The Neurology of Neuroblastoma

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Publisher : Springer Science & Business Media
ISBN 13 : 1461510570
Total Pages : 92 pages
Book Rating : 4.4/5 (615 download)

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Book Synopsis The Neurology of Neuroblastoma by : Nina Felice Schor

Download or read book The Neurology of Neuroblastoma written by Nina Felice Schor and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 92 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neuroblastoma is the single most common solid tumor of childhood. Although children with small primary neuroblastomas alone are almost always cured by surgery, 65% of children with neuroblastoma already have large bulky tumors or metastatic disease by the time of initial diagnosis. For these children, the 5-year survival rate is only somewhere between 5% and 20% with therapies including surgery, radiation, chemotherapy, and bone marrow transplantation. Dr Schor outlines a new approach to these tumors in order to make a difference for these children. There is much information to support the notion that neuroblastomas represent a developmental aberration of the nervous system, rather than a de novo abnormality in a previously normal cell. While the remote, paraneoplastic effects of neuroblastoma are often the purview of the child neurologist, the neoplasm itself has been viewed and approached therapeutically in much the same manner as all other solid tumors, as the purview of the pediatric oncologist. This work takes the view that approaching neuroblastoma rather as a disorder of nervous system development offers new therapeutic possibilities for this common tumor of childhood.

Neuroblastoma

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Publisher : Springer Science & Business Media
ISBN 13 : 354026616X
Total Pages : 303 pages
Book Rating : 4.5/5 (42 download)

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Book Synopsis Neuroblastoma by : Nai-Kong V. Cheung

Download or read book Neuroblastoma written by Nai-Kong V. Cheung and published by Springer Science & Business Media. This book was released on 2005-10-21 with total page 303 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neuroblastoma is a medical enigma. As a childhood neoplasm arising from neural crest cells, it is characterized by diverse clinical behaviors ranging from spontaneous remission to rapid tumor progression and death. Although clinical outcome can be predicted to a large extent by the stage of disease and the age at diagnosis, an in-depth understanding of its clinico-pathological behavior, now greatly aided by sophisticated molecular genetic profiling, will improve diagnostic precision and refine risk-based therapies. Comprehensive international efforts have advanced our understanding of tumor biology and improved the clinical management of children with neuroblastoma. This book reviews our current understanding of the genes and biological pathways that contribute to neuroblastoma pathogenesis, modern risk-based treatment approaches for these patients, and recent advances in biologically based therapy. It provides a concise up-to-date reference for practitioners, students, and researchers.

Progressive Neuroblastoma

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Author :
Publisher : Karger Medical and Scientific Publishers
ISBN 13 : 3318054976
Total Pages : 202 pages
Book Rating : 4.3/5 (18 download)

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Book Synopsis Progressive Neuroblastoma by : H. Christiansen

Download or read book Progressive Neuroblastoma written by H. Christiansen and published by Karger Medical and Scientific Publishers. This book was released on 2015-09-28 with total page 202 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neuroblastoma is a tumor derived from the sympathetic nervous system. It is the most common extracranial solid tumor occurring in children and exhibits a marked variability in outcome when the disease is categorized by clinical (e.g. age or stage) and biologic characteristics. This book gives an introduction into the clinical features of progressive neuroblastoma and focuses on molecular-targeted therapies and immunotherapies of this disease. It has become increasingly clear that MYCN (v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog) holds a key position in neuroblastic transformation and gene expression in normal and transformed cells. In the 14 chapters important topics such as genomic alterations in neuroblastoma and strategies for indirect molecular targeting of MYCN are discussed. Two chapters, for example, review apoptotic pathways and proapoptotic molecular targets in neuroblastoma, one focusing on the p53 pathway and the extrinsic and intrinsic pathways of apoptosis. Other chapters cover topics related to immunology in neuroblastoma, such as immune regulation in neuroblastoma, immunotherapy related to passive and active vaccination approaches and additional immunotherapy in the treatment of progressive disease. This volume will be essential reading for all clinicians and basic researchers who are involved in delivering health care to patients with progressive neuroblastoma.

Tumors of the Central Nervous System, Volume 14

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Publisher : Springer
ISBN 13 : 940177224X
Total Pages : 132 pages
Book Rating : 4.4/5 (17 download)

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Book Synopsis Tumors of the Central Nervous System, Volume 14 by : M.A. Hayat

Download or read book Tumors of the Central Nervous System, Volume 14 written by M.A. Hayat and published by Springer. This book was released on 2015-10-05 with total page 132 pages. Available in PDF, EPUB and Kindle. Book excerpt: This fourteenth volume of the series provides comprehensive, current information on the diagnosis, therapy and prognosis of brain tumors and spinal tumors. For the readers' convenience, contributions are organized into three categories of Pineal Tumors, Pituitary Tumors, and Spinal Tumors. Readers will find discussion of various aspects of a number of tumor types, including angiocentric glioma, pilomyxoid astrocytoma, pituicytoma, pediatric low-grade gliomas, meningiomas and spinal cord tumors. Expert oncologists, neurosurgeons, physicians, research scientists and pathologists from around the world have contributed to this extensive publication. Their chapters highlight practical experience and provide exceptional insight into the nature of cancer. The authors cover topics ranging from the use of molecular criteria in diagnosis and targeting of medicine, through evidence-based approaches, to in-depth discussion of long-term follow-up after surgery. This handbook, as earlier volumes in the series, will appeal to professionals involved in the treatment of cancer, as well as to researchers. The series crosses subjects of diagnosis, drug development, therapy and its assessment and prognosis of tumors of the central nervous system, cancer recurrence and resistance to chemotherapy.

Neuroblastoma

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Author :
Publisher : Springer
ISBN 13 : 9783031512919
Total Pages : 0 pages
Book Rating : 4.5/5 (129 download)

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Book Synopsis Neuroblastoma by : Shahab Asgharzadeh

Download or read book Neuroblastoma written by Shahab Asgharzadeh and published by Springer. This book was released on 2024-04-29 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a state-of-the-art review of the biology, treatment, and other critical aspects of neuroblastoma, reflecting the dramatic advances that have been achieved in understanding and management. Topics are arranged according to the book’s dominant themes of the “seed” (tumor genomics, epigenetics, metabolism, and stem cells) and the “soil” (tumor microenvironment, adaptive and innate immunity, and exosomes) and how both of these influences can serve as rich targets for intervention, whether by targeted molecular therapy or immunotherapy. Therapeutic strategies that are currently in use or under consideration for the future are discussed in detail, with the focus on precision medicine. Further individual chapters are devoted to the biology and genetics of relapsed/refractory neuroblastoma and emerging methods of evaluating tumor burden. Finally, in keeping with the, albeit modest, increase in cure rates in high-risk disease, immune and cellular therapies are reviewed. This coverage of what is becoming a not-so-enigmatic tumor will appeal to a broad readership including both experimental oncologists and clinicians who care for patients with neuroblastoma.

Neuroblastoma

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Author :
Publisher : Springer
ISBN 13 : 3030183963
Total Pages : 375 pages
Book Rating : 4.0/5 (31 download)

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Book Synopsis Neuroblastoma by : Sabine Sarnacki

Download or read book Neuroblastoma written by Sabine Sarnacki and published by Springer. This book was released on 2019-08-12 with total page 375 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book addresses neuroblastoma, a type of embryonic tumor derived from neural crest cells and one of the most frequent extra-cranial solid tumors in children. However, the term also describes a heterogeneous group of tumors, the prognosis of which can differ greatly according to age, stage and biology. Some forms undergo spontaneous regression, and some are cured by surgery alone or after chemo-reduction, while others exhibit extremely aggressive behavior. Their successful treatment is one of the best examples of tailored medicine, which involves close collaboration between pediatric surgeons, pediatric oncologists, radiologists, nuclear medicine specialists, biologists, oncogeneticists and radiotherapists. The book pursues a unique approach, as it combines most essential insights from all of these fields, together with key information regarding epidemiology, physiopathology and palliative care. The respective chapters were written by the leading international experts on neuroblastoma, and present the latest advances in terms of research, surgical approaches and medical treatments. The book offers an invaluable resource to all pediatric surgeons, pediatricians, oncologists, students, researchers and all others involved in neuroblastoma management who want to benefit from their colleagues’ expertise.

Atlas of PET/CT in Pediatric Patients

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Publisher : Springer Science & Business Media
ISBN 13 : 8847053587
Total Pages : 248 pages
Book Rating : 4.8/5 (47 download)

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Book Synopsis Atlas of PET/CT in Pediatric Patients by : Angelina Cistaro

Download or read book Atlas of PET/CT in Pediatric Patients written by Angelina Cistaro and published by Springer Science & Business Media. This book was released on 2013-11-08 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt: This richly illustrated book presents the pediatric applications of PET/CT in the full range of scenarios frequently encountered in a professional setting. It opens with a thorough introduction covering the fundamental science and the clinical basis for use of PET/CT in this age group. Pitfalls and artifacts are examined, and normal variations and benign findings are carefully described. Each subsequent chapter addresses the role of PET/CT with different radiopharmaceuticals in the evaluation and management of a specific disease. The full range of oncological diseases is covered, including the rare ones. Succinct descriptions of clinical cases are included and, when appropriate, comparisons are made with other modalities. In addition, the role of PET/CT in biopsy guidance and in radiation therapy planning is explained. This book will be invaluable for residents and practitioners in nuclear medicine, radiology, oncology, radiation oncology, and nuclear medicine technology

The Epidemiology of Neuroblastoma

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Author :
Publisher : Nova Science Publishers
ISBN 13 : 9781604567519
Total Pages : 0 pages
Book Rating : 4.5/5 (675 download)

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Book Synopsis The Epidemiology of Neuroblastoma by : Stefano Parodi

Download or read book The Epidemiology of Neuroblastoma written by Stefano Parodi and published by Nova Science Publishers. This book was released on 2009 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: As most of the other solid cancers in children, the distribution of Neuroblastoma risk worldwide is only partly known. In Western countries its incidence varies between 7 and 16 cases per million children and it tends to decrease increasing the age. Besides, survival of patients affected by such disease, in relation with clinical and biological characteristics, have been extensively investigated only in recent years, thanks to the making of large co-operative mulit-center research groups, while survival rates at the population are poorly investigated. The risk of developing this cancer has been related to some environmental and parental factors, but most of its etiology still remains unknown.

Pediatric Surgery

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Publisher : Springer Nature
ISBN 13 : 3030814882
Total Pages : 1479 pages
Book Rating : 4.0/5 (38 download)

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Book Synopsis Pediatric Surgery by : Prem Puri

Download or read book Pediatric Surgery written by Prem Puri and published by Springer Nature. This book was released on 2023-01-06 with total page 1479 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive book provides detailed practical advice on the diagnosis and surgical management of congenital and acquired conditions in infants and children. Following the great success of the first edition, the new edition has been fully updated to reflect the major developments in the field of the past decade. Advances in prenatal diagnosis, imaging, anaesthesia and intensive care as well as the introduction of new surgical techniques, including minimally invasive surgery and robotic technology that have radically altered surgical conditions are now discussed in the book. In addition new chapters have been added on surgical safety in children, surgical problems of children with disabilities and surgical implications of HIV infection in children among others. This is a superbly structured and richly illustrated guide aimed at trainees, young pediatric surgeons and general surgeons with interest in pediatric surgery. The book also serves as a handy, quick and easy reference for those making decisions in daily practice. Pediatric Surgery, Diagnosis and Management features contributions by leading experts in pediatric surgery and pediatric urology who have unique experience in their respective fields.

Neuroblastoma

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Publisher : Academic Press
ISBN 13 : 0128120045
Total Pages : 334 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Neuroblastoma by : Swapan K. Ray

Download or read book Neuroblastoma written by Swapan K. Ray and published by Academic Press. This book was released on 2019-01-11 with total page 334 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neuroblastoma: Molecular Mechanisms and Therapeutic Interventions comprehensively reviews current concepts in molecular and histopathological mechanisms that influence the growth of human malignant neuroblastoma, along with exciting therapeutic interventions. This book features a broad collection of contributions from leading investigators in histopathology, molecular mechanisms, genetics, epigenetics, microRNAs, proteomics, and metabolism in controlling growth and death in neuroblastoma. Recent developments in therapeutic interventions for neuroblastoma are also covered extensively, including chapters on surgery, chemotherapy, targeted therapy and immunotherapy. This book is ideal for advanced undergraduate students, graduate students, medical students, postdoctoral fellows, and investigators with an interest in current molecular concepts and therapeutic interventions. Comprehensively covers the histopathological characterization, molecular mechanisms, and most recent therapeutic interventions in neuroblastoma Includes recent developments and therapeutic interventions for neuroblastoma, including chapters on surgery, chemotherapy, targeted therapy and immunotherapy Presents a broad scope that provides basic researchers, practitioners and students with the most current overview of recent advances

Atlas of Sellar and Parasellar Lesions

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Publisher : Springer
ISBN 13 : 3319228552
Total Pages : 514 pages
Book Rating : 4.3/5 (192 download)

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Book Synopsis Atlas of Sellar and Parasellar Lesions by : Gabriel Zada

Download or read book Atlas of Sellar and Parasellar Lesions written by Gabriel Zada and published by Springer. This book was released on 2015-10-27 with total page 514 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents, in a stepwise and interactive fashion, approximately 75 cases that reflect the wide spectrum of pathology encountered in this region. Each case description commences with a concise clinical scenario. High-quality radiologic, laboratory, and histopathologic images depicting the differentiating features of the lesion subtype in question are then presented, and key operative and clinical management pearls are briefly reviewed. The interdisciplinary nature of this easy-to-use color atlas and textbook reflects the fact that the management of patients with sellar and parasellar lesions is itself often interdisciplinary. The format is unique in that no similar interdisciplinary book is available on lesions of this region of the brain. Atlas of Sellar and Parasellar Lesions: Clinical, Imaging, and Pathologic Correlations is of great value for practitioners and trainees in a range of medical specialties, including radiology, neurology, endocriniology, pathology, oncology, radiation oncology, and neurosurgery.

Central Nervous System Tumours: Who Classification of Tumours

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Publisher : WHO Classification of Tumours
ISBN 13 : 9789283245087
Total Pages : 584 pages
Book Rating : 4.2/5 (45 download)

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Book Synopsis Central Nervous System Tumours: Who Classification of Tumours by : WHO Classification of Tumours Editorial Board

Download or read book Central Nervous System Tumours: Who Classification of Tumours written by WHO Classification of Tumours Editorial Board and published by WHO Classification of Tumours. This book was released on 2022-02-15 with total page 584 pages. Available in PDF, EPUB and Kindle. Book excerpt: ****When not purchasing directly from the official sales agents of the WHO, especially at online bookshops, please note that there have been issues with counterfeited copies. Buy only from known sellers and if there are quality issues, please contact the seller for a refund.***** The WHO Classification of Tumours Central Nervous System Tumours is the sixth volume in the 5th edition of the WHO series on the classification of human tumors. This series (also known as the WHO Blue Books) is regarded as the gold standard for the diagnosis of tumors and comprises a unique synthesis of histopathological diagnosis with digital and molecular pathology. These authoritative and concise reference books provide indispensable international standards for anyone involved in the care of patients with cancer or in cancer research, underpinning individual patient treatment as well as research into all aspects of cancer causation, prevention, therapy, and education. What's new in this edition? The 5th edition, guided by the WHO Classification of Tumours Editorial Board, will establish a single coherent cancer classification presented across a collection of individual volumes organized on the basis of anatomical site (digestive system, breast, soft tissue and bone, etc.) and structured in a systematic manner, with each tumor type listed within a taxonomic classification: site, category, family (class), type, and subtype. In each volume, the entities are now listed from benign to malignant and are described under an updated set of headings, including histopathology, diagnostic molecular pathology, staging, and easy-to-read essential and desirable diagnostic criteria. Who should read this book? Pathologists Neuro-oncologists Neuroradiologists Medical oncologists Radiation oncologists Neurosurgeons Oncology nurses Cancer researchers Epidemiologists Cancer registrars This volume Prepared by 199 authors and editors Contributors from around the world More than 1100 high-quality images More than 3600 references WHO Classification of Tumours Online The content of this renowned classification series is now also available in a convenient digital format by purchasing a subscription directly from IARC here.

Neuropsychiatric Disorders

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Publisher : Springer Science & Business Media
ISBN 13 : 3211735747
Total Pages : 326 pages
Book Rating : 4.2/5 (117 download)

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Book Synopsis Neuropsychiatric Disorders by : Manfred Gerlach

Download or read book Neuropsychiatric Disorders written by Manfred Gerlach and published by Springer Science & Business Media. This book was released on 2007-12-28 with total page 326 pages. Available in PDF, EPUB and Kindle. Book excerpt: This multidisciplinary book includes current research papers and reviews in the areas of basic neuroscience, neural mechanisms underlying neurodegenerative disorders. It further includes new approaches for neuroprotective treatments, clinical, neurobiological and treatment aspects of psychiatric disorders. The book was conceived as a celebration of the professional life and work of Peter Riederer to mark the occasion of his retirement.

Neuroblastoma

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Author :
Publisher : BoD – Books on Demand
ISBN 13 : 953513583X
Total Pages : 169 pages
Book Rating : 4.5/5 (351 download)

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Book Synopsis Neuroblastoma by : Chandrika Gowda

Download or read book Neuroblastoma written by Chandrika Gowda and published by BoD – Books on Demand. This book was released on 2017-10-25 with total page 169 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neuroblastoma (NBL) is the most common extracranial solid tumor of childhood, with about 700 new cases of neuroblastoma seen each year in the United States. The 5-year survival rate for children with high-risk NBL is only 50-60%, and this survival rate has not improved over the last 10 years. High-risk patients receive multimodality treatment, including chemotherapy, surgery, radiation therapy, biologic therapy and immunotherapy, all of which are associated with significant morbidity. Recent years have seen many advances in treatment of neuroblastoma, including therapeutic MIBG, immunotherapy, and personalized targeted therapy based on the genetic alterations seen in the tumor. The primary objective of this book is to provide the readers with a comprehensive review of neuroblastoma, from clinical aspects and the currently available treatment to recent advancements and future directions in the field of NBL treatment. The topics and chapters have been compiled keeping in mind a diverse group of readers in different areas of specialty such as pediatric oncology, surgery, radiation oncology, and immunology, as well as physician scientists and basic researchers working in the field of neuroblastoma.

Focus on Neuroblastoma Research

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Publisher : Nova Publishers
ISBN 13 : 9781600214844
Total Pages : 228 pages
Book Rating : 4.2/5 (148 download)

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Book Synopsis Focus on Neuroblastoma Research by : Julio A. Fernandes

Download or read book Focus on Neuroblastoma Research written by Julio A. Fernandes and published by Nova Publishers. This book was released on 2007 with total page 228 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neuroblastoma is a cancer that develops from nerve cells found in several areas of the body. Neuroblastoma most commonly affects children age 5 or younger, though it may rarely occur in older children and adults. Neuroblastoma is the most common cancer in babies. Neuroblastoma develops in tissue that makes up the sympathetic nervous system -- the system of nerves that automatically regulates your heart rate, blood pressure and digestion. Neuroblastoma most commonly arises in and around the adrenal glands, which sit atop the kidneys. However, Neuroblastoma can also develop in other areas of the abdomen and in the chest, neck and pelvis. This book presents important research in this field of research.

Neuroblastoma

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Author :
Publisher : Independently Published
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.3/5 (785 download)

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Book Synopsis Neuroblastoma by : Dr Micheal Samuel

Download or read book Neuroblastoma written by Dr Micheal Samuel and published by Independently Published. This book was released on 2023-02-22 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neuroblastoma is a rare pediatric cancer arising from immature brain and spinal cord cells. It is the most common type of childhood cancer and the most common malignant tumor in children younger than six years old. Symptoms of neuroblastoma may include a rapidly growing lump in the neck, shoulder, or under the arm, significantly if it increases in size or moves. Other signs may include fever, difficulty swallowing, seizures, or problems with vision or speech. If neuroblastoma is found early, treatment with surgery and radiation can often cure the child. But if neuroblastoma is not found or treated quickly, cancer can spread to other body parts. If you are worried your child may have neuroblastoma, please call your doctor. If you or someone you know is experiencing any symptoms, such as a fever, headache, or neck stiffness, please see a medical professional. Neuroblastoma is a highly treatable cancer that can spread to other body parts. It affects both boys and girls equally, and the average age of diagnosis is six months old. Neuroblastomas are often found in the adrenal gland but can also occur in other body parts, such as the brain and spine. Treatment typically involves surgery, radiation therapy, and chemotherapy. SIGNS AND SYMPTOMS OF NEUROBLASTOMA Neuroblastoma is a highly malignant tumor that arises from the cells that make up the nerve tissue in the head and neck. It is the most common solid tumor in children and the most common childhood cancer. Neuroblastoma can occur anywhere in the body but most often occurs in the abdomen (belly), neck, and hands. Most neuroblastomas are preceded by symptoms that may include: weakness, fever, poor appetite, vomiting, and enlarged lymph nodes. These symptoms may take weeks, months, or years to develop. When neuroblastoma is diagnosed, it is often found in an early stage. Early-stage neuroblastoma is treated with surgery and chemotherapy. If the tumor is seen as it is growing, it is treated with radiation and chemotherapy. If the cancer is inoperable, it is treated with radiation and chemotherapy. There is no known cure for neuroblastoma. Most neuroblastomas are cured, but about 10% of patients die from cancer. Treatment options include surgery, radiation therapy, chemotherapy, and immunotherapy.

Neuroblastoma

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Author :
Publisher : Springer Nature
ISBN 13 : 3031512928
Total Pages : 219 pages
Book Rating : 4.0/5 (315 download)

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Book Synopsis Neuroblastoma by : Shahab Asgharzadeh

Download or read book Neuroblastoma written by Shahab Asgharzadeh and published by Springer Nature. This book was released on with total page 219 pages. Available in PDF, EPUB and Kindle. Book excerpt: