The MD Anderson Manual of Medical Oncology, Third Edition

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Publisher : McGraw Hill Professional
ISBN 13 : 0071847952
Total Pages : 1280 pages
Book Rating : 4.0/5 (718 download)

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Book Synopsis The MD Anderson Manual of Medical Oncology, Third Edition by : Hagop M. Kantarjian

Download or read book The MD Anderson Manual of Medical Oncology, Third Edition written by Hagop M. Kantarjian and published by McGraw Hill Professional. This book was released on 2016-05-22 with total page 1280 pages. Available in PDF, EPUB and Kindle. Book excerpt: Authoritative, hands-on desk reference for the practicing oncologist—from the leader in the field of cancer management and treatment A Doody's Core Title for 2019! The MD Anderson Manual of Medical Oncology details the personalized multidisciplinary approach to cancer management and treatment of common and rare cancers pioneered by The University of Texas MD Anderson Cancer Center. Its pragmatic presentation can provide valuable insights at any stage of your career. This completely updated third edition reflects the most recent advancements, including expanded coverage of the rapidly evolving area of biological and immune therapies of cancer, many developed at MD Anderson. It emphasizes and discusses continuing developments in diagnostic procedures, which include the incorporation of new molecular markers and revised staging systems. It also reinforces how imaging and molecular profiling can prevent administration of overly aggressive, toxic treatment regimens or invasive surgery to treat superficial or indolent tumors. To help you quickly assess cancer management options, every chapter includes numerous tables, diagrams, imaging photographs, and prescriptive advice. Evidence-based treatment algorithms in the form of flowcharts and diagrams shaped by the clinical experience of MD Anderson’s world-class faculty enhance the text. The third edition features important new chapters on key topics such as: · Pediatric Cancers · Molecular Biomarkers and Cancer · Immuno-Oncology · Targeted Therapies in Cancer · Onco-Cardiology · Pulmonary Complications of Cancer Therapy · Applied Biostatistics Offering the perfect balance of narrative text, summary tables, and clinical photographs (many in full color), there is truly not a more accessible, up-to-date, or authoritative clinician’s guide to the medical management of patients with cancer and its complications than The MD Anderson Manual of Medical Oncology.

The MD Anderson Manual of Medical Oncology, Third Edition

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Author :
Publisher : McGraw-Hill Education / Medical
ISBN 13 : 9780071847940
Total Pages : 1280 pages
Book Rating : 4.8/5 (479 download)

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Book Synopsis The MD Anderson Manual of Medical Oncology, Third Edition by : Hagop M. Kantarjian

Download or read book The MD Anderson Manual of Medical Oncology, Third Edition written by Hagop M. Kantarjian and published by McGraw-Hill Education / Medical. This book was released on 2016-06-21 with total page 1280 pages. Available in PDF, EPUB and Kindle. Book excerpt: Publisher's Note: Products purchased from Third Party sellers are not guaranteed by the publisher for quality, authenticity, or access to any online entitlements included with the product. Authoritative, hands-on desk reference for the practicing oncologist—from the leader in the field of cancer management and treatment A Doody's Core Title for 2017! The MD Anderson Manual of Medical Oncology details the personalized multidisciplinary approach to cancer management and treatment of common and rare cancers pioneered by The University of Texas MD Anderson Cancer Center. Its pragmatic presentation can provide valuable insights at any stage of your career. This completely updated third edition reflects the most recent advancements, including expanded coverage of the rapidly evolving area of biological and immune therapies of cancer, many developed at MD Anderson. It emphasizes and discusses continuing developments in diagnostic procedures, which include the incorporation of new molecular markers and revised staging systems. It also reinforces how imaging and molecular profiling can prevent administration of overly aggressive, toxic treatment regimens or invasive surgery to treat superficial or indolent tumors. To help you quickly assess cancer management options, every chapter includes numerous tables, diagrams, imaging photographs, and prescriptive advice. Evidence-based treatment algorithms in the form of flowcharts and diagrams shaped by the clinical experience of MD Anderson’s world-class faculty enhance the text.

The MD Anderson Manual of Medical Oncology, Fourth Edition

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Author :
Publisher : McGraw Hill Professional
ISBN 13 : 1260467651
Total Pages : 1694 pages
Book Rating : 4.2/5 (64 download)

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Book Synopsis The MD Anderson Manual of Medical Oncology, Fourth Edition by : Hagop M. Kantarjian

Download or read book The MD Anderson Manual of Medical Oncology, Fourth Edition written by Hagop M. Kantarjian and published by McGraw Hill Professional. This book was released on 2022-04-15 with total page 1694 pages. Available in PDF, EPUB and Kindle. Book excerpt: Expert, hands-on guidance for the practicing oncologist—from the leader in the field of cancer management—completely updated to reflect the latest advances A Doody's Core Title for 2023! Comprehensive and authoritative, The MD Anderson Manual of Medical Oncology delivers everything you need to accurately diagnose and effectively treat a wide range of cancers—including leukemia, lymphoma, myeloma, lung and breast cancer, genitourinary carcinoma, melanoma, and sarcoma. This unmatched resource emphasizes practical, actionable steps to cancer treatment, providing "to the point" recommendations, chapter summary boxes, tables, charts, expert opinion and patient education boxes, practice tips, cases, and prescriptive advice. The new format of this updated edition quickly guides you to the topic, the affiliated relevant chapter, new findings affecting clinical practice, and reference/evidence. This fourth edition features: NEW Q&A, cases, patient education information, and expert advice Expanded coverage of immunotherapy treatment—written by the 2018 Nobel Prize-winner for immunology Access to continually updated online content A comparative table with guidelines from the European Society of Medical Oncology and the American Society of Clinical Oncology An emphasis on recent developments in precision medicine and immunotherapies Plus important NEW chapters on: Cord blood transplant Haploidentical cell transplantation Cellular therapy in allogeneic hematopoietic cell transplantation Pediatric cancers Molecular biomarkers and cancer Immune-oncology Targeted therapies in cancer Applied biostatistics Oncocardiology Pulmonary complications of cancer associated thrombosis

The MD Anderson Manual of Medical Oncology

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Author :
Publisher : McGraw Hill Professional
ISBN 13 : 0071487255
Total Pages : 1168 pages
Book Rating : 4.0/5 (714 download)

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Book Synopsis The MD Anderson Manual of Medical Oncology by : Hagop M. Kantarjian

Download or read book The MD Anderson Manual of Medical Oncology written by Hagop M. Kantarjian and published by McGraw Hill Professional. This book was released on 2006-04-10 with total page 1168 pages. Available in PDF, EPUB and Kindle. Book excerpt: The MD Anderson Manual of Medical Oncology was designed to fill an important void in oncology reference material by serving as a hands-on resource for the practicing oncologist. It was written exclusively by MD Anderson faculty and fellows with the idea of presenting a bird's eye view of medical oncology as it is currently practiced at that institution. While definitely written from the perspective of the medical oncologist, this book clearly emphasizes MD Anderson's multidisciplinary approach to cancer care. Furthermore, while evidence-based rationales are given for patient care strategies, no apologies are offered for articulating the unique perspectives and biases as they apply to cancer biology and therapy as practiced at this top-rated cancer center. The rationales for ongoing clinical trials are clearly articulated as well as the importance of ongoing clinical investigation. The authors have filled the book with tables, graphics, relevant pathology figures, and other illustrative images, making it visually stimulating. Flowchart and diagrammatic algorithms are supplied to provide readers with a practical guide to the diagnostic and therapeutic strategies used at MD Anderson. Numerous chapters address important palliative and supportive measures, such as oncologic emergencies, infections, endocrine manifestations of non-endocrine tumors, palliation, and long-term followup.

The MD Anderson Manual of Medical Oncology, Second Edition

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Author :
Publisher : McGraw Hill Professional
ISBN 13 : 0071701052
Total Pages : 1423 pages
Book Rating : 4.0/5 (717 download)

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Book Synopsis The MD Anderson Manual of Medical Oncology, Second Edition by : Hagop M. Kantarjian

Download or read book The MD Anderson Manual of Medical Oncology, Second Edition written by Hagop M. Kantarjian and published by McGraw Hill Professional. This book was released on 2011-04-22 with total page 1423 pages. Available in PDF, EPUB and Kindle. Book excerpt: State-of-the-art approaches to cancer management from the world's #1 oncology center The perfect clinical desk manual from the experts at MD Anderson Cancer Center Read the outstanding reviews of the previous edition: "As a detailed guide, [the book] offers practitioners a clear, user-friendly approach to the care of patients with cancer." -- New England Journal of Medicine "The portions of the text that summarize the chemotherapeutic literature are helpful and potentially useful to a busy medical oncologist. The graphic representations and flow charts are of high quality, are well designed and easy to follow, and are clinically useful. A number of good photographs have been provided that illustrate pathologic conditions....the Manual is well written, has extremely useful graphics, and represents a useful entry point for those interested in the management of malignant diseases." -- International Journal of Radiation Oncology, Biology, Physics "...[MD Anderson Manual of Medical Oncology] fulfills its goals of helping clinicians quickly evaluate therapeutic regimens and possibilities. Surgeons and radiation oncologists will find the text useful as a reference guide to what the medical oncologist can do and how the medical oncologist views their disciplines. The text is also of considerable help for physicians studying for board certification or recertification in medical oncology. Practicing medical oncologists would do well to have it in their personal libraries." -- Journal of the American Medical Association MD Anderson Manual of Medical Oncology offers clinicians an authoritative, easy-to-follow guide to the medical management of patients with cancer and its complications. Featuring concise but practical text and a large number of decision-making algorithms, the book gives physicians a current, templated approach to each disease and situation -- backed by the clincal expertise and authority of world recognized oncology researchers/practitioners. Key Features REVISED: competely updated coverage of the quickly evolving world of cancer therapeutics NEW: chapters include "Expert Commentary Sidebars" that provide clinical insights from leading subspecialists in radiation therapy, surgical oncology, pathology, and laboratory medicine NEW: brand new chapters on myelodysplasia, myeloproliferative diseases, and appendiceal cancer NEW: a brand new chapter on the important and underpublished topic of psycho-social issues in oncology Consistently formatted for a unified patient management strategy Packed with time-saving features, including The MD Anderson Work-Up Box and The MD Anderson Preferred Treatment Box

The MD Anderson Manual of Medical Oncology, Second Edition

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Author :
Publisher : Mcgraw-hill
ISBN 13 : 9780071701068
Total Pages : 1400 pages
Book Rating : 4.7/5 (1 download)

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Book Synopsis The MD Anderson Manual of Medical Oncology, Second Edition by : Hagop M. Kantarjian

Download or read book The MD Anderson Manual of Medical Oncology, Second Edition written by Hagop M. Kantarjian and published by Mcgraw-hill. This book was released on 2011-06-14 with total page 1400 pages. Available in PDF, EPUB and Kindle. Book excerpt: A hands-on desk reference for the practicing oncologist – from the leader in the field of cancer management A Doody's Core Title for 2011! The MD Anderson Manual of Medical Oncology details the personalized multidisciplinary approach to cancer management pioneered by The University of Texas MD Anderson Cancer Center. It is intended to bring a pragmatic approach to cancer management that can serve as a guide for oncologists around the world. This completely updated second edition emphasizes and discusses recent developments in diagnostic procedures, which include the incorporation of new molecular markers and revised staging systems. It also reinforces how imaging and molecular profiling can prevent administration of overly aggressive, toxic treatment regimens, or invasive surgery to treat superficial or indolent tumors. Also new to the second edition are special commentaries provided by subspecialists in pulmonary medicine, radiation oncology, and surgery which discuss other perspectives on management. To help you quickly assess cancer management options, every chapter includes numerous tables, diagrams, and imaging photographs. These include evidence-based treatment algorithms in the form of flowcharts and diagrams shaped by the clinical experience of MD Anderson’s world-class faculty. Everything is designed to provide you with a practical guide to diagnostic and therapeutic strategies used at MD Anderson. The second edition also features important new chapters on key topics such as: Myelodysplastic syndrome Myeloproliferative neoplasms T-cell lymphomas Small bowel and appendiceal cancers Inflammatory breast cancer Offering the perfect balance of narrative text, summary tables, and clinical photographs (many in full color), there is truly not a more accessible, up-to-date, or authoritative clinician’s guide to the medical management of patients with cancer and its complications than The MD Anderson Manual of Medical Oncology.

MD Anderson Manual of Medical Oncology

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Author :
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (137 download)

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Book Synopsis MD Anderson Manual of Medical Oncology by : Hagop M. Kantarjian

Download or read book MD Anderson Manual of Medical Oncology written by Hagop M. Kantarjian and published by . This book was released on 2022 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The new edition of The MD Anderson Manual of Medical Oncology contains new chapters on cord blood transplant, haploidentical stem cell transplantation, cellular therapy in allogeneic hematopoietic cell transplantation, pediatric cancers, molecular biomarkers and cancer, immuno-oncology, targeted therapies in cancer, applied biostatistics, oncocardiology, pulmonary complications of cancer therapy, and cancer-associated thrombosis. In addition, there is expanded coverage of the rapidly growing areas of biological and immune therapies of cancer, with one chapter co-authored by our very own Nobel Laureate, Jim Allison.

The M.D. Anderson Surgical Oncology Handbook

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Publisher : Lippincott Williams & Wilkins
ISBN 13 : 1451154097
Total Pages : 962 pages
Book Rating : 4.4/5 (511 download)

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Book Synopsis The M.D. Anderson Surgical Oncology Handbook by : Barry W. Feig

Download or read book The M.D. Anderson Surgical Oncology Handbook written by Barry W. Feig and published by Lippincott Williams & Wilkins. This book was released on 2012-10-22 with total page 962 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by current and former surgical oncology fellows of the world-renowned M.D. Anderson Cancer Center, this portable handbook is a practical guide to established surgical oncology principles for each organ system. Maximize your surgical oncology skills with comprehensive coverage, multidisciplinary perspectives, proven therapeutic strategies, useful algorithms, and recommended readings. Concise chapters illustrated with algorithms and line drawings outlining the essential elements of diagnosis, staging, and clinical management of solid tumors treated in surgical practice.

The M.D. Anderson Surgical Oncology Handbook

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Publisher : Lippincott Williams & Wilkins
ISBN 13 : 9780781756433
Total Pages : 726 pages
Book Rating : 4.7/5 (564 download)

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Book Synopsis The M.D. Anderson Surgical Oncology Handbook by : Barry W. Feig

Download or read book The M.D. Anderson Surgical Oncology Handbook written by Barry W. Feig and published by Lippincott Williams & Wilkins. This book was released on 2006 with total page 726 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by current and former surgical oncology fellows of the world-renowned M.D. Anderson Cancer Center, this portable handbook is a practical guide to established surgical oncology principles for each organ system. This new Fourth Edition features extensive updates including new chapters on reconstructive surgery in the cancer patient. Concise chapters illustrated with algorithms and line drawings outline the essential elements of diagnosis, staging, and clinical management of solid tumors treated in surgical practice. The authors emphasize multidisciplinary treatment planning, including therapy sequencing and biologic therapies.

The M.d. Anderson Surgical Oncology Handbook for Pda

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Publisher :
ISBN 13 : 9780781754231
Total Pages : pages
Book Rating : 4.7/5 (542 download)

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Book Synopsis The M.d. Anderson Surgical Oncology Handbook for Pda by : M D Anderson Cancer Center Department

Download or read book The M.d. Anderson Surgical Oncology Handbook for Pda written by M D Anderson Cancer Center Department and published by . This book was released on 2004-06-01 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The Third Edition of The M.D. Anderson Surgical Oncology Handbook is now available in PDA format for instant access at the point of care. Prepared by current and former surgical oncology fellows of the world-renowned M.D. Anderson Cancer Center, this handheld reference is a practical guide to established surgical oncology principles for each organ system. Easy-to-navigate entries with algorithms and line drawings outline the essentials of diagnosis, staging, and clinical management of solid tumors treated in surgical practice. The authors emphasize multidisciplinary treatment planning, including therapy sequencing and biologic therapies. Platform: Palm OS, Windows CE, and Pocket PC handheld devices

The MD Anderson Surgical Oncology Manual

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Author :
Publisher : Lippincott Williams & Wilkins
ISBN 13 : 1975192613
Total Pages : 1274 pages
Book Rating : 4.9/5 (751 download)

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Book Synopsis The MD Anderson Surgical Oncology Manual by : Barry W Feig

Download or read book The MD Anderson Surgical Oncology Manual written by Barry W Feig and published by Lippincott Williams & Wilkins. This book was released on 2023-02-24 with total page 1274 pages. Available in PDF, EPUB and Kindle. Book excerpt: Now with additional review content and a larger page size, The MD Anderson Surgical Oncology Manual, Seventh Edition, focuses on multidisciplinary, cooperative management approaches to issues confronting today’s surgical oncologist. Lead editor Dr. Barry W. Feig is joined by recently graduated surgical oncology fellows Michael G. White, Cameron E. Gaskill, Anai N. Kothari, and Sandra R. DiBrito to bring you comprehensive yet concise information on the complete range of oncologic considerations needed to effectively understand cancer and all aspects of its treatment.

MD Anderson Manual of Psychosocial Oncology

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Author :
Publisher : McGraw Hill Professional
ISBN 13 : 007176660X
Total Pages : 400 pages
Book Rating : 4.0/5 (717 download)

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Book Synopsis MD Anderson Manual of Psychosocial Oncology by : James D. Duffy

Download or read book MD Anderson Manual of Psychosocial Oncology written by James D. Duffy and published by McGraw Hill Professional. This book was released on 2010-12-17 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: A practical and comprehensive guide to fostering behavioral and emotional health in cancer patients – from one of the world’s leading cancer treatment centers Reflecting the collective expertise of more than forty contributors, most from the renowned MD Anderson Cancer Center, this manual addresses key psychological and behavioral issues that should be considered when treating cancer patients, including special populations such as children and the elderly. Coverage includes: Communicating with patients and family Distress and cancer Assessment and management of psychological symptoms, including mood disorders, anxiety, fatigue, substance abuse, and delirium Family and cultural issues, including spirituality and religion and supporting the caregiver Integrative medicine Physical medicine and rehabilitation Grief and end-of-life issues, including non-pharmacologic interventions and palliative medicine Healthcare professional wellbeing MD Anderson Handbook of Psychosocial Oncology is designed to be a practical guide for clinicians and allied professionals in the day-to-day practice of psychosocial oncology, which is an essential component of the comprehensive care of cancer patients and their caregivers.

The MD Anderson Surgical Oncology Handbook

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Author :
Publisher : LWW
ISBN 13 : 9781496358158
Total Pages : 0 pages
Book Rating : 4.3/5 (581 download)

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Book Synopsis The MD Anderson Surgical Oncology Handbook by : Barry W. Feig

Download or read book The MD Anderson Surgical Oncology Handbook written by Barry W. Feig and published by LWW. This book was released on 2018-06-15 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: "The sixth edition of the MD Anderson Surgical Oncology Handbook focuses on multidisciplinary, cooperative approaches to issues confronting the surgical oncologist. Organized by disease and in full color for the first time, this volume is comprehensive yet concise, and takes into account all of the oncologic issues you need to consider in order to fully understand each disease and its relevant treatments. Written by current and former MD Anderson surgical oncology fellows. Each disease- or system-specific chapter covers epidemiology, pathology, staging, diagnosis, clinical presentation, surgical treatment and targeted therapies, and more. Includes a new chapter on peritoneal malignancies and is updated with the latest staging and protocols. Ideal for surgical residents, medical students facing a surgical/oncology rotation, and practicing surgeons. Enrich Your eBook Reading Experience with Enhanced Video, Audio and Interactive Capabilities! Read directly on your preferred device(s), such as computer, tablet, or smartphone. Customize for your language, including right-to-left reading, vertical writing, and enhanced annotation in over 30 languages. Easily convert to audiobook, powering your content with natural language text-to-speech. Adapt for unique reading needs, supporting learning disabilities, visual/auditory impairments, second-language or literacy challenges, and more."--Provided by publisher.

Cancer and the Heart

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Publisher : PMPH USA
ISBN 13 : 160795964X
Total Pages : 1076 pages
Book Rating : 4.6/5 (79 download)

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Book Synopsis Cancer and the Heart by : Michael S. Ewer

Download or read book Cancer and the Heart written by Michael S. Ewer and published by PMPH USA. This book was released on 2019-11-20 with total page 1076 pages. Available in PDF, EPUB and Kindle. Book excerpt: In Cancer and the Heart, third edition, Dr. Ewer and colleagues at MD Anderson are joined by national and international authorities who contributed to the 28 chapters of this volume. The various authors present their insights into the effects of anticancer drugs and radiation treatment on the heart, and other organ systems. Discussions are advanced on imaging strategies and techniques with an emphasis on specific clinical problems experienced by physicians and their patients. Readers will find a useful reference intended to help them recognize the decision-making dilemmas they face providing optimal tumor management, and a useful resource to help them and their cancer patients cope with inevitable challenges.

Manual of Clinical Oncology

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Publisher : Lippincott Williams & Wilkins
ISBN 13 : 1451115601
Total Pages : 945 pages
Book Rating : 4.4/5 (511 download)

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Book Synopsis Manual of Clinical Oncology by : Casciato

Download or read book Manual of Clinical Oncology written by Casciato and published by Lippincott Williams & Wilkins. This book was released on 2012 with total page 945 pages. Available in PDF, EPUB and Kindle. Book excerpt: Manual of Clinical Oncology is a concise pocket manual that incorporates basic science, clinical findings, and available technology into the diagnosis and management of cancer. It focuses on information useful for participating in rounds and for making diagnostic and therapeutic decisions at the bedside of cancer patients. The seventh edition is a practical, accessible, comprehensive guide to the management of patients with cancer.

The Washington Manual of Oncology

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Author :
Publisher : Lippincott Williams & Wilkins
ISBN 13 : 1496318439
Total Pages : 1026 pages
Book Rating : 4.4/5 (963 download)

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Book Synopsis The Washington Manual of Oncology by : Ramaswamy Govindan

Download or read book The Washington Manual of Oncology written by Ramaswamy Govindan and published by Lippincott Williams & Wilkins. This book was released on 2015-04-03 with total page 1026 pages. Available in PDF, EPUB and Kindle. Book excerpt: Get the latest, most reliable cancer management recommendations in the famous fast-access Washington Manual® outline format! Concise, clearly written sections on principles of oncology, site-specific diseases, and supportive therapy make The Washington Manual® of Oncology, 3rd Edition, an invaluable resource for the daily care of cancer patients. The Washington Manual® is a registered mark belonging to Washington University in St. Louis to which international legal protection applies. The mark is used in this publication by LWW under license from Washington University. Better understand innovative developments in oncology with new chapters on Genome Sequencing, Personalized Therapy, Endocrine Tumors, Myelodysplastic Syndromes, Anti-emesis and Survivorship. Focus on new ideas in the field thanks to a greater emphasis on molecular diagnosis, genome sequencing, and targeted therapies. Quickly locate key information in the appendices, such as body surface area, dose adjustments of chemotherapy agents in renal and hepatic failure, and online resources for oncologists. Benefit from proven treatment recommendations from the experts at Washington University in St. Louis – ideal for the busy third and fourth year student, resident, or clinician.

Surgical Oncology Manual

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Author :
Publisher : Springer Nature
ISBN 13 : 3030483630
Total Pages : 526 pages
Book Rating : 4.0/5 (34 download)

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Book Synopsis Surgical Oncology Manual by : Frances C. Wright

Download or read book Surgical Oncology Manual written by Frances C. Wright and published by Springer Nature. This book was released on 2020-08-27 with total page 526 pages. Available in PDF, EPUB and Kindle. Book excerpt: This third edition manual provides a comprehensive, insightful, evidenced-based review of general surgical oncology and serves as a valuable resource for general surgeons in training, practicing general surgeons, and surgical oncologists. The volume describes a multidisciplinary approach that integrates clinical, radiologic, and pathologic data in formulating practical clinical management, and offers a practical approach to the most common situations when treating cancer patients. Each chapter focuses on an individual malignancy and describes the presentation of the malignancy, integrated management based on stage, landmark trials, and suggestions for who to discuss at multidisciplinary cancer conferences. Multiple tables in each chapter provide a concise yet comprehensive summary of the current status of the field. Clinical “pearls” or tips and tricks from high volume surgeons at the University of Toronto are also discussed. The third edition of the Surgical Oncology Manual will serve as a critical resource for general surgeons in training and practicing surgeons dealing with this challenging field.