The Mathematics Of Mechanobiology

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The Mathematics of Mechanobiology

Author : Antonio DeSimone
Publisher : Springer Nature
ISBN 13 : 3030451976
Total Pages : 217 pages
Book Rating : 4.0/5 (34 download)

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Book Synopsis The Mathematics of Mechanobiology by : Antonio DeSimone

Download or read book The Mathematics of Mechanobiology written by Antonio DeSimone and published by Springer Nature. This book was released on 2020-06-29 with total page 217 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents the state of the art in mathematical research on modelling the mechanics of biological systems – a science at the intersection between biology, mechanics and mathematics known as mechanobiology. The book gathers comprehensive surveys of the most significant areas of mechanobiology: cell motility and locomotion by shape control (Antonio DeSimone); models of cell motion and tissue growth (Benoît Perthame); numerical simulation of cardiac electromechanics (Alfio Quarteroni); and power-stroke-driven muscle contraction (Lev Truskinovsky). Each section is self-contained in terms of the biomechanical background, and the content is accessible to all readers with a basic understanding of differential equations and numerical analysis. The book disentangles the phenomenological complexity of the biomechanical problems, while at the same time addressing the mathematical complexity with invaluable clarity. The book is intended for a wide audience, in particular graduate students and applied mathematicians interested in entering this fascinating field.

The Mathematics and Mechanics of Biological Growth

Author : Alain Goriely
Publisher : Springer
ISBN 13 : 038787710X
Total Pages : 646 pages
Book Rating : 4.3/5 (878 download)

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Book Synopsis The Mathematics and Mechanics of Biological Growth by : Alain Goriely

Download or read book The Mathematics and Mechanics of Biological Growth written by Alain Goriely and published by Springer. This book was released on 2017-05-29 with total page 646 pages. Available in PDF, EPUB and Kindle. Book excerpt: This monograph presents a general mathematical theory for biological growth. It provides both a conceptual and a technical foundation for the understanding and analysis of problems arising in biology and physiology. The theory and methods are illustrated on a wide range of examples and applications. A process of extreme complexity, growth plays a fundamental role in many biological processes and is considered to be the hallmark of life itself. Its description has been one of the fundamental problems of life sciences, but until recently, it has not attracted much attention from mathematicians, physicists, and engineers. The author herein presents the first major technical monograph on the problem of growth since D’Arcy Wentworth Thompson’s 1917 book On Growth and Form. The emphasis of the book is on the proper mathematical formulation of growth kinematics and mechanics. Accordingly, the discussion proceeds in order of complexity and the book is divided into five parts. First, a general introduction on the problem of growth from a historical perspective is given. Then, basic concepts are introduced within the context of growth in filamentary structures. These ideas are then generalized to surfaces and membranes and eventually to the general case of volumetric growth. The book concludes with a discussion of open problems and outstanding challenges. Thoughtfully written and richly illustrated to be accessible to readers of varying interests and background, the text will appeal to life scientists, biophysicists, biomedical engineers, and applied mathematicians alike.

Multiscale Modeling in Biomechanics and Mechanobiology

Author : Suvranu De
Publisher : Springer
ISBN 13 : 1447165993
Total Pages : 287 pages
Book Rating : 4.4/5 (471 download)

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Book Synopsis Multiscale Modeling in Biomechanics and Mechanobiology by : Suvranu De

Download or read book Multiscale Modeling in Biomechanics and Mechanobiology written by Suvranu De and published by Springer. This book was released on 2014-10-10 with total page 287 pages. Available in PDF, EPUB and Kindle. Book excerpt: Presenting a state-of-the-art overview of theoretical and computational models that link characteristic biomechanical phenomena, this book provides guidelines and examples for creating multiscale models in representative systems and organisms. It develops the reader's understanding of and intuition for multiscale phenomena in biomechanics and mechanobiology, and introduces a mathematical framework and computational techniques paramount to creating predictive multiscale models. Biomechanics involves the study of the interactions of physical forces with biological systems at all scales – including molecular, cellular, tissue and organ scales. The emerging field of mechanobiology focuses on the way that cells produce and respond to mechanical forces – bridging the science of mechanics with the disciplines of genetics and molecular biology. Linking disparate spatial and temporal scales using computational techniques is emerging as a key concept in investigating some of the complex problems underlying these disciplines. Providing an invaluable field manual for graduate students and researchers of theoretical and computational modelling in biology, this book is also intended for readers interested in biomedical engineering, applied mechanics and mathematical biology.

Introduction to Cell Mechanics and Mechanobiology

Author : Christopher R. Jacobs
Publisher : Garland Science
ISBN 13 : 1135042659
Total Pages : 350 pages
Book Rating : 4.1/5 (35 download)

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Book Synopsis Introduction to Cell Mechanics and Mechanobiology by : Christopher R. Jacobs

Download or read book Introduction to Cell Mechanics and Mechanobiology written by Christopher R. Jacobs and published by Garland Science. This book was released on 2012-11-16 with total page 350 pages. Available in PDF, EPUB and Kindle. Book excerpt: Introduction to Cell Mechanics and Mechanobiology is designed for a one-semester course in the mechanics of the cell offered to advanced undergraduate and graduate students in biomedical engineering, bioengineering, and mechanical engineering. It teaches a quantitative understanding of the way cells detect, modify, and respond to the physical prope

Mechanobiology Handbook

Author : Jiro Nagatomi
Publisher : CRC Press
ISBN 13 : 1420091220
Total Pages : 564 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Mechanobiology Handbook by : Jiro Nagatomi

Download or read book Mechanobiology Handbook written by Jiro Nagatomi and published by CRC Press. This book was released on 2011-03-15 with total page 564 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mechanobiology-the study of the effects of mechanical environments on the biological processes of cells-has evolved from traditional biomechanics via the incorporation of strong elements of molecular and cell biology. Currently, a broad range of organ systems are being studied by surgeons, physicians, basic scientists, and engineers. These mechanob

Mechanobiology Handbook, Second Edition

Author : Jiro Nagatomi
Publisher : CRC Press
ISBN 13 : 042981674X
Total Pages : 705 pages
Book Rating : 4.4/5 (298 download)

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Book Synopsis Mechanobiology Handbook, Second Edition by : Jiro Nagatomi

Download or read book Mechanobiology Handbook, Second Edition written by Jiro Nagatomi and published by CRC Press. This book was released on 2018-12-07 with total page 705 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mechanobiology—the study of the effects of mechanics on biological events—has evolved to answer numerous research questions. Mechanobiology Handbook 2nd Edition is a reference book for engineers, scientists, and clinicians who are interested in mechanobiology and a textbook for senior undergraduate to graduate level students of this growing field. Readers will gain a comprehensive review of recent research findings as well as elementary chapters on solid mechanics, fluid mechanics, and molecular analysis techniques. The new edition presents, in addition to the chapters of the first edition, homework problem sets that are available online and reviews of research in uncovered areas. Moreover, the new edition includes chapters on statistical analysis, design of experiments and optical imaging. The editors of this book are researchers and educators in mechanobiology. They realized a need for a single volume to assist course instructors as a guide for didactic teaching of mechanobiology to a diverse student body. A mechanobiology course is frequently made up of both undergraduate and graduate students pursuing degrees in engineering, biology, or integrated engineering and biology. Their goal was to present both the elementary and cutting-edge aspects of mechanobiology in a manner that is accessible to students from many different academic levels and from various disciplinary backgrounds. Moreover, it is their hope that the readers of Mechanobiology Handbook 2nd Edition will find study questions at the end of each chapter useful for long-term learning and further discussion. Comprehensive collection of reviews of recent research Introductory materials in mechanics, biology, and statistics Discussion of pioneering and emerging mechanobiology concepts Presentation of cutting-edge mechanobiology research findings across various fields and organ systems End of chapter study questions, available online Considering the complexity of the mechanics and the biology of the human body, most of the world of mechanobiology remains to be studied. Since the field is still developing, the Mechanobiology Handbook raises many different viewpoints and approaches with the intention of stimulating further research endeavours.

Mechanics of Biological Systems

Author : Seungman Park
Publisher : Morgan & Claypool Publishers
ISBN 13 : 1643273922
Total Pages : 135 pages
Book Rating : 4.6/5 (432 download)

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Book Synopsis Mechanics of Biological Systems by : Seungman Park

Download or read book Mechanics of Biological Systems written by Seungman Park and published by Morgan & Claypool Publishers. This book was released on 2019-11-06 with total page 135 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is an introduction to the mechanical properties, the force generating capacity, and the sensitivity to mechanical cues of the biological system. To understand how these qualities govern many essential biological processes, we also discuss how to measure them. However, before delving into the details and the techniques, we will first learn the operational definitions in mechanics, such as force, stress, elasticity, viscosity and so on. This book will explore the mechanics at three different length scales – molecular, cellular, and tissue levels – sequentially, and discuss the measurement techniques to quantify the intrinsic mechanical properties, force generating capacity, mechanoresponsive processes in the biological systems, and rupture forces.

Continuum Modeling in Mechanobiology

Author : Larry A. Taber
Publisher : Springer Nature
ISBN 13 : 3030432092
Total Pages : 545 pages
Book Rating : 4.0/5 (34 download)

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Book Synopsis Continuum Modeling in Mechanobiology by : Larry A. Taber

Download or read book Continuum Modeling in Mechanobiology written by Larry A. Taber and published by Springer Nature. This book was released on 2020-06-15 with total page 545 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book examines key theoretical tools that are currently used to develop mathematical models as an aid in understanding the biological response of cells and tissues to mechanical stimuli. Problems in growth and remodeling, tissue and organ development, and functional adaptation are all covered. Chapters on tensor analysis and nonlinear elasticity provide the necessary background for understanding the engineering theories that are currently used to solve challenges in mechanobiology. This is an ideal book for biomechanical engineers who work on problems in mechanobiology and tissue engineering.

Material-based Mechanobiology

Author : Jun Nakanishi
Publisher : Royal Society of Chemistry
ISBN 13 : 1839165383
Total Pages : 302 pages
Book Rating : 4.8/5 (391 download)

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Book Synopsis Material-based Mechanobiology by : Jun Nakanishi

Download or read book Material-based Mechanobiology written by Jun Nakanishi and published by Royal Society of Chemistry. This book was released on 2022-08-12 with total page 302 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mechanobiology is a new research field that investigates how the physical forces and changes in mechanical properties of cells and tissues contribute to their development, physiology and disease. One unique feature in the mechanical regulation, distinct from chemical/biochemical one, is that it can directly react with the multi-layered architectures of living systems, ranging from nano-scale proteins, subcellular organelles, cells, tissues, organs to whole bodies; one could term it “mechanoarchitectonics”. Another important aspect is its time-dependent dynamic feature. Not only time evolution in cells and extracellular matrices, but their intrinsic viscoelastic nature makes mechanical interaction dissipative and such feature is critical in cellular mechanical responses. This book focuses on recent progress in mechanobiology from the materials science perspective, encompassing innovative material designs for force measurements and actuation to resolve dynamic mechanobiology and mechanoarchitectonics, by better mimicking physiologically relevant and time-evolving cellular mechanical environments. It also shows the marriage between cutting-edge materials science which enable spatiotemporal manipulation of material and cell dynamics in multi-dimensions and molecular biological techniques such as genome editing and next generation sequencing for cell fate/motility engineering and disease modelling, with the aim of providing valuable insights into the latest technological advances and discoveries in areas such as stem cell, fibroblast, heart, tumour, and epithelial mechanobiology. Edited by leaders in the field, this book will be suitable for a broad range of readers, including materials scientists, biomaterial and biomedical engineering researchers and those working in chemical and mechanical engineering to expand possibilities of system designs for the developments of medical technologies based on mechanobiology.

Mechanobiology in Health and Disease

Author : Stefaan Verbruggen
Publisher : Academic Press
ISBN 13 : 0128129530
Total Pages : 527 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Mechanobiology in Health and Disease by : Stefaan Verbruggen

Download or read book Mechanobiology in Health and Disease written by Stefaan Verbruggen and published by Academic Press. This book was released on 2018-08-09 with total page 527 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mechanobiology in Health and Disease brings together contributions from leading biologists, clinicians, physicists and engineers in one convenient volume, providing a unified source of information for researchers in this highly multidisciplinary area. Opening chapters provide essential background information on cell mechanotransduction and essential mechanobiology methods and techniques. Other sections focus on the study of mechanobiology in healthy systems, including bone, tendons, muscles, blood vessels, the heart and the skin, as well as mechanobiology studies of pregnancy. Final chapters address the nascent area of mechanobiology in disease, from the study of bone conditions, skin diseases and heart diseases to cancer. A discussion of future perspectives for research completes each chapter in the volume. This is a timely resource for both early-career and established researchers working on mechanobiology. Provides an essential digest of primary research from many fields and disciplines in one convenient volume Covers both experimental approaches and descriptions of mechanobiology problems from mathematical and numerical perspectives Addresses the hot topic of mechanobiology in disease, a particularly dynamic field of frontier science

Basic Orthopaedic Biomechanics & Mechano-biology

Author : Van C. Mow
Publisher : Lippincott Williams & Wilkins
ISBN 13 : 9780781739337
Total Pages : 746 pages
Book Rating : 4.7/5 (393 download)

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Book Synopsis Basic Orthopaedic Biomechanics & Mechano-biology by : Van C. Mow

Download or read book Basic Orthopaedic Biomechanics & Mechano-biology written by Van C. Mow and published by Lippincott Williams & Wilkins. This book was released on 2005 with total page 746 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biomaterials / Ahmed El-Ghannam and Paul Ducheyne -- Biomechanics of the spine / Ian A. F. Stokes and James C. Iatridis -- Biomechanics of fracture fixation and fracture healing / Lutz E. Claes and Keita Ito -- Biomechanics and preclinical testing of artificial joints: the hip / Rik Huiskes and Jan Stolk -- Biomechanics of total knee replacement designs / Peter S. Walker.

Mechanobiology

Author : J. F. Stoltz
Publisher : IOS Press
ISBN 13 : 9781586034368
Total Pages : 758 pages
Book Rating : 4.0/5 (343 download)

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Book Synopsis Mechanobiology by : J. F. Stoltz

Download or read book Mechanobiology written by J. F. Stoltz and published by IOS Press. This book was released on 2004 with total page 758 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mechanobiology is now a vigorous branch of biomechanics and biorheology which is mainly concerned with the study of the influence of mechanical forces on cells and tissues and their clinical or therapeutical applications. As we are now at the age of proteomics and genomics and of cell micromechanical approaches, using methods like laser tweezers or confocal microscopy, mechanobiology brings new challenges. With these new researches, mechanobiology is the promise of new diagnostic and therapeutic approaches. T to the system under scrutiny and that stresses are implicated in tissue physiology (for example by the production of the extracellular matrix), secretions (i.e. production of NO and prostaglandins by endothelial cells), or for the induction of specific functions via intercellular communication; hence the interest from pharmacology in studies on new molecules. Moreover, these new findings have led to the development of tissue engineering, which is the concept of substitute tissue developed in vitro, from bioresorbable or non-bioresorbable scaffolds and from cells harvested in a physiologic mechanical environment such as from cartilage, bone and vessels. At the same time, the problem of cell grafting in tissue repair and especially the use of stem cells have led to new therapeutic fields.

The Science, Etiology and Mechanobiology of Diabetes and its Complications

Author : Amit Gefen
Publisher : Academic Press
ISBN 13 : 0128210710
Total Pages : 436 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis The Science, Etiology and Mechanobiology of Diabetes and its Complications by : Amit Gefen

Download or read book The Science, Etiology and Mechanobiology of Diabetes and its Complications written by Amit Gefen and published by Academic Press. This book was released on 2021-04-21 with total page 436 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Science, Etiology and Mechanobiology of Diabetes and Its Complications presents the most comprehensive synthesis of contemporary global research on diabetes, covering a novel and unique mechanobiological perspective – addressing prevention, management and treatment of tissue, organ and body system damage associated with diabetes and its complications. The book provides a unique approach to communicating diabetes-associated symptoms and opens avenues for development of novel therapeutic and preventive methods. It offers descriptive pathophysiology of diabetes and its complications with great emphasis on mechanobiology. Content coverage also includes management of tissue, organ and body system damage caused by chronic hyperglycemia. Biologists, life scientists, physicians, pharmacists, biomedical engineers, medical physicists, biomathematicians and computer scientists who are interested in the state-of-science and current challenges in the mechanobiology of diabetes should find this book very useful. Likewise, medical researchers in fields such as endocrinology, cardiovascular medicine, oncology, obesity, the immune system, inflammation and wound care and others who wish to be updated about the latest achievements in this exciting arena of research will find that information here. Covers the state-of-knowledge in diabetes research from a mechanobiological perspective, including cell death and (neural, connective, adipose, vascular, renal etc.) tissue damage cascades and healing processes Describes state-of-the-art technology in prevention, diagnosis, prognosis and treatment of tissue, organ and body system damage caused by chronic hyperglycemia and diabetes Explores emerging research directions and future technology trends in the field of diabetes prevention and care, including common complications of diabetes (foot ulcers and amputation, peripheral neuropathy, retinal damage, renal damage, vascular and cardiac damage, connective tissue damage etc.) at the early stage of research and development in academia and industry

Progress in Industrial Mathematics at ECMI 2008

Author : Alistair D. Fitt
Publisher : Springer Science & Business Media
ISBN 13 : 3642121101
Total Pages : 1060 pages
Book Rating : 4.6/5 (421 download)

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Book Synopsis Progress in Industrial Mathematics at ECMI 2008 by : Alistair D. Fitt

Download or read book Progress in Industrial Mathematics at ECMI 2008 written by Alistair D. Fitt and published by Springer Science & Business Media. This book was released on 2010-07-23 with total page 1060 pages. Available in PDF, EPUB and Kindle. Book excerpt: The 15th European Conference on Mathematics for Industry was held in the agreeable surroundings of University College London, just 5 minutes walk from the British Museum in the heart of London, over the ?ve warm, sunny days from 30 June to 4 July 2008. Participants from all over the world met with the commonaimofreinforcingthe roleofmathematics asanoverarching resource for industry and business. The conference attracted over 300 participants from 30 countries, most of them participating with either a contributed talk, a minisymposium pres- tation or a plenary lecture. ‘Mathematics in Industry’ was interpreted in its widest sense as can be seen from the range of applications and techniques described in this volume. We mention just two examples. The Alan Tayler Lecture was given by Mario Primicerio on a problem arising from moving oil through pipelines when temperature variations a?ect the shearing properties of wax and thus modify the ?ow. The Wacker Prize winner, Master’s student Lauri Harhanen from the Helsinki University of Technology, showed how a novel piece of mathematics allowed new software to capture real-time images of teeth from the data supplied by present day dental machinery (see ECMI Newsletter 44). The meeting was attended by leading ?gures from government, bu- ness and science who all shared the same aim – to promote the application of innovative mathematics to industry, and identify industrial sectors that o?er the most exciting opportunities for mathematicians to provide new insight and new ideas.

Mechanobiology

Author : Simon C. F. Rawlinson
Publisher : John Wiley & Sons
ISBN 13 : 1118966147
Total Pages : 440 pages
Book Rating : 4.1/5 (189 download)

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Book Synopsis Mechanobiology by : Simon C. F. Rawlinson

Download or read book Mechanobiology written by Simon C. F. Rawlinson and published by John Wiley & Sons. This book was released on 2017-02-06 with total page 440 pages. Available in PDF, EPUB and Kindle. Book excerpt: An emerging field at the interface of biology and engineering, mechanobiology explores the mechanisms by which cells sense and respond to mechanical signals—and holds great promise in one day unravelling the mysteries of cellular and extracellular matrix mechanics to cure a broad range of diseases. Mechanobiology: Exploitation for Medical Benefit presents a comprehensive overview of principles of mechanobiology, highlighting the extent to which biological tissues are exposed to the mechanical environment, demonstrating the importance of the mechanical environment in living systems, and critically reviewing the latest experimental procedures in this emerging field. Featuring contributions from several top experts in the field, chapters begin with an introduction to fundamental mechanobiological principles; and then proceed to explore the relationship of this extensive force in nature to tissues of musculoskeletal systems, heart and lung vasculature, the kidney glomerulus, and cutaneous tissues. Examples of some current experimental models are presented conveying relevant aspects of mechanobiology, highlighting emerging trends and promising avenues of research in the development of innovative therapies. Timely and important, Mechanobiology: Exploitation for Medical Benefit offers illuminating insights into an emerging field that has the potential to revolutionise our comprehension of appropriate cell biology and the future of biomedical research.

Neural Tissue Biomechanics

Author : Lynne E. Bilston
Publisher : Springer Science & Business Media
ISBN 13 : 364213890X
Total Pages : 288 pages
Book Rating : 4.6/5 (421 download)

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Book Synopsis Neural Tissue Biomechanics by : Lynne E. Bilston

Download or read book Neural Tissue Biomechanics written by Lynne E. Bilston and published by Springer Science & Business Media. This book was released on 2011-07-23 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: Damage to the central nervous system resulting from pathological mechanical loading can occur as a result of trauma or disease. Such injuries lead to significant disability and mortality. The peripheral nervous system, while also subject to injury from trauma and disease, also transduces physiological loading to give rise to sensation, and mechanotransduction is also thought to play a role in neural development and growth. This book gives a complete and quantitative description of the fundamental mechanical properties of neural tissues, and their responses to both physiological and pathological loading. This book reviews the methods used to characterize the nonlinear viscoelastic properties of central and peripheral neural tissues, and the mathematical and sophisticated computational models used to describe this behaviour. Mechanisms and models of neural injury from both trauma and disease are reviewed from the molecular to macroscopic scale. The book provides a comprehensive picture of the mechanical and biological response of neural tissues to the full spectrum of mechanical loading to which they are exposed. This book provides a comprehensive reference for professionals involved in pre prevention of injury to the nervous system, whether this arises from trauma or disease.

Mechanobiology

Author : Glen L. Niebur
Publisher : Elsevier
ISBN 13 : 0128179325
Total Pages : 256 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Mechanobiology by : Glen L. Niebur

Download or read book Mechanobiology written by Glen L. Niebur and published by Elsevier. This book was released on 2019-12-01 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mechanobiology: From Molecular Sensing to Disease will provide a review of the current state of understanding of mechanobiology and its role in health and disease. It covers: Current understanding of the main molecular pathways by which cells sense and respond to mechanical stimuli, A review of diseases that with known or purported mechanobiological underpinnings; The role of mechanobiology in tissue engineering and regenerative medicine; Experimental methods to capture mechanobiological phenomena; Computational models in mechanobiology. Presents our current understanding of the main molecular pathways by which cells sense and respond to mechanical stimuli Provides a review of diseases with known or purported mechanobiological underpinnings Includes the role of mechanobiology in tissue engineering and regenerative medicine Covers experimental methods to capture mechanobiological phenomena