence of our researchers and their Research Units. Nowadays, science is essential for fostering social and economic development. Through this publication we reveal the relevant role that UMinho is playing in this enterprise. Rui Vieira de Castro Rector
Book Synopsis Antimicrobial Peptides by : Katsumi Matsuzaki
Download or read book Antimicrobial Peptides written by Katsumi Matsuzaki and published by Springer. This book was released on 2019-04-12 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents an overview of antimicrobial peptides (AMPs), their mechanisms of antimicrobial action, other activities, and various problems that must still be overcome regarding their clinical application. Divided into four major parts, the book begins with a general overview of AMPs (Part I), and subsequently discusses the various mechanisms of antimicrobial action and methods for researching them (Part 2). It then addresses a range of activities other than antimicrobial action, such as cell penetration, antisepsis, anticancer, and immunomodulatory activities (Part 3), and explores the prospects of clinical application from various standpoints such as the selective toxicity, design, and discovery of AMPs (Part 4). A huge number of AMPs have been discovered in plants, insects, and vertebrates including humans, and constitute host defense systems against invading pathogenic microorganisms. Consequently, many attempts have been made to utilize AMPs as antibiotics. AMPs could help to solve the urgent problem of drug-resistant bacteria, and are also promising with regard to sepsis and cancer therapy. Gathering a wealth of information, this book will be a bible for all those seeking to develop antibiotics, anti-sepsis, or anticancer agents based on AMPs.
Book Synopsis Infectious Diseases and Your Health by : Prati Pal Singh
Download or read book Infectious Diseases and Your Health written by Prati Pal Singh and published by Springer. This book was released on 2018-11-27 with total page 424 pages. Available in PDF, EPUB and Kindle. Book excerpt: Infectious Diseases and Your Health has the potential to impact and improve your life, and the lives of your loved ones. Every day, nearly 40, 000 people including small children and women die of infectious diseases. Many of these innocent lives could be saved. Your journey through the pages of this book will take you to an amazing world of infectious diseases. You will learn about various infectious diseases, how they can affect your life, the problems associated with their treatment and prevention, and how to overcome these problems. Additionally, you will hear the success story of new drug research, be introduced to the hard facts, and find fascinating pictures of microorganisms and parasites. The book provides instant solutions to several of your concerns about infectious diseases, and you will learn to live a highly productive, long and healthy life. So, join thousands of readers of this book worldwide, enhance your life and the lives of your loving family, become an informed healthy citizen, and contribute to achieving the UN’s Sustainable Development Goals. Let us never forget: life and quality of life are very precious.
Book Synopsis Immunology of Infectious Diseases by : Stefan H. E. Kaufmann
Download or read book Immunology of Infectious Diseases written by Stefan H. E. Kaufmann and published by . This book was released on 2002 with total page 532 pages. Available in PDF, EPUB and Kindle. Book excerpt: Resumen: Offers an integrated view of principal aspects of immune response to all types of infectious agents. Deals with the immune system primarily as a host defense system. Various infectious agents and diseases are integrated under general topics rather than treated in separate chapters.
Book Synopsis Metabolic Interaction in Infection by : Ricardo Silvestre
Download or read book Metabolic Interaction in Infection written by Ricardo Silvestre and published by Springer. This book was released on 2018-04-06 with total page 478 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on host–pathogen interactions at the metabolic level. It explores the metabolic requirements of the infectious agents, the microbial metabolic pathways that are dedicated to circumvent host immune mechanisms as well as the molecular mechanisms by which pathogens hijack host cell metabolism for their own benefit. Finally, it provides insights on the possible clinical and immunotherapeutic applications, as well as on the available experimental and analytical methods. The contributions break new ground in understanding the metabolic crosstalk between host and pathogen.
Book Synopsis Targeted Drug Delivery : Concepts and Design by : Padma V. Devarajan
Download or read book Targeted Drug Delivery : Concepts and Design written by Padma V. Devarajan and published by Springer. This book was released on 2014-12-08 with total page 788 pages. Available in PDF, EPUB and Kindle. Book excerpt: This authoritative volume explores the fundamental concepts and numerous applications of targeted delivery of drugs to the body. This compilation has been divided into eight sections comprised of the basic principles of drug targeting, disease and organ/organelle-based targeting, passive and active targeting strategies, and various advanced drug delivery tools such as functionalized lipidic, polymeric and inorganic nanocarriers. Together, the twenty-three chapters cover a wide range of topics in the field, including tumor and hepatic targeting, polymer-drug conjugates, nanoemulsion, physical and biophysical characteristics of nanoparticles, and in vivo imaging techniques, among others. The book also examines advanced characterization techniques, regulatory hurdles and toxicity-related issues that are key features for successful commercialization of targeted drug delivery system products. Targeted Drug Delivery is a comprehensive reference guide for drug delivery researchers, both beginners and those already working in the field.
Book Synopsis Pharmacology and Applications of Naturally Occurring Iridoids by : Biswanath Dinda
Download or read book Pharmacology and Applications of Naturally Occurring Iridoids written by Biswanath Dinda and published by Springer. This book was released on 2019-03-26 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this book, the author provides expert analysis on naturally occurring iridoids, their chemistry and their distribution in plants and insects. Particular attention is given to the pharmacology of iridoids and their prospective applications in pharmaceutical and agricultural industries. Iridoids are found in a wide variety of plants and some insects, and they are structurally derived from monoterpenoid natural products. In the first two chapters of this book, the author describes the iridoids classification, occurrence and distribution in plants and insects. The following chapters cover different chromatographic and spectroscopic techniques that can be used to identify and quantify iridoids in herbal formulations, and also the biosynthesis of iridoids, in which the reader will discover a metabolomics and transcriptomics analysis to identify the genes involved in the biosynthesis. The final chapters provide insights on several pharmacological activities of iridoids, their physiological role in insects, pharmacokinetics in mammals, insects and microorganisms, and their applications in medicine and agriculture. This book will engage students and researchers interested in the chemistry of natural products, and it will also appeal to medicinal chemists and practitioners working in the design of new herbal drugs with bioactive pure iridoids.
Book Synopsis Stiehm's Immune Deficiencies by : Kathleen E. Sullivan
Download or read book Stiehm's Immune Deficiencies written by Kathleen E. Sullivan and published by Academic Press. This book was released on 2020-05-23 with total page 1334 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stiehm's Immune Deficiencies: Inborn Errors in Immunity, Second Edition, is ideal for physicians and other caregivers who specialize in immunology, allergies, infectious diseases and pulmonary medicine. It provides a validated source of information for care delivery to patients, covering approaches to diagnosis that use both new genetic information and emphasize screening strategies. Management has changed dramatically over the past five years, so approaches to infection and autoimmunity are emphasized in an effort to improve outcomes and disseminate new information on the uses of targeted therapy. - Covers immune deficiencies that are presented in a practical way, providing helpful information for active clinicians - Fills an increasingly deep gap in the information available to clinicians - Presents both clinical management and scientific advances for immune deficiencies - Provides a primary resource for physicians in the field of immunodeficiencies - Includes website access to a range of videos relevant to the topics discussed
Book Synopsis Concise Pathology for Exam Preparation_4e-E-book by : Geetika Khanna
Download or read book Concise Pathology for Exam Preparation_4e-E-book written by Geetika Khanna and published by Elsevier Health Sciences. This book was released on 2020-11-12 with total page 649 pages. Available in PDF, EPUB and Kindle. Book excerpt: The fourth edition of this book has been thoroughly updated and revised in accordance with the competency-based curriculum of Pathology. It has been structured in question-answer format that incorporates information in a concise manner with bulleted points for rapid review and easy recapitulation. This is an endeavour to make understanding of Pathology easier so as to facilitate learning by students and help them apply their knowledge to the problems they encounter in their clinical practice later in life. This edition is based on Robbins & Cotran, Pathologic Basis of Disease, 10th edition.• Covers questions that are commonly/frequently asked in major universities.• Covers all "must know topics in a very simple language and easily comprehensible style.• Organized in small paragraphs and bulleted points to help in rapid revision before examination.• Tabulation of contrasting features of morphologically similar conditions for further clarification of concepts.• Text enriched with flowcharts explaining mechanism of evolution of disease.• Special emphasis has been laid on clinical presentation (symptoms and signs) and understanding the evolution of disease.• Prioritization of laboratory investigations has been stressed upon in order to provide an integrated approach to the study of pathology and to strengthen the clinical decision-making ability.
Book Synopsis Mass Spectrometry-Based Lipidomics by : Fong-Fu Hsu
Download or read book Mass Spectrometry-Based Lipidomics written by Fong-Fu Hsu and published by Humana. This book was released on 2021-05-29 with total page 314 pages. Available in PDF, EPUB and Kindle. Book excerpt: This detailed volume covers conventional MS-based “shotgun lipidomics” by which samples are introduced by infusion or loop injection, as well as LC-MS-based lipidomics, which are becoming increasingly important due to the ever-increasing demand for a complete and precise lipid analysis of the complex and diversified lipids in nature. The volume features protocols applying chemical reactions, the on-line photochemical reactions combined with various MS methods for comprehensive characterization of various lipid classes, and quantification of specific and rare lipids. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Mass Spectrometry-Based Lipidomics: Methods and Protocols serves as an invaluable guide for biochemists and mass spectroscopists who are interested in lipid studies.
Book Synopsis Therapeutic and Nutritional Uses of Algae by : Leonel Pereira
Download or read book Therapeutic and Nutritional Uses of Algae written by Leonel Pereira and published by CRC Press. This book was released on 2018-01-29 with total page 862 pages. Available in PDF, EPUB and Kindle. Book excerpt: Algae have been used since ancient times as food, fodder, fertilizer and as source of medicine. Nowadays seaweeds represent an unlimited source of the raw materials used in pharmaceutical, food industries, medicine and cosmetics. They are nutritionally valuable as fresh or dried vegetables, or as ingredients in a wide variety of prepared foods. In particular, seaweeds contain significant quantities of protein, lipids, minerals and vitamins. There is limited information about the role of algae and algal metabolites in medicine. Only a few taxa have been studied for their use in medicine. Many traditional cultures report curative powers from selected alga, in particular tropical and subtropical marine forms. This is especially true in the maritime areas of Asia, where the sea plays a significant role in daily activities. Nonetheless, at present, only a few genera and species of algae are involved in aspects of medicine and therapy. Beneficial uses of algae or algal products include those that may mimic specific manifestations of human diseases, production of antibiotic compounds, or improvement of human nutrition in obstetrics, dental research, thallassotherapy, and forensic medicine.
Book Synopsis Kala Azar in South Asia by : T.K. Jha
Download or read book Kala Azar in South Asia written by T.K. Jha and published by Springer Science & Business Media. This book was released on 2011-01-05 with total page 149 pages. Available in PDF, EPUB and Kindle. Book excerpt: Therapeutic regimens for visceral leishmaniasis (also Kala-azar, Dum-dum fever or black fever), caused by parasitic protozoa of the Leishmania genus, evolve at a pace never seen before. Spread by tiny and abundant sand flies, the parasite infects internal organs and bone marrow and if left untreated will almost always result in the death of the host. In developing countries successful diagnosis and treatment are complicated by asymptomatic cases, undernutrition and Kala-azar/HIV co-infections. This book brings together world-renown experts writing state-of-arts review on the progress in diagnosis and treatment of visceral leishmaniasis, ultimately leading to the complete elimination of this fatal disease from South Asia. The chapters provide valuable information for disease control as well as therapy and the diagnostic improvements necessary for early treatment, subclinical detection and drug-resistant cases. The presented methods allow for points-of-care testing in the endemic area, enabling rapid detection in resource-poor settings with easy handling and low costs. This book provides essential information for scientists, medical practitioners and policy makers involved in the diagnosis, treatment and elimination of Kala-azar.
Book Synopsis Inhibitors of Protein Kinases and Protein Phosphates by : Denis Alexander
Download or read book Inhibitors of Protein Kinases and Protein Phosphates written by Denis Alexander and published by Handbook of Experimental Pharmacology. This book was released on 2004-10-04 with total page 476 pages. Available in PDF, EPUB and Kindle. Book excerpt: with contributions by numerous experts
Book Synopsis Biochemistry and Molecular Biology of Parasites by : Joseph Marr
Download or read book Biochemistry and Molecular Biology of Parasites written by Joseph Marr and published by Elsevier. This book was released on 1995-09-06 with total page 363 pages. Available in PDF, EPUB and Kindle. Book excerpt: The study of parasitic organisms at the molecular level has yielded fascinating new insights of great medical, social, and economical importance, and has pointed the way for the treatment and prevention of the diseases they cause. Biochemistry and Molecular Biology of Parasites presents an up-to-date account of this modern scientific discipline in a manner that allows and encourages the reader to place the biochemistry and molecular biology of these organisms in their biological context. The chapters are cross-referenced and grouped in an arrangement that provides a fully integrated whole, and permits the reader to create a composite of the biochemical function of these organisms.Individual chapter includes those devoted to metabolism, in both aerobic and anaerobic protozoa; antioxidant mechanisms; parasite surfaces; organelles; invasion mechanisms; and chemotherapy. The helminths are discussed not only from the point of view of their cellular biochemistry and metabolism, but also with respect to both their integrated functions such as neurochemistry, structure and functions of surfaces, and reproduction. Written by expert investigators, this book will be of interest to all experienced researchers, graduate students, and to the newcomer eager to become familiar with the biochemistry and molecular biology of parasites.
Book Synopsis Antimicrobial Drug Resistance by : Douglas L. Mayers
Download or read book Antimicrobial Drug Resistance written by Douglas L. Mayers and published by Springer. This book was released on 2017-07-07 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The two volumes included in Antimicrobial Drug Resistance, Second Edition is an updated, comprehensive and multidisciplinary reference covering the area of antimicrobial drug resistance in bacteria, fungi, viruses, and parasites from basic science, clinical, and epidemiological perspectives. This newly revised compendium reviews the most current research and development on drug resistance while still providing the information in the accessible format of the first edition. The first volume, Antimicrobial Drug Resistance: Mechanisms of Drug Resistance, is dedicated to the biological basis of drug resistance and effective avenues for drug development. With the emergence of more drug-resistant organisms, the approach to dealing with the drug resistance problem must include the research of different aspects of the mechanisms of bacterial resistance and the dissemination of resistance genes as well as research utilizing new genomic information. These approaches will permit the design of novel strategies to develop new antibiotics and preserve the effectiveness of those currently available. The second volume, Antimicrobial Drug Resistance: Clinical and Epidemiological Aspects, is devoted to the clinical aspects of drug resistance. Although there is evidence that restricted use of a specific antibiotic can be followed by a decrease in drug resistance to that agent, drug resistance control is not easily achieved. Thus, the infectious diseases physician requires input from the clinical microbiologist, antimicrobial stewardship personnel, and infection control specialist to make informed choices for the effective management of various strains of drug-resistant pathogens in individual patients. This 2-volume set is an important reference for students in microbiology, infectious diseases physicians, medical students, basic scientists, drug development researchers, microbiologists, epidemiologists, and public health practitioners.
Book Synopsis Principles and Practice of Clinical Parasitology by : Stephen Gillespie
Download or read book Principles and Practice of Clinical Parasitology written by Stephen Gillespie and published by John Wiley & Sons. This book was released on 2003-01-24 with total page 680 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive account of protozoan and metozoan diseases in modern clinical practice, with orientation towards clinical management of parasitic infections. In the past, parasitology was considered as an obscure subject of little relevance to the majority of clinicians and microbiologists. Over the last decade, however, much has happened to change this, not least the explosion in foreign travel This textbook is the forth in the Principles and Practice series, providing an expansive and detailed coverage of clinical microbiology. It has a similar appeal to that of Zuckerman's, Principles & Practice of Clinical Virology, with an international authorship and emphasis placed on integrating new knowledge in a clinically relevant manner. . An essential, up-to-date sourcebook on the fundamentals of human parasitology . Provides a global approach with renowned and international authorship . Completes the quartet of Principles and Practice series in Microbiology
