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Author : Bruce Alberts
Publisher :
ISBN 13 : 9780815332183
Total Pages : 0 pages
Book Rating : 4.3/5 (321 download)
Download or read book Molecular Biology of The Cell written by Bruce Alberts and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Jerry L. Workman
Publisher : Springer Science & Business Media
ISBN 13 : 1461486246
Total Pages : 594 pages
Book Rating : 4.4/5 (614 download)
Download or read book Fundamentals of Chromatin written by Jerry L. Workman and published by Springer Science & Business Media. This book was released on 2013-12-04 with total page 594 pages. Available in PDF, EPUB and Kindle. Book excerpt: While there has been an increasing number of books on various aspects of epigenetics, there has been a gap over the years in books that provide a comprehensive understanding of the fundamentals of chromatin. Chromatin is the combination of DNA and proteins that make up the genetic material of chromosomes. Its primary function is to package DNA to fit into the cell, to strengthen the DNA to prevent damage, to allow mitosis and meiosis, and to control the expression of genes and DNA replication. The audience for this book is mainly newly established scientists and graduate students. Rather than going into the more specific areas of recent research on chromatin the chapters in this book give a strong, updated groundwork about the topic. Some the fundamentals that this book will cover include the structure of chromatin and biochemistry and the enzyme complexes that manage it.
Author : Guohui Zheng
Publisher :
ISBN 13 :
Total Pages : 191 pages
Book Rating : 4.:/5 (67 download)
Download or read book The Packaging of DNA in Chromatin written by Guohui Zheng and published by . This book was released on 2010 with total page 191 pages. Available in PDF, EPUB and Kindle. Book excerpt: The mechanical properties of DNA play a key role in its biological processing, determining how the long, thin, double-helical molecule responds to the binding of proteins and functions in confined spaces within a cell. In eukaryotes, about 75-90% of genomic DNA exists in the form of nucleosomes, which are the fundamental units of DNA packaging in chromatin and the primary determinate of DNA accessibility. The structure of chromatin undergoes various changes that depend, at least in part, upon the requirements of gene expression and other functional environments. The dynamics of DNA packaging in chromatin is thus fundamental to numerous biological processes. The flexibility of DNA is important in packaging DNA over lengths comparable to its persistence length during genetic processing and the sequence-dependent properties of DNA determine the positioning of nucleosomes in the genome and the sites of binding of enzymes and transcription factors. In addition, understanding the correlation between DNA flexibility and histone-DNA interactions inside the nucleosome is essential for unraveling currently unsolved mechanisms of gene regulation. Furthermore, although many experimental techniques have emerged to examine the overall structure of chromatin fibers, the internal arrangement of DNA and histones remains unclear. Thus an appropriate computational model able to incorporate experimental observations is key to interpretation of the folding and unfolding of chromatin. The major goal of this thesis is to understand some of biophysical mechanisms involved in the packaging of DNA into chromatin using computational techniques at multi-scales: (i) to determine the sequence-dependent flexibility of DNA by developing DNA deformation analysis tools and databases; (ii) to design DNA spatial configurations using knowledge-based Monte-Carlo sampling; (iii) to map protein-DNA recognition inside nucleosomes in terms of realistic molecular treatments; and (iv) to interpret the internal structure of chromatin fibers and examine chromatin looping using novel modeling and simulation methods.
Author :
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (14 download)
Download or read book Studies of DNA packaging in nucleosomes and chromatin containing acetylated core histones written by and published by . This book was released on with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : David W. FitzSimons
Publisher : John Wiley & Sons
ISBN 13 : 0470717785
Total Pages : 192 pages
Book Rating : 4.4/5 (77 download)
Download or read book The Structure and Function of Chromatin written by David W. FitzSimons and published by John Wiley & Sons. This book was released on 2009-09-16 with total page 192 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Novartis Foundation Series is a popular collection of the proceedings from Novartis Foundation Symposia, in which groups of leading scientists from a range of topics across biology, chemistry and medicine assembled to present papers and discuss results. The Novartis Foundation, originally known as the Ciba Foundation, is well known to scientists and clinicians around the world.
Author :
Publisher :
ISBN 13 : 9781855782297
Total Pages : pages
Book Rating : 4.7/5 (822 download)
Download or read book DNA PACKAGING written by and published by . This book was released on 2019 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Joseph Salvatore Siino
Publisher :
ISBN 13 :
Total Pages : 448 pages
Book Rating : 4.:/5 (65 download)
Download or read book Studies of DNA Packaging in Nucleosomes and Chromatin Containing Acetylated Core Histones, Histone Mutants, and the Histone Variant H2AX by Scanning Probe Microscopy written by Joseph Salvatore Siino and published by . This book was released on 2002 with total page 448 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Renato Paro
Publisher : Springer Nature
ISBN 13 : 3030686701
Total Pages : 215 pages
Book Rating : 4.0/5 (36 download)
Download or read book Introduction to Epigenetics written by Renato Paro and published by Springer Nature. This book was released on 2021-03-23 with total page 215 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access textbook leads the reader from basic concepts of chromatin structure and function and RNA mechanisms to the understanding of epigenetics, imprinting, regeneration and reprogramming. The textbook treats epigenetic phenomena in animals, as well as plants. Written by four internationally known experts and senior lecturers in this field, it provides a valuable tool for Master- and PhD- students who need to comprehend the principles of epigenetics, or wish to gain a deeper knowledge in this field. After reading this book, the student will: Have an understanding of the basic toolbox of epigenetic regulation Know how genetic and epigenetic information layers are interconnected Be able to explain complex epigenetic phenomena by understanding the structures and principles of the underlying molecular mechanisms Understand how misregulated epigenetic mechanisms can lead to disease
Author : J. Zlatanova
Publisher : Gulf Professional Publishing
ISBN 13 : 9780444515940
Total Pages : 546 pages
Book Rating : 4.5/5 (159 download)
Download or read book Chromatin Structure and Dynamics written by J. Zlatanova and published by Gulf Professional Publishing. This book was released on 2004 with total page 546 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biological processes that replicate, preserve and use the genetic information encoded in DNA must operate in the context of chromatin, a highly organized complex of DNA and proteins. These proteins do not merely package the DNA in the tiny volume of the nucleus, but impart the structure the ability to change according to the requirements of the specific process the DNA is involved in. Moreover, chromatin structure is used by the cell to control the activity of DNA. In this volume the basics of chromatin structure and dynamics are presented by established experts in the field.
Author : Anita Göndör
Publisher : Academic Press
ISBN 13 : 0128034025
Total Pages : 498 pages
Book Rating : 4.1/5 (28 download)
Download or read book Chromatin Regulation and Dynamics written by Anita Göndör and published by Academic Press. This book was released on 2016-10-25 with total page 498 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chromatin Regulation and Dynamics integrates knowledge on the dynamic regulation of primary chromatin fiber with the 3D nuclear architecture, then connects related processes to circadian regulation of cellular metabolic states, representing a paradigm of adaptation to environmental changes. The final chapters discuss the many ways chromatin dynamics can synergize to fundamentally contribute to the development of complex diseases. Chromatin dynamics, which is strategically positioned at the gene-environment interface, is at the core of disease development. As such, Chromatin Regulation and Dynamics, part of the Translational Epigenetics series, facilitates the flow of information between research areas such as chromatin regulation, developmental biology, and epidemiology by focusing on recent findings of the fast-moving field of chromatin regulation. Presents and discusses novel principles of chromatin regulation and dynamics with a cross-disciplinary perspective Promotes crosstalk between basic sciences and their applications in medicine Provides a framework for future studies on complex diseases by integrating various aspects of chromatin biology with cellular metabolic states, with an emphasis on the dynamic nature of chromatin and stochastic principles Integrates knowledge on the dynamic regulation of primary chromatin fiber with 3D nuclear architecture, then connects related processes to circadian regulation of cellular metabolic states, representing a paradigm of adaptation to environmental changes
Author : A. Wolffe
Publisher :
ISBN 13 :
Total Pages : 232 pages
Book Rating : 4.3/5 (91 download)
Download or read book Chromatin written by A. Wolffe and published by . This book was released on 1992 with total page 232 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Roumen G. Tsanev
Publisher : CRC Press
ISBN 13 : 9780849368035
Total Pages : 288 pages
Book Rating : 4.3/5 (68 download)
Download or read book Replication and Transcription of Chromatin written by Roumen G. Tsanev and published by CRC Press. This book was released on 1992-11-23 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: Replication and Transcription of Chromatin summarizes the main structural features of chromatin and presents results on replication and transcription gained over the last 20 years. The book emphasizes DNA-histone complexes and their importance in restricting genetic information encoded in DNA. Figures are used to illustrate many of the most important concepts of chromatin replication and transcription, and promising hypotheses and models are discussed to promote further research. Replication and Transcription of Chromatin is an important reference for biochemists, biophysicists, molecular biologists, cell biologists, and other researchers interested in this topic.
Author : Ralf Blossey
Publisher : CRC Press
ISBN 13 : 1351646818
Total Pages : 204 pages
Book Rating : 4.3/5 (516 download)
Download or read book Chromatin written by Ralf Blossey and published by CRC Press. This book was released on 2017-08-04 with total page 204 pages. Available in PDF, EPUB and Kindle. Book excerpt: An invaluable resource for computational biologists and researchers from other fields seeking an introduction to the topic, Chromatin: Structure, Dynamics, Regulation offers comprehensive coverage of this dynamic interdisciplinary field, from the basics to the latest research. Computational methods from statistical physics and bioinformatics are detailed whenever possible without lengthy recourse to specialized techniques.
Author : Hiromi Yamakawa
Publisher : Springer
ISBN 13 : 3662487160
Total Pages : 517 pages
Book Rating : 4.6/5 (624 download)
Download or read book Helical Wormlike Chains in Polymer Solutions written by Hiromi Yamakawa and published by Springer. This book was released on 2016-02-22 with total page 517 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents the "helical wormlike chain" model – a general model for both flexible and semiflexible polymer chains. It explains how statistical-mechanical, hydrodynamic, and dynamic theories of their solution properties can be developed on the basis of this model. This new second edition has been carefully updated and thoroughly revised. It includes a new chapter covering "Simulation and More on Excluded-Volume Effects", as well as the discussion of new experimental data and the application of the theory to ring polymers. The authors provide analysis of important recent experimental data by the use of their theories for flexible polymers over a wide range of molecular weights, including the oligomer region, and for semiflexible polymers, including biological macromolecules such as DNA. This is all clearly illustrated using a reasonable number of theoretical equations, tables, figures, and computer-aided forms, which support the understanding of the basic theory and help to facilitate its application to experimental data for the polymer molecular characterization.
Author : Peter B. Becker
Publisher : Springer Science & Business Media
ISBN 13 : 1592596819
Total Pages : 525 pages
Book Rating : 4.5/5 (925 download)
Download or read book Chromatin Protocols written by Peter B. Becker and published by Springer Science & Business Media. This book was released on 2008-02-03 with total page 525 pages. Available in PDF, EPUB and Kindle. Book excerpt: More than 40 years after the discovery of the nucleosome as the fun- mental unit of chromatin, the multifaceted problem of how variations in ch- matin structure affect the activity of the eukaryotic genome has not been solved. However, during the past few years research on chromatin structure and fu- tion has gained considerable momentum, and impressive progress has been made at the level of concept development as well as filling in crucial detail. The structure of the nucleosome has been visualized at unprecedented reso- tion. Powerful multisubunit enzymes have been identified that alter histone/ DNA interactions in ways that expose regulatory sequences to factors initi- ing and regulating such nuclear processes as transcription. Though the imp- tance of posttranslational modifications of histones, notably their acetylation, has long been known, the finding that a number of bona fide regulators increase transcription by acetylating nucleosomes has lent new support to the old idea that the process of gene regulation is intimately related to the nature of the chromatin environment. A wealth of nonhistone proteins contribute to a continuum of structures with distinct biochemical properties and varying degrees of DNA condensation. Perhaps the most important conclusion from a large number of studies is a fresh appreciation of the dynamic nature of chromatin structure, the built-in flexibility providing the basis for regulation.
Author : Daniel Kirchhoff
Publisher :
ISBN 13 :
Total Pages : 142 pages
Book Rating : 4.:/5 (113 download)
Download or read book Illuminating DNA Packaging in Sperm Chromatin written by Daniel Kirchhoff and published by . This book was released on 2019 with total page 142 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Claudio O. Gualerzi
Publisher : Springer Science & Business Media
ISBN 13 : 3642712665
Total Pages : 236 pages
Book Rating : 4.6/5 (427 download)
Download or read book Bacterial Chromatin written by Claudio O. Gualerzi and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book brings together various contributions aimed at the elucida tion of the structural and functional organization of the bacterial nucleoid. Most of these papers, spanning the fields of physical chemistry through biochemistry to genetics, were presented at the session on bac terial chromatin during the Symposium "Selected topics on chromatin structure and function" held at the University of Camerino, Italy, at the end of May 1985. Times when the bacterial DNA was regarded as "naked" or, at most, complexed with polyamines, and when the absence of histones and organized chromatin was considered to be a distinct feature of the pro karyotic cell, now appear remote. Our concepts of how DNA is packaged in bacteria are changing rapidly. Studies on the structure of the bacterial nucleoid are not new. Recently, however, investigations in this field have flourished again, leading to some important contributions such as the elucidation of the three-dimensional structure of what appears to be the major protein constituent of the bacterial nucleoid or the development of methods to titrate the extent of DNA supercoiling within the bacterial cell.
