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The Nuclear Overhauser Effect In Structural And Conformational Analysis
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Book Synopsis The Nuclear Overhauser Effect in Structural and Conformational Analysis by : David Neuhaus
Download or read book The Nuclear Overhauser Effect in Structural and Conformational Analysis written by David Neuhaus and published by Wiley-VCH. This book was released on 1989 with total page 568 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Nuclear Overhauser Effect in Structural and Conformational Analysis, Second Edition, uniquely explains the NOE in detail, making it an indispensable resource for the novice as well as the experienced NMR researcher.
Book Synopsis The Nuclear Overhauser Effect in Structural and Conformational Analysis by : David Neuhaus
Download or read book The Nuclear Overhauser Effect in Structural and Conformational Analysis written by David Neuhaus and published by . This book was released on 1992-06-01 with total page 522 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Nuclear Overhauser Effect in Structural and Conformational Analysis by : David Neuhaus
Download or read book The Nuclear Overhauser Effect in Structural and Conformational Analysis written by David Neuhaus and published by Wiley-VCH. This book was released on 1989 with total page 522 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Nuclear Overhauser Effect in Structural and Conformational Analysis by : David Neuhaus
Download or read book The Nuclear Overhauser Effect in Structural and Conformational Analysis written by David Neuhaus and published by Wiley-VCH. This book was released on 2000-04-24 with total page 670 pages. Available in PDF, EPUB and Kindle. Book excerpt: An authoritative review of the state of the art in the Nuclear Overhauser Effect-essential information for organic chemists, biochemists, biophysicists, and NMR spectroscopists The field of NMR spectroscopy has seen tremendous growth in the last twenty years, particularly advances relating to Nuclear Overhauser Effect (NOE) spectroscopy-the most powerful technique for obtaining structural information on molecules in solution. Extensive and engaging, the Second Edition of the leading reference on the NOE is significantly updated to reflect the latest changes and new approaches in the field. Neuhaus and Williamson provide an essential guide to the complexities and use of the NOE in a readily accessible, straightforward manner. Their practical handbook features a new chapter addressing the use of NOE data to calculate biomolecular structures. Chapters dealing with the kinetics of the NOE, the effects of exchange and internal motion, and applications of the NOE, are also extensively revised. Cross-referenced in remarkable depth, The Nuclear Overhauser Effect is organized into three main parts: * Part I describes the theory of the Nuclear Overhauser Effect in a clear, comprehensive fashion * Part II discusses the considerations involved in implementing NOE experiments, including full coverage of all necessary details for both new and established techniques * Part III offers examples of how the NOE is used, including applications to defining molecular geometry, stereochemistry, conformation, and biomolecular structure and interactions The Nuclear Overhauser Effect in Structural and Conformational Analysis, Second Edition, uniquely explains the NOE in detail, making it an indispensable resource for the novice as well as the experienced NMR researcher.
Book Synopsis Modern NMR Approaches to the Structure Elucidation of Natural Products by : Antony Williams
Download or read book Modern NMR Approaches to the Structure Elucidation of Natural Products written by Antony Williams and published by Royal Society of Chemistry. This book was released on 2016-12-14 with total page 532 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Ghanian plant Cryptolepis sanguinolenta is the source of a series of fascinating indoloquinoline alkaloids. The most unusual member of this alkaloid series was initially proposed to be a spiro nonacyclic structure, named cryptospirolepine, and was elucidated in 1993 based on the technologies available at that time. There were, however, several annoying attributes to the structure that bothered analysts for the ensuing 22 years. During the two decades that followed the initial work there have been enormous developments in NMR technology. Using new experimental approaches, specifically homodecoupled 1,1- and 1,n-HD-ADEQUATE NMR experiments developed in 2014, the structure of only a 700 µg sample of cryptospirolepine has been revised and is shown on the cover of this volume. The confluence of the NMR technological and methodological advances that allowed the revision of the structure of cryptospirolepine using a submilligram sample seems a fitting example for this book, which is dedicated to the NMR characterization of various classes of natural products. Volume 2 considers data processing and algorithmic based analyses tailored to natural product structure elucidation and reviews the application of NMR to the analysis of a series of different natural product families including marine natural products, terpenes, steroids, alkaloids and carbohydrates. Volume 1 discusses contemporary NMR approaches including optimized and future hardware and experimental approaches to obtain both the highest quality and most appropriate spectral data for analysis. These books, bringing together acknowledged experts, uniquely focus on the combination of experimental approaches and modern hardware and software applied to the structure elucidation of natural products. The volumes will be an essential resource for NMR spectroscopists, natural product chemists and industrial researchers working on natural product analysis or the characterization of impurities and degradation products of pharmaceuticals that can be as scarce as natural product samples.
Book Synopsis Biological NMR Spectroscopy by : John L. Markley
Download or read book Biological NMR Spectroscopy written by John L. Markley and published by Oxford University Press. This book was released on 1997-01-30 with total page 375 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents a critical assessment of progress on the use of nuclear magnetic resonance spectroscopy to determine the structure of proteins, including brief reviews of the history of the field along with coverage of current clinical and in vivo applications. The book, in honor of Oleg Jardetsky, one of the pioneers of the field, is edited by two of the most highly respected investigators using NMR, and features contributions by most of the leading workers in the field. It will be valued as a landmark publication that presents the state-of-the-art perspectives regarding one of today's most important technologies.
Book Synopsis The Nuclear Overhauser Effect by : Joseph Noggle
Download or read book The Nuclear Overhauser Effect written by Joseph Noggle and published by Elsevier. This book was released on 2012-12-02 with total page 271 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Nuclear Overhauser Effect aims to provide a unified treatment of both the theory and applications of the NOE that would be accessible to the chemist who is not a specialist in NMR, but who would nevertheless like to use the NOE to solve problems in his own area of interest. Assuming only that the reader has a typical chemist's working knowledge of NMR, an attempt is made to present the results in each section in a sufficiently simple form so that little mathematical sophistication will be required to apply them with understanding. This book comprises eight chapters, and begins with a focus on nuclear spin-lattice relaxation. The following chapters then discuss mechanisms of spin-lattice relaxation; the nuclear overhauser effect in rigid molecules; the effects of internal motions; experimental methods; transient methods; the effects of chemical exchange; and applications of the nuclear overhauser effect, with a review of available literature. This book will be of interest to practitioners in the fields of chemistry and physics.
Book Synopsis NMR as a Structural Tool for Macromolecules by : M.D. Kemple
Download or read book NMR as a Structural Tool for Macromolecules written by M.D. Kemple and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 373 pages. Available in PDF, EPUB and Kindle. Book excerpt: The contemplation of truth and beauty is the proper object for which we were created, which calls forth the most intense desires of the soul, and of which it never tires -Hazlitt In his Nobel lecture Purcell commented that when he saw snow in New England after the discovery of NMR, it appeared like "heaps of protons quietly precessing in earth's magnetic field. " If he were to make the comment in the context of how NMR is being used today, he could have conjured up an image of hydrogen, carbon, and nitrogen nuclei in proteins of an earthbound 8rganism subtly orchestrating a quiet symphony of frequencies, from 150 Hz to 2 kHz, carrying clues to the three-dimensional structure of the macromolecules. The manner in which the basic discoveries of Bloch and Purcell have led to the emergence of NMR, several decades later, as a major technique of biological and medical physics (and chemistry) is a striking example of the power of basic research. It is also a fascinating saga whereby whenever it was felt that the field had reached a plateau, new directions, new technologies, and sometimes serendipity produced new developments that revolutionized the technique and enhanced its capability. As Richard Ernst points out "NMR is intellectually attractive, . . . the practical importance of NMR is enormous, and can justify much of the playful activities of an addicted spectroscopist" (Nobel lecture).
Book Synopsis Structure Elucidation by Modern NMR by : Helmut Duddeck
Download or read book Structure Elucidation by Modern NMR written by Helmut Duddeck and published by Springer Science & Business Media. This book was released on 2013-04-18 with total page 214 pages. Available in PDF, EPUB and Kindle. Book excerpt: During the last few years, routine applications of NMR (Nuclear Magnetic Resonance) techniques have developed at a tremendous pace. The latest generation of spectrometers have enabled chemists to perform new types of experiments, such as spinlock and inverse-detected methods. This third, revised and expanded edition introduces the latest methodologies and incorporates them into new exercises.
Book Synopsis Encyclopedia of Spectroscopy and Spectrometry by :
Download or read book Encyclopedia of Spectroscopy and Spectrometry written by and published by Academic Press. This book was released on 2016-09-22 with total page 3716 pages. Available in PDF, EPUB and Kindle. Book excerpt: This third edition of the Encyclopedia of Spectroscopy and Spectrometry, Three Volume Set provides authoritative and comprehensive coverage of all aspects of spectroscopy and closely related subjects that use the same fundamental principles, including mass spectrometry, imaging techniques and applications. It includes the history, theoretical background, details of instrumentation and technology, and current applications of the key areas of spectroscopy. The new edition will include over 80 new articles across the field. These will complement those from the previous edition, which have been brought up-to-date to reflect the latest trends in the field. Coverage in the third edition includes: Atomic spectroscopy Electronic spectroscopy Fundamentals in spectroscopy High-Energy spectroscopy Magnetic resonance Mass spectrometry Spatially-resolved spectroscopic analysis Vibrational, rotational and Raman spectroscopies The new edition is aimed at professional scientists seeking to familiarize themselves with particular topics quickly and easily. This major reference work continues to be clear and accessible and focus on the fundamental principles, techniques and applications of spectroscopy and spectrometry. Incorporates more than 150 color figures, 5,000 references, and 300 articles for a thorough examination of the field Highlights new research and promotes innovation in applied areas ranging from food science and forensics to biomedicine and health Presents a one-stop resource for quick access to answers and an in-depth examination of topics in the spectroscopy and spectrometry arenas
Book Synopsis Lectins and Glycobiology by : Hans-Joachim Gabius
Download or read book Lectins and Glycobiology written by Hans-Joachim Gabius and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 524 pages. Available in PDF, EPUB and Kindle. Book excerpt: The intriguing complexity, precision, and regulation of the wide range of biologi cal processes is determined by intricate mechanisms of molecular recognition. Their nature is under intense scrutiny. In addition to the well-appreciated interac tion of proteins either with amino acid or nucleotide sequences, the investigation of their interplay with carbohydrate elements of cellular glycoconjugates current ly exerts increasing attraction. In the group of carbohydrate-binding proteins, lec tins are distinguished from antibodies or ligand-affecting enzymes, according to the most recent definition. The thorough analysis of their structure and function is considered as a focus to collect a critical mass of information for delineating details of a further array of biochemical processes with pivotal physiological im pact. Following an already century-long history of scientific description, reflected by subjectively chosen highlights (see the Brief History of Lectin Research at page VI), the excitement in glycobiological research that prevails today can easily be ex plained by our growing awareness of the multifarious significance of a sugar-code system of biological information. This present notion unmistakably has an im pact on lines of research in diverse disciplines like cell and molecular biology, histochemistry, or clinical sciences. It also prompts inherent practical questions such as how to obtain lectins, or how to employ them as instruments in various assay systems with the best possible results. Thus, this book is devoted intentionally to cover the techniques in different research fields that deal with lectins.
Book Synopsis The Nuclear Overhauser Effect by : Joseph H. Noggle
Download or read book The Nuclear Overhauser Effect written by Joseph H. Noggle and published by . This book was released on 1971 with total page 272 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Nuclear Overhauser Effect aims to provide a unified treatment of both the theory and applications of the NOE that would be accessible to the chemist who is not a specialist in NMR, but who would nevertheless like to use the NOE to solve problems in his own area of interest. Assuming only that the reader has a typical chemist's working knowledge of NMR, an attempt is made to present the results in each section in a sufficiently simple form so that little mathematical sophistication will be required to apply them with understanding. This book comprises eight chapters, and begins with a focus on nuclear spin-lattice relaxation. The following chapters then discuss mechanisms of spin-lattice relaxation; the nuclear overhauser effect in rigid molecules; the effects of internal motions; experimental methods; transient methods; the effects of chemical exchange; and applications of the nuclear overhauser effect, with a review of available literature. This book will be of interest to practitioners in the fields of chemistry and physics.
Book Synopsis Immunological Recognition of Peptides in Medicine and Biology by : N. D. Zegers
Download or read book Immunological Recognition of Peptides in Medicine and Biology written by N. D. Zegers and published by CRC Press. This book was released on 1995-07-19 with total page 498 pages. Available in PDF, EPUB and Kindle. Book excerpt: Immunological Recognition of Peptides in Medicine and Biology gives a state-of-the-art overview on the use of peptides and peptide-ligand interactions, and the critical role they play in recognition patterns for the regulation of various biological functions. A wide range of applications are discussed, including some experimental preclinical ones such as epitope mapping, peptide libraries, and production of amino acid-specific antibodies and their therapeutic use in oncology and infectious disease vaccines. Each chapter also includes step-by-step protocols to aid in actual experiments. Several alternative techniques and strategies are discussed by different authors offering the reader an opportunity to select the most favorable application for a specific biological problem.
Book Synopsis Bioactive Natural Products by : Steven M. Colegate
Download or read book Bioactive Natural Products written by Steven M. Colegate and published by CRC Press. This book was released on 2007-12-14 with total page 624 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bioactive natural products are proving to be a rich source of novel therapeutics to both protect against and combat diseases, as well as serve as lead compounds in crop protection. Following the successful format of the first edition, this volume brings together collective research from many new contributors and emphasizes the rationale behind the
Book Synopsis Dynamics and the Problem of Recognition in Biological Macromolecules by : Oleg Jardetzky
Download or read book Dynamics and the Problem of Recognition in Biological Macromolecules written by Oleg Jardetzky and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 308 pages. Available in PDF, EPUB and Kindle. Book excerpt: From within complex structures of organisms and cells down to the molecular level, biological processes all involve movement. Muscular fibers slide on each other to activate the muscle, as polymerases do along nucleic acids for replicating and transcribing the genetic material. Cells move and organize themselves into organs by recognizing each other through macromolecular surface-specific interactions. These recognition processes involve the mu tual adaptation of structures that rely on their flexibility. All sorts of conformational changes occur in proteins involved in through-membrane signal transmission, showing another aspect of the flexibility of these macromolecules. The movement and flexibility are inscribed in the polymeric nature of essential biological macromolecules such as proteins and nucleic acids. For instance, the well-defined structures formed by the long protein chain are held together by weak noncovalent interac tions that design a complex potential well in which the protein floats, permanently fluctuating between several micro- or macroconformations in a wide range of frequencies and ampli tudes. The inherent mobility of biomolecular edifices may be crucial to the adaptation of their structures to particular functions. Progress in methods for investigating macromolecular structures and dynamics make this hypothesis not only attractive but more and more testable.
Book Synopsis Stereochemistry of Organic Compounds by : Ernest L. Eliel
Download or read book Stereochemistry of Organic Compounds written by Ernest L. Eliel and published by John Wiley & Sons. This book was released on 1994-09-28 with total page 1296 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stereochemistry of Organic Compounds The first fully referenced, comprehensive book on this subject in more than thirty years, Stereochemistry of Organic Compounds contains up-to-date coverage and insightful exposition of all important new concepts, developments, and tools in the rapidly advancing field of stereochemistry, including: * Asymmetric and diastereoselective synthesis * Conformational analysis * Properties of enantiomers and racemates * Separation and analysis of enantiomers and diastereoisomers * Developments in spectroscopy (including NMR), chromatography, and molecular mechanics as applied to stereochemistry * Prostereoisomerism * Conceptual foundations of stereochemistry, including terminology and symmetry concepts * Chiroptical properties Written by the leading authorities in the field, the text includes more than 4,000 references, 1,000 illustrations, and a glossary of stereochemical terms.
Download or read book LC-NMR written by Nina C. Gonnella and published by CRC Press. This book was released on 2020-01-15 with total page 321 pages. Available in PDF, EPUB and Kindle. Book excerpt: The isolation and structural characterization of substances present at very low concentrations, as is necessary to satisfy regulatory requirements for pharmaceutical drug degradants and impurities, can present scientific challenges. The coupling of HPLC with NMR spectroscopy has been at the forefront of cutting-edge technologies to address these issues. LC-NMR: Expanding the Limits of Structure Elucidation presents a comprehensive overview of key concepts in HPLC and NMR that are required to achieve definitive structure elucidation with very low levels of analytes. Because skill sets from both of these highly established disciplines are involved in LC-NMR, the author provides introductory background to facilitate readers’ proficiency in both areas, including an entire chapter on NMR theory. The much-anticipated second edition provides guidance in setting up LC-NMR systems, discussion of LC methods that are compatible with NMR, and an update on recent hardware and software advances for system performance, such as improvements in magnet design, probe technology, and solvent suppression techniques that enable unprecedented mass sensitivity in NMR. This edition features methods to quantify concentration and assess purity of isolated metabolites on the micro scale and incorporates computational approaches to accelerate the structure elucidation process. The author also includes implementation and application of qNMR and automated and practical use of computational chemistry combined with QM and DFT to predict highly accurate NMR chemical shifts. The text focuses on current developments in chromatographic-NMR integration, with particular emphasis on utility in the pharmaceutical industry. Applications include trace analysis, analysis of mixtures, and structural characterization of degradation products, impurities, metabolites, peptides, and more. The text discusses novel uses and emerging technologies that challenge detection limits as well future directions for this important technique. This book is a practical primary resource for NMR structure determination—including theory and application—that guides the reader through the steps required for isolation and NMR structure elucidation on the micro scale.
