The Role Of Chromenes In Drug Discovery And Development

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The Role of Chromenes in Drug Discovery and Development

Author : Ashutosh Kumar Dash
Publisher : Bentham Science Publishers
ISBN 13 : 981512434X
Total Pages : 302 pages
Book Rating : 4.8/5 (151 download)

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Book Synopsis The Role of Chromenes in Drug Discovery and Development by : Ashutosh Kumar Dash

Download or read book The Role of Chromenes in Drug Discovery and Development written by Ashutosh Kumar Dash and published by Bentham Science Publishers. This book was released on 2023-08-08 with total page 302 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chromene is a naturally abundant heterocyclic compound found in alkaloids, tocopherols, terpenes and other compounds. Its derivatives can be used as a scaffold that exhibits pharmacological activity in the human body. Chromene drugs and related bioactive molecules are the prime focus of this reference. It presents 13 thoroughly researched chapters that comprehensively cover all aspects about the molecule. Starting with a detailed introduction to its role and importance in drug discovery, the book goes into the details of chromene structure, synthesis and pharmacology. Readers can gain knowledge of different commercial medicines based on chromene and its pharmacological activity against different diseases. The elaborate topics in the book will help researchers working on chromene based drugs. Key highlights of the book include: - Complete coverage of chromene’s role in nature and drug development with references to historical background and current developments - References to commercial and preclinical drugs and patents of interest - Explanation of chromene bioacivity in different diseases (antioxidant, antidiabetic, antinflammatory, antibacterial and antifungal activities, antitumour, immunomodulatory activity) - Explanation of chromene activity against SARS-Cov2

Anti-Angiogenesis Drug Discovery and Development: Volume 5

Author : Atta-ur-Rahman
Publisher : Bentham Science Publishers
ISBN 13 : 9811432864
Total Pages : 212 pages
Book Rating : 4.8/5 (114 download)

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Book Synopsis Anti-Angiogenesis Drug Discovery and Development: Volume 5 by : Atta-ur-Rahman

Download or read book Anti-Angiogenesis Drug Discovery and Development: Volume 5 written by Atta-ur-Rahman and published by Bentham Science Publishers. This book was released on 2020-10-05 with total page 212 pages. Available in PDF, EPUB and Kindle. Book excerpt: The inhibition of angiogenesis is an effective mechanism of slowing down tumor growth and malignancies. The process of induction or pro-angiogenesis is highly desirable for the treatment of cardiovascular diseases, and wound healing disorders. Efforts to understand the molecular basis, both for inhibition and induction, have yielded fascinating results. Anti-angiogenesis Drug Discovery and Development provides an excellent compilation of well-written reviews on various aspects of the anti-angiogenesis process. These reviews have been contributed by leading practitioners in drug discovery science and highlight the major developments in this exciting field in the last two decades. The feast of these reader-friendly reviews on topics of great scientific importance – many of which are considered significant medical breakthroughs, makes this series excellent reading both for the novice as well as for expert medicinal chemists and clinicians. The fifth volume brings together reviews on the following topics: - Targeted therapy for tumor vasculature - Anti-angiogenic therapy for breast and prostate cancers (including information updates on clinical trials) - Microbe-based and other novel antiangiogenesis therapies such as chromene-based agents

Medicinal and Pharmaceutical Chemistry Editor’s Pick 2021

Author : Michael Kassiou
Publisher : Frontiers Media SA
ISBN 13 : 2889667952
Total Pages : 290 pages
Book Rating : 4.8/5 (896 download)

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Book Synopsis Medicinal and Pharmaceutical Chemistry Editor’s Pick 2021 by : Michael Kassiou

Download or read book Medicinal and Pharmaceutical Chemistry Editor’s Pick 2021 written by Michael Kassiou and published by Frontiers Media SA. This book was released on 2021-05-21 with total page 290 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Flow Cytometry in Drug Discovery and Development

Author : Virginia Litwin
Publisher : John Wiley & Sons
ISBN 13 : 0470922788
Total Pages : 404 pages
Book Rating : 4.4/5 (79 download)

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Book Synopsis Flow Cytometry in Drug Discovery and Development by : Virginia Litwin

Download or read book Flow Cytometry in Drug Discovery and Development written by Virginia Litwin and published by John Wiley & Sons. This book was released on 2011-04-20 with total page 404 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers the unique application of flow cytometry in drug discovery and development. The first section includes two introductory chapters, one on flow cytometry and one on biomarkers, as well as a chapter on recent advances in flow cytometry. The second section focuses on the unique challenges and added benefits associated with the use of flow cytometry in the drug development process. The third section contains a single chapter presenting an in depth discussion of validation considerations and regulatory compliance issues associated with drug development.

3D QSAR in Drug Design

Author : Hugo Kubinyi
Publisher : Springer Science & Business Media
ISBN 13 : 0306468573
Total Pages : 413 pages
Book Rating : 4.3/5 (64 download)

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Book Synopsis 3D QSAR in Drug Design by : Hugo Kubinyi

Download or read book 3D QSAR in Drug Design written by Hugo Kubinyi and published by Springer Science & Business Media. This book was released on 2006-04-11 with total page 413 pages. Available in PDF, EPUB and Kindle. Book excerpt: Significant progress has been made in the study of three-dimensional quantitative structure-activity relationships (3D QSAR) since the first publication by Richard Cramer in 1988 and the first volume in the series. 3D QSAR in Drug Design. Theory, Methods and Applications, published in 1993. The aim of that early book was to contribute to the understanding and the further application of CoMFA and related approaches and to facilitate the appropriate use of these methods. Since then, hundreds of papers have appeared using the quickly developing techniques of both 3D QSAR and computational sciences to study a broad variety of biological problems. Again the editor(s) felt that the time had come to solicit reviews on published and new viewpoints to document the state of the art of 3D QSAR in its broadest definition and to provide visions of where new techniques will emerge or new appli- tions may be found. The intention is not only to highlight new ideas but also to show the shortcomings, inaccuracies, and abuses of the methods. We hope this book will enable others to separate trivial from visionary approaches and me-too methodology from in- vative techniques. These concerns guided our choice of contributors. To our delight, our call for papers elicited a great many manuscripts.

Metal and Nonmetal Assisted Synthesis of Six-Membered Heterocycles

Author : Navjeet Kaur
Publisher : Elsevier
ISBN 13 : 0128202831
Total Pages : 526 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis Metal and Nonmetal Assisted Synthesis of Six-Membered Heterocycles by : Navjeet Kaur

Download or read book Metal and Nonmetal Assisted Synthesis of Six-Membered Heterocycles written by Navjeet Kaur and published by Elsevier. This book was released on 2020-04-25 with total page 526 pages. Available in PDF, EPUB and Kindle. Book excerpt: Metal and Nonmetal Assisted Synthesis of Six-Membered Heterocycles provides a useful guide to key approaches being explored in this area. The volume highlights synthetic approaches and catalytic options that facilitate the construction of multiple substituted molecules under mild conditions from easily available starting substrates. Drawing on the experience of its expert author, the book is a useful guide on the key approaches being explored in this area. Following a user-friendly structure based on specific six-membered heterocycle ring groups, this volume highlights synthetic approaches and catalytic options that facilitate the construction of multiple substituted molecules under mild conditions from easily available starting substrates. Highlights new methodologies for the synthesis of different six-membered heterocycles Provides an up-to-date overview of this fast-moving field with an easy-to-use structure Includes novel approaches used in the study and application of catalysts in synthetic organic reactions

Burger's Medicinal Chemistry, Drug Discovery and Development, 8 Volume Set

Author :
Publisher : John Wiley & Sons
ISBN 13 : 111953030X
Total Pages : 6057 pages
Book Rating : 4.1/5 (195 download)

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Book Synopsis Burger's Medicinal Chemistry, Drug Discovery and Development, 8 Volume Set by :

Download or read book Burger's Medicinal Chemistry, Drug Discovery and Development, 8 Volume Set written by and published by John Wiley & Sons. This book was released on 2021-04-20 with total page 6057 pages. Available in PDF, EPUB and Kindle. Book excerpt: Burger’s Medicinal Chemistry, Drug Discovery and Development Explore the freshly updated flagship reference for medicinal chemists and pharmaceutical professionals The newly revised eighth edition of the eight-volume Burger’s Medicinal Chemistry, Drug Discovery and Development is the latest installment in this celebrated series covering the entirety of the drug development and discovery process. With the addition of expert editors in each subject area, this eight-volume set adds 35 chapters to the extensive existing chapters. New additions include analyses of opioid addiction treatments, antibody and gene therapy for cancer, blood-brain barrier, HIV treatments, and industrial-academic collaboration structures. Along with the incorporation of practical material on drug hunting, the set features sections on drug discovery, drug development, cardiovascular diseases, metabolic diseases, immunology, cancer, anti-Infectives, and CNS disorders. The text continues the legacy of previous volumes in the series by providing recognized, renowned, authoritative, and comprehensive information in the area of drug discovery and development while adding cutting-edge new material on issues like the use of artificial intelligence in medicinal chemistry. Included: Volume 1: Methods in Drug Discovery, edited by Kent D. Stewart Volume 2: Discovering Lead Molecules, edited by Kent D. Stewart Volume 3: Drug Development, edited by Ramnarayan S. Randad and Michael Myers Volume 4: Cardiovascular, Endocrine, and Metabolic Diseases, edited by Scott D. Edmondson Volume 5: Pulmonary, Bone, Immunology, Vitamins, and Autocoid Therapeutic Agents, edited by Bryan H. Norman Volume 6: Cancer, edited by Barry Gold and Donna M. Huryn Volume 7: Anti-Infectives, edited by Roland E. Dolle Volume 8: CNS Disorders, edited by Richard A. Glennon Perfect for research departments in the pharmaceutical and biotechnology industries, Burger’s Medicinal Chemistry, Drug Discovery and Development can be used by graduate students seeking a one-stop reference for drug development and discovery and deserves its place in the libraries of biomedical research institutes, medical, pharmaceutical, and veterinary schools.

Privileged Structures in Drug Discovery

Author : Larry Yet
Publisher : John Wiley & Sons
ISBN 13 : 1118686357
Total Pages : 562 pages
Book Rating : 4.1/5 (186 download)

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Book Synopsis Privileged Structures in Drug Discovery by : Larry Yet

Download or read book Privileged Structures in Drug Discovery written by Larry Yet and published by John Wiley & Sons. This book was released on 2018-03-07 with total page 562 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive guide to privileged structures and their application in the discovery of new drugs The use of privileged structures is a viable strategy in the discovery of new medicines at the lead optimization stages of the drug discovery process. Privileged Structures in Drug Discovery offers a comprehensive text that reviews privileged structures from the point of view of medicinal chemistry and contains the synthetic routes to these structures. In this text, the author—a noted expert in the field—includes an historical perspective on the topic, presents a practical compendium to privileged structures, and offers an informed perspective on the future direction for the field. The book describes the up-to-date and state-of-the-art methods of organic synthesis that describe the use of privileged structures that are of most interest. Chapters included information on benzodiazepines, 1,4-dihydropyridines, biaryls, 4-(hetero)arylpiperidines, spiropiperidines, 2-aminopyrimidines, 2-aminothiazoles, 2-(hetero)arylindoles, tetrahydroisoquinolines, 2,2-dimethylbenzopyrans, hydroxamates, and bicyclic pyridines containing ring-junction nitrogen as privileged scaffolds in medicinal chemistry. Numerous, illustrative case studies document the current use of the privileged structures in the discovery of drugs. This important volume: Describes the drug compounds that have successfully made it to the marketplace and the chemistry associated with them Offers the experience from an author who has worked in many therapeutic areas of medicinal chemistry Details many of the recent developments in organic chemistry that prepare target molecules Includes a wealth of medicinal chemistry case studies that clearly illustrate the use of privileged structures Designed for use by industrial medicinal chemists and process chemists, academic organic and medicinal chemists, as well as chemistry students and faculty, Privileged Structures in Drug Discovery offers a current guide to organic synthesis methods to access the privileged structures of interest, and contains medicinal chemistry case studies that document their application.

Real World Drug Discovery

Author : Robert M. Rydzewski
Publisher : Elsevier
ISBN 13 : 0080914888
Total Pages : 535 pages
Book Rating : 4.0/5 (89 download)

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Book Synopsis Real World Drug Discovery by : Robert M. Rydzewski

Download or read book Real World Drug Discovery written by Robert M. Rydzewski and published by Elsevier. This book was released on 2010-07-07 with total page 535 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug discovery increasingly requires a common understanding by researchers of the many and diverse factors that go into the making of new medicines. The scientist entering the field will immediately face important issues for which his education may not have prepared him: project teams, patent law, consultants, target product profiles, industry trends, Gantt charts, target validation, pharmacokinetics, proteomics, phenotype assays, biomarkers, and many other unfamiliar topics for which a basic understanding must somehow be obtained. Even the more experienced scientist can find it frustratingly difficult to get an overview of the many factors involved in modern drug discovery and often only after years of exploring does a whole and integrated picture emerge in the mind of the researcher.Real World Drug Discovery: A Chemist’s Guide to Biotech and Pharmaceutical Research presents this kind of map of the landscape of drug discovery. In a single, readable volume it outlines processes and explains essential concepts and terms for the recent science graduate wondering what to expect in pharma or biotech, the medicinal chemist seeking a broader and more timely understanding of the industry, or the contractor or collaborator whose understanding of the commercial drug discovery process could increase the value of his contribution to it. Interviews with well-known experts in many of the fields involved, giving insightful comments from authorities on many of the sub-disciplines important to cutting edge drug discovery. Helpful suggestions gleaned from years of experience in biotech and pharma, which represents a repository drug discovery "lore" not previously available in any book. "Periodic Table of Drugs" listing current top-selling drugs arranged by target and laid out so that structural similarities and differences are plain and clear. Extensive use of diagrams to illustrate concepts like biotech startup models, preteomic profiling for target identification, Gantt charts for project planning, etc.

Plant-derived Bioactives

Author : Mallappa Kumara Swamy
Publisher : Springer Nature
ISBN 13 : 9811523614
Total Pages : 592 pages
Book Rating : 4.8/5 (115 download)

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Book Synopsis Plant-derived Bioactives by : Mallappa Kumara Swamy

Download or read book Plant-derived Bioactives written by Mallappa Kumara Swamy and published by Springer Nature. This book was released on 2020-06-27 with total page 592 pages. Available in PDF, EPUB and Kindle. Book excerpt: Plants produce a vast number of bioactive compounds with different chemical scaffolds, which modulate a diverse range of molecular targets and are used as drugs for treating numerous diseases. Most present-day medicines are derived either from plant compounds or their derivatives, and plant compounds continue to offer limitless reserves for the discovery of new medicines. While different classes of plant compounds, like phenolics, flavonoids, saponins and alkaloids, and their potential pharmacological applications are currently being explored, their curative mechanisms are yet to be understood in detail. This book is divided into 2 volumes and offers detailed information on plant-derived bioactive compounds, including recent research findings. Volume 1, “Plant-derived Bioactives: Chemistry and Mode of Action” discusses the chemistry of highly valued plant bioactive compounds and their mode of actions at the molecular level. Volume 2, “Plant-derived Bioactives: Production, Properties and Therapeutic Applications” explores the sources, biosynthesis, production, biological properties and therapeutic applications of plant bioactives. Given their scope, these books are valuable resources for members of the scientific community wishing to further explore various medicinal plants and the therapeutic applications of their bioactive compounds. They appeal to scholars, teachers and scientists involved in plant product research, and facilitate the development of new drugs.

New Approaches Against Drug-Resistant M. tuberculosis

Author : Maria Rosalia Pasca
Publisher : Frontiers Media SA
ISBN 13 : 288966869X
Total Pages : 153 pages
Book Rating : 4.8/5 (896 download)

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Book Synopsis New Approaches Against Drug-Resistant M. tuberculosis by : Maria Rosalia Pasca

Download or read book New Approaches Against Drug-Resistant M. tuberculosis written by Maria Rosalia Pasca and published by Frontiers Media SA. This book was released on 2021-06-09 with total page 153 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Plant Bioactives and Drug Discovery

Author : Valdir Cechinel-Filho
Publisher : John Wiley & Sons
ISBN 13 : 047058226X
Total Pages : 600 pages
Book Rating : 4.4/5 (75 download)

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Book Synopsis Plant Bioactives and Drug Discovery by : Valdir Cechinel-Filho

Download or read book Plant Bioactives and Drug Discovery written by Valdir Cechinel-Filho and published by John Wiley & Sons. This book was released on 2012-05-22 with total page 600 pages. Available in PDF, EPUB and Kindle. Book excerpt: An in-depth exploration of the applications of plant bioactive metabolites in drug research and development Highlighting the complexity and applications of plant bioactive metabolites in organic and medicinal chemistry, Plant Bioactives and Drug Discovery: Principles, Practice, and Perspectives provides an in-depth overview of the ways in which plants can inform drug research and development. An edited volume featuring multidisciplinary international contributions from acclaimed scientists researching bioactive natural products, the book provides an incisive overview of one of the most important topics in pharmaceutical studies today. With coverage of strategic methods of natural compound isolation, structural manipulation, natural products in clinical trials, quality control, and more, and featuring case studies on medicinal plants, the book serves as a definitive guide to the field of plant biodiversity as it relates to medicine. In addition, chapters on using natural products as drugs that target specific disease areas, including neurological disorders, inflammation, infectious diseases, and cancer, illustrate the myriad possibilities for therapeutic applications. Wide ranging and comprehensive, Plant Bioactives and Drug Discovery also includes important information on marketing, regulations, intellectual property rights, and academic-industry collaboration as they relate to plant-based drug research, making it an essential resource for advanced students and academic and industry professionals working in biochemical, pharmaceutical, and related fields.

Medicinal Chemistry of Anticancer Drugs

Author : Carmen Avendaño
Publisher : Elsevier
ISBN 13 : 0444626670
Total Pages : 767 pages
Book Rating : 4.4/5 (446 download)

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Book Synopsis Medicinal Chemistry of Anticancer Drugs by : Carmen Avendaño

Download or read book Medicinal Chemistry of Anticancer Drugs written by Carmen Avendaño and published by Elsevier. This book was released on 2015-06-11 with total page 767 pages. Available in PDF, EPUB and Kindle. Book excerpt: Medicinal Chemistry of Anticancer Drugs, Second Edition, provides an updated treatment from the point of view of medicinal chemistry and drug design, focusing on the mechanism of action of antitumor drugs from the molecular level, and on the relationship between chemical structure and chemical and biochemical reactivity of antitumor agents. Antitumor chemotherapy is a very active field of research, and a huge amount of information on the topic is generated every year. Cytotoxic chemotherapy is gradually being supplemented by a new generation of drugs that recognize specific targets on the surface or inside cancer cells, and resistance to antitumor drugs continues to be investigated. While these therapies are in their infancy, they hold promise of more effective therapies with fewer side effects. Although many books are available that deal with clinical aspects of cancer chemotherapy, this book provides a sorely needed update from the point of view of medicinal chemistry and drug design. Presents information in a clear and concise way using a large number of figures Historical background provides insights on how the process of drug discovery in the anticancer field has evolved Extensive references to primary literature

Diversity Oriented Synthesis

Author : Andrea Basso
Publisher : Frontiers Media SA
ISBN 13 : 2889457885
Total Pages : 150 pages
Book Rating : 4.8/5 (894 download)

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Book Synopsis Diversity Oriented Synthesis by : Andrea Basso

Download or read book Diversity Oriented Synthesis written by Andrea Basso and published by Frontiers Media SA. This book was released on 2019-03-22 with total page 150 pages. Available in PDF, EPUB and Kindle. Book excerpt: Has the concept of Diversity Oriented Synthesis remained unchanged over these two decades, or do we observe improvements or deviations from the original guidelines drawn by the pioneers? The aim of this Research Topic is to collect contributions on the state-of-the-art and progress of Diversity Oriented Synthesis, and to foresee its shape in the next decade.

Molecular Interaction Fields

Author : Gabriele Cruciani
Publisher : John Wiley & Sons
ISBN 13 : 3527607137
Total Pages : 328 pages
Book Rating : 4.5/5 (276 download)

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Book Synopsis Molecular Interaction Fields by : Gabriele Cruciani

Download or read book Molecular Interaction Fields written by Gabriele Cruciani and published by John Wiley & Sons. This book was released on 2006-05-12 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: This unique reference source, edited by the world's most respected expert on molecular interaction field software, covers all relevant principles of the GRID force field and its applications in medicinal chemistry. Entire chapters on 3D-QSAR, pharmacophore searches, docking studies, metabolism predictions and protein selectivity studies, among others, offer a concise overview of this emerging field. As an added bonus, this handbook includes a CD-ROM with the latest commercial versions of the GRID program and related software.

Advances in Bioinformatics

Author : Vijai Singh
Publisher : Springer Nature
ISBN 13 : 9813361913
Total Pages : 446 pages
Book Rating : 4.8/5 (133 download)

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Book Synopsis Advances in Bioinformatics by : Vijai Singh

Download or read book Advances in Bioinformatics written by Vijai Singh and published by Springer Nature. This book was released on 2021-07-31 with total page 446 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents the latest developments in bioinformatics, highlighting the importance of bioinformatics in genomics, transcriptomics, metabolism and cheminformatics analysis, as well as in drug discovery and development. It covers tools, data mining and analysis, protein analysis, computational vaccine, and drug design. Covering cheminformatics, computational evolutionary biology and the role of next-generation sequencing and neural network analysis, it also discusses the use of bioinformatics tools in the development of precision medicine. This book offers a valuable source of information for not only beginners in bioinformatics, but also for students, researchers, scientists, clinicians, practitioners, policymakers, and stakeholders who are interested in harnessing the potential of bioinformatics in many areas.

Natural Products as Source of Molecules with Therapeutic Potential

Author : Valdir Cechinel Filho
Publisher : Springer
ISBN 13 : 3030005453
Total Pages : 531 pages
Book Rating : 4.0/5 (3 download)

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Book Synopsis Natural Products as Source of Molecules with Therapeutic Potential by : Valdir Cechinel Filho

Download or read book Natural Products as Source of Molecules with Therapeutic Potential written by Valdir Cechinel Filho and published by Springer. This book was released on 2018-12-07 with total page 531 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book addresses the highly relevant and complex subject of research on drugs from natural products, discussing the current hot topics in the field. It also provides a detailed overview of the strategies used to research and develop these drugs. Respected experts explore issues involved in the production chain and when looking for new medicinal agents, including aspects such as therapeutic potential, functional foods, ethnopharmacology, metabolomics, virtual screening and regulatory scenarios. Further, the book describes strategic methods of isolation and characterization of active principles, biological assays, biotechnology of plants, synthesis, clinical trials and the use of tools to identity active principles.