The Retinal Muller Cell

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The Retinal Müller Cell

Author : Vijay Sarthy
Publisher : Springer Science & Business Media
ISBN 13 : 0306468417
Total Pages : 290 pages
Book Rating : 4.3/5 (64 download)

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Book Synopsis The Retinal Müller Cell by : Vijay Sarthy

Download or read book The Retinal Müller Cell written by Vijay Sarthy and published by Springer Science & Business Media. This book was released on 2005-12-08 with total page 290 pages. Available in PDF, EPUB and Kindle. Book excerpt: The human brain contains more than a billion neurons which interconnect to form networks that process, store, and recall sensory information. These neuronal activities are supported by a group of accessory brain cells coll- tively known as neuroglia. Surprisingly, glial cells are ten times more - merous than neurons, and occupy more than half the brain volume (Hydén, 1961). Although long considered a passive, albeit necessary, component of the nervous system, many interesting and unusual functional properties of glial cells are only now being brought to light. As a result, the status of these cellular elements is approaching parity with nerve cells as a subject for experimental study. The term glia (or glue) seems today to be a misnomer in view of the diverse functions attributed to glial cells. Experimental studies in the last three decades have clearly established that the behavior of glial cells is far from passive, and that they are at least as complex as neurons with regard to their membrane properties. In addition, glial cells are of importance in signal processing, cellular metabolism, nervous system development, and the pathophysiology of neurological diseases. The Müller cell of the ver- brate retina provides a splendid example of an accessory cell that exhibits features illustrating every aspect of the complex behavior now associated with glial cells.

Müller Cells in the Healthy and Diseased Retina

Author : Andreas Reichenbach
Publisher : Springer
ISBN 13 : 9781489985026
Total Pages : 0 pages
Book Rating : 4.9/5 (85 download)

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Book Synopsis Müller Cells in the Healthy and Diseased Retina by : Andreas Reichenbach

Download or read book Müller Cells in the Healthy and Diseased Retina written by Andreas Reichenbach and published by Springer. This book was released on 2014-11-30 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Müller cells may be used in the future for novel therapeutic strategies to protect neurons against apoptosis (for example, somatic gene therapy), or to differentiate retinal neurons from Müller/stem cells. Meanwhile, a proper understanding of the gliotic responses of Müller cells in the diseased retina, and of their protective vs. detrimental effects, is essential for the development of efficient therapeutic strategies that use and stimulate the neuron-supportive/-protective - and prevent the destructive - mechanisms of gliosis.

Webvision

Author : Helga Kolb
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (53 download)

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Book Synopsis Webvision by : Helga Kolb

Download or read book Webvision written by Helga Kolb and published by . This book was released on 2007 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

na

Author : Andreas Reichenbach
Publisher : Springer Science & Business Media
ISBN 13 : 1441916822
Total Pages : 428 pages
Book Rating : 4.4/5 (419 download)

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Book Synopsis na by : Andreas Reichenbach

Download or read book na written by Andreas Reichenbach and published by Springer Science & Business Media. This book was released on 2011-02-18 with total page 428 pages. Available in PDF, EPUB and Kindle. Book excerpt: Müller cells make up just 0.005% of the cells in our central nervous system. They do not belong to the more esteemed family of neuronal cells but to the glia, a family of cells that until recently were seen as mere filling material between the neurons. Now, however, all that has changed. Sharing the insights of more than a quarter century of research into Müller cells, Drs. Andreas Reichenbach and Andreas Bringmann of Leipzig University make a compelling case for the central role Müller cells play. Everyone agrees that the eye is a very special and versatile sense organ, yet it has turned out in recent years that Müller cells are peculiar and multipotent glial cells. In the retina of most vertebrates and even of many mammals, Müller cells are the only type of (macro- ) glial cells; thus, they are responsible for a wealth of neuron-supportive functions that, in the brain, rely upon a division of labour among astrocytes, oligodendrocytes, and ependymal cells. Even beyond such a role in the central nervous system as "model glia", Müller cells are adapted to several exciting roles in support of vision. They deliver the light stimuli to the photoreceptor cells in the inverted vertebrate retina, aid the processing of visual information, and are responsible for the homeostatic maintenance of the retinal extracellular milieu. In Müller Cells in the Healthy and Diseased Retina, aimed not just at neurobiologists but at anyone concerned with retinal degeneration, every angle of Müller cells is covered, from an introduction to their basic properties, through their roles as 'light cables' and 'shock absorbers', to the part they play in diseases and disorders of the eye. Once these have all been covered in detail, the authors move on to discuss the future direction of research into these small but potent cellular phenomena. About the Authors Dr. Andreas Reichenbach was born in 1950 in Leipzig, Germany. He studied medicine and specialized as a physiologist, working on the mammalian retina. Since 1984, he has focused his efforts - and those of a growing number of fellows in his team - on Müller cell research. He has held a professorship at Leipzig University since 1994. After studying biology, Dr. Andreas Bringmann (* 1960) worked in the field of systemic neurophysiology until he was inspired in 1996 by Andreas Reichenbach to research the most interesting cell, the Müller cell. He is now in the Department of Ophthalmology of the University of Leipzig where he is the head of the Basic Research Laboratory

The Retinal Muller Cell

Author : Vijay Sarthy
Publisher :
ISBN 13 : 9781475774559
Total Pages : 300 pages
Book Rating : 4.7/5 (745 download)

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Book Synopsis The Retinal Muller Cell by : Vijay Sarthy

Download or read book The Retinal Muller Cell written by Vijay Sarthy and published by . This book was released on 2014-09-01 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Neurobiology and Clinical Aspects of the Outer Retina

Author : M.B. Djamgoz
Publisher : Springer Science & Business Media
ISBN 13 : 9401105332
Total Pages : 503 pages
Book Rating : 4.4/5 (11 download)

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Book Synopsis Neurobiology and Clinical Aspects of the Outer Retina by : M.B. Djamgoz

Download or read book Neurobiology and Clinical Aspects of the Outer Retina written by M.B. Djamgoz and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 503 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book deals with the cellular biology, biochemistry and physiology of photoreceptors and their interactions with the second-order neurons, bipolar and horizontal cells. The focus is upon the contributions made by these neurons to vision. Thus the basic neurobiology of the outer retina is related to the visual process, and visual defects that could arise from abnormalities in this part of the retina are highlighted in the first 16 chapters. Since all vertebrate retinas have the same basic structure and physiological plan, examples are given from a variety of species, with an emphasis upon mammals, extending to human vision. The last four chapters approach the problem from the other end. This part of the book covers a range of clinical conditions involving visual abnormalities that are due to cellular defects in the outer retina. Although the contents of this book do not represent the proceedings of a conference, the concept arose at an international symposium on 'Recent Advances in Retinal Research' which was held at the International Marine Centre in Oristano, Sardinia. We hope that the book will give a coherent, up to date review of the neurobiology and clinical aspects of the outer retina and encourage further integration of these areas. Retinal neurobiology has been an intense field of investigation for several decades. More recently, it has seen significant advances with the application of modern techniques of cell and molecular biology.

Müller Cells in the Healthy and Diseased Retina

Author : Andreas Reichenbach
Publisher : Springer
ISBN 13 : 9781441916716
Total Pages : 417 pages
Book Rating : 4.9/5 (167 download)

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Book Synopsis Müller Cells in the Healthy and Diseased Retina by : Andreas Reichenbach

Download or read book Müller Cells in the Healthy and Diseased Retina written by Andreas Reichenbach and published by Springer. This book was released on 2010-03-18 with total page 417 pages. Available in PDF, EPUB and Kindle. Book excerpt: Müller cells may be used in the future for novel therapeutic strategies to protect neurons against apoptosis (for example, somatic gene therapy), or to differentiate retinal neurons from Müller/stem cells. Meanwhile, a proper understanding of the gliotic responses of Müller cells in the diseased retina, and of their protective vs. detrimental effects, is essential for the development of efficient therapeutic strategies that use and stimulate the neuron-supportive/-protective - and prevent the destructive - mechanisms of gliosis.

Pituitary Adenylate Cyclase-Activating Polypeptide

Author : Hubert Vaudry
Publisher : Springer Science & Business Media
ISBN 13 : 1461502438
Total Pages : 432 pages
Book Rating : 4.4/5 (615 download)

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Book Synopsis Pituitary Adenylate Cyclase-Activating Polypeptide by : Hubert Vaudry

Download or read book Pituitary Adenylate Cyclase-Activating Polypeptide written by Hubert Vaudry and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pituitary Adenylate Cyclase-Activating Polypeptide is the first volume to be written on the neuropeptide PACAP. It covers all domains of PACAP from molecular and cellular aspects to physiological activities and promises for new therapeutic strategies. Pituitary Adenylate Cyclase-Activating Polypeptide is the twentieth volume published in the Endocrine Updates book series under the Series Editorship of Shlomo Melmed, MD.

The Fovea

Author : Andreas Bringmann
Publisher : Academic Press
ISBN 13 : 0323904688
Total Pages : 292 pages
Book Rating : 4.3/5 (239 download)

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Book Synopsis The Fovea by : Andreas Bringmann

Download or read book The Fovea written by Andreas Bringmann and published by Academic Press. This book was released on 2021-08-28 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Fovea: Structure, Function, Development, and Disease summarizes the current biological knowledge regarding the two types of the vertebrate fovea (and its main structural elements, the Müller cells). This information is then used to explain different aspects of human vision, foveal development, and macular disorders. Sections give an overview of the retinal structure and the different types of retinal glia, survey the structure and function of the primate and non-mammalian fovea types, discuss foveal development—with a focus on the human fovea, cover the roles of Müller cells and astrocytes in the pathogenesis and regeneration of various human macular disorders are described. Using a translational approach, this reference is a valuable text for scientists, clinicians and physicians interested in the fovea. Readers will gain a new understanding of the cellular basics of the fovea, which is the most important part of the eye. Adopts a translational approach, summarizing the biological knowledge regarding the structure and function of the fovea, the roles of Müller cells in mediating the structural integrity, and function of the fovea Provides overviews of both basic types of the vertebrate fovea, countering the popular belief that there is only one type of the vertebrate fovea, the human fovea Thoroughly shows the mechanisms involved in the development of the fovea that explain the rapid improvement of visual acuity in newborns Explains pathological changes in the foveal structure and function with evaluation pointing toward possible prevention and/or cure

The Retina in Health and Disease

Author : Maurice Ptito
Publisher : Mdpi AG
ISBN 13 : 9783036526539
Total Pages : 498 pages
Book Rating : 4.5/5 (265 download)

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Book Synopsis The Retina in Health and Disease by : Maurice Ptito

Download or read book The Retina in Health and Disease written by Maurice Ptito and published by Mdpi AG. This book was released on 2021-12-27 with total page 498 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vision is the most important sense in higher mammals. The retina is the first step in visual processing and the window to the brain. It is not surprising that problems arising in the retina lead to moderate to severe visual impairments. We offer here a collection of reviews as well as original papers dealing with various aspects of retinal function as well as dysfunction. New approaches in retinal research are described, such as the expression and localization of the endocannabinoid system in the normal retina and the role of cannabinoid receptors that could offer new avenues of research in the development of potential treatments for retinal diseases. Moreover, new insights are offered in advancing knowledge towards the prevention and cure of visual pathologies, mainly AMD, RP, and diabetic retinopathy.

Retinal Glia

Author : Andreas Reichenbach
Publisher : Biota Publishing
ISBN 13 : 1615046712
Total Pages : 666 pages
Book Rating : 4.6/5 (15 download)

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Book Synopsis Retinal Glia by : Andreas Reichenbach

Download or read book Retinal Glia written by Andreas Reichenbach and published by Biota Publishing. This book was released on 2015-02-01 with total page 666 pages. Available in PDF, EPUB and Kindle. Book excerpt: In 1851, Heinrich Müller discovered what he called “radial fibers” and what we now call Müller cells, as the principal glial cells of the vertebrate retina. Later on, other glial cell types were found in the retina, including astrocytes, microglia, and even oligodendrocytes. It turned out that retinal glial cells are essential constituents of the tissue. For instance, Müller cells appear to constitute the “core” of columnar units of clonally and functionally related groups of neurons. Their primary function is to support neuronal functioning by guiding the light towards the photoreceptor cells, removing excess neurotransmitter molecules from extracellular space, and performing efficient clearance of excess extracellular potassium ions. The latter two functions are also crucial for neuronal survival and are coupled to water clearance which is also essential. Müller cells are capable of “sensing” neuronal activity and modifying it by the release of signal substances (gliotransmitters). In cases of retinal injuries the Müller cells become reactive, and all above-mentioned functions are impaired. However, such de-differentiated Müller cells may proliferate, and may even serve as stem cells for the regeneration of a damaged retina. As well as the Müller cells, retinal astrocytes and microglial cells are important players in retinal development and function. This book gives a comprehensive survey of the present knowledge on retinal glia.

Primate Retina and Choroid

Author : Wolf Krebs
Publisher : Springer Science & Business Media
ISBN 13 : 1461390958
Total Pages : 178 pages
Book Rating : 4.4/5 (613 download)

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Book Synopsis Primate Retina and Choroid by : Wolf Krebs

Download or read book Primate Retina and Choroid written by Wolf Krebs and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 178 pages. Available in PDF, EPUB and Kindle. Book excerpt: Contents Introduction .......................................... . 1 The Primate Eye ...................................... . 2 Embryology of Retina and Choroid ....................... . 4 Microscopic Anatomy .................................. . 4 Retina ............................................ . 4 Choroid ........................................... . 8 Material and Methods .................................. . 10 Fine Structure of the Retina 14 RetinaI Pigment Epithelium ............................. . 16 Photoreceptor Cells ................................... . 30 Outer Plexiform Layer and Horizontal Cells .................. . 64 Bipolar, Radial Clial, and Amacrine Cells .................... . 76 Canglion Cells and InternaI Limiting Membrane ............... . 98 Spatial Density of RetinaI Cells .......................... . 112 Fine Structure of the Choroid ........................... . 116 Choroidocapillaris and Its Fiber System ..................... . 118 Arteries, Veins, and Lymphatic Spaces ...................... . 134 Choroidal Nerves .................................... . 142 Cells of Choroidal Connective Tissue ....................... . 148 References ........................................... . 153 Index ................................................ . 157 vii This volume describes the morphology of the primate re tina as seen with the electron microscope. As it is an atlas, the electron micrographs are its most In trad lietian important part. The text accompanies the figures, highlighting selected topics either to explain structures or to point out structure-function relation ships. A scholarly review of the whole spectrum of research on the re tina and choroid is not feasible in a single volume. Thus, whenever available, review artides or monographs, rather than original work, are cited for reference.

Textbook of Vascular Medicine

Author : Rhian M. Touyz
Publisher : Springer
ISBN 13 : 3030164810
Total Pages : 503 pages
Book Rating : 4.0/5 (31 download)

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Book Synopsis Textbook of Vascular Medicine by : Rhian M. Touyz

Download or read book Textbook of Vascular Medicine written by Rhian M. Touyz and published by Springer. This book was released on 2019-08-02 with total page 503 pages. Available in PDF, EPUB and Kindle. Book excerpt: This textbook focuses on the vascular biology and physiology that underlie vascular disorders in clinical medicine. Vascular biomedicine is a rapidly growing field as new molecular mechanisms of vascular health and disease are unraveled. Many of the major cardiovascular diseases including coronary artery disease, heart failure, stroke and vascular dementia are diseases of the vasculature. In addition vascular injury underpins conditions like kidney failure and cardiovascular complications of diabetes. This field is truly multidisciplinary involving scientists in many domains such as molecular and vascular biology, cardiovascular physiology and pharmacology and immunology and inflammation. Clinically, specialists across multiple disciplines are involved in the management of patients with vascular disorders, including cardiologists, nephrologists, endocrinologists, neurologists and vascular surgeons. This book covers a wide range of topics and provides an overview of the discipline of vascular biomedicine without aiming at in-depth reviews, but rather offering up-to-date knowledge organized in concise and structured chapters, with key points and pertinent references. The structure of the content provides an integrative and translational approach from basic science (e.g. stem cells) to clinical medicine (e.g. cardiovascular disease). The content of this book is targeted to those who are new in the field of vascular biology and vascular medicine and is ideal for medical students, graduate and postgraduate students, clinical fellows and academic clinicians with an interest in the vascular biology and physiology of cardiovascular disease and related pathologies.

Therapies for Retinal Degeneration

Author : de la Rosa (Enrique J.)
Publisher : Royal Society of Chemistry
ISBN 13 : 1782629491
Total Pages : 276 pages
Book Rating : 4.7/5 (826 download)

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Book Synopsis Therapies for Retinal Degeneration by : de la Rosa (Enrique J.)

Download or read book Therapies for Retinal Degeneration written by de la Rosa (Enrique J.) and published by Royal Society of Chemistry. This book was released on 2018 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book addresses approaches to the treatment of retinal diseases, targeting common processes and components.

Atlas of Inherited Retinal Diseases

Author : Stephen H. Tsang
Publisher : Springer
ISBN 13 : 3319950460
Total Pages : 274 pages
Book Rating : 4.3/5 (199 download)

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Book Synopsis Atlas of Inherited Retinal Diseases by : Stephen H. Tsang

Download or read book Atlas of Inherited Retinal Diseases written by Stephen H. Tsang and published by Springer. This book was released on 2018-12-21 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Atlas of Inherited Retinal Disorders provides a thorough overview of various inherited retinal dystrophies with emphasis on phenotype characteristics and how they relate to the most frequently encountered genes. It also meets the previously unmet needs of PhD students who will benefit from seeing the phenotypes of genes they work on and study. Further, because genetic-testing costs are quite high and spiraling higher, this Atlas will help geneticists familiarize themselves with the candidate gene approach to test patients’ genomes, enabling more cost-efficient testing. This invaluable atlas is organized into eight sections starting with an introduction to the basic knowledge on retinal imaging, followed by diseases listed according to inheritance pattern and disorders with extraocular manifestations grouped by defining features. This structure will be intuitive to clinicians and students studying inherited retinal disorders.

The Retina

Author : John E. Dowling
Publisher : Harvard University Press
ISBN 13 : 9780674766808
Total Pages : 310 pages
Book Rating : 4.7/5 (668 download)

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Book Synopsis The Retina by : John E. Dowling

Download or read book The Retina written by John E. Dowling and published by Harvard University Press. This book was released on 1987 with total page 310 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Principles and Practice of Clinical Electrophysiology of Vision, second edition

Author : John R. Heckenlively
Publisher : MIT Press
ISBN 13 : 0262083469
Total Pages : 1033 pages
Book Rating : 4.2/5 (62 download)

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Book Synopsis Principles and Practice of Clinical Electrophysiology of Vision, second edition by : John R. Heckenlively

Download or read book Principles and Practice of Clinical Electrophysiology of Vision, second edition written by John R. Heckenlively and published by MIT Press. This book was released on 2006-04-07 with total page 1033 pages. Available in PDF, EPUB and Kindle. Book excerpt: The long-awaited second edition of an authoritative reference on electrophysiologic vision testing, including detailed information on techniques and problems, basic physiology and anatomy, theoretical concepts, and clinical findings; with extensive new material. This authoritative text is the only comprehensive reference available on electrophysiologic vision testing, offering both practical information on techniques and problems as well as basic physiology and anatomy, theoretical concepts, and clinical correlations. The second edition, of the widely used text, offers extensive new material and updated information: 65 of the 84 chapters are completely new, with the changes reflecting recent advances in the field. The book will continue to be an essential resource for practitioners and scholars from a range of disciplines within vision science. The contributions not only cover new information—important material that is likely to become more important in the next decade—but also offer a long-range perspective on the field and its remarkable development in the last century. After discussing the history and background of clinical electrophysiology, the book introduces the anatomy of the retina and principles of cell biology in the visual pathways at the molecular, physiological, and biochemical levels. It relates these new findings to the techniques and interpretations of clinical tests, including the electro-oculogram (EOG), electroretinogram (ERG), and visual evoked potentials (VEP), which are discussed in detail, as are equipment, data acquisition and analysis, principles and protocols for clinical testing, diseases and dysfunction, and animal testing. Notable additions for this edition include chapters on the origin of electroretinogram waveforms, multifocal techniques, testing in standard laboratory animals, recent advances in analysis of abnormalities in disease, and the applications of these techniques to the study of genetic abnormalities.