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The Rho Gtpases In Cancer
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Book Synopsis The Rho GTPases in Cancer by : Kenneth van Golen
Download or read book The Rho GTPases in Cancer written by Kenneth van Golen and published by Springer Science & Business Media. This book was released on 2009-12-04 with total page 219 pages. Available in PDF, EPUB and Kindle. Book excerpt: Channing Der and colleagues provide an encyclopedic overview of the Rho GTPases, providing enough detail to make any reader well-versed in the Rho field. Finally, Sofia Merajver’s laboratory provides an overview, which details the roles of the Rho proteins in cancer progression. She provides us with the history of the study of the Rho GTPases, their regulatory and effector proteins in cancer and gives us a benchmark of where the field is today. The second section of the book details the current knowledge of the Rho regu- tory proteins in cancer progression: aberrant expression and activation of these proteins leads to dysfunctional Rho signaling and a cancer phenotype. Gary Bokoch’s laboratory has provided a detailed overview of the role of Rho guanine dissociation inhibitors (GDIs) in cancer. These molecules are involved in preventing the Rho protein from associating with the inner plasma membrane and exchanging GDP for GTP, and thus becoming active. Next, Tozu Kazasa’s labo- tory has worked on the link between heterotrimeric G proteins and Rho activation via the RGS–RhoGEFs. This aspect of Rho activation is particularly interesting in that heterotrimeric G proteins and their associated G-protein-coupled receptors are attractive and attainable therapeutic targets. Dan Billadeau’s laboratory has worked extensively on the Vav RhoGEFs, which are potent oncogenes in their own right.
Book Synopsis The Rho Gtpases in Cancer by : Kenneth Van Golen
Download or read book The Rho Gtpases in Cancer written by Kenneth Van Golen and published by . This book was released on 2010-04-17 with total page 230 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Metastasis written by Ulrike S. Stein and published by Humana. This book was released on 2022-04-03 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides the most recent developments and methodologies on metastatic process, formation, and detection. Chapters guide readers through functional metastasis in vitro assays, non-mouse and mice metastasis models, methods for imaging metastasis, analyzing the tumor microenvironment, senescence and inflammation with respect to metastasis, methods to investgate the premetastatic/ metastatic, detecting biomarkers in patient, and bioinformatics to simulate the metastatic process. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Metastasis: Methods and Protocols aims to be a useful practical guide to researches to help further their study in this field.
Book Synopsis Rho Family GTPases by : Edward J. Manser
Download or read book Rho Family GTPases written by Edward J. Manser and published by Springer Science & Business Media. This book was released on 2006-03-30 with total page 307 pages. Available in PDF, EPUB and Kindle. Book excerpt: Humans contain more than 20 Rho type GTPases. This volume not only presents a detailed phylogenetic analysis of Rho proteins, but also discusses the possible origins of the human members. Such an analysis of human Rho GTPases has not previously been attempted. The book includes an overview of how Rho GTPases become activated which is complemented by an extensive Chapter by Darerca Owen and Helen Mott who unravel the beautiful molecular details given to us by the many structural studies of Rho GTPases. The key areas currently being investigated in relation to these ubiquitous proteins are described for both in vitro and in vivo systems. These are presented in a format that ensures the reader can approach the topic with minimal background knowledge, while ultimately bringing the subject to the level of an expert. Timely and highly authoritative, this volume illuminates newer findings, particularly as they relate to Rho proteins in vertebrate biology.
Download or read book Rho GTPases written by Marc H. Symons and published by Springer Science & Business Media. This book was released on 2004-05-31 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt: Members of the Rho family of small GTP-binding proteins (GTPases) are key signal transduction proteins that mediate signals initiated by growth factors, cytokines and cell adhesion proteins. Our knowledge about Rho GTPases has rapidly expanded over the past several years and Rho GTPases is the first book to provide a comprehensive overview of the regulation and functions of this important class of proteins. This book includes several chapters dedicated to the review of various classes of proteins that control the localization and activation state of Rho GTPases. Additional chapters discuss the wide range of biological functions that are controlled by Rho GTPases, including the organization of the actin cytoskeleton, cell proliferation and cell motility. Rho GTPases is essential reading for cell and molecular biologists, biochemists and geneticists. The critical roles of Rho family members in cancer and inflammatory diseases makes Rho GTPases also an invaluable guide for clinical investigators and pharmacologists.
Book Synopsis Schweißen mit magnetisch bewegtem Lichtbogen by :
Download or read book Schweißen mit magnetisch bewegtem Lichtbogen written by and published by . This book was released on 1980 with total page 116 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Rho Gtpases: Molecular Biology In Health And Disease by : Philippe Fort
Download or read book Rho Gtpases: Molecular Biology In Health And Disease written by Philippe Fort and published by World Scientific. This book was released on 2017-12-12 with total page 213 pages. Available in PDF, EPUB and Kindle. Book excerpt: Rho GTPases control many aspects of cell physiology. This includes polarity, endo/exocytosis, adhesion, motility, transcriptional activation, cell cycle progression or apoptosis. In view of such pleiotropic activities, Rho-controlled signaling has proven to be of medical relevance, especially in tumorigenesis, disease-associated bone remodeling and infectiology.This book is divided into three parts. Part 1 gives an evolutionary perspective of the Rho family, its atypical members, and an overview of how Rho activity is regulated. Part 2 addresses two important aspects of multicellularity controlled by Rho-dependent pathways, namely, cell-cell interactions and mechanotransduction. It also describes how post-translational modifications control Rho activity and how this is exploited by pathogenic bacteria. Part 3 explores several examples of the variety of pathophysiological processes controlled by Rho signaling, and gives a successful example of translational research, from the inhibition of Rho activation to the development of new molecules against osteoporosis.This updated review on the biology of Rho GTPases is an essential read for molecular and cell biologists. It is also an invaluable guide to post-graduate and medical students who wish to deepen their knowledge in cell biology.
Book Synopsis Assessment of the Activation of Rho Family GTP-Binding Proteins in Breast Cancer Cells and Specimens by :
Download or read book Assessment of the Activation of Rho Family GTP-Binding Proteins in Breast Cancer Cells and Specimens written by and published by . This book was released on 2001 with total page 112 pages. Available in PDF, EPUB and Kindle. Book excerpt: Rho GTPases have begun to be appreciated to play roles in breast carcinogenesis. To establish a causal link between activation of individual Rho signaling events and certain aspects of breast cancer development, we have started to search for direct effect on Rho GTPases in mitogenic conditions and in various physiological situations that may be connected to mammary cell transformation. As stated in this first annual report, we have established a method using the Rho GTPase-interactive effector domains of WASP, PAK1, and Rhotekin to quantitatively define the activation-states of Rho family members Cdc42, Rac, and Rho in cells, and applied this method to four cellular conditions which are related to mammary tumorigenesis. These studies are significant since the findings further confirmed the involvement of Rho GTPases in diverse physiological situations that may contribute to oncogenesis, and have paved the way for us to examine the endogenous Rho family GTPases in mitogen-stimulated or oncogene-transformed mammary cells and in breast cancer specimens. The results obtained also strengthened our working hypothesis that certain Rho GTPases are activated in breast cancer cells and tissues and that exploration of the role Rho proteins in breast may lead to novel anti-cancer therapeutics.
Book Synopsis Encyclopedia of Signaling Molecules by : Sangdun Choi
Download or read book Encyclopedia of Signaling Molecules written by Sangdun Choi and published by Springer. This book was released on 2017-12-15 with total page 6330 pages. Available in PDF, EPUB and Kindle. Book excerpt: The second edition of this encyclopedia presents over 400 biologically important signaling molecules and the content is built on the core concepts of their functions along with early findings written by some of the world’s foremost experts. The molecules are described by recognized leaders in each molecule. The interactions of these single molecules in signal transduction networks will also be explored. This encyclopedia marks a new era in overview of current cellular signaling molecules for the specialist and the interested non-specialist alike. Currently, there are more than 30,000 genes in human genome. However, not all the proteins encoded by these genes work equally in order to maintain homeostasis. Understanding the important signaling molecules as completely as possible will significantly improve our research-based teaching and scientific capabilities.
Book Synopsis The Heterogeneity of Cancer Metabolism by : Anne Le
Download or read book The Heterogeneity of Cancer Metabolism written by Anne Le and published by Springer. This book was released on 2018-06-26 with total page 186 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genetic alterations in cancer, in addition to being the fundamental drivers of tumorigenesis, can give rise to a variety of metabolic adaptations that allow cancer cells to survive and proliferate in diverse tumor microenvironments. This metabolic flexibility is different from normal cellular metabolic processes and leads to heterogeneity in cancer metabolism within the same cancer type or even within the same tumor. In this book, we delve into the complexity and diversity of cancer metabolism, and highlight how understanding the heterogeneity of cancer metabolism is fundamental to the development of effective metabolism-based therapeutic strategies. Deciphering how cancer cells utilize various nutrient resources will enable clinicians and researchers to pair specific chemotherapeutic agents with patients who are most likely to respond with positive outcomes, allowing for more cost-effective and personalized cancer therapeutic strategies.
Book Synopsis Extracellular Matrix Degradation by : William C. Parks
Download or read book Extracellular Matrix Degradation written by William C. Parks and published by Springer Science & Business Media. This book was released on 2011-04-07 with total page 262 pages. Available in PDF, EPUB and Kindle. Book excerpt: Regulated turnover of extracellular matrix (ECM) is an important component of tissue homeostasis. In recent years, the enzymes that participate in, and control ECM turnover have been the focus of research that touches on development, tissue remodeling, inflammation and disease. This volume in the Biology of Extracellular Matrix series provides a review of the known classes of proteases that degrade ECM both outside and inside the cell. The specific EMC proteases that are discussed include cathepsins, bacterial collagenases, matrix metalloproteinases, meprins, serine proteases, and elastases. The volume also discusses the domains responsible for specific biochemical characteristics of the proteases and the physical interactions that occur when the protease interacts with substrate. The topics covered in this volume provide an important context for understanding the role that matrix-degrading proteases play in normal tissue remodeling and in diseases such as cancer and lung disease.
Book Synopsis Handbook of Cell Signaling by : Ralph A. Bradshaw
Download or read book Handbook of Cell Signaling written by Ralph A. Bradshaw and published by Academic Press. This book was released on 2009-11-03 with total page 3188 pages. Available in PDF, EPUB and Kindle. Book excerpt: Handbook of Cell Signaling, Three-Volume Set, 2e, is a comprehensive work covering all aspects of intracellular signal processing, including extra/intracellular membrane receptors, signal transduction, gene expression/translation, and cellular/organotypic signal responses. The second edition is an up-to-date, expanded reference with each section edited by a recognized expert in the field. Tabular and well illustrated, the Handbook will serve as an in-depth reference for this complex and evolving field. Handbook of Cell Signaling, 2/e will appeal to a broad, cross-disciplinary audience interested in the structure, biochemistry, molecular biology and pathology of cellular effectors. - Contains over 350 chapters of comprehensive coverage on cell signaling - Includes discussion on topics from ligand/receptor interactions to organ/organism responses - Provides user-friendly, well-illustrated, reputable content by experts in the field
Book Synopsis THE THERAPEUTIC ROLE OF RHO GTPASES IN TUMORIGENESIS AND CHEMOTHEARPY-INDUCED PERIPHERAL NEUROPATHY. by : Yi Zhu
Download or read book THE THERAPEUTIC ROLE OF RHO GTPASES IN TUMORIGENESIS AND CHEMOTHEARPY-INDUCED PERIPHERAL NEUROPATHY. written by Yi Zhu and published by . This book was released on 2019 with total page 153 pages. Available in PDF, EPUB and Kindle. Book excerpt: With the advancement of chemotherapy drugs, the general life expectancy of cancer patients has drastically improved. However, persistent side effects, such as chemotherapy-induced peripheral neuropathy (CIPN), often severely devastate patients' quality of life post chemotherapy. Since the mechanisms underlying CIPN remain unclear, no effective method of preventing or treating CIPN is currently available. In the current study, we aim to determine the potential therapeutic effects of targeting small GTPases of Rho family (Rho GTPases) in the prevention of CIPN, as well as suppression of tumor progression by utilizing Rho GTPases modulators. The Rho GTPases are master regulators in many critical cellular functions, which include cellular differentiation, cytoskeleton remodeling, cell motility, and vesicle transport. Rho GTPases can be activated by binding to guanosine triphosphate (GTP) and deactivated by binding to guanosine diphosphate (GDP). Two groups of regulators tightly control the activity of Rho GTPases: guanine nucleotide exchange factors (GEFs) induce Rho GTPases activation by facilitating GDP to GTP exchange, whereas GTPase activating proteins (GAPs) induce Rho GTPases deactivation by accelerating GTP hydrolysis. Additionally, abnormal activity of Rho GTPases is reported in a wide variety of human diseases ranging from neurological diseases to cancers. Therefore, Rho GTPases have become valuable targets for therapeutic intervention due to their unique "on and off" molecular switch mechanisms and their broad involvement in human diseases. We used a syngeneic immunocompetent mouse line with transplanted Lewis Lung Carcinoma (LLCab) to create a novel tumor-bearing CIPN animal model and examined the therapeutic effect of RhoA signaling pathway suppression. Y-27632, a selective inhibitor of Rho kinase/p160ROCK directly downstream of RhoA modulating actin dynamics, was used to treat both tumorigenesis and cisplatin-induced peripheral neuropathy. Several key findings were observed from our experiments. First, Y-27632 enhanced the antineoplastic effect of cisplatin in both our in vitro and in vivo studies by promoting cellular apoptosis in the tumor. Second, Y-27632 alleviated the reduction of touch sensitivity induced by cisplatin treatment. Third, crucial touch sensitivity-associated peripheral nervous structures, such as epidermal nerve fibers (ENFs) and Meissner corpuscles (MCs), were protected from cisplatin-induced impairment by Y-27632 treatment. Importantly, quantitative proteomic studies of mouse footpad tissues revealed that Y-27632 attenuated cisplatin-induced dysregulation of cellular stress-associated proteins and suppressed the hyper-activation of NF-kB. Lastly, in order to understand the potential mechanism of cisplatin on the dynamic changes of actin polymerization in live cells, we utilized advanced molecular tools to record both nuclear and cytoplasmic actin reorganization in mitotic and non-mitotic cells. We found that cisplatin caused nuclear actin polymerization in the mitotic cells, and concomitantly induced cytoplasmic actin reorganization in the non-mitotic cells. In summary, these studies, for the first time, highlighted a dual anti-neoplastic and neuroprotective effects of Rho kinase/p160ROCK inhibition in a syngeneic immunocompetent tumor-bearing mouse model, as well as demonstrated the differential influence of cisplatin on the actin dynamics in both mitotic and non-mitotic cells. Due to the close association between Rho GTPases and cellular actin regulation, it is possible that Rho GTPases mediate the cisplatin-induced differential actin reorganization in the mitotic and non-mitotic cells, providing a potential explanation for the mechanism underlying cisplatin-induced neurotoxicity in the cancer patients. Finally, since Y-27632 cooperates with cisplatin to curtail tumor growth while protecting the host from CIPN through RhoA-NF-kB axis to inflammation and cellular stress, Y-27632 or its optimized modulators should be further investigated for the development of clinical adjuvants to improve chemotherapeutic outcomes.
Download or read book GTPase Protocols written by Ed Manser and published by Humana. This book was released on 2002-06-05 with total page 267 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the last 10 years researchers have firmly established key roles for R- related GTPases in almost every aspect of cell biology. In the 1980s the pro- oncogene Ras itself was the focus of interest, though in the 1990s this shifted to the increasing variety of Ras-related proteins. In this new decade much yet needs to be done to establish the role for all the small GTPases now uncovered by the human genome project. In particular, these GTPases need to be und- stood in the appropriate biochemical and cellular contexts. In the process of trying to uncover the role of these versatile proteins, a variety of novel te- niques and methodologies has been developed. These now enable investi- tors to move easily within a diversity of fields ranging from structural studies to real-time in vivo analysis of a GTPase. In recognition of the need for access to key background methodologies, GTPase Protocols: The Ras Superfamily is devoted to techniques that are pr- ently widely used and that will continue to be the standard for researchers worldwide. Each chapter is aimed at supplying detailed methodologies to allow reproduction in any laboratory, while also providing the general pr- ciples on which the methods are based. Some of the techniques grouped in the first section apply broadly to small GTPases, whereas others in Part II are more applicable within each GTPase subfamily.
Book Synopsis Rho GTPases in Breast Cancer Progression by : Yufeng Zuo
Download or read book Rho GTPases in Breast Cancer Progression written by Yufeng Zuo and published by . This book was released on 2010 with total page 490 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Small GTPases in Disease, Part B by :
Download or read book Small GTPases in Disease, Part B written by and published by Academic Press. This book was released on 2008-04-01 with total page 610 pages. Available in PDF, EPUB and Kindle. Book excerpt: The critically acclaimed laboratory standard for more than 40 years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with over 400 volumes (all of them still in print), the series contains much material still relevant today—truly an essential publication for researchers in all fields of life sciences. Methods in Enzymology is now available online at ScienceDirect — full-text online of volume 1 onward.
Book Synopsis Encyclopedic Reference of Cancer by : Manfred Schwab
Download or read book Encyclopedic Reference of Cancer written by Manfred Schwab and published by Springer Science & Business Media. This book was released on 2001-10-15 with total page 1017 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive encyclopedic reference provides rapid and focused information about topics of cancer research for the clinical and basic scientist, students and informed laymen. It will be readily accessible, both electronically and in print, such that it will be of value to both the scientific community and the public.
