The Lec Rat

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The LEC Rat

Author : Michio Mori
Publisher : Springer Science & Business Media
ISBN 13 : 4431681531
Total Pages : 365 pages
Book Rating : 4.4/5 (316 download)

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Book Synopsis The LEC Rat by : Michio Mori

Download or read book The LEC Rat written by Michio Mori and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 365 pages. Available in PDF, EPUB and Kindle. Book excerpt: The LEC strain of rats, which spontaneously develop acute hepatitis as sociated with jaundice, chronic hepatitis, and ultimately hepatocellular carcinomas, was established by scientists in Sapporo, Japan. Careful ob servation and breeding led to the initial discovery of this characteristic, inherited liver disease in rats. Subsequent collaboration between scientists in Sapporo and other centers has revealed an autosomal recessive nature of inheritance, along with a variety of histopathological and biochemical findings. The causative mechanism(s) underlying this abnormality remained a mystery for some time, providing a challenge for many scientists who were attracted to the quest for clues to this enigma. In particular, the mech anism of spontaneous development of hepatocellular carcinomas in rats overcoming the acute phase of hepatitis and surviving with chronic hepatitis proved extremely interesting, because the involvement of a causative virus had been excluded in the early stages of investigation. Professor Michio Mori of Sapporo Medical College played a key role in the study of LEC rats, especially in the elucidation of the pathogenesis of hepatitis and hepatocellular carcinoma. He is one of the editors of this monograph which is composed of original contributions by the many scientists who have carried out their own studies on LEC rats. Of the various histopathological and biochemical alterations which have been reported, some are clearly secondary or tertiary events sequential to the primary change caused by gene mutation.

Trace Elements in Man and Animals--9

Author : National Research Council Canada
Publisher : NRC Research Press
ISBN 13 : 9780660164045
Total Pages : 710 pages
Book Rating : 4.1/5 (64 download)

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Book Synopsis Trace Elements in Man and Animals--9 by : National Research Council Canada

Download or read book Trace Elements in Man and Animals--9 written by National Research Council Canada and published by NRC Research Press. This book was released on 1997 with total page 710 pages. Available in PDF, EPUB and Kindle. Book excerpt: Presents papers from an international meeting of specialists from a variety of disciplines sharing an interest in trace elements. The papers are organized into broad categories covering such topics as trace element interactions in the food supply and nutrition; trace elements and genetic regulation; trace elements in pregnancy and lactation; assessment of trace element status; kinetic modelling; trace elements in the environment and food supply; trace elements, brain function, and behaviour; membrane function and cell signalling; analytical, experimental, and isotopic techniques; ethics of trace element research; defining trace element requirements of infants; trace element intervention studies; trace elements and animal production, free-radical mediated disease, and food and nutrition policy; analytical quality control; infection and immune function; trace element binding proteins; trace elements in growth and metabolism; mechanisms of trace element toxicity; and metabolic and physiological consequences of trace element deficiencies.

Copper in Drinking Water

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309172209
Total Pages : 161 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Copper in Drinking Water by : National Research Council

Download or read book Copper in Drinking Water written by National Research Council and published by National Academies Press. This book was released on 2000-04-12 with total page 161 pages. Available in PDF, EPUB and Kindle. Book excerpt: The safety of the nation's drinking water must be maintained to ensure the health of the public. The U.S. Environmental Protection Agency (EPA) is responsible for regulating the levels of substances in the drinking water supply. Copper can leach into drinking water from the pipes in the distribution system, and the allowable levels are regulated by the EPA. The regulation of copper, however, is complicated by the fact that it is both necessary to the normal functioning of the body and toxic to the body at too high a level. The National Research Council was requested to form a committee to review the scientific validity of the EPA's maximum contaminant level goal for copper in drinking water. Copper in Drinking Water outlines the findings of the committee's review. The book provides a review of the toxicity of copper as well as a discussion of the essential nature of this metal. The risks posed by both short-term and long-term exposure to copper are characterized, and the implications for public health are discussed. This book is a valuable reference for individuals involved in the regulation of water supplies and individuals interested in issues surrounding this metal.

Clinical and Translational Perspectives on WILSON DISEASE

Author : Nanda Kerkar
Publisher : Academic Press
ISBN 13 : 012810533X
Total Pages : 503 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Clinical and Translational Perspectives on WILSON DISEASE by : Nanda Kerkar

Download or read book Clinical and Translational Perspectives on WILSON DISEASE written by Nanda Kerkar and published by Academic Press. This book was released on 2018-09-18 with total page 503 pages. Available in PDF, EPUB and Kindle. Book excerpt: Clinical and Translational Perspectives on Wilson Disease brings together the genetics, cell and structural biology of Wilson Disease into one contemporary, easy to navigate handbook. Created to meet the diverse needs of the clinical and research communities surrounding Wilson Disease, this reference provides a worldwide approach that is concise and translational. Specifically, it provides a basis for clinicians to appreciate 'basic science' aspects of Wilson disease, presenting a guide for researchers to understand the clinical disorder on which their research is focused and fostering constructive dialogue and progress for this puzzling disorder. - Delivers numerous, succinct, expert chapters with summaries designed for quick reference - Includes a 'How-to appendix' for diagnosis and management tips - Contains access to a companion website with a self-help teaching module, links to key resources, and an extended reference list

The Laboratory Rat

Author : George J. Krinke
Publisher : Elsevier
ISBN 13 : 0080533469
Total Pages : 783 pages
Book Rating : 4.0/5 (85 download)

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Book Synopsis The Laboratory Rat by : George J. Krinke

Download or read book The Laboratory Rat written by George J. Krinke and published by Elsevier. This book was released on 2000-06-20 with total page 783 pages. Available in PDF, EPUB and Kindle. Book excerpt: This reference series will provide all researchers using laboratory animals with comprehensive practical information on the various species. Each title in the series is devoted to a particular species, and draws together all available data in a "one-stop", easily accessible source. Each has similar format, with sections on the strains available, their husbandry, and special diets. Also included are sections on gross anatomy, endocrinology, and reproduction, followed by more detailed sections on neuroanatomy, vasculature, cell biology, and histology of particular organs and structures, and a section on molecular biology. High quality illustrations are included throughout and a color plate section is provided. A glossary, list of equipment suppliers, and "Quick Reference Section" are added features. The "Quick Reference Section" brings together all tables from the text, allowing readers to find data swiftly. The first volume in The Handbook of Experimental Animals Series, The Laboratory Rat, provides researchers in academia and industry using laboratory animals with comprehensive, practical information on the species. The Laboratory Rat has been divided into eight sections dealing with:* Strains and their selection for research* Housing and maintenance* Pathogens and diseases* Breeding and reproduction* Anatomy* Physiology* Procedures, including experimental surgery* Emerging techniques, including genetic engineering and molecular technologyKey Features* Provides a valuable, comprehensive reference source for anybody working with the laboratory rat* Formatted in a two-color, user-friendly layout* Includes high-quality illustrations throughout as well as a color plate section* Glossary* Tables in the text are also arranged into one Quick Reference Section for ease of access to the data* Appendix of equipment suppliers

Hepatocyte Transplantation

Author : S. Gupta
Publisher : Springer Science & Business Media
ISBN 13 : 9780792387763
Total Pages : 386 pages
Book Rating : 4.3/5 (877 download)

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Book Synopsis Hepatocyte Transplantation by : S. Gupta

Download or read book Hepatocyte Transplantation written by S. Gupta and published by Springer Science & Business Media. This book was released on 2002-09-30 with total page 386 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years there has been an increasing need for transplantation, but the number of donor livers available has increased only slightly, despite intensive public relations activities. New concepts in the field of transplantation, for instance the transplantation of living donor organs or the splitting of organs, are urgently required, to safeguard the treatment of patients with severe liver disease. The development and clinical application of cell therapy for patients with liver disease could soon present a significant enhancement of the therapeutic options. The aim of such cell therapy is to repair or improve the biological function of the chronically and acutely damaged liver. Even though systematic trials are not available, individual case reports and small series already show promising clinical results. Present concepts of cell therapy for liver diseases based on the use of primary hepatocytes have recently been considerably extended through new data on the biology of stem cells. The adult haematopoetic stem cell as a pool for hepatocyte grafts - what would be the perspectives for the clinical application? This book is the proceedings of the Falk Symposium No. 126 on `Hepatocyte Transplantation' (Progress in Gastroenterology and Hepatology Part III) held in Hannover, Germany, October 2-3, 2001, and is a forum for basic research, but also for questions concerning clinical applications in the field of hepatocyte transplantation.

Copper in Drinking Water

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309069394
Total Pages : 162 pages
Book Rating : 4.3/5 (9 download)

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Book Synopsis Copper in Drinking Water by : National Research Council

Download or read book Copper in Drinking Water written by National Research Council and published by National Academies Press. This book was released on 2000-05-12 with total page 162 pages. Available in PDF, EPUB and Kindle. Book excerpt: The safety of the nation's drinking water must be maintained to ensure the health of the public. The U.S. Environmental Protection Agency (EPA) is responsible for regulating the levels of substances in the drinking water supply. Copper can leach into drinking water from the pipes in the distribution system, and the allowable levels are regulated by the EPA. The regulation of copper, however, is complicated by the fact that it is both necessary to the normal functioning of the body and toxic to the body at too high a level. The National Research Council was requested to form a committee to review the scientific validity of the EPA's maximum contaminant level goal for copper in drinking water. Copper in Drinking Water outlines the findings of the committee's review. The book provides a review of the toxicity of copper as well as a discussion of the essential nature of this metal. The risks posed by both short-term and long-term exposure to copper are characterized, and the implications for public health are discussed. This book is a valuable reference for individuals involved in the regulation of water supplies and individuals interested in issues surrounding this metal.

Experimental Protocols for Reactive Oxygen and Nitrogen Species

Author : Naoyuki Taniguchi
Publisher : OUP Oxford
ISBN 13 : 0191589098
Total Pages : 361 pages
Book Rating : 4.1/5 (915 download)

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Book Synopsis Experimental Protocols for Reactive Oxygen and Nitrogen Species by : Naoyuki Taniguchi

Download or read book Experimental Protocols for Reactive Oxygen and Nitrogen Species written by Naoyuki Taniguchi and published by OUP Oxford. This book was released on 2000-06-15 with total page 361 pages. Available in PDF, EPUB and Kindle. Book excerpt: Experimental Protocols for Reactive Oxygen and Nitrogen Species is a translated, expanded, and fully updated of the Japanese book Experimental Protocols for Reactive Oxygen Research: assay methods, gene analysis, and pathophysiology models published in 1994. The aim of the book is to provide experimental protocols covering many aspects of free radical research: biochemistry, molecular and cellular biology, genetics, physiology, and medicine. The protocols are all self-contained describing the equipment and reagents needed and then detailing the experimental procedure.

Wilson Disease

Author : Karl Heinz Weiss
Publisher : Academic Press
ISBN 13 : 0128110783
Total Pages : 266 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Wilson Disease by : Karl Heinz Weiss

Download or read book Wilson Disease written by Karl Heinz Weiss and published by Academic Press. This book was released on 2019-05-21 with total page 266 pages. Available in PDF, EPUB and Kindle. Book excerpt: Wilson Disease: Pathogenesis, Molecular Mechanisms, Diagnosis, Treatment and Monitoring translates both clinical and experimental findings into a comprehensive approach for anyone involved in research and patient care. While the clinical variability of Wilson Disease poses a challenge from a diagnostic approach, the book uses the translational impact of new research findings to relate to new treatment concepts. Comprehensive chapters include common knowledge, guideline consensus statements, and discussions of clinical evidence. This is a must-have reference for researchers and clinicians in translational research. - Delivers a substantial overview of evidence driven diagnostic pathways and treatment concepts for Wilson disease - Provides an understanding of the translational impact of new research findings in Wilson Disease - Reveals the current controversies in treatment decisions for Wilson disease, providing the best decisions for optimal patient care

Comparative Pathology Bulletin

Author :
Publisher :
ISBN 13 :
Total Pages : 140 pages
Book Rating : 4.:/5 (31 download)

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Book Synopsis Comparative Pathology Bulletin by :

Download or read book Comparative Pathology Bulletin written by and published by . This book was released on 1992 with total page 140 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Wilson Disease

Author : Anna Czlonkowska
Publisher : Elsevier
ISBN 13 : 0444636277
Total Pages : 264 pages
Book Rating : 4.4/5 (446 download)

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Book Synopsis Wilson Disease by : Anna Czlonkowska

Download or read book Wilson Disease written by Anna Czlonkowska and published by Elsevier. This book was released on 2017-04-18 with total page 264 pages. Available in PDF, EPUB and Kindle. Book excerpt: Wilson Disease provides a comprehensive guide on this inherited genetic disorder that has devastating consequences for both the liver and neurologic/psychiatric health. This disease is of increasing interest to neurologists, hepatologists, and geneticists, but when the disease is diagnosed early, it is treatable, with patients living normal lives. This volume describes the molecular pathophysiology of WD and the clinical and pathological effects of copper. Separate sections address both diagnosis and medical and surgical approaches to treatment. Both adult and pediatric perspectives on diagnosis and treatment are addressed, and a section on genetics highlights advances in molecular diagnostics. Patient support groups that can aid in coping with this disease are also discussed, as are animal models for those interested in basic research on cell biology, pathophysiology, and treatment. - Addresses the molecular pathophysiology of WD and the clinical and pathological effects of copper - Offers coverage of both diagnosis and medical and surgical approaches to treatment - Includes perspectives on both adult and pediatric diagnosis and treatment - Edited work with chapters authored by leaders in the field from around the globe—the broadest, most expert coverage available

Wilson’s Disease

Author : George J. Brewer
Publisher : Springer Science & Business Media
ISBN 13 : 9780792373544
Total Pages : 222 pages
Book Rating : 4.3/5 (735 download)

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Book Synopsis Wilson’s Disease by : George J. Brewer

Download or read book Wilson’s Disease written by George J. Brewer and published by Springer Science & Business Media. This book was released on 2001-05-31 with total page 222 pages. Available in PDF, EPUB and Kindle. Book excerpt: Movement disorder specialists, general neurologists, hepatologists, general gastroenterologists, and psychiatrists are the specialists who will most likely see some Wilson's disease patients during their careers. See them - yes. Recognize and diagnose them - maybe. If you are in one of these specialties, and a patient with tremor, hepatitis, cirrhosis, apparent Parkinsonism, or mood disorder, is referred to you, will you appropriately recognize the possibility that the underlying diagnosis may be Wilson's disease? Wilson's disease is both treatable and reversible, and commonly misdiagnosed. This book aims to change this with comprehensive coverage of every aspect of Wilson's disease, from well-catalogued, easy-to-use clinical diagnostic tools to treatment methods to molecular biology. Dr. Brewer is the world's leading expert on Wilson's disease, seeing and caring for over 300 patients with the disease during the last 20 years. He is a professor of human genetics at the University of Michigan.

Handbook of Copper Pharmacology and Toxicology

Author : Edward J. Massaro
Publisher : Springer Science & Business Media
ISBN 13 : 1592592880
Total Pages : 600 pages
Book Rating : 4.5/5 (925 download)

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Book Synopsis Handbook of Copper Pharmacology and Toxicology by : Edward J. Massaro

Download or read book Handbook of Copper Pharmacology and Toxicology written by Edward J. Massaro and published by Springer Science & Business Media. This book was released on 2002-07-01 with total page 600 pages. Available in PDF, EPUB and Kindle. Book excerpt: Edward J. Massaro and a panel of leading biomedical researchers and clinical practitioners review, in-depth, the status of our current knowledge concerning the biochemistry of copper in general and its role in health and disease in particular. Drawing on the wealth of new information emerging from the molecular biology revolution, these experts survey the most important research areas of copper pharmacology and toxicology, including copper proteins and transport, copper toxicity and therapeutics, and copper metabolism and homeostasis. They also discuss the molecular pathogenesis of copper in a variety of metabolic diseases, Menkes and Wilson's diseases and occipital horn syndrome, as well as the role of copper in Parkinson's disease, prion disease, familial amytrophic lateral sclerosis (ALS), and Alzheimer's disease.

Advances in Genetics

Author :
Publisher : Academic Press
ISBN 13 : 0080568203
Total Pages : 349 pages
Book Rating : 4.0/5 (85 download)

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Book Synopsis Advances in Genetics by :

Download or read book Advances in Genetics written by and published by Academic Press. This book was released on 1995-11-14 with total page 349 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Genetics increases its focus on modern human genetics and its relation to medicine with Volume 33 of this long-standing serial. The recent merger of Molecular Genetic Medicine with Advances in Genetics affirms the Academic Press commitment to publish important reviews of the broadest interest to geneticists and their colleagues in affiliated disciplines.In this volume, Petes and Pukkila synthesize the latest research on meiotic recombination, with specific reference to crossover and gene conversions. The "absurd size and complex" structure of the Dystrophin gene is considered in another chapter, with discussions of strategies for future diagnosis and treatment of muscular dystrophy. Two chapters also examine the molecular genetics of sex determination, including the influence of maternal age and resulting chromosomal aberrations. Volume 33 also includes a review of the PAX and HOX gene families and their links to the developmental process, cellular growth control, and forms of cancer. Case studies of thrombophilia, Menkes, and Wilson diseases are used to exemplify the genetic disorders of blood clotting, copper deficiency, and toxicity, respectively. Triman takes a genetic approach to understanding the function of ribosomal RNA using E. coli as the model best able to reveal the inherent complications of the translation process. Leach and O'Connell describe the use of radiation hybrids for constructing high-resolution maps of the human genome. With these reviews the alliance of Molecular Genetic Medicine with Advances in Genetics is completed under the banner of Advances in Genetics.Key Features* Presents technical and historical overviews of molecular biology applied to disease detection, diagnosis, and treatment* Chronicles the continuing explosion of knowledge in molecular genetic medicine by highlighting current approaches to understanding human illness* Documents the revolution in human and molecular genetics leading to a new field of medicine* This volume highlights Analysis of human chromosomes with chapters on pathology of sex determination and numerical chromosomal abnormalities Molecular and genetic bases of muscular dystrophy and Menkes and Wilson diseases Techniques including FISH, IRS-PCR, and radiation hybrids

Trace Elements in Laboratory Rodents

Author : Ronald R. Watson
Publisher : CRC Press
ISBN 13 : 1000151794
Total Pages : 420 pages
Book Rating : 4.0/5 (1 download)

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Book Synopsis Trace Elements in Laboratory Rodents by : Ronald R. Watson

Download or read book Trace Elements in Laboratory Rodents written by Ronald R. Watson and published by CRC Press. This book was released on 2020-10-28 with total page 420 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by the international community's leading experts, Trace Elements in Laboratory Rodents describes the best and most current methods to provide deficient or supplemental trace elements to laboratory animals, as well as how to assay them. The experts warn of the common pitfalls and hidden problems in nutritional testing and how to avoid them. This how-to approach focuses on the technical details that make good, reliable studies. Common as well as rare or recently recognized minerals are described relating to both dietary supplementation and measurement in tissues. If you are a researcher, professor, or student working in nutrition, food science, biochemistry, or veterinary medicine, you can't afford to be without this excellent hands-on methods manual!

Molecular Biology of Metal Homeostasis and Detoxification

Author : Markus J. Tamás
Publisher : Springer Science & Business Media
ISBN 13 : 3540317198
Total Pages : 519 pages
Book Rating : 4.5/5 (43 download)

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Book Synopsis Molecular Biology of Metal Homeostasis and Detoxification by : Markus J. Tamás

Download or read book Molecular Biology of Metal Homeostasis and Detoxification written by Markus J. Tamás and published by Springer Science & Business Media. This book was released on 2006-07-07 with total page 519 pages. Available in PDF, EPUB and Kindle. Book excerpt: One of the challenges faced by every cell as well as by whole organisms is to maintain appropriate concentrations of essential nutrient metals while excluding nonessential toxic metals. Toward that end, all organisms have developed mechanisms for metal homeostasis and detoxification to maintain metal levels within physiological limits. This book brings together current knowledge of the molecular basis of metal homeostasis and detoxification in various eukaryotic model systems, including yeasts, plants, and mammals. It focuses on the cellular systems controlling metal transport, intracellular distribution, and immobilization as well as on systems regulating metal-dependent transcription. In addition to environmental aspects (including phytoremediation), the book treats the pathophysiology of metal deficiency and overload in relation to disease.

Handbook of Vertebrate Immunology

Author : Paul-Pierre Pastoret
Publisher : Academic Press
ISBN 13 : 0125464010
Total Pages : 699 pages
Book Rating : 4.1/5 (254 download)

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Book Synopsis Handbook of Vertebrate Immunology by : Paul-Pierre Pastoret

Download or read book Handbook of Vertebrate Immunology written by Paul-Pierre Pastoret and published by Academic Press. This book was released on 1998-06-02 with total page 699 pages. Available in PDF, EPUB and Kindle. Book excerpt: This unique book provides a comprehensive and comparative guide to the immune systems of major vertebrate species, including domestic and wild animals of veterinary or medical interest, fish and amphibia. Data in this essential reference work has been compiled by world-renowned editors and an international group of authors. For each species, the information is presented in a structured 'user-friendly' format allowing easy cross reference and comparison between the various species. This book will be considered the definitive reference work on vertebrate immunology and will be essential for scientists and professionals working in Immunology, Vaccinology or with Animal Models, for students of Veterinary or Human Medicine, Biology and researchers in Comparative Medicine and Physiology. Each section, devoted to a major animal group covers: Lymphoid organs and their anatomical disposition Leukocytes and their markers Leukocyte traffic and associated molecules Cytokines T cell receptors Immunoglobulins MHC antigens Ontogeny of the immune system Passive transfer of immunity Neonatal immune responses Non-specific immunity Complement system Mucosal immunity Immunodeficiencies Tumours of the immune system Autoimmunity